{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:17:03Z","timestamp":1789687023894,"version":"4.0.1"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T00:00:00Z","timestamp":1591142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 107-2635-B-532-001"],"award-info":[{"award-number":["MOST 107-2635-B-532-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 108-2321-B-197-001"],"award-info":[{"award-number":["MOST 108-2321-B-197-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 108-2628-B-197-001"],"award-info":[{"award-number":["MOST 108-2628-B-197-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 108-2923-B-197-001-MY3"],"award-info":[{"award-number":["MOST 108-2923-B-197-001-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.01115","type":"journal-article","created":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T05:34:19Z","timestamp":1591162459000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Critical Role for the NLRP3 Inflammasome in Mediating IL-1\u03b2 Production in Shigella sonnei-Infected Macrophages"],"prefix":"10.3389","volume":"11","author":[{"given":"Lan-Hui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao-Wen","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Hua","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Chun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Ting","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tz-Chuen","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Hsin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleg V.","family":"Chernikov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chiuan","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Feng","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,6,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"491","DOI":"10.4269\/ajtmh.14-0804","article-title":"Shigellosis in subjects with traveler's diarrhea versus domestically acquired diarrhea: implications for antimicrobial therapy and human immunodeficiency virus surveillance","volume":"93","author":"Toro","year":"2015","journal-title":"Am J Trop Med Hyg."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/S1473-3099(18)30475-4","article-title":"Morbidity and mortality due to shigella and enterotoxigenic Escherichia coli diarrhoea: the global burden of disease study 1990-2016","volume":"18","author":"Khalil","year":"2018","journal-title":"Lancet Infect Dis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1186\/s12889-018-5115-4","article-title":"Disparities in severe shigellosis among adults - foodborne diseases active surveillance network, 2002-2014","volume":"18","author":"McCrickard","year":"2018","journal-title":"BMC Public Health."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.3201\/eid2209.160624","article-title":"Elevated risk for antimicrobial drug-resistant shigella infection among men who have sex with men, United States, 2011-2015","volume":"22","author":"Bowen","year":"2016","journal-title":"Emerg Infect Dis."},{"key":"B5","doi-asserted-by":"publisher","first-page":"383.e11","DOI":"10.1016\/j.cmi.2015.12.021","article-title":"The worldwide spread of ciprofloxacin-resistant Shigella sonnei among HIV-infected men who have sex with men, Taiwan","volume":"22","author":"Chiou","year":"2016","journal-title":"Clin Microbiol Infect."},{"key":"B6","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/S0140-6736(17)33296-8","article-title":"Shigellosis","volume":"391","author":"Kotloff","year":"2018","journal-title":"Lancet."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.1017\/S0950268812000738","article-title":"Shifting dominance of Shigella species in men who have sex with men","volume":"140","author":"Ratnayake","year":"2012","journal-title":"Epidemiol Infect."},{"key":"B8","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1136\/sextrans-2017-053410","article-title":"Shigellosis outbreak among MSM living with HIV: a case-control study in Taiwan, 2015-2016","volume":"95","author":"Wu","year":"2019","journal-title":"Sex Transm Infect."},{"key":"B9","doi-asserted-by":"publisher","first-page":"76","DOI":"10.3389\/fcimb.2013.00076","article-title":"Subversion of inflammasome activation and pyroptosis by pathogenic bacteria","volume":"3","author":"Cunha","year":"2013","journal-title":"Front Cell Infect Microbiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"E4345","DOI":"10.1073\/pnas.1303641110","article-title":"Intracellular shigella remodels its LPS to dampen the innate immune recognition and evade inflammasome activation","volume":"110","author":"Paciello","year":"2013","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B11","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.abb.2018.12.031","article-title":"Application of immobilized ATP to the study of NLRP inflammasomes","volume":"670","author":"Liao","year":"2019","journal-title":"Arch Biochem Biophys."},{"key":"B12","doi-asserted-by":"publisher","first-page":"540","DOI":"10.3389\/fimmu.2016.00540","article-title":"Inflammasomes and their role in innate immunity of sexually transmitted infections","volume":"7","author":"Verma","year":"2016","journal-title":"Front Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1056\/NEJMcibr1706536","article-title":"Inflammatory bowel disease and the NLRP3 inflammasome","volume":"377","author":"Kanneganti","year":"2017","journal-title":"N Engl J Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"41123","DOI":"10.1038\/srep41123","article-title":"NLRP3 inflammasome: Pathogenic role and potential therapeutic target for IgA nephropathy","volume":"7","author":"Tsai","year":"2017","journal-title":"Sci Rep."},{"key":"B15","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/nm.3893","article-title":"Inflammasomes: mechanism of action, role in disease, and therapeutics","volume":"21","author":"Guo","year":"2015","journal-title":"Nat Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1002\/JLB.MA0318-112RR","article-title":"The Salmonella pathogenicity island-2 subverts human NLRP3 and NLRC4 inflammasome responses","volume":"105","author":"Bierschenk","year":"2019","journal-title":"J Leukoc Biol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.vetimm.2018.08.004","article-title":"Effects of a pathogenic ETEC strain and a probiotic Enterococcus faecium strain on the inflammasome response in porcine dendritic cells","volume":"203","author":"Loss","year":"2018","journal-title":"Vet Immunol Immunopathol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature."},{"key":"B19","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1159\/000455988","article-title":"Inflammasome activation by ATP enhances Citrobacter rodentium clearance through ROS generation","volume":"41","author":"Bording-Jorgensen","year":"2017","journal-title":"Cell Physiol Biochem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"e111","DOI":"10.1371\/journal.ppat.0030111","article-title":"Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages","volume":"3","author":"Suzuki","year":"2007","journal-title":"PLoS Pathog."},{"key":"B21","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.chom.2007.07.009","article-title":"Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1\/cryopyrin\/NLRP3 and ASC","volume":"2","author":"Willingham","year":"2007","journal-title":"Cell Host Microbe"},{"key":"B22","doi-asserted-by":"publisher","first-page":"E4254","DOI":"10.1073\/pnas.1324021111","article-title":"Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages","volume":"111","author":"Suzuki","year":"2014","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B23","doi-asserted-by":"publisher","first-page":"6315","DOI":"10.1038\/s41598-017-06647-5","article-title":"A GalNAc\/Gal-specific lectin from the sea mussel Crenomytilus grayanus modulates immune response in macrophages and in mice","volume":"7","author":"Chernikov","year":"2017","journal-title":"Sci Rep."},{"key":"B24","doi-asserted-by":"publisher","first-page":"E54","DOI":"10.3390\/antibiotics8020054","article-title":"Intracellular penetration and effects of antibiotics on Staphylococcus aureus inside human neutrophils: a comprehensive review","volume":"8","author":"Bongers","year":"2019","journal-title":"Antibiotics (Basel)."},{"key":"B25","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s00011-012-0555-2","article-title":"Lipopolysaccharide\/adenosine triphosphate-mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1-mediated interleukin-1\u03b2 secretion","volume":"62","author":"Liao","year":"2013","journal-title":"Inflamm Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.3389\/fimmu.2019.01815","article-title":"Mechanistic insight into the activation of the NLRP3 inflammasome by Neisseria gonorrhoeae in macrophages","volume":"10","author":"Li","year":"2019","journal-title":"Front Immunol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1038\/ni.2919","article-title":"The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response","volume":"15","author":"Baroja-Mazo","year":"2014","journal-title":"Nat Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1016\/j.immuni.2013.05.016","article-title":"K+ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter","volume":"38","author":"Mu\u00f1oz-Planillo","year":"2013","journal-title":"Immunity."},{"key":"B29","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/nri2725","article-title":"NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?","volume":"10","author":"Tschopp","year":"2010","journal-title":"Nat Rev Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.3389\/fimmu.2018.01427","article-title":"lysosomal cathepsin release is required for NLRP3-inflammasome activation by Mycobacterium tuberculosis in infected macrophages","volume":"9","author":"Amaral","year":"2018","journal-title":"Front Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"6460","DOI":"10.4049\/jimmunol.0802696","article-title":"Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome","volume":"182","author":"Duncan","year":"2009","journal-title":"J Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nm.2999","article-title":"Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth","volume":"19","author":"Bruchard","year":"2013","journal-title":"Nat Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/ni.1980","article-title":"Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome","volume":"12","author":"Nakahira","year":"2011","journal-title":"Nat Immunol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"E3328","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 inflammasome: an overview of mechanisms of activation and regulation","volume":"20","author":"Kelley","year":"2019","journal-title":"Int J Mol Sci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3502","DOI":"10.1172\/JCI40599","article-title":"Inflammasomes: too big to miss","volume":"119","author":"Stutz","year":"2009","journal-title":"J Clin Invest."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e1003926","DOI":"10.1371\/journal.ppat.1003926","article-title":"Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkc\u03b4","volume":"10","author":"Suzuki","year":"2014","journal-title":"PLoS Pathog."},{"key":"B37","doi-asserted-by":"publisher","first-page":"89","DOI":"10.15252\/embr.201643841","article-title":"Shigella hijacks the glomulin-cIAPs-inflammasome axis to promote inflammation","volume":"19","author":"Suzuki","year":"2018","journal-title":"EMBO Rep."},{"key":"B38","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1084\/jem.20160006","article-title":"Genetic functions of the NAIP family of inflammasome receptors for bacterial ligands in mice","volume":"213","author":"Zhao","year":"2016","journal-title":"J Exp Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.1128\/IAI.01705-14","article-title":"Type III secretion needle proteins induce cell signaling and cytokine secretion via Toll-like receptors","volume":"82","author":"Jessen","year":"2014","journal-title":"Infect Immun."},{"key":"B40","doi-asserted-by":"publisher","first-page":"14408","DOI":"10.1073\/pnas.1306376110","article-title":"Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation","volume":"110","author":"Yang","year":"2013","journal-title":"Proc Natl Acad Sci U S A."},{"key":"B41","doi-asserted-by":"publisher","first-page":"e00338","DOI":"10.1128\/IAI.00338-17","article-title":"Listeria monocytogenes and Shigella flexneri activate the NLRP1B inflammasome","volume":"85","author":"Neiman-Zenevich","year":"2017","journal-title":"Infect Immun."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e02654","DOI":"10.1128\/mBio.02654-19","article-title":"Shigella sonnei O-antigen inhibits internalization, vacuole escape, and inflammasome activation","volume":"10","author":"Watson","year":"2019","journal-title":"mBio."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e1007887","DOI":"10.1371\/journal.ppat.1007887","article-title":"Non-canonical NLRP3 inflammasome activation and IL-1\u03b2 signaling are necessary to L. amazonensis control mediated by P2X7 receptor and leukotriene B4","volume":"15","author":"Chaves","year":"2019","journal-title":"PLoS Pathog."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.2174\/1570159X16666180516094500","article-title":"P2X7 Receptor-associated programmed cell death in the pathophysiology of hemorrhagic stroke","volume":"16","author":"Zhao","year":"2018","journal-title":"Curr Neuropharmacol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"862","DOI":"10.3389\/fimmu.2017.00862","article-title":"P2X7 receptor induces tumor necrosis factor-\u03b1 converting enzyme activation and release to boost TNF-\u03b1 production","volume":"8","author":"Barber\u00e0-Cremades","year":"2017","journal-title":"Front Immunol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.3389\/fimmu.2019.01385","article-title":"The secreted virulence factor NADase of group A Streptococcus INHIBITS P2X7 receptor-mediated release of IL-1\u03b2","volume":"10","author":"Westerlund","year":"2019","journal-title":"Front Immunol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"3834","DOI":"10.1111\/bph.14787","article-title":"Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and disease during influenza virus infection","volume":"176","author":"Rosli","year":"2019","journal-title":"Br J Pharmacol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2711","DOI":"10.1038\/s41467-019-10626-x","article-title":"P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis","volume":"10","author":"Mart\u00ednez-Garc\u00eda","year":"2019","journal-title":"Nat Commun."},{"key":"B49","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.autrev.2019.06.009","article-title":"P2X7 receptor: a potential therapeutic target for autoimmune diseases","volume":"18","author":"Cao","year":"2019","journal-title":"Autoimmun Rev."},{"key":"B50","doi-asserted-by":"publisher","first-page":"e00733","DOI":"10.1128\/IAI.00733-18","article-title":"Human intestinal enteroids as a model system of shigella pathogenesis","volume":"87","author":"Koestler","year":"2019","journal-title":"Infect Immun."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01115\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T05:34:21Z","timestamp":1591162461000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01115\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,3]]},"references-count":50,"alternative-id":["10.3389\/fimmu.2020.01115"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.01115","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,3]]},"article-number":"1115"}}