{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:41:43Z","timestamp":1790757703937,"version":"4.1.0"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:00:00Z","timestamp":1588809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.00815","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T05:29:26Z","timestamp":1588829366000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Cortical Thymocytes Along With Their Selecting Ligands Are Required for the Further Thymic Maturation of NKT Cells in Mice"],"prefix":"10.3389","volume":"11","author":[{"given":"Jihene","family":"Klibi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamel","family":"Benlagha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,5,7]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1146\/annurev.immunol.25.022106.141711","article-title":"The biology of NKT cells.","volume":"25","author":"Bendelac","year":"2007","journal-title":"Annu Rev Immunol."},{"key":"B2","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1146\/annurev.immunol.15.1.535","article-title":"Mouse CD1-specific NK1 T cells: development, specificity, and function.","volume":"15","author":"Bendelac","year":"1997","journal-title":"Annu Rev Immunol."},{"key":"B3","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1084\/jem.191.11.1895","article-title":"In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers.","volume":"191","author":"Benlagha","year":"2000","journal-title":"J Exp Med."},{"key":"B4","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1126\/science.1069017","article-title":"A thymic precursor to the NK T cell lineage.","volume":"296","author":"Benlagha","year":"2002","journal-title":"Science."},{"key":"B5","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S1074-7613(04)00076-7","article-title":"T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells.","volume":"20","author":"Townsend","year":"2004","journal-title":"Immunity."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1038\/ni.2731","article-title":"Steady-state production of IL-4 modulates immunity in mouse strains and is determined by lineage diversity of iNKT cells.","volume":"14","author":"Lee","year":"2013","journal-title":"Nat Immunol."},{"key":"B7","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34793","article-title":"CCR7 defines a precursor for murine iNKT cells in thymus and periphery.","volume":"7","author":"Wang","year":"2018","journal-title":"eLife."},{"key":"B8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1084\/jem.184.1.9","article-title":"Positive and negative selection invoke distinct signaling pathways.","volume":"184","author":"Alberola-Ila","year":"1996","journal-title":"J Exp Med."},{"key":"B9","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.immuni.2007.08.020","article-title":"Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development.","volume":"27","author":"Griewank","year":"2007","journal-title":"Immunity."},{"key":"B10","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1126\/science.7538697","article-title":"CD1 recognition by mouse NK1+ T lymphocytes.","volume":"268","author":"Bendelac","year":"1995","journal-title":"Science."},{"key":"B11","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1084\/jem.182.6.1913","article-title":"TAP-independent, beta 2-microglobulin-dependent surface expression of functional mouse CD1.1.","volume":"182","author":"Brutkiewicz","year":"1995","journal-title":"J Exp Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1038\/ni.1641","article-title":"The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions.","volume":"9","author":"Kovalovsky","year":"2008","journal-title":"Nat Immunol."},{"key":"B13","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1084\/jem.182.6.2091","article-title":"Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes.","volume":"182","author":"Bendelac","year":"1995","journal-title":"J Exp Med."},{"key":"B14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1084\/jem.20050413","article-title":"Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes.","volume":"202","author":"Wei","year":"2005","journal-title":"J Exp Med."},{"key":"B15","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.4049\/jimmunol.175.6.3762","article-title":"The influence of CD1d in postselection NKT cell maturation and homeostasis.","volume":"175","author":"McNab","year":"2005","journal-title":"J Immunol."},{"key":"B16","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.4049\/jimmunol.171.8.4096","article-title":"T cell development in mice expressing CD1d directed by a classical MHC class II promoter.","volume":"171","author":"Forestier","year":"2003","journal-title":"J Immunol."},{"key":"B17","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/ni844","article-title":"Thymocyte expression of cathepsin L is essential for NKT cell development.","volume":"3","author":"Honey","year":"2002","journal-title":"Nat Immunol."},{"key":"B18","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1126\/science.278.5343.1626","article-title":"CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides.","volume":"278","author":"Kawano","year":"1997","journal-title":"Science."},{"key":"B19","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1126\/science.1103440","article-title":"Lysosomal glycosphingolipid recognition by NKT cells.","volume":"306","author":"Zhou","year":"2004","journal-title":"Science."},{"key":"B20","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.immuni.2015.06.025","article-title":"Tissue-specific distribution of iNKT cells impacts their cytokine response.","volume":"43","author":"Lee","year":"2015","journal-title":"Immunity."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.4049\/jimmunol.1303057","article-title":"An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cells.","volume":"192","author":"White","year":"2014","journal-title":"J Immunol."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05095-7","article-title":"Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70.","volume":"9","author":"Zhao","year":"2018","journal-title":"Nat Commun."},{"key":"B23","doi-asserted-by":"publisher","first-page":"22262","DOI":"10.1073\/pnas.1910412116","article-title":"Myeloid cells activate iNKT cells to produce IL-4 in the thymic medulla.","volume":"116","author":"Wang","year":"2019","journal-title":"Proc Natl Acad Sci USA."},{"key":"B24","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1038\/s41590-019-0334-0","article-title":"SLAM receptors foster iNKT cell development by reducing TCR signal strength after positive selection.","volume":"20","author":"Lu","year":"2019","journal-title":"Nat Immunol."},{"key":"B25","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1084\/jem.20060921","article-title":"Impaired selection of invariant natural killer T cells in diverse mouse models of glycosphingolipid lysosomal storage diseases.","volume":"203","author":"Gadola","year":"2006","journal-title":"J Exp Med."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00815\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T05:29:34Z","timestamp":1588829374000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00815\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,7]]},"references-count":25,"alternative-id":["10.3389\/fimmu.2020.00815"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.00815","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,7]]},"article-number":"815"}}