{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:54:22Z","timestamp":1790744062850,"version":"4.1.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T00:00:00Z","timestamp":1586390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.00601","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T04:37:30Z","timestamp":1586407050000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Tissue Infiltrating LTi\u2014Like Group 3 Innate Lymphoid Cells and T Follicular Helper Cells in Graves' and Hashimoto's Thyroiditis"],"prefix":"10.3389","volume":"11","author":[{"given":"Audrey","family":"Mohr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Tr\u00e9sallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natacha","family":"Monot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeline","family":"Bauvois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Abiven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Atif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Cla\u00ebr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajneesh","family":"Malhotra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00ebll","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Balderas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Outi","family":"Vaarala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Deniziaut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Brocheriou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Buffet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Leenhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Gorochov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Miyara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,4,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"979167","DOI":"10.1155\/2015\/979167","article-title":"Immune disorders in Hashimoto's thyroiditis: what do we know so far?","volume":"2015","author":"Pyzik","year":"2015","journal-title":"J Immunol Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2646","DOI":"10.1056\/NEJMra021194","article-title":"Thyroiditis","volume":"348","author":"Pearce","year":"2003","journal-title":"N Engl J Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.cell.2008.05.009","article-title":"Regulatory T cells and immune tolerance","volume":"133","author":"Sakaguchi","year":"2008","journal-title":"Cell."},{"key":"B4","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.immuni.2009.03.019","article-title":"Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor","volume":"30","author":"Miyara","year":"2009","journal-title":"Immunity."},{"key":"B5","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.autrev.2011.05.004","article-title":"Human FoxP3+ regulatory T cells in systemic autoimmune diseases","volume":"10","author":"Miyara","year":"2011","journal-title":"Autoimmun Rev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"a029041","DOI":"10.1101\/cshperspect.a029041","article-title":"Regulatory T cells: from discovery to autoimmunity","volume":"8","author":"Kitz","year":"2018","journal-title":"Cold Spring Harb Perspect Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/cei.13288","article-title":"The role of FOXP3(+) regulatory T cells in human autoimmune and inflammatory diseases","volume":"197","author":"Mohr","year":"2019","journal-title":"Clin Exp Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"3639","DOI":"10.1210\/jc.2005-2337","article-title":"Regulatory T cells in human autoimmune thyroid disease","volume":"91","author":"Marazuela","year":"2006","journal-title":"J Clin Endocrinol Metab."},{"key":"B9","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1111\/j.1365-2265.2009.03544.x","article-title":"Regulatory T cells in Graves' disease","volume":"71","author":"Pan","year":"2009","journal-title":"Clin Endocrinol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"4734","DOI":"10.4049\/jimmunol.0904135","article-title":"Impairment of regulatory capacity of CD4+CD25+ regulatory T cells mediated by dendritic cell polarization and hyperthyroidism in Graves' disease","volume":"186","author":"Mao","year":"2011","journal-title":"J Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1089\/thy.2012.0514","article-title":"Impairment of regulatory T-cell function in autoimmune thyroid disease","volume":"23","author":"Glick","year":"2013","journal-title":"Thyroid."},{"key":"B12","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/S0002-9440(10)61762-2","article-title":"Thyroid autoimmune disease: demonstration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing active intrathyroidal germinal centers","volume":"159","author":"Armengol","year":"2001","journal-title":"Am J Pathol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.3389\/fimmu.2018.01637","article-title":"T follicular helper cells in autoimmune disorders","volume":"9","author":"Gensous","year":"2018","journal-title":"Front Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1111\/imm.12697","article-title":"Functional and phenotypic heterogeneity of group 3 innate lymphoid cells","volume":"150","author":"Melo-Gonzalez","year":"2017","journal-title":"Immunology."},{"key":"B15","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1210\/jc.2011-2003","article-title":"Increased frequency of follicular helper T cells in patients with autoimmune thyroid disease","volume":"97","author":"Zhu","year":"2012","journal-title":"J Clin Endocrinol Metab."},{"key":"B16","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1007\/s12026-015-8647-z","article-title":"Elevated follicular helper T cells and expression of IL-21 in thyroid tissues are involved in the pathogenesis of Graves' disease","volume":"62","author":"Zhang","year":"2015","journal-title":"Immunol Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"7225","DOI":"10.1073\/pnas.1508224112","article-title":"Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3high regulatory T cells in humans","volume":"112","author":"Miyara","year":"2015","journal-title":"Proc Natl Acad Sci USA."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science."},{"key":"B19","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s12020-015-0569-y","article-title":"The possible role of CD4(+)CD25(high)Foxp3(+)\/CD4(+)IL-17A(+) cell imbalance in the autoimmunity of patients with Hashimoto thyroiditis","volume":"50","author":"Xue","year":"2015","journal-title":"Endocrine."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.3389\/fimmu.2018.01910","article-title":"Control of germinal center responses by T-follicular regulatory cells","volume":"9","author":"Wing","year":"2018","journal-title":"Front Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"401","DOI":"10.3389\/fimmu.2016.00401","article-title":"Understanding immune cells in tertiary lymphoid organ development: it is all starting to come together","volume":"7","author":"Jones","year":"2016","journal-title":"Front Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.immuni.2014.10.004","article-title":"T follicular helper cell differentiation, function, and roles in disease","volume":"41","author":"Crotty","year":"2014","journal-title":"Immunity."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1136\/ard.2008.096172","article-title":"Is the blood B-cell subset profile diagnostic for Sjogren syndrome?","volume":"68","author":"Binard","year":"2009","journal-title":"Ann Rheum Dis."},{"key":"B24","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1007\/s12020-015-0662-2","article-title":"Levels of regulatory T cells CD69(+)NKG2D(+)IL-10(+) are increased in patients with autoimmune thyroid disorders","volume":"51","author":"Rodriguez-Munoz","year":"2016","journal-title":"Endocrine."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2983","DOI":"10.1182\/blood-2007-06-094656","article-title":"Induction of FOXP3 expression in naive human CD4+FOXP3 T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype","volume":"110","author":"Tran","year":"2007","journal-title":"Blood."},{"key":"B26","doi-asserted-by":"publisher","first-page":"3869","DOI":"10.4049\/jimmunol.1103627","article-title":"The TIGIT\/CD226 axis regulates human T cell function","volume":"188","author":"Lozano","year":"2012","journal-title":"J Immunol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"3687","DOI":"10.4049\/jimmunol.1401803","article-title":"Coexpression of TIGIT and FCRL3 identifies Helios+ human memory regulatory T cells","volume":"194","author":"Bin Dhuban","year":"2015","journal-title":"J Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"E2116","DOI":"10.1073\/pnas.1307185110","article-title":"Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression","volume":"110","author":"Yamaguchi","year":"2013","journal-title":"Proc Natl Acad Sci USA."},{"key":"B29","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1038\/nri1054","article-title":"Organogenesis of lymphoid tissues","volume":"3","author":"Mebius","year":"2003","journal-title":"Nat Rev Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.cytogfr.2018.02.004","article-title":"Lymphoid tissue inducer-A divergent member of the ILC family","volume":"42","author":"Zhong","year":"2018","journal-title":"Cytokine Growth Factor Rev."},{"key":"B31","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1182\/blood-2013-11-427781","article-title":"Human innate lymphoid cells","volume":"124","author":"Hazenberg","year":"2014","journal-title":"Blood."},{"key":"B32","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1530\/eje.0.1500225","article-title":"The role of CXCR5 and its ligand CXCL13 in the compartmentalization of lymphocytes in thyroids affected by autoimmune thyroid diseases","volume":"150","author":"Aust","year":"2004","journal-title":"Eur J Endocrinol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1056\/NEJMra0905750","article-title":"Graves' ophthalmopathy","volume":"362","author":"Bahn","year":"2010","journal-title":"N Engl J Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1055\/s-0035-1555762","article-title":"Current insights into the pathogenesis of Graves' ophthalmopathy","volume":"47","author":"Bahn","year":"2015","journal-title":"Horm Metab Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"7010196","DOI":"10.1155\/2018\/7010196","article-title":"Thyroid-associated orbitopathy and biomarkers: where we are and what we can hope for the future","volume":"2018","author":"Turck","year":"2018","journal-title":"Dis Markers."},{"key":"B36","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1089\/thy.1994.4.145","article-title":"The immunomodulatory effects of antithyroid drugs","volume":"4","author":"Weetman","year":"1994","journal-title":"Thyroid."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00601\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T04:37:33Z","timestamp":1586407053000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00601\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,9]]},"references-count":36,"alternative-id":["10.3389\/fimmu.2020.00601"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.00601","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,9]]},"article-number":"601"}}