{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:02:00Z","timestamp":1789009320684,"version":"build-2803163510"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.00854","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T01:09:23Z","timestamp":1590541763000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Analysis of the Targets and Glycosylation of Monoclonal IgAs From MGUS and Myeloma Patients"],"prefix":"10.3389","volume":"11","author":[{"given":"Adrien","family":"Bosseboeuf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia","family":"Seillier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Mennesson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Allain-Maillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maeva","family":"Fourny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Tallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Piver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lehours","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"M\u00e9graud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laureline","family":"Berthelot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Harb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Bigot-Corbel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Hermouet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/0002-9343(78)90522-3","article-title":"Monoclonal gammopathy of undetermined significance. Natural history in 241 cases","volume":"64","author":"Kyle","year":"1978","journal-title":"Am J Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1056\/NEJMoa01133202","article-title":"A long-term study of prognosis of monoclonal gammopathy of undetermined significance","volume":"346","author":"Kyle","year":"2002","journal-title":"N Engl J Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2599","DOI":"10.1182\/blood-2016-09-692954","article-title":"MGUS to myeloma: a mysterious gammopathy of underexplored significance","volume":"128","author":"Dhodapkar","year":"2016","journal-title":"Blood"},{"key":"B4","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1056\/NEJMoa1709974","article-title":"Long-term follow-up of monoclonal gammopathy of undetermined significance","volume":"378","author":"Kyle","year":"2018","journal-title":"New Engl J Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1056\/NEJM198006123022405","article-title":"Smoldering multiple myeloma","volume":"302","author":"Kyle","year":"1980","journal-title":"N Engl J Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e538","DOI":"10.1016\/S1470-2045(14)70442-5","article-title":"International myeloma working group updated criteria for the diagnosis of multiple myeloma","volume":"15","author":"Rajkumar","year":"2014","journal-title":"Lancet Oncol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1515\/CCLM.2007.029","article-title":"Retrospective study of monoclonal gammopathies detected in the clinical laboratory of a Spanish healthcare district: 14-year series","volume":"45","author":"Berg\u00f3n","year":"2007","journal-title":"Clin Chem Lab Med"},{"key":"B8","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.4049\/jimmunol.155.5.2487","article-title":"Myeloma Ig heavy chain V region sequences reveal prior antigenic selection and marked somatic mutation but no intraclonal diversity","volume":"155","author":"Vescio","year":"1995","journal-title":"J Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1182\/blood.V89.1.219.219_219_226","article-title":"Myeloma VL and VH gene sequences reveal a complementary imprint of antigen selection in tumor cells","volume":"89","author":"Sahota","year":"1997","journal-title":"Blood"},{"key":"B10","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1056\/NEJMoa1508808","article-title":"Clonal immunoglobulin against lysolipids in the origin of myeloma","volume":"374","author":"Nair","year":"2016","journal-title":"N Engl J Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e98259","DOI":"10.1172\/jci.insight.98259","article-title":"Antigen-mediated regulation in monoclonal gammopathies and myeloma","volume":"3","author":"Nair","year":"2018","journal-title":"J Clin Invest Insight"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e95367","DOI":"10.1172\/jci.insight.95367","article-title":"Monoclonal IgG in MGUS and multiple myeloma target infectious pathogens","volume":"2","author":"Bosseboeuf","year":"2017","journal-title":"J Clin Invest Insight"},{"key":"B13","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1056\/NEJM200301093480219","article-title":"Hepatitis C virus, human herpesvirus 8, and the development of plasma-cell leukemia","volume":"348","author":"Hermouet","year":"2003","journal-title":"N Engl J Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"4357","DOI":"10.1182\/blood-2008-07-167569","article-title":"Hepatitis C virus (HCV) infection, monoclonal immunoglobulin specific for HCV core protein, and plasma-cell malignancy","volume":"112","author":"Bigot-Corbel","year":"2008","journal-title":"Blood"},{"key":"B15","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.ab.2012.10.012","article-title":"Multiplexed infectious protein microarray immunoassay suitable for the study of the specificity of monoclonal immunoglobulins","volume":"433","author":"Feron","year":"2013","journal-title":"Anal Biochem"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e609","DOI":"10.1016\/S2214-109X(16)30143-7","article-title":"Global burden of cancers attributable to infections in 2012: a synthetic analysis","volume":"4","author":"Plummer","year":"2016","journal-title":"Lancet Glob Health"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-62703-269-8_1","article-title":"Origin and pathogenesis of B cell lymphomas","volume":"971","author":"Seifert","year":"2013","journal-title":"Methods Mol Biol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"3056","DOI":"10.1158\/1078-0432.CCR-10-2578","article-title":"Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes","volume":"17","author":"Saha","year":"2011","journal-title":"Clin Cancer Res"},{"key":"B19","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1158\/1055-9965.EPI-10-0889","article-title":"Infection with hepatitis B and C viruses and risk of lymphoid malignancies in the European prospective investigation into cancer and nutrition (EPIC)","volume":"20","author":"Franceschi","year":"2011","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"B20","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/sj.leu.2402748","article-title":"Qualitative and quantitative analysis of human herpesvirus expression in chronic and acute B-cell lymphocytic leukemia and in multiple myeloma","volume":"17","author":"Hermouet","year":"2003","journal-title":"Leukemia"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.3389\/fimmu.2017.01347","article-title":"Pro-inflammatory state in MGUS and myeloma is characterized by low sialylation of pathogen-specific and other monoclonal and polyclonal immunoglobulin G","volume":"8","author":"Bosseboeuf","year":"2017","journal-title":"Front Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/j.1365-2141.2008.07547.x","article-title":"Immunoglobulin isotypes in multiple myeloma: laboratory correlates and prognostic implications in total therapy protocols","volume":"145","author":"Nair","year":"2009","journal-title":"Br J Haematol"},{"key":"B23","first-page":"143","article-title":"Simple variables predict survival after autologous transplantation: a single centre experience in 181 multiple myeloma patients","volume":"54","author":"Krejci","year":"2007","journal-title":"Neoplasma"},{"key":"B24","first-page":"93","article-title":"Classification and prognostic evaluation in multiple myeloma. A retrospective study of relationship of survivals and responses to chemotherapy to immunological types, 20 single prognostic factors, 15 clinical staging systems, and 6 morphological classifications","volume":"33","author":"Pasqualetti","year":"1991","journal-title":"Panminerva Med"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.4103\/0366-6999.231513","article-title":"IgA type multiple myeloma, clinical features, and prognosis","volume":"131","author":"Wang","year":"2018","journal-title":"Chinese Med J"},{"key":"B26","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V128.22.2062.2062","article-title":"Distinct immunogenetic signatures in IgA versus IgG multiple myeloma","volume-title":"58th American Society of Hematology (ASH) Annual Meeting & Exposition","author":"Gemenetzi","year":"2016"},{"key":"B27","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/j.1365-2141.1976.tb00978.x","article-title":"Relationship between paraprotein clinical features in IgA polymerization and myeloma","volume":"33","author":"Roberts-Thomson","year":"1976","journal-title":"Br J Haematol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2582","DOI":"10.1056\/NEJMoa070389","article-title":"Clinical course and prognosis of smoldering (asymptomatic) multiple myeloma","volume":"356","author":"Kyle","year":"2007","journal-title":"New Engl J Med"},{"key":"B29","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/0022-1759(90)90389-D","article-title":"Immunoblotting techniques for the detection of low level homogeneous immunoglobulin components in serum","volume":"134","author":"Nooij","year":"1990","journal-title":"J Immunol Methods"},{"key":"B30","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1002\/elps.1150100406","article-title":"Modified diffusion blotting for rapid and efficient protein transfer with PhastSystem","volume":"10","author":"Braun","year":"1989","journal-title":"Electrophoresis"},{"key":"B31","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1002\/jmv.1890200405","article-title":"Significance of specific epstein-barr virus IgA and elevated IgG antibodies to viral capsid antigens in nasopharyngeal carcinoma patients","volume":"20","author":"Hadar","year":"1986","journal-title":"J Med Virol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1002\/jmv.1890350306","article-title":"Cytomegalovirus IgG and IgA serum antibodies in a study of HIV infection and HIV-related diseases in homosexual men","volume":"35","author":"Levy","year":"1991","journal-title":"J Med Virol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1128\/IAI.37.1.374-377.1982","article-title":"Herpes Simplex virus-specific serum immunoglobulin a: detection in patients with primary or recurrent herpes infections and in healthy adults","volume":"1","author":"Friedman","year":"1982","journal-title":"Infect Immun."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1128\/JCM.18.5.1146-1149.1983","article-title":"Serum immunoglobulin A antibody to varicella-zoster virus in subjects with primary varicella and herpes zoster infections and in immune subjects","volume":"18","author":"Wittek","year":"1983","journal-title":"J Clin Microbiology"},{"key":"B35","doi-asserted-by":"publisher","first-page":"548","DOI":"10.2169\/internalmedicine.43.548","article-title":"Comparison of serum IgA and IgG antibodies for detecting helicobacter pylori infection","volume":"43","author":"Urita","year":"2004","journal-title":"Int Med"},{"key":"B36","doi-asserted-by":"publisher","first-page":"aaa0698","DOI":"10.1126\/science.aaa0698","article-title":"Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome","volume":"348","author":"Xu","year":"2015","journal-title":"Science"},{"key":"B37","first-page":"2121","article-title":"Serum immunoglobulins (IgG, IgA, IgM) in chronic hepatitis C. A comparison with non-cirrhotic alcoholic liver disease","volume":"54","author":"Gonz\u00e0lez-Quintela","year":"2003","journal-title":"Hepatogastroenterol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"e32","DOI":"10.1038\/cti.2014.27","article-title":"Epstein-Barr virus vaccines","volume":"4","author":"Cohen","year":"2015","journal-title":"Clin Translat Immunol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/978-981-10-7230-7_22","article-title":"Vaccine development for epstein-barr virus","volume":"1045","author":"Cohen","year":"2018","journal-title":"Adv Exp Med Biol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1172\/JCI3009","article-title":"Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors","volume":"102","author":"Fais","year":"1998","journal-title":"J Clin Invest"},{"key":"B41","doi-asserted-by":"publisher","first-page":"897","DOI":"10.3324\/haematol.2013.098913","article-title":"Molecular and cytogenetic characterization of expanded B-cell clones from multiclonal versus monoclonal B-cell chronic lymphoproliferative disorders","volume":"99","author":"Henriques","year":"2014","journal-title":"Haematologica"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1182\/blood.V94.6.1840.418k06_1840_1847","article-title":"Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia","volume":"94","author":"Damle","year":"1999","journal-title":"Blood"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1182\/blood.V94.6.1848.418k05_1848_1854","article-title":"Unmutated Ig VH genes are associated with a more aggressive form of chronic lymphocytic leukemia","volume":"94","author":"Hamblin","year":"1999","journal-title":"Blood"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1196\/annals.1358.002","article-title":"B-cell chronic lymphocytic leukemia, a clonal disease of B lymphocytes with receptors that vary in specificity for (auto)antigens","volume":"1062","author":"Chiorazzi","year":"2005","journal-title":"Ann N Y Acad Sci"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.5604\/17322693.1078852","article-title":"Antigen stimulation in the development of chronic lymphocytic leukemia","volume":"67","author":"Karp","year":"2013","journal-title":"Postepy Hig Med Dosw."},{"key":"B46","doi-asserted-by":"publisher","first-page":"665","DOI":"10.2119\/2008-00102.Catera","article-title":"Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation","volume":"14","author":"Catera","year":"2008","journal-title":"Mol Med"},{"key":"B47","doi-asserted-by":"publisher","first-page":"5122","DOI":"10.1182\/blood-2008-06-162024","article-title":"Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA","volume":"112","author":"Chu","year":"2008","journal-title":"Blood"},{"key":"B48","doi-asserted-by":"publisher","first-page":"3838","DOI":"10.1182\/blood-2007-11-125450","article-title":"A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies","volume":"111","author":"Lanemo Myhrinder","year":"2008","journal-title":"Blood"},{"key":"B49","doi-asserted-by":"publisher","first-page":"3615","DOI":"10.1182\/blood-2009-01-197822","article-title":"Characterization of structurally defined epitopes recognized by monoclonal antibodies produced by chronic lymphocytic leukemia B cells","volume":"114","author":"Seiler","year":"2009","journal-title":"Blood"},{"key":"B50","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.semcancer.2010.09.004","article-title":"Antigens in chronic lymphocytic leukemia\u2013implications for cell origin and leukemogenesis","volume":"20","author":"Ros\u00e9n","year":"2010","journal-title":"Semin Cancer Biol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3390\/cancers10050129","article-title":"EBV positive diffuse large B cell lymphoma and chronic lymphocytic leukemia patients exhibit increased Anti-dUTPase antibodies","volume":"10","author":"Williams","year":"2018","journal-title":"Cancers (Basel)"},{"key":"B52","doi-asserted-by":"publisher","first-page":"e52808","DOI":"10.1371\/journal.pone.0052808","article-title":"Common infectious agents and monoclonal B-cell lymphocytosis: a cross-sectional epidemiological study among healthy adults","volume":"7","author":"Casabonne","year":"2012","journal-title":"PLoS ONE"},{"key":"B53","doi-asserted-by":"publisher","first-page":"638185","DOI":"10.1155\/2012\/638185","article-title":"Indolent B-cell lymphomas associated with HCV infection: clinical and virological features and role of antiviral therapy","volume":"2012","author":"Arcaini","year":"2012","journal-title":"Clin Dev Immunol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"e90725","DOI":"10.1371\/journal.pone.0090725","article-title":"IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria","volume":"9","author":"Hwang","year":"2014","journal-title":"PLoS ONE"},{"key":"B55","doi-asserted-by":"publisher","first-page":"18653","DOI":"10.18632\/oncotarget.4418","article-title":"Epstein-Barr virus DNA load in chronic lymphocytic leukemia is an independent predictor of clinical course and survival","volume":"6","author":"Visco","year":"2015","journal-title":"Oncotarget"},{"key":"B56","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1002\/ijc.28971","article-title":"Epstein-Barr virus and risk of non-Hodgkin lymphoma in the cancer prevention study-II and a meta-analysis of serologic studies","volume":"136","author":"Teras","year":"2015","journal-title":"Int J Cancer"},{"key":"B57","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1750-9378-10-5","article-title":"Aberrant epstein-barr virus antibody patterns and chronic lymphocytic leukemia in a Spanish multicentric case-control study","volume":"10","author":"Casabonne","year":"2015","journal-title":"Infect Agent Cancer"},{"key":"B58","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/j.ebiom.2015.04.018","article-title":"Epstein-barr virus micrornas are expressed in patients with chronic lymphocytic leukemia and correlate with overall survival","volume":"2","author":"Ferrajoli","year":"2015","journal-title":"EBioMedicine"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1128\/JVI.01964-12","article-title":"Gangliosides have a functional role during rotavirus cell entry","volume":"87","author":"Mart\u00ednez","year":"2013","journal-title":"J Virol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.mayocp.2012.06.014","article-title":"Incidence of monoclonal gammopathy of undetermined significance and estimation of duration before first clinical recognition","volume":"87","author":"Therneau","year":"2012","journal-title":"Mayo Clin Proc"},{"key":"B61","doi-asserted-by":"publisher","first-page":"685","DOI":"10.4065\/84.8.685","article-title":"Disease associations with monoclonal gammopathy of undetermined significance: a population-based study of 17,398 patients","volume":"84","author":"Bida","year":"2009","journal-title":"Mayo Clin Proc"},{"key":"B62","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.lrr.2013.01.002","article-title":"Regression of a case of multiple myeloma with antiviral treatment in a patient with chronic HCV infection","volume":"2","author":"Panfilio","year":"2013","journal-title":"Leuk Res Rep"},{"key":"B63","doi-asserted-by":"publisher","first-page":"5592","DOI":"10.1182\/blood-2018-99-112842","article-title":"The role of Hepatitis C virus in the development of multiple myeloma: A case study. 60th Annual Meeting of the American Society of Hematology (ASH), San Diego, CA, USA, December 1-4, (2018). Abstract Nbr: 5592, Submission ID: 112842","volume":"132","author":"Rodr\u00edguez Garc\u00eda","year":"2018","journal-title":"Blood"},{"key":"B64","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12943-018-0779-z","article-title":"Role of Bruton's tyrosine kinase in B cells and malignancies","volume":"17","author":"Pal Singh","year":"2018","journal-title":"Mol Cancer"},{"key":"B65","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1016\/j.it.2013.07.002","article-title":"B cell receptor signaling in chronic lymphocytic leukemia","volume":"34","author":"Burger","year":"2013","journal-title":"Trends Immunol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"E197","DOI":"10.3390\/cancers10060197","article-title":"Antiviral drugs for EBV","volume":"10","author":"Pagano","year":"2018","journal-title":"Cancers (Basel)"},{"key":"B67","doi-asserted-by":"publisher","first-page":"3609","DOI":"10.1073\/pnas.1523686113","article-title":"Spironolactone blocks epstein-barr virus production by inhibiting EBV SM protein function","volume":"113","author":"Verma","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"B68","doi-asserted-by":"publisher","first-page":"E3621","DOI":"10.3390\/ijms19113621","article-title":"Prevention is the best treatment: the case for understanding the transition from monoclonal gammopathy of undetermined significance to myeloma","volume":"19","author":"Tomasson","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B69","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/S0002-9343(02)01150-6","article-title":"Effectiveness of enzyme replacement therapy in 1028 patients with type 1 gaucher disease after 2 to 5 years of treatment: a report from the gaucher registry","volume":"113","author":"Weinreb","year":"2002","journal-title":"Am J Med"},{"key":"B70","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/s10545-012-9528-4","article-title":"Long-term clinical outcomes in type 1 Gaucher disease following 10 years of imiglucerase treatment","volume":"36","author":"Weinreb","year":"2013","journal-title":"J Inherit Metab Dis."},{"key":"B71","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1001\/jama.2015.459","article-title":"Effect of oral eliglustat on splenomagealy in patients with Gaucher disease type 1 : the ENGAGE randomized clinical trial","volume":"313","author":"Mistry","year":"2015","journal-title":"JAMA"},{"key":"B72","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1007\/s10545-017-0123-6","article-title":"Olipudase alfa for treatment of acid sphingomyelinase deficiency (ASMD): safety and efficacy in adults treated for 30 months","volume":"41","author":"Wasserstein","year":"2018","journal-title":"J Inherit Metab Dis"},{"key":"B73","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1002\/jimd.12131","article-title":"Treating lysosomal storage disorders: what have we learnt?","volume":"43","author":"Lachmann","year":"2019","journal-title":"J Inherit Metab Dis"},{"key":"B74","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/leu.2014.295","article-title":"Diet-induced obesity promotes a myeloma-like condition in vivo","volume":"29","author":"Lwin","year":"2015","journal-title":"Leukemia"},{"key":"B75","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1002\/path.4452","article-title":"Inhibition of UDP-glucosylceramide synthase in mice prevents Gaucher disease-associated B-cell malignancy","volume":"235","author":"Pavlova","year":"2015","journal-title":"J Pathol"},{"key":"B76","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.ymgme.2020.01.009","article-title":"Glucosylsphingosine but not saposin C, is the target antigen in Gaucher disease-associated gammopathy","volume":"129","author":"Nair","year":"2020","journal-title":"Mol Genet Metab"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00854\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T10:43:46Z","timestamp":1696157026000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00854\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,27]]},"references-count":76,"alternative-id":["10.3389\/fimmu.2020.00854"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.00854","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,27]]},"article-number":"854"}}