{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:33:47Z","timestamp":1791930827964,"version":"4.3.4"},"reference-count":104,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T00:00:00Z","timestamp":1590105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.01041","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T13:01:14Z","timestamp":1590152474000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":39,"title":["Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-Causing Aspergillus fumigatus"],"prefix":"10.3389","volume":"11","author":[{"given":"Jeanne","family":"Bigot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Guillot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Guitard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manon","family":"Ruffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet","family":"Corvol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviane","family":"Balloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Hennequin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,5,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e00140","DOI":"10.1128\/CMR.00140-18","article-title":"Aspergillus fumigatus and aspergillosis in 2019","volume":"33","author":"Latg\u00e9","year":"2019","journal-title":"Clin Microbiol Rev."},{"key":"B2","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.simyco.2014.07.004","article-title":"Phylogeny, identification and nomenclature of the genus Aspergillus","volume":"78","author":"Samson","year":"2014","journal-title":"Stud Mycol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1111\/1751-7915.12367","article-title":"Ecology of aspergillosis: insights into the pathogenic potency of Aspergillus fumigatus and some other Aspergillus species","volume":"10","author":"Paulussen","year":"2017","journal-title":"Microb Biotechnol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1128\/CMR.12.2.310","article-title":"Aspergillus fumigatus and aspergillosis","volume":"12","author":"Latg\u00e9","year":"1999","journal-title":"Clin Microbiol Rev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nrmicro.2017.90","article-title":"Aspergillus fumigatus morphology and dynamic host interactions","volume":"15","author":"van de Veerdonk","year":"2017","journal-title":"Nat Rev Microbiol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1007\/s11046-014-9796-7","article-title":"Neutrophil responses to aspergillosis: new roles for old players","volume":"178","author":"Cunha","year":"2014","journal-title":"Mycopathologia."},{"key":"B7","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1128\/IAI.73.1.494-503.2005","article-title":"Differences in patterns of infection and inflammation for corticosteroid treatment and chemotherapy in experimental invasive pulmonary aspergillosis","volume":"73","author":"Balloy","year":"2005","journal-title":"Infect Immun."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1128\/JCM.34.6.1433-1439.1996","article-title":"Murine model of invasive pulmonary aspergillosis following an earlier stage, noninvasive Aspergillus infection","volume":"34","author":"Nawada","year":"1996","journal-title":"J Clin Microbiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1128\/IAI.71.2.891-903.2003","article-title":"Phagocytosis and intracellular fate of Aspergillus fumigatus conidia in alveolar macrophages","volume":"71","author":"Ibrahim-Granet","year":"2003","journal-title":"Infect Immun."},{"key":"B10","doi-asserted-by":"publisher","first-page":"3034","DOI":"10.1128\/IAI.71.6.3034-3042.2003","article-title":"Killing of Aspergillus fumigatus by alveolar macrophages is mediated by reactive oxidant intermediates","volume":"71","author":"Philippe","year":"2003","journal-title":"Infect Immun."},{"key":"B11","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nri2939","article-title":"Immunity to fungal infections","volume":"11","author":"Romani","year":"2011","journal-title":"Nat Rev Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s11046-017-0190-0","article-title":"Aspergillus bronchitis in patients with cystic fibrosis","volume":"183","author":"Brandt","year":"2018","journal-title":"Mycopathologia."},{"key":"B13","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.micpath.2018.09.010","article-title":"The Co-colonization prevalence of Pseudomonas aeruginosa and Aspergillus fumigatus in cystic fibrosis: a systematic review and meta-analysis","volume":"125","author":"Zhao","year":"2018","journal-title":"Microbial Pathog."},{"key":"B14","doi-asserted-by":"publisher","first-page":"e98502","DOI":"10.1371\/journal.pone.0098502","article-title":"Multi-country estimate of different manifestations of aspergillosis in cystic fibrosis","volume":"9","author":"Armstead","year":"2014","journal-title":"PLoS ONE."},{"key":"B15","doi-asserted-by":"publisher","first-page":"S219","DOI":"10.1093\/mmy\/myy076","article-title":"Pathophysiological aspects of Aspergillus colonization in disease","volume":"57","author":"Gago","year":"2019","journal-title":"Med Mycol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"S225","DOI":"10.1086\/376525","article-title":"Allergic bronchopulmonary aspergillosis in cystic fibrosis\u2014state of the art: cystic fibrosis foundation consensus conference","volume":"37","author":"Stevens","year":"2003","journal-title":"Clin Infect Dis."},{"key":"B17","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1378\/chest.08-2586","article-title":"Allergic bronchopulmonary aspergillosis","volume":"135","author":"Agarwal","year":"2009","journal-title":"Chest."},{"key":"B18","first-page":"1904","article-title":"Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes","volume":"48","author":"Reddel","year":"1988","journal-title":"Cancer Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"5951","DOI":"10.1073\/pnas.85.16.5951","article-title":"Characterization of human tracheal epithelial cells transformed by an origin-defective Simian virus 40","volume":"85","author":"Gruenert","year":"1988","journal-title":"Proceedings Natl Acad Sci USA."},{"key":"B20","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.tiv.2017.11.005","article-title":"Human lung epithelial cell cultures for analysis of inhaled toxicants: lessons learned and future directions","volume":"47","author":"Hiemstra","year":"2018","journal-title":"Toxicology In Vitro."},{"key":"B21","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1165\/ajrcmb.14.1.8534481","article-title":"Mucociliary differentiation of serially passaged normal human tracheobronchial epithelial cells","volume":"14","author":"Gray","year":"1996","journal-title":"Am J Respir Cell Mol Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"841","DOI":"10.3389\/fmicb.2017.00841","article-title":"Rodent models of invasive aspergillosis due to Aspergillus fumigatus: still a long path toward standardization","volume":"8","author":"Desoubeaux","year":"2017","journal-title":"Front Microbiol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1056\/NEJMra0910061","article-title":"Airway mucus function and dysfunction","volume":"363","author":"Fahy","year":"2010","journal-title":"N Engl J Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1002\/ppul.23618","article-title":"Aspergillosis and the role of mucins in cystic fibrosis","volume":"52","author":"Cowley","year":"2017","journal-title":"Pediatr Pulmonol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3390\/cells5040040","article-title":"Airway epithelial cell cilia and obstructive lung disease","volume":"5","author":"Yaghi","year":"2016","journal-title":"Cells."},{"key":"B26","doi-asserted-by":"publisher","first-page":"bcr2015211493","DOI":"10.1136\/bcr-2015-211493","article-title":"Allergic bronchopulmonary aspergillosis in an adult with Kartagener syndrome","volume":"2015","author":"Sehgal","year":"2015","journal-title":"BMJ Case Rep."},{"key":"B27","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s11046-014-9768-y","article-title":"Immunoevasive Aspergillus virulence factors","volume":"178","author":"Chotirmall","year":"2014","journal-title":"Mycopathologia."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.3389\/fimmu.2018.02549","article-title":"Preparations for invasion: modulation of host lung immunity during pulmonary aspergillosis by gliotoxin and other fungal secondary metabolites","volume":"9","author":"Arias","year":"2018","journal-title":"Front Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2755","DOI":"10.1007\/s10096-012-1624-8","article-title":"Dectin-1 is inducible and plays a crucial role in Aspergillus-induced innate immune responses in human bronchial epithelial cells","volume":"31","author":"Sun","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"e83077","DOI":"10.1371\/journal.pone.0083077","article-title":"A soluble fucose-specific lectin from Aspergillus fumigatus conidia - structure, specificity and possible role in fungal pathogenicity","volume":"8","author":"Houser","year":"2013","journal-title":"PLoS ONE."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e1005555","DOI":"10.1371\/journal.ppat.1005555","article-title":"FleA expression in Aspergillus fumigatus is recognized by fucosylated structures on mucins and macrophages to prevent lung infection","volume":"12","author":"Kerr","year":"2016","journal-title":"PLoS Pathog."},{"key":"B32","doi-asserted-by":"publisher","first-page":"15699","DOI":"10.1038\/s41598-018-33902-0","article-title":"Human bronchial epithelial cells inhibit Aspergillus fumigatus germination of extracellular conidia via FleA recognition","volume":"8","author":"Richard","year":"2018","journal-title":"Sci Rep."},{"key":"B33","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1183\/09031936.00096110","article-title":"Aspergillus fumigatus conidia induce interferon-\u03b2 signalling in respiratory epithelial cells","volume":"39","author":"Beisswenger","year":"2012","journal-title":"Eur Respir J."},{"key":"B34","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1165\/rcmb.2003-0388OC","article-title":"Activation of airway epithelial cells by toll-like receptor agonists","volume":"31","author":"Sha","year":"2004","journal-title":"Am J Respir Cell Mol Biol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3134","DOI":"10.4049\/jimmunol.178.5.3134","article-title":"Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells","volume":"178","author":"Mayer","year":"2007","journal-title":"J Immunol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"8303","DOI":"10.4049\/jimmunol.175.12.8303","article-title":"TNF\u03b1-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK","volume":"175","author":"Han","year":"2005","journal-title":"J Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e00049","DOI":"10.1128\/MMBR.00049-19","article-title":"Molecular mechanisms of conidial germination in Aspergillus spp","volume":"84","author":"Baltussen","year":"2020","journal-title":"Microbiol Mol Biol Rev."},{"key":"B38","doi-asserted-by":"publisher","first-page":"3141","DOI":"10.1128\/IAI.01726-14","article-title":"Surface structure characterization of Aspergillus fumigatus conidia mutated in the melanin synthesis pathway and their human cellular immune response","volume":"82","author":"Bayry","year":"2014","journal-title":"Infect Immun."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3390\/jof4010002","article-title":"Role of hydrophobins in Aspergillus fumigatus","volume":"4","author":"Valsecchi","year":"2018","journal-title":"J Fungi."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1038\/nature08264","article-title":"Surface hydrophobin prevents immune recognition of airborne fungal spores","volume":"460","author":"Aimanianda","year":"2009","journal-title":"Nature."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1007\/s10156-013-0614-9","article-title":"Molecular characterization of AfuFleA, an l-fucose-specific lectin from Aspergillus fumigatus","volume":"19","author":"Kuboi","year":"2013","journal-title":"J Infect Chemother."},{"key":"B42","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1007\/s00284-006-0413-y","article-title":"Role of respiration in the germination process of the pathogenic mold Aspergillus fumigatus","volume":"54","author":"Taubitz","year":"2007","journal-title":"Curr Microbiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev-micro-030117-020406","article-title":"The cell wall of the human fungal pathogen Aspergillus fumigatus: biosynthesis, organization, immune response, and virulence","volume":"71","author":"Latg\u00e9","year":"2017","journal-title":"Annu Rev Microbiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"e1002372","DOI":"10.1371\/journal.ppat.1002372","article-title":"Galactosaminogalactan, a new immunosuppressive polysaccharide of Aspergillus fumigatus","volume":"7","author":"Fontaine","year":"2011","journal-title":"PLoS Pathog."},{"key":"B45","doi-asserted-by":"publisher","first-page":"e1003575","DOI":"10.1371\/journal.ppat.1003575","article-title":"Aspergillus galactosaminogalactan mediates adherence to host constituents and conceals hyphal \u03b2-glucan from the immune system","volume":"9","author":"Gravelat","year":"2013","journal-title":"PLoS Pathog."},{"key":"B46","doi-asserted-by":"publisher","first-page":"e1003936","DOI":"10.1371\/journal.ppat.1003936","article-title":"A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of interleukin-1 receptor antagonist","volume":"10","author":"Gresnigt","year":"2014","journal-title":"PLoS Pathog."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.3389\/fimmu.2018.01261","article-title":"The interaction of human pathogenic fungi with C-type lectin receptors","volume":"9","author":"Goyal","year":"2018","journal-title":"Front Immunol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"4938","DOI":"10.4049\/jimmunol.0804250","article-title":"Requisite role for the Dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus","volume":"182","author":"Werner","year":"2009","journal-title":"J Immunol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"e32273","DOI":"10.1371\/journal.pone.0032273","article-title":"Dectin-1 and DC-SIGN polymorphisms associated with invasive pulmonary aspergillosis infection","volume":"7","author":"Sainz","year":"2012","journal-title":"PLoS ONE."},{"key":"B50","first-page":"17489","article-title":"Up-regulation of Dectin-1 in airway epithelial cells promotes mice defense against invasive pulmonary aspergillosis","volume":"8","author":"Liu","year":"2015","journal-title":"Int J Clin Exp Med."},{"key":"B51","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.mib.2011.07.001","article-title":"The role of dectin-1 in the host defence against fungal infections","volume":"14","author":"Drummond","year":"2011","journal-title":"Curr Opin Microbiol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/nri2569","article-title":"Signalling through C-type lectin receptors: shaping immune responses","volume":"9","author":"Geijtenbeek","year":"2009","journal-title":"Nat Rev Immunol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1136\/thoraxjnl-2017-210326","article-title":"Airway epithelial phosphoinositide 3-kinase-\u03b4 contributes to the modulation of fungi-induced innate immune response","volume":"73","author":"Jeong","year":"2018","journal-title":"Thorax."},{"key":"B54","doi-asserted-by":"publisher","first-page":"8903982","DOI":"10.1155\/2017\/8903982","article-title":"Airway epithelial repair by a prebiotic mannan derived from Saccharomyces cerevisiae","volume":"2017","author":"Michael","year":"2017","journal-title":"J Immunol Res."},{"key":"B55","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.imbio.2008.11.004","article-title":"Influence of the mannose receptor in host immune responses","volume":"214","author":"Gazi","year":"2009","journal-title":"Immunobiology"},{"key":"B56","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.cyto.2015.02.025","article-title":"Toll-like receptors: activation, signalling and transcriptional modulation","volume":"74","author":"De Nardo","year":"2015","journal-title":"Cytokine."},{"key":"B57","doi-asserted-by":"publisher","first-page":"5420","DOI":"10.1128\/IAI.73.9.5420-5425.2005","article-title":"Involvement of toll-like receptor 2 in experimental invasive pulmonary aspergillosis","volume":"73","author":"Balloy","year":"2005","journal-title":"Infect Immun."},{"key":"B58","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1016\/j.clim.2007.05.004","article-title":"Role of toll-like receptors in lung innate defense against invasive aspergillosis. Distinct impact in immunocompetent and immunocompromized hosts","volume":"124","author":"Chignard","year":"2007","journal-title":"Clin Immunol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.3390\/ijerph16061085","article-title":"Pro-Inflammatory responses in human bronchial epithelial cells induced by spores and hyphal fragments of common damp indoor molds","volume":"16","author":"\u00d8ya","year":"2019","journal-title":"Int J Environ Res Public Health"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1056\/NEJMoa0802629","article-title":"Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation","volume":"359","author":"Bochud","year":"2008","journal-title":"N Engl J Med."},{"key":"B61","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1128\/IAI.00047-08","article-title":"Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA","volume":"76","author":"Ramirez-Ortiz","year":"2008","journal-title":"Infect Immun."},{"key":"B62","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1182\/blood-2016-03-708511","article-title":"Inducible epithelial resistance protects mice against leukemia-associated pneumonia","volume":"128","author":"Leiva-Ju\u00e1rez","year":"2016","journal-title":"Blood."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.4049\/jimmunol.174.3.1638","article-title":"TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells","volume":"174","author":"Greene","year":"2005","journal-title":"J Immunol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/nature01195","article-title":"Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response","volume":"420","author":"Garlanda","year":"2002","journal-title":"Nature."},{"key":"B65","doi-asserted-by":"publisher","first-page":"2340","DOI":"10.4049\/jimmunol.1400814","article-title":"PTX3 binds MD-2 and promotes TRIF-dependent immune protection in aspergillosis","volume":"193","author":"Bozza","year":"2014","journal-title":"J Immunol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1242\/jcs.00329","article-title":"Aspergillus fumigatus conidia survive and germinate in acidic organelles of A549 epithelial cells","volume":"116","author":"Wasylnka","year":"2003","journal-title":"J Cell Sci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1093\/infdis\/175.1.146","article-title":"Binding and germination of Aspergillus fumigatus conidia on cultured A549 pneumocytes","volume":"175","author":"DeHart","year":"1997","journal-title":"J Infect Dis."},{"key":"B68","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.jinf.2004.12.012","article-title":"Interaction of airway epithelial cells (A549) with spores and mycelium of Aspergillus fumigatus","volume":"51","author":"Zhang","year":"2005","journal-title":"J Infect."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1128\/IAI.65.4.1510-1514.1997","article-title":"Internalization of Aspergillus fumigatus conidia by epithelial and endothelial cells","volume":"65","author":"Paris","year":"1997","journal-title":"Infect Immunity."},{"key":"B70","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1186\/1471-2164-11-358","article-title":"Functional genomics of human bronchial epithelial cells directly interacting with conidia of Aspergillus fumigatus","volume":"11","author":"Gomez","year":"2010","journal-title":"BMC Genomics."},{"key":"B71","doi-asserted-by":"publisher","first-page":"e00663","DOI":"10.1128\/mSphere.00663-18","article-title":"Endocytic markers associated with the internalization and processing of Aspergillus fumigatus conidia by BEAS-2B cells","volume":"4","author":"Clark","year":"2019","journal-title":"mSphere."},{"key":"B72","doi-asserted-by":"publisher","first-page":"e0209652","DOI":"10.1371\/journal.pone.0209652","article-title":"Transcriptomic and proteomic host response to Aspergillus fumigatus conidia in an air-liquid interface model of human bronchial epithelium","volume":"13","author":"Toor","year":"2018","journal-title":"PLoS ONE."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1093\/infdis\/jiy298","article-title":"Penetration of the human pulmonary epithelium by Aspergillus fumigatus hyphae","volume":"218","author":"Fernandes","year":"2018","journal-title":"J Infect Dis."},{"key":"B74","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.1016\/j.ajpath.2015.04.027","article-title":"Absence of fungal spore internalization by bronchial epithelium in mouse models evidenced by a new bioimaging approach and transmission electronic microscopy","volume":"185","author":"Rammaert","year":"2015","journal-title":"Am J Pathol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"472","DOI":"10.3389\/fmicb.2016.00472","article-title":"Interactions of Aspergillus fumigatus conidia with airway epithelial cells: a critical review","volume":"7","author":"Croft","year":"2016","journal-title":"Front Microbiol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3389\/fcimb.2019.00016","article-title":"Phagocytosis of Aspergillus fumigatus by human bronchial epithelial cells is mediated by the Arp2\/3 complex and WIPF2","volume":"9","author":"Culibrk","year":"2019","journal-title":"Front Cell Infect Microbiol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"S127","DOI":"10.1080\/13693780802558959","article-title":"Interaction of Aspergillus with human respiratory mucosa: a study with organ culture model","volume":"47","author":"Amitani","year":"2009","journal-title":"Med Mycol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"S22","DOI":"10.3109\/13693786.2010.511286","article-title":"Local innate host response and filamentous fungi in patients with cystic fibrosis","volume":"48","author":"Roilides","year":"2010","journal-title":"Med Mycol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"30513","DOI":"10.1074\/jbc.M803149200","article-title":"Aspergillus fumigatus-induced interleukin-8 synthesis by respiratory epithelial cells is controlled by the phosphatidylinositol 3-kinase, P38 MAPK, and ERK1\/2 pathways and not by the toll-like receptor-MyD88 pathway","volume":"283","author":"Balloy","year":"2008","journal-title":"J Biol Chem."},{"key":"B80","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1086\/517272","article-title":"Proteases from Aspergillus fumigatus induce release of proinflammatory cytokines and cell detachment in airway epithelial cell lines","volume":"176","author":"Tomee","year":"1997","journal-title":"J Infect Dis."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1093\/infdis\/jiz569","article-title":"Respiratory epithelial cells can remember infection: a proof of concept study","volume":"221","author":"Bigot","year":"2019","journal-title":"J Infect Dis."},{"key":"B82","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.micinf.2009.07.002","article-title":"The innate immune response to Aspergillus fumigatus","volume":"11","author":"Balloy","year":"2009","journal-title":"Microbes Infect."},{"key":"B83","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1128\/CVI.00688-13","article-title":"Trained immunity or tolerance: opposing functional programs induced in human monocytes after engagement of various pattern recognition receptors","volume":"21","author":"Ifrim","year":"2014","journal-title":"Clin Vaccine Immunol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.chom.2011.04.006","article-title":"Trained immunity: a memory for innate host defense","volume":"9","author":"Netea","year":"2011","journal-title":"Cell Host Microbe."},{"key":"B85","doi-asserted-by":"publisher","first-page":"aaf1098","DOI":"10.1126\/science.aaf1098","article-title":"Trained immunity: a program of innate immune memory in health and disease","volume":"352","author":"Netea","year":"2016","journal-title":"Science."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12275-017-6452-1","article-title":"The therapeutic applications of antimicrobial peptides (AMPs): a patent review","volume":"55","author":"Kang","year":"2017","journal-title":"J Microbiol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1080\/14712598.2017.1315402","article-title":"An overview of antimicrobial peptides and the latest advances in their development","volume":"17","author":"Sierra","year":"2017","journal-title":"Expert Opin Biol Ther."},{"key":"B88","first-page":"343","article-title":"Antimicrobial peptides of phagocytes and epithelia","volume":"34","author":"Ganz","year":"1997","journal-title":"Semin Hematol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"e0175963","DOI":"10.1371\/journal.pone.0175963","article-title":"Human \u03b2-defensin-2 production upon viral and bacterial co-infection is attenuated in COPD","volume":"12","author":"Arnason","year":"2017","journal-title":"PLoS ONE."},{"key":"B90","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1471-2180-9-33","article-title":"Inducible expression of beta defensins by human respiratory epithelial cells exposed to Aspergillus fumigatus organisms","volume":"9","author":"Alekseeva","year":"2009","journal-title":"BMC Microbiol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.pupt.2018.04.002","article-title":"H. Effects of fluticasone propionate and budesonide on the expression of immune defense genes in bronchial epithelial cells","volume":"50","author":"van den Berge","year":"2018","journal-title":"Pulmon Pharmacol Ther."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1007\/s10096-008-0553-z","article-title":"Human antimicrobial peptides' antifungal activity against Aspergillus fumigatus","volume":"27","author":"Lupetti","year":"2008","journal-title":"Eur J Clin Microbiol Infect Dis."},{"key":"B93","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.toxicon.2018.04.017","article-title":"Lactoferrin inhibits aflatoxin B1- and aflatoxin M1-induced cytotoxicity and DNA damage in Caco-2, HEK, Hep-G2, SK-N-SH cells","volume":"150","author":"Zheng","year":"2018","journal-title":"Toxicon."},{"key":"B94","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1042\/CS20050115","article-title":"SLPI and Elafin: one glove, many fingers","volume":"110","author":"Williams","year":"2006","journal-title":"Clin Sci."},{"key":"B95","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1165\/ajrcmb.11.6.7946401","article-title":"Regulation of secretory leukocyte proteinase inhibitor (SLPI) and elastase-specific inhibitor (ESI\/elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes","volume":"11","author":"Sallenave","year":"1994","journal-title":"Am J Respir Cell Mol Biol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1165\/rcmb.2010-0095RT","article-title":"Secretory leukocyte protease inhibitor and elafin\/trappin-2","volume":"42","author":"Sallenave","year":"2010","journal-title":"Am J Respir Cell Mol Biol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1111\/j.1742-4658.2008.06355.x","article-title":"The antibacterial and antifungal properties of trappin-2 (Pre-Elafin) do not depend on its protease inhibitory function","volume":"275","author":"Baranger","year":"2008","journal-title":"FEBS J."},{"key":"B98","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1086\/514098","article-title":"Antileukoprotease: an endogenous protein in the innate mucosal defense against fungi","volume":"176","author":"Tomee","year":"1997","journal-title":"J Infect Dis."},{"key":"B99","doi-asserted-by":"publisher","first-page":"39","DOI":"10.4049\/jimmunol.1600657","article-title":"Aeroallergens induce reactive oxygen species production and DNA damage and dampen antioxidant responses in bronchial epithelial cells","volume":"199","author":"Chan","year":"2017","journal-title":"J Immunol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1016\/j.jaci.2016.02.026","article-title":"Calcineurin inhibitors impair neutrophil activity against Aspergillus fumigatus in allogeneic hematopoietic stem cell transplant recipients","volume":"138","author":"Imbert","year":"2016","journal-title":"J Allergy Clin Immunol."},{"key":"B101","doi-asserted-by":"publisher","first-page":"723129","DOI":"10.1155\/2013\/723129","article-title":"Aspergillus-associated airway disease, inflammation, and the innate immune response","volume":"2013","author":"Chotirmall","year":"2013","journal-title":"Biomed Res Int."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1093\/infdis\/jis031","article-title":"Secretome of human bronchial epithelial cells in response to the fungal pathogen aspergillus fumigatus analyzed by differential in-gel electrophoresis","volume":"205","author":"Fekkar","year":"2012","journal-title":"J Infect Dis."},{"key":"B103","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/S0923-2508(99)80065-5","article-title":"Endo-N-Acetyl-\u03b2-D-glucosaminidases and their potential substrates : structure\/function relationships","volume":"148","author":"Karamanos","year":"1997","journal-title":"Res Microbiol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/j.1365-2230.2008.03092.x","article-title":"Expression, purification and in vitro antifungal activity of acidic mammalian chitinase against Candida albicans, Aspergillus fumigatus and Trichophyton rubrum strains","volume":"34","author":"Chen","year":"2009","journal-title":"Clin Exp Dermatol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01041\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T13:01:18Z","timestamp":1590152478000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01041\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,22]]},"references-count":104,"alternative-id":["10.3389\/fimmu.2020.01041"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.01041","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,22]]},"article-number":"1041"}}