{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:59:55Z","timestamp":1787237995612,"version":"build-2736575974"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:00:00Z","timestamp":1591833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701616"],"award-info":[{"award-number":["81701616"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800698"],"award-info":[{"award-number":["81800698"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011383","name":"Jiangsu Provincial Key Laboratory for Interventional Medical Devices","doi-asserted-by":"publisher","award":["QNRC2016455"],"award-info":[{"award-number":["QNRC2016455"]}],"id":[{"id":"10.13039\/501100011383","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011383","name":"Jiangsu Provincial Key Laboratory for Interventional Medical Devices","doi-asserted-by":"publisher","award":["QNRC2016456"],"award-info":[{"award-number":["QNRC2016456"]}],"id":[{"id":"10.13039\/501100011383","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013094","name":"Science and Technology Planning Social Development Project of Zhenjiang City","doi-asserted-by":"publisher","award":["SH2018051"],"award-info":[{"award-number":["SH2018051"]}],"id":[{"id":"10.13039\/501100013094","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013094","name":"Science and Technology Planning Social Development Project of Zhenjiang City","doi-asserted-by":"publisher","award":["SH2016043"],"award-info":[{"award-number":["SH2016043"]}],"id":[{"id":"10.13039\/501100013094","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013094","name":"Science and Technology Planning Social Development Project of Zhenjiang City","doi-asserted-by":"publisher","award":["SH2019045"],"award-info":[{"award-number":["SH2019045"]}],"id":[{"id":"10.13039\/501100013094","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.01195","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:43:06Z","timestamp":1591836186000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Circulating microRNA Expression Profiling Identifies miR-125a-5p Promoting T Helper 1 Cells Response in the Pathogenesis of Hashimoto's Thyroiditis"],"prefix":"10.3389","volume":"11","author":[{"given":"Yingzhao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangmei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.autrev.2014.01.007","article-title":"Hashimoto thyroiditis: clinical and diagnostic criteria","volume":"13","author":"Caturegli","year":"2014","journal-title":"Autoimmun Rev."},{"key":"B2","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1159\/000363162","article-title":"Clinical aspects of Hashimoto's thyroiditis","volume":"26","author":"Radetti","year":"2014","journal-title":"Endocr Dev"},{"key":"B3","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1111\/j.1440-1827.1990.tb01587.x","article-title":"Hashimoto's thyroiditis as a risk factor of thyroid lymphoma","volume":"40","author":"Aozasa","year":"1990","journal-title":"Acta Pathol Jpn"},{"key":"B4","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.autrev.2014.10.016","article-title":"Autoimmune thyroid disorders","volume":"14","author":"Antonelli","year":"2015","journal-title":"Autoimmun Rev"},{"key":"B5","doi-asserted-by":"publisher","first-page":"17702","DOI":"10.1038\/srep17702","article-title":"The long noncoding RNA IFNG-AS1 promotes T helper type 1 cells response in patients with hashimoto's thyroiditis","volume":"5","author":"Peng","year":"2015","journal-title":"Sci Rep"},{"key":"B6","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.omtn.2019.05.004","article-title":"Circular RNA expression profiling and the potential role of hsa_circ_0089172 in hashimoto's thyroiditis via sponging miR125a-3p","volume":"17","author":"Xiong","year":"2019","journal-title":"Mol Ther Nucleic Acids"},{"key":"B7","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/nrm2347","article-title":"Small non-coding RNAs in animal development","volume":"9","author":"Stefani","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1210\/jc.2017-02318","article-title":"A MicroRNA signature for evaluation of risk and severity of autoimmune thyroid diseases","volume":"103","author":"Martinez-Hernandez","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"B9","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1080\/08916934.2019.1710135","article-title":"Identifying the differentially expressed microRNAs in autoimmunity: a systemic review and meta-analysis","volume":"53","author":"Zhang","year":"2020","journal-title":"Autoimmunity"},{"key":"B10","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/s12967-016-0917-6","article-title":"MicroRNA-142-5p contributes to Hashimoto's thyroiditis by targeting CLDN1","volume":"14","author":"Zhu","year":"2016","journal-title":"J Transl Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.gene.2017.10.053","article-title":"Differential expression levels of plasma microRNA in Hashimoto's disease","volume":"642","author":"Zhao","year":"2018","journal-title":"Gene"},{"key":"B12","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1096\/fj.201600838R","article-title":"Linc-MAF-4 regulates Th1\/Th2 differentiation and is associated with the pathogenesis of multiple sclerosis by targeting MAF","volume":"31","author":"Zhang","year":"2017","journal-title":"FASEB J"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1084\/jem.188.10.1859","article-title":"c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms","volume":"188","author":"Ho","year":"1998","journal-title":"J Exp Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s13044-018-0046-9","article-title":"Role of the T and B lymphocytes in pathogenesis of autoimmune thyroid diseases","volume":"11","author":"Rydzewska","year":"2018","journal-title":"Thyroid Res"},{"key":"B15","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/0014-4827(92)90360-K","article-title":"Internalization, lysosomal degradation and new synthesis of surface membrane CD4 in phorbol ester-activated T-lymphocytes and U-937 cells","volume":"201","author":"Petersen","year":"1992","journal-title":"Exp Cell Res"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.autrev.2016.09.003","article-title":"The role of microRNAs in the pathogenesis of autoimmune diseases","volume":"15","author":"Chen","year":"2016","journal-title":"Autoimmun Rev"},{"key":"B17","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1007\/s12264-019-00418-0","article-title":"MiR-125a-5p regulates vitamin D receptor expression in a mouse model of experimental autoimmune encephalomyelitis","volume":"36","author":"Long","year":"2020","journal-title":"Neurosci Bull"},{"key":"B18","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.jneuroim.2018.10.002","article-title":"Increased expression of mir-301a in PBMCs of patients with relapsing-remitting multiple sclerosis is associated with reduced NKRF and PIAS3 expression levels and disease activity","volume":"325","author":"Tavakolpour","year":"2018","journal-title":"J Neuroimmunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3389\/fmicb.2017.00270","article-title":"Specific and novel microRNAs are regulated as response to fungal infection in human dendritic cells","volume":"8","author":"Dix","year":"2017","journal-title":"Front Microbiol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/09537104.2019.1585527","article-title":"Circulating microRNAs in patients with immune thrombocytopenia before and after treatment with thrombopoietin-receptor agonists","volume":"31","author":"Garabet","year":"2019","journal-title":"Platelets"},{"key":"B21","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1002\/ana.24931","article-title":"Global exosome transcriptome profiling reveals biomarkers for multiple sclerosis","volume":"81","author":"Selmaj","year":"2017","journal-title":"Ann Neurol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"e24","DOI":"10.4081\/ejh.2010.e24","article-title":"The tyrosine kinase receptor c-met, its cognate ligand HGF and the tyrosine kinase receptor trasducers STAT3, PI3K and RHO in thyroid nodules associated with Hashimoto's thyroiditis: an immunohistochemical characterization","volume":"54","author":"Ruggeri","year":"2010","journal-title":"Eur J Histochem"},{"key":"B23","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/onc.2010.396","article-title":"The RET\/PTC3 oncogene activates classical NF-\u03baB by stabilizing NIK","volume":"30","author":"Neely","year":"2011","journal-title":"Oncogene"},{"key":"B24","doi-asserted-by":"publisher","first-page":"547","DOI":"10.5152\/balkanmedj.2016.15881","article-title":"Evaluation of serum S100A8\/S100A9 levels in patients with autoimmune thyroid diseases","volume":"33","author":"Korkmaz","year":"2016","journal-title":"Balkan Med J"},{"key":"B25","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/S0002-9440(10)61762-2","article-title":"Thyroid autoimmune disease: demonstration of thyroid antigen-specific B cells and recombination-activating gene expression in chemokine-containing active intrathyroidal germinal centers","volume":"159","author":"Armengol","year":"2001","journal-title":"Am J Pathol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1089\/thy.1996.6.575","article-title":"TSH-receptor expression and human thyroid disease: relation to clinical, endocrine, and molecular thyroid parameters","volume":"6","author":"Schuppert","year":"1996","journal-title":"Thyroid"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1038\/s41598-020-58457-x","article-title":"AATF and SMARCA2 are associated with thyroid volume in Hashimoto's thyroiditis patients","volume":"10","author":"Brcic","year":"2020","journal-title":"Sci Rep"},{"key":"B28","doi-asserted-by":"publisher","first-page":"96","DOI":"10.3389\/fimmu.2018.00096","article-title":"Increased interleukin-23 in Hashimoto's thyroiditis disease induces autophagy suppression and reactive oxygen species accumulation","volume":"9","author":"Zheng","year":"2018","journal-title":"Front Immunol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.jamcollsurg.2006.12.037","article-title":"Increased incidence of well-differentiated thyroid cancer associated with Hashimoto thyroiditis and the role of the PI3k\/Akt pathway","volume":"204","author":"Larson","year":"2007","journal-title":"J Am Coll Surg"},{"key":"B30","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1515\/cmble-2015-0004","article-title":"Single nucleotide polymorphisms in the STAT3 gene influence AITD susceptibility, thyroid autoantibody levels, and IL6 and IL17 secretion","volume":"20","author":"Kotkowska","year":"2015","journal-title":"Cell Mol Biol Lett"},{"key":"B31","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1530\/EC-18-0019","article-title":"Aberrant MRP14 expression in thyroid follicular cells mediates chemokine secretion through the IL-1beta\/MAPK pathway in Hashimoto's thyroiditis","volume":"7","author":"Luo","year":"2018","journal-title":"Endocr Connect"},{"key":"B32","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1021\/acs.analchem.9b03492","article-title":"One-to-many single entity electrochemistry biosensing for ultrasensitive detection of microRNA","volume":"92","author":"Bai","year":"2020","journal-title":"Anal Chem"},{"key":"B33","doi-asserted-by":"publisher","first-page":"13951","DOI":"10.1096\/fj.201901446R","article-title":"miR-223-3p promotes autoreactive Th17 cell responses in experimental autoimmune uveitis (EAU) by inhibiting transcription factor FOXO3 expression","volume":"33","author":"Wei","year":"2019","journal-title":"FASEB J"},{"key":"B34","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/ni.1690","article-title":"The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells","volume":"10","author":"Bauquet","year":"2009","journal-title":"Nat Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/S0092-8674(00)81299-4","article-title":"The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4","volume":"85","author":"Ho","year":"1996","journal-title":"Cell"},{"key":"B36","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/s41467-019-08332-9","article-title":"The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells","volume":"10","author":"Perucha","year":"2019","journal-title":"Nat Commun"},{"key":"B37","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/s41590-018-0274-0","article-title":"The transcription factor c-Maf is essential for the commitment of IL-17-producing gammadelta T cells","volume":"20","author":"Zuberbuehler","year":"2019","journal-title":"Nat Immunol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/nature25500","article-title":"c-MAF-dependent regulatory T cells mediate immunological tolerance to a gut pathobiont","volume":"554","author":"Xu","year":"2018","journal-title":"Nature"},{"key":"B39","doi-asserted-by":"publisher","first-page":"6702","DOI":"10.1038\/ncomms7702","article-title":"IL-6-mediated environmental conditioning of defective Th1 differentiation dampens antitumour immune responses in old age","volume":"6","author":"Tsukamoto","year":"2015","journal-title":"Nat Commun"},{"key":"B40","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/ni.3093","article-title":"The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4","volume":"16","author":"Ranzani","year":"2015","journal-title":"Nat Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1002\/eji.200425483","article-title":"Impaired IL-4 production by CD8+ T cells in NOD mice is related to a defect of c-Maf binding to the IL-4 promoter","volume":"35","author":"Chen","year":"2005","journal-title":"Eur J Immunol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/j.1365-2567.2008.03014.x","article-title":"c-Maf increases apoptosis in peripheral CD8 cells by transactivating Caspase 6","volume":"127","author":"Peng","year":"2009","journal-title":"Immunology"},{"key":"B43","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/s41590-018-0083-5","article-title":"c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4(+) T cells","volume":"19","author":"Gabrysova","year":"2018","journal-title":"Nat Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1093\/emboj\/18.2.420","article-title":"Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation","volume":"18","author":"Li","year":"1999","journal-title":"EMBO J"},{"key":"B45","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/978-94-017-9487-9_2","article-title":"TH1\/TH2 cell differentiation and molecular signals","volume":"841","author":"Zhang","year":"2014","journal-title":"Adv Exp Med Biol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1126\/science.274.5294.1903","article-title":"NF-AT-Driven interleukin-4 transcription potentiated by NIP45","volume":"274","author":"Hodge","year":"1996","journal-title":"Science"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1002\/j.1460-2075.1991.tb08059.x","article-title":"Human GATA-3: a lineage-restricted transcription factor that regulates the expression of the T cell receptor alpha gene","volume":"10","author":"Ho","year":"1991","journal-title":"EMBO J"},{"key":"B48","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.cyto.2010.03.018","article-title":"Differential effects of lactacystin on cytokine production in activated Jurkat cells and murine splenocytes","volume":"51","author":"Rockwell","year":"2010","journal-title":"Cytokine"},{"key":"B49","doi-asserted-by":"publisher","first-page":"4060","DOI":"10.1210\/jc.2014-3011","article-title":"Graves' hyperthyroidism is antibody-mediated but is predominantly a Th1-type cytokine disease","volume":"99","author":"Rapoport","year":"2014","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01195\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:43:10Z","timestamp":1591836190000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01195\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,11]]},"references-count":49,"alternative-id":["10.3389\/fimmu.2020.01195"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.01195","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,11]]},"article-number":"1195"}}