{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:36:57Z","timestamp":1789033017818,"version":"build-2803163510"},"reference-count":213,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T00:00:00Z","timestamp":1591920000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.01203","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T11:46:49Z","timestamp":1591962409000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":49,"title":["The Role of Diverse Liver Cells in Liver Transplantation Tolerance"],"prefix":"10.3389","volume":"11","author":[{"given":"Yanzhi","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weitao","family":"Que","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Kang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,6,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1111\/j.1600-6143.2010.03126.x","article-title":"Evolution of causes and risk factors for mortality post-liver transplant: results of the NIDDK long-term follow-up study","volume":"10","author":"Watt","year":"2010","journal-title":"Am J Transplant."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1002\/lt.24845","article-title":"Tolerance after liver transplantation: where are we?","volume":"23","author":"Feng","year":"2017","journal-title":"Liver Transpl."},{"key":"B3","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1097\/00007890-198404000-00019","article-title":"Orthotopic liver allografts in the rat. The influence of strain combination on the fate of the graft","volume":"37","author":"Zimmermann","year":"1984","journal-title":"Transplantation."},{"key":"B4","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1002\/hep.1840190418","article-title":"Murine liver allograft transplantation: tolerance and donor cell chimerism","volume":"19","author":"Qian","year":"1994","journal-title":"Hepatology."},{"key":"B5","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/223472a0","article-title":"L. Induction of immunological tolerance by porcine liver allografts","volume":"223","author":"Calne","year":"1969","journal-title":"Nature."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1002\/hep.26426","article-title":"Prospective multicenter clinical trial of immunosuppressive drug withdrawal in stable adult liver transplant recipients","volume":"58","author":"Ben\u00edtez","year":"2013","journal-title":"Hepatology."},{"key":"B7","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1001\/jama.2011.2014","article-title":"Complete immunosuppression withdrawal and subsequent allograft function among pediatric recipients of parental living donor liver transplants","volume":"307","author":"Feng","year":"2012","journal-title":"JAMA."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1097\/00007890-200211270-00008","article-title":"Prolongation of long-term kidney graft survival by a simultaneous liver transplant: the liver does it, and the heart does it too","volume":"74","author":"Opelz","year":"2002","journal-title":"Transplantation."},{"key":"B9","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1097\/00007890-199503000-00025","article-title":"Combined transplantation of liver and kidney from the same donor protects the kidney from rejection and improves kidney graft survival","volume":"59","author":"Rasmussen","year":"1995","journal-title":"Transplantation."},{"key":"B10","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1034\/j.1600-6143.2003.00050.x","article-title":"Incidence of renal and liver rejection and patient survival rate following combined liver and kidney transplantation","volume":"3","author":"Creput","year":"2003","journal-title":"Am J Transplant."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2995","DOI":"10.1016\/S0041-1345(01)02285-0","article-title":"Induction of systemic tolerance in islet allograft by liver transplantation","volume":"33","author":"Sawada","year":"2001","journal-title":"Transplant Proc."},{"key":"B12","first-page":"1605","article-title":"Transplantation unresponsiveness induced by liver allografts in mouse strains with various histocompatibility disparities","volume":"24","author":"Qian","year":"1992","journal-title":"Transplant Proc."},{"key":"B13","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1002\/hep.1840070527","article-title":"Conceptual review of the hepatic vascular bed","volume":"7","author":"Lautt","year":"1987","journal-title":"Hepatology."},{"key":"B14","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/0026-2862(73)90021-6","article-title":"The microcirculatory hepatic unit","volume":"6","author":"Rappaport","year":"1973","journal-title":"Microvasc Res."},{"key":"B15","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1002\/hep.22306","article-title":"Toll-like receptors and adaptor molecules in liver disease: update","volume":"48","author":"Seki","year":"2008","journal-title":"Hepatology."},{"key":"B16","doi-asserted-by":"publisher","first-page":"S54","DOI":"10.1002\/hep.21060","article-title":"The liver as an immunological organ","volume":"43","author":"Racanelli","year":"2006","journal-title":"Hepatology."},{"key":"B17","doi-asserted-by":"publisher","first-page":"3433","DOI":"10.1128\/IAI.70.7.3433-3442.2002","article-title":"Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide","volume":"70","author":"Liu","year":"2002","journal-title":"Infect Immun."},{"key":"B18","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1146\/annurev-immunol-051116-052415","article-title":"Immune Responses in the Liver","volume":"36","author":"Kubes","year":"2018","journal-title":"Ann Rev Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1002\/hep.21378","article-title":"T lymphocytes interact with hepatocytes through fenestrations in murine liver sinusoidal endothelial cells","volume":"44","author":"Warren","year":"2006","journal-title":"Hepatology."},{"key":"B20","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1002\/(SICI)1521-4141(199801)28:01<221::AID-IMMU221>3.0.CO;2-F","article-title":"Hepatocytes induce functional activation of naive CD8+ T lymphocytes but fail to promote survival","volume":"28","author":"Bertolino","year":"1998","journal-title":"Eur J Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jaut.2009.08.005","article-title":"CD8+ T cell tolerance following antigen recognition on hepatocytes","volume":"34","author":"Holz","year":"2010","journal-title":"J Autoimmun."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2341","DOI":"10.4049\/jimmunol.1502234","article-title":"Cross-Presentation of soluble and cell-associated antigen by murine hepatocytes is enhanced by collectrin expression","volume":"198","author":"Dolina","year":"2017","journal-title":"J Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1053\/j.gastro.2008.05.078","article-title":"Intrahepatic murine CD8 T-cell activation associates with a distinct phenotype leading to Bim-dependent death","volume":"135","author":"Holz","year":"2008","journal-title":"Gastroenterology."},{"key":"B24","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1038\/nri981","article-title":"Hepatic T cells and liver tolerance","volume":"3","author":"Crispe","year":"2003","journal-title":"Nat Rev Immunol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.4049\/jimmunol.178.4.2083","article-title":"Type I IFN-producing CD4 Valpha14i NKT cells facilitate priming of IL-10-producing CD8 T cells by hepatocytes","volume":"178","author":"Wahl","year":"2007","journal-title":"J Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1053\/jhep.2003.50191","article-title":"MHC class II-expressing hepatocytes function as antigen-presenting cells and activate specific CD4 T lymphocyutes","volume":"37","author":"Herkel","year":"2003","journal-title":"Hepatology."},{"key":"B27","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1002\/lt.25019","article-title":"Hepatocyte-induced CD4+ T cell alloresponse is associated with major histocompatibility complex class II up-regulation on hepatocytes and suppressible by regulatory T cells","volume":"24","author":"DeTemple","year":"2018","journal-title":"Liver Transpl."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1053\/j.gastro.2007.09.007","article-title":"Defective T helper response of hepatocyte-stimulated CD4 T cells impairs antiviral CD8 response and viral clearance","volume":"133","author":"Wiegard","year":"2007","journal-title":"Gastroenterology."},{"key":"B29","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1189\/jlb.2AB0613-342RR","article-title":"Hepatocytes induce Foxp3+ regulatory T cells by notch signaling","volume":"96","author":"Burghardt","year":"2014","journal-title":"J Leukocyte Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1093\/toxsci\/kfz112","article-title":"Hepatocyte-derived exosomes promote liver immune tolerance: possible implications for idiosyncratic drug-induced liver injury","volume":"170","author":"Holman","year":"2019","journal-title":"Toxicol Sci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"819","DOI":"10.2174\/1566524015666151026102143","article-title":"Suicidal emperipolesis: a process leading to cell-in-cell structures, T cell clearance and immune homeostasis","volume":"15","author":"Sierro","year":"2015","journal-title":"Curr Mol Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1002\/cphy.c140078","article-title":"Liver sinusoidal endothelial cells","volume":"5","author":"S\u00f8rensen","year":"2015","journal-title":"Comp Physiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jhep.2012.09.008","article-title":"Inhibition of inflammatory CD4 T cell activity by murine liver sinusoidal endothelial cells","volume":"58","author":"Carambia","year":"2013","journal-title":"J Hepatol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2970","DOI":"10.1002\/eji.200526034","article-title":"Cross-presentation of oral antigens by liver sinusoidal endothelial cells leads to CD8 T cell tolerance","volume":"35","author":"Limmer","year":"2005","journal-title":"Eur J Immunol."},{"key":"B35","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.4049\/jimmunol.137.6.1803","article-title":"Liver sinusoidal lining cells express class II major histocompatibility antigens but are poor stimulators of fresh allogeneic T lymphocytes","volume":"137","author":"Rubinstein","year":"1986","journal-title":"J Immunol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1034\/j.1600-0528.2002.017408.x","article-title":"Local control of the immune response in the liver","volume":"174","author":"Knolle","year":"2000","journal-title":"Immunol Rev."},{"key":"B37","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1146\/annurev.immunol.021908.132629","article-title":"The liver as a lymphoid organ","volume":"27","author":"Crispe","year":"2009","journal-title":"Annu Rev Immunol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1016\/S0016-5085(99)70508-1","article-title":"Induction of cytokine production in naive CD4(+) T cells by antigen-presenting murine liver sinusoidal endothelial cells but failure to induce differentiation toward Th1 cells","volume":"116","author":"Knolle","year":"1999","journal-title":"Gastroenterology."},{"key":"B39","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.jhep.2014.04.028","article-title":"Transfer of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance","volume":"61","author":"Sch\u00f6lzel","year":"2014","journal-title":"J Hepatol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1002\/hep.23191","article-title":"Priming of CD4+ T cells by liver sinusoidal endothelial cells induces CD25low forkhead box protein 3-regulatory T cells suppressing autoimmune hepatitis","volume":"50","author":"Kruse","year":"2009","journal-title":"Hepatology."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.4049\/jimmunol.169.5.2407","article-title":"Immunomodulatory effects of the liver: deletion of activated CD4+ effector cells and suppression of IFN-gamma-producing cells after intravenous protein immunization","volume":"169","author":"Klugewitz","year":"2002","journal-title":"J Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"3615","DOI":"10.4049\/jimmunol.177.6.3615","article-title":"Liver sinusoidal endothelial cells that endocytose allogeneic cells suppress T cells with indirect allospecificity","volume":"177","author":"Tokita","year":"2006","journal-title":"J Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"4107","DOI":"10.4049\/jimmunol.0902580","article-title":"Dynamic regulation of CD8 T cell tolerance induction by liver sinusoidal endothelial cells","volume":"184","author":"Schurich","year":"2010","journal-title":"J Immunol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1002\/hep.21965","article-title":"Tolerogenic maturation of liver sinusoidal endothelial cells promotes B7-homolog 1-dependent CD8+ T cell tolerance","volume":"47","author":"Diehl","year":"2007","journal-title":"Hepatology."},{"key":"B45","doi-asserted-by":"publisher","first-page":"11054","DOI":"10.1073\/pnas.1804094115","article-title":"C-type lectin receptor LSECtin-mediated apoptotic cell clearance by macrophages directs intestinal repair in experimental colitis","volume":"115","author":"Yang","year":"2018","journal-title":"Proc Natl Acad Sci USA."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1053\/j.gastro.2009.07.051","article-title":"Liver sinusoidal endothelial cell lectin, LSECtin, negatively regulates hepatic T-cell immune response","volume":"137","author":"Tang","year":"2009","journal-title":"Gastroenterology."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1111\/j.1478-3231.2006.01342.x","article-title":"Role of Kupffer cells in host defense and liver disease","volume":"26","author":"Bilzer","year":"2006","journal-title":"Liver Int."},{"key":"B48","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/ni.2691","article-title":"Immune surveillance by the liver","volume":"14","author":"Jenne","year":"2013","journal-title":"Nat Immunol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/nri2858","article-title":"Antigen-presenting cell function in the tolerogenic liver environment","volume":"10","author":"Thomson","year":"2010","journal-title":"Nat Rev Immunol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1172\/JCI118055","article-title":"Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation","volume":"96","author":"Bissell","year":"1995","journal-title":"J Clin Invest."},{"key":"B51","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1002\/hep.510270116","article-title":"Interleukin-10 expression is autoregulated at the transcriptional level in human and murine Kupffer cells","volume":"27","author":"Knolle","year":"1998","journal-title":"Hepatology."},{"key":"B52","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1002\/hep.22395","article-title":"Mechanism of T cell tolerance induction by murine hepatic Kupffer cells","volume":"48","author":"You","year":"2008","journal-title":"Hepatology."},{"key":"B53","doi-asserted-by":"crossref","first-page":"5453","DOI":"10.4049\/jimmunol.153.12.5453","article-title":"Outcome of Kupffer cell antigen presentation to a cloned murine Th1 lymphocyte depends on the inducibility of nitric oxide synthase by IFN-gamma","volume":"153","author":"Roland","year":"1994","journal-title":"J Immunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2985","DOI":"10.1016\/j.transproceed.2015.10.038","article-title":"Down-Regulation of donor Kupffer cell B7 expression reduced recipient lymphocyte activation and secretion of interleukin-2 in vitro","volume":"47","author":"Li","year":"2015","journal-title":"Transpl Proc."},{"key":"B55","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1002\/hep.27793","article-title":"Liver inflammation abrogates immunological tolerance induced by Kupffer cells","volume":"62","author":"Heymann","year":"2015","journal-title":"Hepatology."},{"key":"B56","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1002\/hep.23043","article-title":"Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver","volume":"50","author":"Breous","year":"2009","journal-title":"Hepatology."},{"key":"B57","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/0022-4804(90)90001-I","article-title":"Kupffer cell blockade prevents induction of portal venous tolerance in rat cardiac allograft transplantation","volume":"48","author":"Kamei","year":"1990","journal-title":"J Surg Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1006\/jsre.1996.0288","article-title":"Role of Kupffer cells in the induction of tolerance after liver transplantation","volume":"63","author":"Sato","year":"1996","journal-title":"J Surg Res."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1097\/00007890-198906000-00041","article-title":"Kupffer cell blockade inhibits induction of tolerance by the portal venous route","volume":"47","author":"Callery","year":"1989","journal-title":"Transplantation."},{"key":"B60","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1002\/hep.1840060531","article-title":"Interactions between liver allografts and lymphocytotoxic alloantibodies in inbred rats","volume":"6","author":"Houssin","year":"1986","journal-title":"Hepatology."},{"key":"B61","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1097\/00007890-199008000-00027","article-title":"Specific absorption of lymphocytotoxic alloantibodies by the liver in inbred rats","volume":"50","author":"Gugenheim","year":"1990","journal-title":"Transplantation."},{"key":"B62","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1002\/lt.21450","article-title":"Role of Kupffer cells in the induction of tolerance of orthotopic liver transplantation in rats","volume":"14","author":"Chen","year":"2008","journal-title":"Liver Transpl."},{"key":"B63","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1002\/hep.27909","article-title":"Rejection triggers liver transplant tolerance: involvement of mesenchyme-mediated immune control mechanisms in mice","volume":"62","author":"Morita","year":"2015","journal-title":"Hepatology."},{"key":"B64","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.jhep.2016.05.037","article-title":"Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions","volume":"65","author":"Beattie","year":"2016","journal-title":"J Hepatol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"E3186","DOI":"10.1073\/pnas.1119964109","article-title":"Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis","volume":"109","author":"Ramachandran","year":"2012","journal-title":"Proc Natl Acad Sci USA."},{"key":"B66","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature."},{"key":"B67","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1146\/annurev.immunol.21.120601.141040","article-title":"Tolerogenic dendritic cells","volume":"21","author":"Steinman","year":"2003","journal-title":"Annu Rev Immunol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1146\/annurev-immunol-020711-074950","article-title":"The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting","volume":"31","author":"Merad","year":"2013","journal-title":"Ann Rev Immunol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/B978-0-12-417028-5.00001-6","article-title":"Ontogeny and functional specialization of dendritic cells in human and mouse","volume":"120","author":"Haniffa","year":"2013","journal-title":"Adv Immunol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S0966-3274(00)00010-1","article-title":"Comparative analysis of dendritic cell density and total number in commonly transplanted organs: morphometric estimation in normal mice","volume":"8","author":"Steptoe","year":"2000","journal-title":"Transpl Immunol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.4049\/jimmunol.174.4.2037","article-title":"Low TLR4 expression by liver dendritic cells correlates with reduced capacity to activate allogeneic T cells in response to endotoxin","volume":"174","author":"Creus","year":"2005","journal-title":"J Immunol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.it.2009.07.009","article-title":"Endotoxin tolerance: new mechanisms, molecules and clinical significance","volume":"30","author":"Biswas","year":"2009","journal-title":"Trends Immunol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.4049\/jimmunol.172.2.1009","article-title":"Liver dendritic cells are less immunogenic than spleen dendritic cells because of differences in subtype composition","volume":"172","author":"Pillarisetty","year":"2004","journal-title":"J Immunol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1046\/j.0818-9641.2001.01048.x","article-title":"Role of primary intrahepatic T-cell activation in the \u201cliver tolerance effect","volume":"80","author":"Bertolino","year":"2002","journal-title":"Immunol Cell Biol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1002\/jlb.66.2.322","article-title":"Hepatic dendritic cells: immunobiology and role in liver transplantation","volume":"66","author":"Thomson","year":"1999","journal-title":"J Leukoc Biol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"795","DOI":"10.4049\/jimmunol.165.2.795","article-title":"Phenotypic and functional characterization of mouse hepatic CD8 alpha+ lymphoid-related dendritic cells","volume":"165","author":"O'Connell","year":"2000","journal-title":"J Immunol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.jhep.2009.04.026","article-title":"Distinct response of liver myeloid dendritic cells to endotoxin is mediated by IL-27","volume":"51","author":"Chen","year":"2009","journal-title":"J Hepatol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1002\/eji.200535767","article-title":"Endotoxin modulates the capacity of CpG-activated liver myeloid DC to direct Th1-type responses","volume":"36","author":"Abe","year":"2006","journal-title":"Eur J Immunol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.4049\/jimmunol.164.3.1346","article-title":"Effects of liver-derived dendritic cell progenitors on Th1- and Th2-like cytokine responses in vitro and in vivo","volume":"164","author":"Khanna","year":"2000","journal-title":"J Immunol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.4049\/jimmunol.0803404","article-title":"Human liver dendritic cells promote T cell hyporesponsiveness","volume":"182","author":"Bamboat","year":"2009","journal-title":"J Immunol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"4433","DOI":"10.4049\/jimmunol.173.7.4433","article-title":"Human plasmacytoid dendritic cells activated by CpG oligodeoxynucleotides induce the generation of CD4+CD25+ regulatory T cells","volume":"173","author":"Moseman","year":"2004","journal-title":"J Immunol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"5227","DOI":"10.4049\/jimmunol.1103382","article-title":"IL-27 production and STAT3-dependent upregulation of B7-H1 mediate immune regulatory functions of liver plasmacytoid dendritic cells","volume":"188","author":"Matta","year":"2012","journal-title":"J Immunol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1084\/jem.20061660","article-title":"Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand","volume":"204","author":"Ito","year":"2007","journal-title":"J Exp Med."},{"key":"B84","doi-asserted-by":"publisher","first-page":"2548","DOI":"10.3389\/fimmu.2018.02548","article-title":"T cell allorecognition pathways in solid organ transplantation","volume":"9","author":"Siu","year":"2018","journal-title":"Front Immunol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1097\/MOT.0000000000000263","article-title":"Direct and indirect allograft recognition: pathways dictating graft rejection mechanisms","volume":"21","author":"Lin","year":"2016","journal-title":"Curr Opin Organ Transplant."},{"key":"B86","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1002\/lt.24394","article-title":"Liver transplantation in the mouse: insights into liver immunobiology, tissue injury, and allograft tolerance","volume":"22","author":"Yokota","year":"2016","journal-title":"Liver Transpl."},{"key":"B87","doi-asserted-by":"publisher","first-page":"5619","DOI":"10.4049\/jimmunol.166.9.5619","article-title":"Il-12 antagonism enhances apoptotic death of T cells within hepatic allografts from Flt3 ligand-treated donors and promotes graft acceptance","volume":"166","author":"Li","year":"2001","journal-title":"J Immunol."},{"key":"B88","doi-asserted-by":"crossref","first-page":"5483","DOI":"10.4049\/jimmunol.159.11.5483","article-title":"Augmentation of dendritic cells in murine organ donors by Flt3 ligand alters the balance between transplant tolerance and immunity","volume":"159","author":"Steptoe","year":"1997","journal-title":"J Immunol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1111\/ajt.12757","article-title":"DAP12 deficiency in liver allografts results in enhanced donor DC migration, augmented effector T cell responses and abrogation of transplant tolerance","volume":"14","author":"Yoshida","year":"2014","journal-title":"Am J Transplant."},{"key":"B90","doi-asserted-by":"publisher","first-page":"aaf8759","DOI":"10.1126\/sciimmunol.aaf8759","article-title":"Donor exosomes rather than passenger leukocytes initiate alloreactive T cell responses after transplantation","volume":"1","author":"Marino","year":"2016","journal-title":"Sci Immunol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"2805","DOI":"10.1172\/JCI84577","article-title":"Donor dendritic cell-derived exosomes promote allograft-targeting immune response","volume":"126","author":"Liu","year":"2016","journal-title":"J Clin Invest."},{"key":"B92","doi-asserted-by":"publisher","first-page":"3717","DOI":"10.4049\/jimmunol.166.6.3717","article-title":"Dendritic cells acquire antigens from live cells for cross-presentation to CTL","volume":"166","author":"Harshyne","year":"2001","journal-title":"J Immunol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1111\/j.1600-6143.2005.00916.x","article-title":"Acquisition of HLA-DR and costimulatory molecules by T cells from allogeneic antigen presenting cells","volume":"5","author":"Game","year":"2005","journal-title":"Am J Transplant."},{"key":"B94","doi-asserted-by":"publisher","first-page":"3473","DOI":"10.1182\/blood.V95.11.3473.011k06_3473_3477","article-title":"Acquisition of intact allogeneic human leukocyte antigen molecules by human dendritic cells","volume":"95","author":"Russo","year":"2000","journal-title":"Blood."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1097\/01.tp.0000520343.32573.7c","article-title":"Graft-infiltrating PD-L1 high cross-dressed dendritic cells regulate anti-donor T cell responses in mouse liver transplant tolerance","volume":"67","author":"Ono","year":"2017","journal-title":"Hepatology."},{"key":"B96","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/1479-5876-9-89","article-title":"Comparative study of clinical grade human tolerogenic dendritic cells","volume":"9","author":"Naranjo-G\u00f3mez","year":"2011","journal-title":"J Transl Med."},{"key":"B97","doi-asserted-by":"publisher","first-page":"2405","DOI":"10.4049\/jimmunol.164.5.2405","article-title":"1 alpha,25-dihydroxyvitamin D3 inhibits differentiation, maturation, activation, and survival of dendritic cells leading to impaired alloreactive T cell activation","volume":"164","author":"Penna","year":"2000","journal-title":"J Immunol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"7018","DOI":"10.4049\/jimmunol.178.11.7018","article-title":"Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance","volume":"178","author":"Turnquist","year":"2007","journal-title":"J Immunol."},{"key":"B99","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/tri.13504","article-title":"Tolerogenic dendritic cells in organ transplantation","volume":"33","author":"Ochando","year":"2019","journal-title":"Transpl Int."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1097\/TP.0000000000002239","article-title":"State of the art: role of the dendritic cell in induction of allograft tolerance","volume":"102","author":"Rosen","year":"2018","journal-title":"Transplantation."},{"key":"B101","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1097\/MOT.0000000000000565","article-title":"Regulatory dendritic cells: profiling, targeting, and therapeutic application","volume":"23","author":"Thomson","year":"2018","journal-title":"Curr Opin Organ Transplant."},{"key":"B102","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.trre.2019.05.001","article-title":"Regulatory dendritic cells for human organ transplantation","volume":"33","author":"Thomson","year":"2019","journal-title":"Transpl Rev."},{"key":"B103","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1136\/gut.50.4.571","article-title":"Hepatic stellate cells: role in microcirculation and pathophysiology of portal hypertension","volume":"50","author":"Reynaert","year":"2002","journal-title":"Gut."},{"key":"B104","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1002\/lt.24412","article-title":"Relevance of activated hepatic stellate cells in predicting the development of pediatric liver allograft fibrosis","volume":"22","author":"Venturi","year":"2016","journal-title":"Liver Transpl."},{"key":"B106","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1097\/TP.0b013e318294caae","article-title":"Human hepatic stellate cells inhibit T-cell response through B7-H1 pathway","volume":"96","author":"Charles","year":"2013","journal-title":"Transplantation."},{"key":"B107","doi-asserted-by":"publisher","first-page":"2177","DOI":"10.1002\/hep.23953","article-title":"B7-H4 mediates inhibition of T cell responses by activated murine hepatic stellate cells","volume":"52","author":"Chinnadurai","year":"2010","journal-title":"Hepatology."},{"key":"B108","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1002\/hep.20488","article-title":"Inhibition of T-cell responses by hepatic stellate cells via B7-H1-mediated T-cell apoptosis in mice","volume":"40","author":"Yu","year":"2004","journal-title":"Hepatology."},{"key":"B109","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1002\/hep.24352","article-title":"Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism","volume":"54","author":"Schildberg","year":"2011","journal-title":"Hepatology."},{"key":"B110","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3892\/etm.2012.801","article-title":"Hepatic stellate cells promote immunotolerance following orthotopic liver transplantation in rats via induction of T cell apoptosis and regulation of Th2\/Th3-like cell cytokine production","volume":"5","author":"Jiang","year":"2013","journal-title":"Exp Ther Med."},{"key":"B111","doi-asserted-by":"publisher","first-page":"3848","DOI":"10.4049\/jimmunol.1200819","article-title":"Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO","volume":"189","author":"Sumpter","year":"2012","journal-title":"J Immunol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1002\/micr.20697","article-title":"A critical role of TRAIL expressed on cotransplanted hepatic stellate cells in prevention of islet allograft rejection","volume":"30","author":"Yang","year":"2010","journal-title":"Microsurgery."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1002\/hep.21379","article-title":"In vivo immune modulatory activity of hepatic stellate cells in mice","volume":"44","author":"Chen","year":"2006","journal-title":"Hepatology."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1002\/hep.24162","article-title":"Hepatic stellate cells regulate immune response by way of induction of myeloid suppressor cells in mice","volume":"53","author":"Chou","year":"2011","journal-title":"Hepatology."},{"key":"B115","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.jhep.2013.04.033","article-title":"Activated human hepatic stellate cells induce myeloid derived suppressor cells from peripheral blood monocytes in a CD44-dependent fashion","volume":"59","author":"H\u00f6chst","year":"2013","journal-title":"J Hepatol."},{"key":"B116","doi-asserted-by":"publisher","first-page":"2009","DOI":"10.4049\/jimmunol.1201937","article-title":"Hepatic stellate cells preferentially induce Foxp3+ regulatory T cells by production of retinoic acid","volume":"190","author":"Dunham","year":"2013","journal-title":"J Immunol."},{"key":"B117","doi-asserted-by":"publisher","first-page":"3667","DOI":"10.4049\/jimmunol.1102460","article-title":"Selective expansion of allogeneic regulatory T cells by hepatic stellate cells: role of endotoxin and implications for allograft tolerance","volume":"188","author":"Dangi","year":"2012","journal-title":"J Immunol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1189\/jlb.2A0516-239R","article-title":"Hepatic stellate cells increase the immunosuppressive function of natural Foxp3+ regulatory T cells via IDO-induced AhR activation","volume":"101","author":"Kumar","year":"2017","journal-title":"J Leukoc Biol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1097\/TP.0b013e31818bfd13","article-title":"Hepatic stellate cells preferentially expand allogeneic CD4+ CD25+ FoxP3+ regulatory T cells in an IL-2-dependent manner","volume":"86","author":"Jiang","year":"2008","journal-title":"Transplantation."},{"key":"B120","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1002\/lt.23720","article-title":"Differential migration of passenger leukocytes and rapid deletion of naive alloreactive CD8 T cells after mouse liver transplantation","volume":"19","author":"Tay","year":"2013","journal-title":"Liver Transpl."},{"key":"B121","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.it.2004.09.006","article-title":"The composition of intrahepatic lymphocytes: shaped by selective recruitment?","volume":"25","author":"Klugewitz","year":"2004","journal-title":"Trends Immunol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"946","DOI":"10.3389\/fimmu.2019.00946","article-title":"Hepatic natural killer cells: organ-specific sentinels of liver immune homeostasis and physiopathology","volume":"10","author":"Mikulak","year":"2019","journal-title":"Front Immunol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s11684-018-0621-4","article-title":"Natural killer cells in liver diseases","volume":"12","author":"Zheng","year":"2018","journal-title":"Front Med."},{"key":"B124","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.coi.2005.01.007","article-title":"Exploitation of alloreactive NK cells in adoptive immunotherapy of cancer","volume":"17","author":"Ruggeri","year":"2005","journal-title":"Curr Opin Immunol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1146\/annurev.immunol.23.021704.115526","article-title":"NK cell recognition","volume":"23","author":"Lanier","year":"2005","journal-title":"Annu Rev Immunol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1111\/ajt.13565","article-title":"Natural killer cells and liver transplantation: orchestrators of rejection or tolerance?","volume":"16","author":"Harmon","year":"2016","journal-title":"Am J Transplant."},{"key":"B127","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1002\/lt.22080","article-title":"Liver grafts contain a unique subset of natural killer cells that are transferred into the recipient after liver transplantation","volume":"16","author":"Moroso","year":"2010","journal-title":"Liver Transpl."},{"key":"B128","doi-asserted-by":"publisher","first-page":"4283","DOI":"10.4049\/jimmunol.1601424","article-title":"Eomeshi NK cells in human liver are long-lived and do not recirculate but can be replenished from the circulation","volume":"197","author":"Cuff","year":"2016","journal-title":"J Immunol."},{"key":"B129","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1182\/blood-2006-10-052720","article-title":"Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM\/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis","volume":"110","author":"Cerboni","year":"2007","journal-title":"Blood."},{"key":"B130","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.it.2003.10.012","article-title":"NK cell and DC interactions","volume":"25","author":"Cooper","year":"2004","journal-title":"Trends Immunol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/S1499-3872(11)60065-9","article-title":"Donor liver natural killer cells alleviate liver allograft acute rejection in rats","volume":"10","author":"Yu","year":"2011","journal-title":"HBPD INT."},{"key":"B132","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.4049\/jimmunol.0901362","article-title":"Intrahepatic IL-10 maintains NKG2A+Ly49\u2212 Liver NK cells in a functionally hyporesponsive state","volume":"184","author":"Lassen","year":"2010","journal-title":"J Immunol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1136\/gutjnl-2015-309395","article-title":"STAT4-associated natural killer cell tolerance following liver transplantation","volume":"66","author":"Jamil","year":"2017","journal-title":"Gut."},{"key":"B134","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.4049\/jimmunol.0902748","article-title":"NK cell patrolling and elimination of donor-derived dendritic cells favor indirect alloreactivity","volume":"184","author":"Garrod","year":"2010","journal-title":"J Immunol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1034\/j.1600-6143.2002.20604.x","article-title":"Inability to induce tolerance through direct antigen presentation","volume":"2","author":"Rulifson","year":"2002","journal-title":"Am J Transplant."},{"key":"B136","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1084\/jem.20060603","article-title":"NK cells promote transplant tolerance by killing donor antigen-presenting cells","volume":"203","author":"Yu","year":"2006","journal-title":"J Exp Med."},{"key":"B137","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1182\/blood-2007-10-120089","article-title":"Natural killer cells recruited into lymph nodes inhibit alloreactive T-cell activation through perforin-mediated killing of donor allogeneic dendritic cells","volume":"112","author":"Laffont","year":"2008","journal-title":"Blood."},{"key":"B138","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1111\/j.1600-6143.2011.03928.x","article-title":"A common peripheral blood gene set for diagnosis of operational tolerance in pediatric and adult liver transplantation","volume":"12","author":"Li","year":"2012","journal-title":"Am J Transplant."},{"key":"B139","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.clinbiochem.2016.01.007","article-title":"Fingerprints of transplant tolerance suggest opportunities for immunosuppression minimization","volume":"49","author":"Sarwal","year":"2016","journal-title":"Clin Biochem."},{"key":"B140","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1111\/j.1478-3231.2005.01147.x","article-title":"Induction of immune tolerance: a role for natural killer T lymphocytes?","volume":"25","author":"Margalit","year":"2005","journal-title":"Liver Int."},{"key":"B141","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.trim.2007.05.015","article-title":"Spontaneous tolerance involving natural killer T cells after hepatic grafting in mice","volume":"18","author":"Morita","year":"2007","journal-title":"Transpl Immunol."},{"key":"B142","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1084\/jem.171.3.801","article-title":"Naive and memory T cells show distinct pathways of lymphocyte recirculation","volume":"171","author":"Mackay","year":"1990","journal-title":"J Exp Med."},{"key":"B143","doi-asserted-by":"publisher","first-page":"5430","DOI":"10.4049\/jimmunol.166.9.5430","article-title":"Groth B. Antigen-specific primary activation of CD8+ T cells within the liver","volume":"166","author":"Bertolino","year":"2001","journal-title":"J Immunol."},{"key":"B144","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1053\/gast.1996.v110.pm8613007","article-title":"Antigen-presenting function and B7 expression of murine sinusoidal endothelial cells and kupffer cells","volume":"110","author":"Lohse","year":"1996","journal-title":"Gastroenterology."},{"key":"B145","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1016\/j.jhep.2006.05.007","article-title":"PD-L1 is induced in hepatocytes by viral infection and by interferon-\u03b1 and -\u03b3 and mediates T cell apoptosis","volume":"45","author":"M\u00fchlbauer","year":"2006","journal-title":"J Hepatol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"2714","DOI":"10.4049\/jimmunol.178.5.2714","article-title":"PD-1: PD-L1 interactions contribute to the functional suppression of virus-specific CD8+ T lymphocytes in the liver","volume":"178","author":"Maier","year":"2007","journal-title":"J Immunol."},{"key":"B147","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/S0168-8278(97)80257-7","article-title":"Transforming growth factor-\u03b2 gene expression in normal and fibrotic rat liver","volume":"26","author":"De Bleser","year":"1997","journal-title":"J Hepatol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/j.jhep.2014.04.027","article-title":"TGF-\u03b2-dependent induction of CD4+CD25+Foxp3+ Tregs by liver sinusoidal endothelial cells","volume":"61","author":"Carambia","year":"2014","journal-title":"J Hepatol."},{"key":"B149","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.jhep.2010.10.005","article-title":"Liver antigen-presenting cells","volume":"54","author":"Crispe","year":"2011","journal-title":"J Hepatol."},{"key":"B150","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/cmi.2015.112","article-title":"Modulation of liver tolerance by conventional and nonconventional antigen-presenting cells and regulatory immune cells","volume":"13","author":"Horst","year":"2016","journal-title":"Cell Mol Immunol."},{"key":"B151","doi-asserted-by":"publisher","first-page":"635","DOI":"10.3389\/fimmu.2018.00635","article-title":"The contribution of non-professional antigen-presenting cells to immunity and tolerance in the liver","volume":"9","author":"Mehrfeld","year":"2018","journal-title":"Front Immunol."},{"key":"B152","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1034\/j.1600-0528.2002.017412.x","article-title":"The liver as a site of T-cell apoptosis: graveyard, or killing field?","volume":"174","author":"Crispe","year":"2000","journal-title":"Immunol Rev."},{"key":"B153","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/S1074-7613(94)80016-2","article-title":"The liver eliminates T cells undergoing antigen-triggered apoptosis in vivo","volume":"1","author":"Huang","year":"1994","journal-title":"Immunity."},{"key":"B154","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.4049\/jimmunol.163.6.3202","article-title":"Selective retention of activated CD8+ T cells by the normal liver","volume":"163","author":"Mehal","year":"1999","journal-title":"J Immunol."},{"key":"B155","doi-asserted-by":"publisher","first-page":"16735","DOI":"10.1073\/pnas.1112251108","article-title":"Hepatocyte entry leads to degradation of autoreactive CD8 T cells","volume":"108","author":"Benseler","year":"2011","journal-title":"Proc Natl Acad Sci USA."},{"key":"B156","doi-asserted-by":"crossref","first-page":"4654","DOI":"10.4049\/jimmunol.158.10.4654","article-title":"Apoptosis within spontaneously accepted mouse liver allografts: evidence for deletion of cytotoxic T cells and implications for tolerance induction","volume":"158","author":"Qian","year":"1997","journal-title":"J Immunol."},{"key":"B157","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1002\/lt.500030204","article-title":"Interleukin-2 and interleukin-12 mediate distinct effector mechanisms of liver allograft rejection","volume":"3","author":"Thai","year":"1997","journal-title":"Liver Transpl Surg."},{"key":"B158","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1097\/00007890-200206150-00022","article-title":"Lymphocyte apoptosis and cell replacement in human liver allografts","volume":"73","author":"Clouston","year":"2002","journal-title":"Transplantation."},{"key":"B159","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1146\/annurev-immunol-041015-055318","article-title":"CD8 T cell exhaustion during chronic viral infection and cancer","volume":"37","author":"McLane","year":"2019","journal-title":"Annu Rev Immunol."},{"key":"B160","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/nri3862","article-title":"Molecular and cellular insights into T cell exhaustion","volume":"15","author":"Wherry","year":"2015","journal-title":"Nat Rev Immunol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1146\/annurev-med-012017-043208","article-title":"CD8 T cell exhaustion in chronic infection and cancer: opportunities for interventions","volume":"69","author":"Hashimoto","year":"2018","journal-title":"Annu Rev Med."},{"key":"B162","doi-asserted-by":"publisher","first-page":"8623","DOI":"10.1073\/pnas.0809818106","article-title":"High antigen levels are the cause of T cell exhaustion during chronic viral infection","volume":"106","author":"Mueller","year":"2009","journal-title":"Proc Natl Acad Sci USA."},{"key":"B163","doi-asserted-by":"publisher","first-page":"20453","DOI":"10.1073\/pnas.1008437107","article-title":"Role of antigen persistence and dose for CD4+ T-cell exhaustion and recovery","volume":"107","author":"Han","year":"2010","journal-title":"Proc Natl Acad Sci USA."},{"key":"B164","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1002\/eji.201242852","article-title":"T cell exhaustion due to persistent antigen: quantity not quality?","volume":"42","author":"Zuniga","year":"2012","journal-title":"Eur J Immunol."},{"key":"B165","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1097\/TP.0b013e31816dd64a","article-title":"Exhaustive differentiation of alloreactive CD8+ T cells: critical for determination of graft acceptance or rejection","volume":"85","author":"Steger","year":"2008","journal-title":"Transplantation."},{"key":"B166","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/ni.3790","article-title":"A guiding map for inflammation","volume":"18","author":"Netea","year":"2017","journal-title":"Nat Immunol."},{"key":"B167","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.immuni.2009.05.001","article-title":"Plasticity of CD4+ T cell lineage differentiation","volume":"30","author":"Zhou","year":"2009","journal-title":"Immunity."},{"key":"B168","doi-asserted-by":"publisher","first-page":"218","DOI":"10.3389\/fimmu.2017.00218","article-title":"The induction and maintenance of transplant tolerance engages both regulatory and anergic CD4+ T cells","volume":"8","author":"Besan\u00e7on","year":"2017","journal-title":"Front Immunol."},{"key":"B169","doi-asserted-by":"publisher","first-page":"4705","DOI":"10.4049\/jimmunol.1202027","article-title":"Treg induction, migration, and function in transplantation","volume":"189","author":"Burrell","year":"2012","journal-title":"J Immunol."},{"key":"B170","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3389\/fimmu.2019.00043","article-title":"Past, present, and future of regulatory T cell therapy in transplantation and autoimmunity","volume":"10","author":"Romano","year":"2019","journal-title":"Front Immunol."},{"key":"B171","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1111\/j.1600-6143.2008.02300.x","article-title":"New insights into mechanisms of spontaneous liver transplant tolerance: the role of Foxp3-expressing CD25+CD4+ regulatory T cells","volume":"8","author":"Li","year":"2008","journal-title":"Am J Transplant."},{"key":"B172","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1002\/lt.20787","article-title":"The importance of CD25+ CD4+ regulatory T cells in mouse hepatic allograft tolerance","volume":"12","author":"Jiang","year":"2006","journal-title":"Liver Transpl."},{"key":"B173","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1097\/00007890-198903000-00025","article-title":"Soluble HLA antigens in the circulation of liver graft recipients","volume":"47","author":"Davies","year":"1989","journal-title":"Transplantation."},{"key":"B174","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/S0092-8674(05)80055-8","article-title":"Costimulation of T lymphocytes: the role of CD28, CTLA-4, and B7\/BB1 in interleukin-2 production and immunotherapy","volume":"71","author":"Schwartz","year":"1992","journal-title":"Cell."},{"key":"B175","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1097\/00007890-199010000-00029","article-title":"Specific suppression of allograft rejection by soluble class I antigen and complexes with monoclonal antibody","volume":"50","author":"Sumimoto","year":"1990","journal-title":"Transplantation."},{"key":"B176","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1097\/00007890-199709150-00024","article-title":"Secreted donor-MHC class I antigen prolongs liver allograft survival and inhibits recipient anti-donor cytotoxic T lymphocyte responses","volume":"64","author":"Geissler","year":"1997","journal-title":"Transplantation."},{"key":"B177","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1089\/10430340050015923","article-title":"Effective use of donor MHC class I gene therapy in organ transplantation: prevention of antibody-mediated hyperacute heart allograft rejection in highly sensitized rat recipients","volume":"11","author":"Geissler","year":"2000","journal-title":"Hum Gene Ther."},{"key":"B178","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1016\/S0198-8859(02)00460-3","article-title":"Use of an adenoviral vector to express soluble donor-major histocompatibility complex molecules capable of suppressing the immune response in rat transplant recipients","volume":"63","author":"Graeb","year":"2002","journal-title":"Hum Immunol."},{"key":"B179","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1046\/j.1365-2567.1996.d01-633.x","article-title":"Impact of donor MHC class I or class II antigen deficiency on first- and second-set rejection of mouse heart or liver allografts","volume":"88","author":"Qian","year":"1996","journal-title":"Immunology."},{"key":"B180","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/BF00364273","article-title":"Water-soluble form of RT1.A class I MHC molecules in the kidney and liver of the rat","volume":"25","author":"Spencer","year":"1987","journal-title":"Immunogenetics."},{"key":"B181","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1111\/j.1365-2249.1993.tb03376.x","article-title":"Interaction of papain-digested HLA class I molecules with human alloreactive cytotoxic T lymphocytes (CTL)","volume":"91","author":"Hausmann","year":"1993","journal-title":"Clin Exp Immunol."},{"key":"B182","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1046\/j.1365-2249.2000.01092.x","article-title":"Inhibition of Epstein-Barr virus (EBV)-specific CD8+ cytotoxic T lymphocyte (CTL) activity by soluble HLA class I in vitro","volume":"119","author":"Gansuvd","year":"2000","journal-title":"Clin Exp Immunol."},{"key":"B183","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1097\/00007890-200112270-00018","article-title":"Donor-derived soluble MHC antigens plus low-dose cyclosporine induce transplantation unresponsiveness independent of the thymus by down-regulating T cell-mediated alloresponses in a rat transplantation model","volume":"72","author":"Behrens","year":"2001","journal-title":"Transplantation."},{"key":"B184","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1016\/j.transproceed.2005.02.114","article-title":"Donor MHC class I peptides in conjunction with self-epitopes induce donor-specific tolerance in a dose-dependent manner but unable to abrogate chronic rejection","volume":"37","author":"Semiletova","year":"2005","journal-title":"Transplant Proc."},{"key":"B185","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s00423-008-0298-2","article-title":"Prolongation of heart allograft survival after long-term expression of soluble MHC class I antigens and vIL-10 in the liver by AAV-plasmid-mediated gene transfer","volume":"393","author":"Doenecke","year":"2008","journal-title":"Langenbecks Arch Surg."},{"key":"B186","doi-asserted-by":"publisher","first-page":"6671","DOI":"10.1073\/pnas.90.14.6671","article-title":"A soluble divalent class I major histocompatibility complex molecule inhibits alloreactive T cells at nanomolar concentrations","volume":"90","author":"Porto","year":"1993","journal-title":"Proc Natl Acad Sci USA."},{"key":"B187","doi-asserted-by":"publisher","first-page":"2555","DOI":"10.4049\/jimmunol.167.5.2555","article-title":"Antigen-Specific blockade of t cells in vivo using dimeric mhc peptide","volume":"167","author":"O'Herrin","year":"2001","journal-title":"J Immunol."},{"key":"B188","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1189\/jlb.0205078","article-title":"Recombinant dimeric MHC antigens protect cardiac allografts from rejection and visualize alloreactive T cells","volume":"78","author":"Fried","year":"2005","journal-title":"J Leukocyte Biol."},{"key":"B189","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1097\/00007890-199310000-00042","article-title":"Persistence of donor lymphocytes in liver allograft recipients","volume":"56","author":"Schlitt","year":"1993","journal-title":"Transplantation."},{"key":"B190","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1002\/hep.1840170629","article-title":"Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance","volume":"17","author":"Starzl","year":"1993","journal-title":"Hepatology."},{"key":"B191","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/0140-6736(92)93286-V","article-title":"Systemic chimerism in human female recipients of male livers","volume":"340","author":"Starzl","year":"1992","journal-title":"Lancet."},{"key":"B192","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1097\/00007890-198707000-00022","article-title":"Prolonged survival of cultured keratinocyte allografts in the nonimmunosuppressed mouse","volume":"44","author":"Hammond","year":"1987","journal-title":"Transplantation."},{"key":"B193","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/ajt.13446","article-title":"Altered immunogenicity of donor lungs via removal of passenger leukocytes using ex vivo lung perfusion","volume":"16","author":"Stone","year":"2016","journal-title":"Am J Transplant."},{"key":"B194","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1111\/ajt.13584","article-title":"Immunotoxin against a donor mhc class ii molecule induces indefinite survival of murine kidney allografts","volume":"16","author":"Brown","year":"2016","journal-title":"Am J Transplant."},{"key":"B195","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.4049\/jimmunol.156.12.4925","article-title":"Tolerance to rat liver allografts. III. Donor cell migration and tolerance-associated cytokine production in peripheral lymphoid tissues","volume":"156","author":"Bishop","year":"1996","journal-title":"J Immunol."},{"key":"B196","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1097\/00007890-199508000-00004","article-title":"Deletion of spontaneous rat liver allograft acceptance by donor irradiation","volume":"60","author":"Sun","year":"1995","journal-title":"Transplantation."},{"key":"B197","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1111\/j.1432-2277.1996.tb00920.x","article-title":"Restoration of tolerance to rat hepatic allografts by spleen-derived passenger leukocytes","volume":"9","author":"Shimizu","year":"1996","journal-title":"Transpl Int."},{"key":"B198","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1097\/00007890-199612270-00005","article-title":"Tolerance to rat liver allografts: IV. Acceptance depends on the quantity of donor tissue and on donor leukocytes","volume":"62","author":"Sun","year":"1996","journal-title":"Transplantation."},{"key":"B199","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1097\/00007890-199912150-00018","article-title":"Evidence that apoptosis of activated T cells occurs in spontaneous tolerance of liver allografts and is blocked by manipulations which break tolerance","volume":"68","author":"Sharland","year":"1999","journal-title":"Transplantation."},{"key":"B200","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1002\/hep.510270406","article-title":"Defining the outcome of immunosuppression withdrawal after liver transplantation","volume":"27","author":"Devlin","year":"1998","journal-title":"Hepatology."},{"key":"B201","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1016\/j.transproceed.2005.03.070","article-title":"Long-term outcome of immunosuppression withdrawal after liver transplantation","volume":"37","author":"Girlanda","year":"2005","journal-title":"Transplant Proc."},{"key":"B202","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/S0167-5699(96)10069-4","article-title":"Chimerism and transplantation tolerance: cause and effect","volume":"17","author":"Wood","year":"1996","journal-title":"Immunol Today."},{"key":"B203","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1097\/00007890-196811000-00003","article-title":"On prolonged survival of massive skin allografts in mice","volume":"6","author":"Zanella","year":"1968","journal-title":"Transplantation."},{"key":"B204","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1097\/00007890-196905000-00006","article-title":"The importance of target size in the destruction of skin grafts with non-H-2 incompatibility","volume":"7","author":"Lapp\u00e9","year":"1969","journal-title":"Transplantation."},{"key":"B205","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1002\/(SICI)1098-2752-1999-19:7<318::AID-MICR5>3.0.CO","article-title":"Outcome of different models of multiorgan transplantation in rats","volume":"19","author":"Wang","year":"1999","journal-title":"Microsurgery."},{"key":"B206","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1080\/08941930802216823","article-title":"Induction of rejection after small-for-size liver transplantation: size matters","volume":"21","author":"Dirsch","year":"2008","journal-title":"J Invest Surg."},{"key":"B207","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1046\/j.1600-6143.2003.00313.x","article-title":"Linking inflammation to acute rejection in small-for-size liver allografts: the potential role of early macrophage activation","volume":"4","author":"Yang","year":"2004","journal-title":"Am J Transplant."},{"key":"B208","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1097\/00007890-199402150-00004","article-title":"Regeneration-induced accelerated rejection in reduced-size liver grafts","volume":"57","author":"Shiraishi","year":"1994","journal-title":"Transplantation."},{"key":"B209","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1097\/00007890-199711270-00001","article-title":"High-dose\/activation-associated tolerance: a mechanism for allograft tolerance","volume":"64","author":"Bishop","year":"1997","journal-title":"Transplantation."},{"key":"B210","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1097\/01.TP.0000071204.03720.BB","article-title":"Analysis of the united network for organ sharing database comparing renal allografts and patient survival in combined liver-kidney transplantation with the contralateral allografts in kidney alone or kidney-pancreas transplantation","volume":"76","author":"Fong","year":"2003","journal-title":"Transplantation."},{"key":"B211","doi-asserted-by":"publisher","first-page":"240","DOI":"10.4049\/jimmunol.172.1.240","article-title":"Effects of T cell frequency and graft size on transplant outcome in mice","volume":"172","author":"He","year":"2004","journal-title":"J Immunol."},{"key":"B212","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.trim.2012.08.001","article-title":"Expression of common gamma chain signalling cytokines and their receptors distinguishes rejection from tolerance in a rat organ transplant model","volume":"27","author":"Ganbold","year":"2012","journal-title":"Transplant Immunol."},{"key":"B213","doi-asserted-by":"publisher","first-page":"E2540","DOI":"10.1073\/pnas.1406674111","article-title":"Antigen expression level threshold tunes the fate of CD8 T cells during primary hepatic immune responses","volume":"111","author":"Tay","year":"2014","journal-title":"Proc Natl Acad Sci USA."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01203\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T04:55:55Z","timestamp":1696222555000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01203\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,12]]},"references-count":213,"alternative-id":["10.3389\/fimmu.2020.01203"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.01203","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,12]]},"article-number":"1203"}}