{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:57:38Z","timestamp":1753891058827,"version":"3.41.2"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T00:00:00Z","timestamp":1589846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.00930","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T05:16:13Z","timestamp":1589865373000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Evidence for the Effect of Vaccination on Host-Pathogen Interactions in a Murine Model of Pulmonary Tuberculosis by Mycobacterium tuberculosis"],"prefix":"10.3389","volume":"11","author":[{"given":"Zyanya Lucia","family":"Zatarain-Barr\u00f3n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Octavio","family":"Ramos-Espinosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda","family":"Marquina-Castillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Barrios-Pay\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Cornejo-Granados","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Otoniel","family":"Maya-Lucas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamaliel","family":"L\u00f3pez-Leal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilo","family":"Molina-Romero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M.","family":"Anthony","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adri\u00e1n","family":"Ochoa-Leyva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inti Alberto","family":"De La Rosa-Vel\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Gloria","family":"Rebollar-Vega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin M.","family":"Warren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dulce Adriana","family":"Mata-Espinosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rogelio","family":"Hern\u00e1ndez-Pando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dick","family":"van Soolingen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,5,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"S262","DOI":"10.1086\/313886","article-title":"Applying experiences from trials of bacille Calmette-Guerin vaccine","volume":"30","author":"Wilson","year":"2000","journal-title":"Clin Infect Dis."},{"volume-title":"Global Tuberculosis Report","year":"2018","key":"B2"},{"key":"B3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.33073\/pjm-2012-001","article-title":"Latent M. tuberculosis infection\u2013pathogenesis, diagnosis, treatment and prevention strategies","volume":"61","author":"Druszczynska","year":"2012","journal-title":"Pol J Microbiol."},{"key":"B4","first-page":"53","article-title":"History of BCG vaccine","volume":"8","author":"Luca","year":"2013","journal-title":"Maedica."},{"key":"B5","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/j.1365-2249.2006.03162.x","article-title":"The emergence of Beijing family genotypes of Mycobacterium tuberculosis and low-level protection by bacille Calmette-Guerin (BCG) vaccines: is there a link?","volume":"145","author":"Abebe","year":"2006","journal-title":"Clin Exp Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"70","DOI":"10.4161\/hv.5.2.7210","article-title":"BCG vaccines: their mechanisms of attenuation and impact on safety and protective efficacy","volume":"5","author":"Liu","year":"2009","journal-title":"Hum Vaccin."},{"key":"B7","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.tube.2013.12.006","article-title":"Non-tuberculous mycobacteria have diverse effects on BCG efficacy against Mycobacterium tuberculosis","volume":"94","author":"Poyntz","year":"2014","journal-title":"Tuberculosis."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2869","DOI":"10.1073\/pnas.0511240103","article-title":"Variable host-pathogen compatibility in Mycobacterium tuberculosis","volume":"103","author":"Gagneux","year":"2006","journal-title":"Proc Natl Acad Sci USA."},{"key":"B9","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1111\/1469-0691.12253","article-title":"The re-emergence of tuberculosis: what have we learnt from molecular epidemiology?","volume":"19","author":"Borgdorff","year":"2013","journal-title":"Clin Microbiol Infect."},{"key":"B10","doi-asserted-by":"publisher","first-page":"335","DOI":"10.3201\/eid1502.080795","article-title":"Vaccine-induced immunity circumvented by typical Mycobacterium tuberculosis Beijing strains","volume":"15","author":"Kremer","year":"2009","journal-title":"Emerg Infect Dis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/ng.3195","article-title":"Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage","volume":"47","author":"Merker","year":"2015","journal-title":"Nat Genet."},{"key":"B12","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S1473-3099(09)70330-5","article-title":"Possible underlying mechanisms for successful emergence of the Mycobacterium tuberculosis Beijing genotype strains","volume":"10","author":"Parwati","year":"2010","journal-title":"Lancet Infect Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.tube.2011.07.005","article-title":"Mycobacterium tuberculosis Beijing genotype: a template for success","volume":"91","author":"Hanekom","year":"2011","journal-title":"Tuberculosis."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.3201\/eid1710.110546","article-title":"Multidrug-resistant tuberculosis, People's Republic of China, 2007-2009","volume":"17","author":"He","year":"2011","journal-title":"Emerg Infect Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"15076","DOI":"10.1038\/s41598-017-14119-z","article-title":"The study on the association between Beijing genotype family and drug susceptibility phenotypes of Mycobacterium tuberculosis in Beijing","volume":"7","author":"Liu","year":"2017","journal-title":"Sci Rep."},{"key":"B16","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.ijantimicag.2019.08.005","article-title":"Beijing genotype of Mycobacterium tuberculosis is less associated with drug resistance in south China","volume":"54","author":"Zhao","year":"2019","journal-title":"Int J Antimicrob Agents."},{"key":"B17","doi-asserted-by":"publisher","first-page":"843","DOI":"10.3201\/eid0805.020002","article-title":"Worldwide occurrence of Beijing\/W strains of Mycobacterium tuberculosis: a systematic review","volume":"8","author":"Glynn","year":"2002","journal-title":"Emerg Infect Dis."},{"key":"B18","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1186\/1471-2334-12-354","article-title":"Risk factors and clinical phenotypes of Beijing genotype strains in tuberculosis patients in China","volume":"12","author":"Pang","year":"2012","journal-title":"BMC Infect Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.cmi.2019.07.016","article-title":"Mycobacterium tuberculosis Beijing genotype strains and unfavourable treatment outcomes: a systematic review and meta-analysis","volume":"26","author":"Liu","year":"2019","journal-title":"Clin Microbiol Infect"},{"key":"B20","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1046\/j.1365-2249.2003.02171.x","article-title":"A marked difference in pathogenesis and immune response induced by different Mycobacterium tuberculosis genotypes","volume":"133","author":"Lopez","year":"2003","journal-title":"Clin Exp Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1128\/CVI.05127-11","article-title":"Mycobacterium bovis BCG-mediated protection against W-Beijing strains of Mycobacterium tuberculosis is diminished concomitant with the emergence of regulatory T cells","volume":"18","author":"Ordway","year":"2011","journal-title":"Clin Vaccine Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1098\/rspb.2003.2370","article-title":"Imperfect vaccination: some epidemiological and evolutionary consequences","volume":"270","author":"Gandon","year":"2003","journal-title":"Proc Biol Sci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3389\/fmicb.2017.00128","article-title":"Secretome prediction of two M. tuberculosis clinical isolates reveals their high antigenic density and potential drug targets","volume":"8","author":"Cornejo-Granados","year":"2017","journal-title":"Front Microbiol"},{"key":"B24","first-page":"26","article-title":"Correlation between the kinetics of Th1, Th2 cells and pathology in a murine model of experimental pulmonary tuberculosis","volume":"89","author":"Hernandez-Pando","year":"1996","journal-title":"Immunology."},{"key":"B25","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1111\/j.1365-2567.2008.03004.x","article-title":"Virulence, immunopathology and transmissibility of selected strains of Mycobacterium tuberculosis in a murine model","volume":"128","author":"Marquina-Castillo","year":"2009","journal-title":"Immunology."},{"key":"B26","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/nri3211","article-title":"Revisiting the role of the granuloma in tuberculosis","volume":"12","author":"Ramakrishnan","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1093\/bioinformatics\/btu153","article-title":"Prokka: rapid prokaryotic genome annotation","volume":"30","author":"Seemann","year":"2014","journal-title":"Bioinformatics."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics."},{"key":"B30","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2013a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics."},{"key":"B31","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"W130","DOI":"10.1093\/nar\/gkx356","article-title":"WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Res."},{"volume-title":"Bending the Curve - Ending TB: Annual Report 2017","year":"2017","key":"B33"},{"key":"B34","first-page":"233","article-title":"Tuberculosis","volume-title":"Major Infectious Diseases.","author":"Bloom","year":"2017"},{"key":"B35","doi-asserted-by":"publisher","first-page":"3750","DOI":"10.1128\/IAI.00282-13","article-title":"Low induction of proinflammatory cytokines parallels evolutionary success of modern strains within the Mycobacterium tuberculosis Beijing genotype","volume":"81","author":"Van Laarhoven","year":"2013","journal-title":"Infect Immun"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.2217\/fmb.09.94","article-title":"Adjusting to a new home: Mycobacterium tuberculosis gene expression in response to an intracellular lifestyle","volume":"4","author":"Stokes","year":"2009","journal-title":"Future Microbiol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e5","DOI":"10.1038\/emi.2013.5","article-title":"Pathogen-host-environment interplay and disease emergence","volume":"2","author":"Engering","year":"2013","journal-title":"Emerg Microbes Infect."},{"key":"B38","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1093\/oxfordjournals.bmb.a011709","article-title":"Vaccines and their impact on the control of disease","volume":"54","author":"Mclean","year":"1998","journal-title":"Br Med Bull."},{"key":"B39","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1128\/IAI.66.2.670-675.1998","article-title":"Polymorphism in the Bordetella pertussis virulence factors P.69\/pertactin and pertussis toxin in The Netherlands: temporal trends and evidence for vaccine-driven evolution","volume":"66","author":"Mooi","year":"1998","journal-title":"Infect Immun."},{"key":"B40","unstructured":"van Loo IngeHM\n          Vaccine-Driven Evolution of Bordetella pertussis: Changes in Population Structure and Strain Fitness2002"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1093\/clinids\/22.6.1069","article-title":"Invasive disease due to Haemophilus influenzae serotype F: clinical and epidemiologic characteristics in the H. influenzae serotype b vaccine era. The Haemophilus influenzae Study Group","volume":"22","author":"Urwin","year":"1996","journal-title":"Clin Infect Dis"},{"key":"B42","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1006\/viro.1994.1086","article-title":"Evolution of the nucleoprotein and matrix genes of wild-type strains of measles virus isolated from recent epidemics","volume":"198","author":"Rota","year":"1994","journal-title":"Virology"},{"key":"B43","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1093\/infdis\/170.4.795","article-title":"Antigenic analysis of current wild type and vaccine strains of measles virus","volume":"170","author":"Tamin","year":"1994","journal-title":"J Infect Dis"},{"key":"B44","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1186\/s12879-019-4496-z","article-title":"Mumps: MMR vaccination and genetic diversity of mumps virus, 2007-2011 in Catalonia, Spain","volume":"19","author":"Barrabeig","year":"2019","journal-title":"BMC Infect Dis."},{"key":"B45","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1086\/520187","article-title":"Spread of strain W, a highly drug-resistant strain of Mycobacterium tuberculosis, across the United States","volume":"29","author":"Agerton","year":"1999","journal-title":"Clin Infect Dis."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1128\/IAI.74.3.1718-1724.2006","article-title":"Mycobacterium bovis BCG substrains confer different levels of protection against Mycobacterium tuberculosis infection in a BALB\/c model of progressive pulmonary tuberculosis","volume":"74","author":"Castillo-Rodal","year":"2006","journal-title":"Infect Immun"},{"key":"B47","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/j.1365-2567.2008.02840.x","article-title":"CD14 contributes to pulmonary inflammation and mortality during murine tuberculosis","volume":"125","author":"Wieland","year":"2008","journal-title":"Immunology."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/microbiolspec.TBTB2-0018-2016","article-title":"Cytokines and chemokines in Mycobacterium tuberculosis infection","volume":"4","author":"Domingo-Gonzalez","year":"2016","journal-title":"Microbiol Spectr."},{"key":"B49","doi-asserted-by":"publisher","first-page":"41240","DOI":"10.1038\/srep41240","article-title":"M2 macrophages or IL-33 treatment attenuate ongoing Mycobacterium tuberculosis infection","volume":"7","author":"Pineros","year":"2017","journal-title":"Sci Rep."},{"key":"B50","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1002\/eji.200636054","article-title":"Vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection","volume":"37","author":"Meghari","year":"2007","journal-title":"Eur J Immunol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fimmu.2019.02948","article-title":"Transcriptional profiling of human peripheral blood mononuclear cells identifies diagnostic biomarkers that distinguish active and latent tuberculosis","volume":"18","author":"Wang","year":"2019","journal-title":"Front Immunol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00430-017-0524-z","article-title":"Bordetella pertussis virulence factors in the continuing evolution of whooping cough vaccines for improved performance","volume":"207","author":"Dorji","year":"2018","journal-title":"Med Microbiol Immunol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/s41426-018-0039-8","article-title":"Bordetella pertussis pertactin knock-out strains reveal immunomodulatory properties of this virulence factor","volume":"7","author":"Hovingh","year":"2018","journal-title":"Emerg Microbes Infect."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00930\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T05:16:24Z","timestamp":1589865384000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.00930\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,19]]},"references-count":53,"alternative-id":["10.3389\/fimmu.2020.00930"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.00930","relation":{},"ISSN":["1664-3224"],"issn-type":[{"type":"electronic","value":"1664-3224"}],"subject":[],"published":{"date-parts":[[2020,5,19]]},"article-number":"930"}}