{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:02:54Z","timestamp":1790355774488,"version":"4.1.0"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009230","name":"Norris Cotton Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.01096","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T04:47:15Z","timestamp":1591246035000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Differential Cytotoxic Function of Resident and Non-resident CD8+ T Cells in the Human Female Reproductive Tract Before and After Menopause"],"prefix":"10.3389","volume":"11","author":[{"given":"Marta","family":"Rodriguez-Garcia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared M.","family":"Fortier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R.","family":"Wira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,6,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nri3819","article-title":"The role of sex hormones in immune protection of the female reproductive tract","volume":"15","author":"Wira","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1095\/biolreprod.108.068536","article-title":"Menopause in nonhuman primates?","volume":"79","author":"Walker","year":"2008","journal-title":"Biol Reprod"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1038\/mi.2014.26","article-title":"Phenotype and susceptibility to HIV infection of CD4+ Th17 cells in the human female reproductive tract","volume":"7","author":"Rodriguez-Garcia","year":"2014","journal-title":"Mucosal Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1111\/aji.12532","article-title":"Menopausal status influences the expression of programmed death (PD)-1 and its ligand PD-L1 on immune cells from the human female reproductive tract","volume":"76","author":"Shen","year":"2016","journal-title":"Am J Reprod Immunol"},{"key":"B5","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.4049\/jimmunol.158.6.3017","article-title":"CD3+ CD8+ CTL activity within the human female reproductive tract: influence of stage of the menstrual cycle and menopause","volume":"158","author":"White","year":"1997","journal-title":"J Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e12733","DOI":"10.1111\/acel.12733","article-title":"Aging impacts CD103(+) CD8(+) T cell presence and induction by dendritic cells in the genital tract","volume":"17","author":"Rodriguez-Garcia","year":"2018","journal-title":"Aging Cell."},{"key":"B7","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1038\/nri.2015.3","article-title":"Tissue-resident memory T cells: local specialists in immune defence","volume":"16","author":"Mueller","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1146\/annurev-immunol-042617-053214","article-title":"Tissue-resident T cells and other resident leukocytes","volume":"37","author":"Masopust","year":"2019","journal-title":"Annu Rev Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.coviro.2016.11.011","article-title":"Tissue resident memory T cells and viral immunity","volume":"22","author":"Rosato","year":"2017","journal-title":"Curr Opin Virol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/ni.1718","article-title":"Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus","volume":"10","author":"Gebhardt","year":"2009","journal-title":"Nat Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1126\/science.1254536","article-title":"T cell memory. Resident memory CD8 T cells trigger protective innate and adaptive immune responses","volume":"346","author":"Schenkel","year":"2014","journal-title":"Science."},{"key":"B12","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/mi.2012.104","article-title":"Functional diversity of human vaginal APC subsets in directing T-cell responses","volume":"6","author":"Duluc","year":"2013","journal-title":"Mucosal Immunol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"371","DOI":"10.20411\/pai.v1i2.166","article-title":"Diminished CD103 (alphaEbeta7) expression on resident T cells from the female genital tract of HIV-positive women","volume":"1","author":"Moylan","year":"2016","journal-title":"Pathog Immun"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1038\/mi.2016.118","article-title":"Enrichment of herpes simplex virus type 2 (HSV-2) reactive mucosal T cells in the human female genital tract","volume":"10","author":"Posavad","year":"2017","journal-title":"Mucosal Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1038\/mi.2016.72","article-title":"Dendritic cells from the human female reproductive tract rapidly capture and respond to HIV","volume":"10","author":"Rodriguez-Garcia","year":"2017","journal-title":"Mucosal Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1086\/319253","article-title":"Human immunodeficiency virus-specific and CD3-redirected cytotoxic T lymphocyte activity in the human female reproductive tract: lack of correlation between mucosa and peripheral blood","volume":"183","author":"White","year":"2001","journal-title":"J Infect Dis"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1038\/s41385-018-0045-0","article-title":"Neutrophil extracellular traps prevent HIV infection in the female genital tract","volume":"11","author":"Barr","year":"2018","journal-title":"Mucosal Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"57100","DOI":"10.3791\/57100","article-title":"Isolation of dendritic cells from the human female reproductive tract for phenotypical and functional studies","author":"Rodriguez-Garcia","year":"2018","journal-title":"J Vis Exp."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e14306","DOI":"10.1371\/journal.pone.0014306","article-title":"Uterine epithelial cell regulation of DC-SIGN expression inhibits transmitted\/founder HIV-1 trans infection by immature dendritic cells","volume":"5","author":"Ochiel","year":"2010","journal-title":"PLoS ONE."},{"key":"B20","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/S0022-1759(03)00265-5","article-title":"Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation","volume":"281","author":"Betts","year":"2003","journal-title":"J Immunol Methods."},{"key":"B21","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1046\/j.1365-2567.2003.01670.x","article-title":"Oestradiol regulation of antigen presentation by uterine stromal cells: role of transforming growth factor-beta production by epithelial cells in mediating antigen-presenting cell function","volume":"109","author":"Wira","year":"2003","journal-title":"Immunology"},{"key":"B22","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1093\/humrep\/dep382","article-title":"Role of TGF-betas in normal human endometrium and endometriosis","volume":"25","author":"Omwandho","year":"2010","journal-title":"Hum Reprod"},{"key":"B23","doi-asserted-by":"crossref","first-page":"668","DOI":"10.4049\/jimmunol.151.2.668","article-title":"Differential activation of CD8+ T cells by transforming growth factor-beta 1","volume":"151","author":"Lee","year":"1993","journal-title":"J Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"4606","DOI":"10.1172\/JCI63287","article-title":"Intravaginal immunization with HPV vectors induces tissue-resident CD8+ T cell responses","volume":"122","author":"Cuburu","year":"2012","journal-title":"J Clin Invest"},{"key":"B25","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nature11522","article-title":"A vaccine strategy that protects against genital herpes by establishing local memory T cells","volume":"491","author":"Shin","year":"2012","journal-title":"Nature"},{"key":"B26","doi-asserted-by":"publisher","first-page":"13346","DOI":"10.1038\/ncomms13346","article-title":"CD301b+dendritic cells stimulate tissue-resident memory CD8+T cells to protect against genital HSV-2","volume":"7","author":"Shin","year":"2016","journal-title":"Nat Commun."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1343","DOI":"10.1095\/biolreprod58.6.1343","article-title":"Transforming growth factor beta1 in the human endometrium. Cyclic variation, increased expression by estradiol and progesterone, and regulation of plasminogen activators and plasminogen activator inhibitor-1","volume":"58","author":"Casslen","year":"1998","journal-title":"Biol Reprod."},{"key":"B28","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/978-3-319-18881-2_6","article-title":"Seminal fluid signalling in the female reproductive tract: implications for reproductive success and offspring health","volume":"868","author":"Schjenken","year":"2015","journal-title":"Adv Exp Med Biol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"6970","DOI":"10.1126\/sciimmunol.aam6970","article-title":"Resident memory CD8+ T cells in the upper respiratory tract prevent pulmonary influenza virus infection","volume":"2","author":"Pizzolla","year":"2017","journal-title":"Sci Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1038\/mi.2016.100","article-title":"Predominance of weakly cytotoxic, T-betLowEomesNeg CD8+ T-cells in human gastrointestinal mucosa: implications for HIV infection","volume":"10","author":"Kiniry","year":"2017","journal-title":"Mucosal Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2810","DOI":"10.3389\/fimmu.2018.02810","article-title":"Tissue resident CD8 memory T cell responses in cancer and autoimmunity","volume":"9","author":"Molodtsov","year":"2018","journal-title":"Front Immunol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"eaam6346","DOI":"10.1126\/sciimmunol.aam6346","article-title":"Resident memory T cells in the skin mediate durable immunity to melanoma","volume":"2","author":"Malik","year":"2017","journal-title":"Sci Immunol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.jid.2018.10.032","article-title":"Resident memory and recirculating memory T cells cooperate to maintain disease in a mouse model of vitiligo","volume":"139","author":"Richmond","year":"2019","journal-title":"J Invest Dermatol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.4049\/jimmunol.1701532","article-title":"Differential Expression of CD8(+) T cell cytotoxic effector molecules in blood and gastrointestinal mucosa in HIV-1 infection","volume":"200","author":"Kiniry","year":"2018","journal-title":"J Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1126\/science.1254803","article-title":"T cell memory. Skin-resident memory CD8(+) T cells trigger a state of tissue-wide pathogen alert","volume":"346","author":"Ariotti","year":"2014","journal-title":"Science."},{"key":"B36","doi-asserted-by":"publisher","first-page":"491","DOI":"10.4049\/jimmunol.1401214","article-title":"Granzymes regulate proinflammatory cytokine responses","volume":"194","author":"Wensink","year":"2015","journal-title":"J Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.trecan.2017.04.001","article-title":"The untold story of granzymes in oncoimmunology: novel opportunities with old acquaintances","volume":"3","author":"Arias","year":"2017","journal-title":"Trends Cancer"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01096\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T22:41:04Z","timestamp":1696200064000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01096\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,4]]},"references-count":37,"alternative-id":["10.3389\/fimmu.2020.01096"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.01096","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,4]]},"article-number":"1096"}}