{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T17:34:26Z","timestamp":1793900066678,"version":"4.8.0"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000550","name":"British Geriatrics Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000550","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.01403","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T07:28:43Z","timestamp":1594106923000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["C-Reactive Protein Predicts Further Ischemic Events in Patients With Transient Ischemic Attack or Lacunar Stroke"],"prefix":"10.3389","volume":"11","author":[{"given":"Manuela","family":"Mengozzi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances A.","family":"Kirkham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esme E. R.","family":"Girdwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Bunting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Drazich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Timeyin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Ghezzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chakravarthi","family":"Rajkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/S1474-4422(19)30034-1","article-title":"Global, regional, and national burden of stroke, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"Collaborators","year":"2019","journal-title":"Lancet Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S1474-4422(19)30030-4","article-title":"The global burden of stroke: persistent and disabling","volume":"18","author":"Gorelick","year":"2019","journal-title":"Lancet Neurol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1056\/NEJMoa1412981","article-title":"One-year risk of stroke after transient ischemic attack or minor stroke","volume":"374","author":"Amarenco","year":"2016","journal-title":"N Engl J Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/ane.13093","article-title":"Recurrent ischemic stroke: incidence, predictors, and impact on mortality","volume":"140","author":"Khanevski","year":"2019","journal-title":"Acta Neurol Scand."},{"key":"B5","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/S0140-6736(10)60834-3","article-title":"Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study","volume":"376","author":"O'Donnell","year":"2010","journal-title":"Lancet."},{"key":"B6","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/S1474-4422(16)00114-9","article-title":"Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation","volume":"15","author":"Chamorro","year":"2016","journal-title":"Lancet Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1161\/hs1101.098151","article-title":"Plasma concentration of C-reactive protein and risk of ischemic stroke and transient ischemic attack: the Framingham study","volume":"32","author":"Rost","year":"2001","journal-title":"Stroke."},{"key":"B8","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/S0140-6736(09)61717-7","article-title":"C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis","volume":"375","author":"Kaptoge","year":"2010","journal-title":"Lancet."},{"key":"B9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cca.2015.11.027","article-title":"Hs-CRP in stroke: a meta-analysis","volume":"453","author":"Zhou","year":"2016","journal-title":"Clin Chim Acta."},{"key":"B10","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.atherosclerosis.2017.02.003","article-title":"Hs-CRP and all-cause, cardiovascular, and cancer mortality risk: a meta-analysis","volume":"259","author":"Li","year":"2017","journal-title":"Atherosclerosis."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2459","DOI":"10.1161\/01.STR.0000029828.51413.82","article-title":"Prognostic relevance of early serial C-reactive protein measurements after first ischemic stroke","volume":"33","author":"Winbeck","year":"2002","journal-title":"Stroke."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2463","DOI":"10.1161\/01.STR.0000089920.93927.A7","article-title":"C-reactive protein predicts further ischemic events in first-ever transient ischemic attack or stroke patients with intracranial large-artery occlusive disease","volume":"34","author":"Arenillas","year":"2003","journal-title":"Stroke."},{"key":"B13","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/j.1365-2796.2005.01514.x","article-title":"Prognostic role of C-reactive protein in very old patients with acute ischaemic stroke","volume":"258","author":"Masotti","year":"2005","journal-title":"J Intern Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/j.1600-0404.2006.00715.x","article-title":"C-reactive protein predicts further ischemic events in transient ischemic attack patients","volume":"115","author":"Purroy","year":"2007","journal-title":"Acta Neurol Scand."},{"key":"B15","doi-asserted-by":"publisher","first-page":"363","DOI":"10.2217\/bmm.09.30","article-title":"Molecular biomarkers in stroke diagnosis and prognosis","volume":"3","author":"Maas","year":"2009","journal-title":"Biomark Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e003678","DOI":"10.1136\/bmjopen-2013-003678","article-title":"Predictive role of C reactive protein in stroke recurrence after cardioembolic stroke: the Fukuoka Stroke Registry","volume":"3","author":"Kuwashiro","year":"2013","journal-title":"BMJ Open."},{"key":"B17","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1161\/ATVBAHA.112.300350","article-title":"Association between interleukin-6 levels and first-ever cerebrovascular events in patients with vascular risk factors","volume":"33","author":"Miwa","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.11.016","article-title":"Prognostic value of C-reactive protein and homocysteine in large-artery atherosclerotic stroke: a prospective observational study","volume":"26","author":"Ye","year":"2017","journal-title":"J Stroke Cerebrovasc Dis."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1089\/ars.2015.6433","article-title":"Reactive oxygen-related diseases: therapeutic targets and emerging clinical indications","volume":"23","author":"Casas","year":"2015","journal-title":"Antioxid Redox Signal."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1089\/ars.2015.6317","article-title":"Clinical relevance of biomarkers of oxidative stress","volume":"23","author":"Frijhoff","year":"2015","journal-title":"Antioxid Redox Signal."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1021\/pr101123t","article-title":"Brain extracellular fluid protein changes in acute stroke patients","volume":"10","author":"Dayon","year":"2011","journal-title":"J Proteome Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"38300","DOI":"10.1038\/srep38300","article-title":"Diagnostic performance of peroxiredoxin 1 to determine time-of-onset of acute cerebral infarction","volume":"6","author":"Richard","year":"2016","journal-title":"Sci Rep."},{"key":"B23","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1038\/nm.2749","article-title":"Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain","volume":"18","author":"Shichita","year":"2012","journal-title":"Nat Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.1242\/jeb.01049","article-title":"Erythropoietin and the hypoxic brain","volume":"207","author":"Marti","year":"2004","journal-title":"J Exp Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/2040-7378-1-4","article-title":"Erythropoietin: a multimodal neuroprotective agent","volume":"1","author":"Byts","year":"2009","journal-title":"Exp. Transl. Stroke Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e647","DOI":"10.1161\/STROKEAHA.109.564872","article-title":"Recombinant human erythropoietin in the treatment of acute ischemic stroke","volume":"40","author":"Ehrenreich","year":"2009","journal-title":"Stroke."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.2119\/molmed.2011.00259","article-title":"Circulating damage marker profiles support a neuroprotective effect of erythropoietin in ischemic stroke patients","volume":"17","author":"Ehrenreich","year":"2011","journal-title":"Mol Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s13054-015-0761-8","article-title":"Erythropoietin improves long-term neurological outcome in acute ischemic stroke patients: a randomized, prospective, placebo-controlled clinical trial","volume":"19","author":"Tsai","year":"2015","journal-title":"Crit Care."},{"key":"B29","doi-asserted-by":"publisher","first-page":"853","DOI":"10.2174\/1567201813666160822104813","article-title":"Erythropoietin treatment in patients with acute ischemic stroke: a systematic review and meta-analysis of randomized controlled trials","volume":"14","author":"Yao","year":"2017","journal-title":"Curr Drug Deliv."},{"key":"B30","doi-asserted-by":"publisher","first-page":"e009827","DOI":"10.1136\/bmjopen-2015-009827","article-title":"Serum erythropoietin and outcome after ischaemic stroke: a prospective study","volume":"6","author":"Aberg","year":"2016","journal-title":"BMJ Open."},{"key":"B31","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.jacc.2004.03.052","article-title":"Prognostic value of plasma erythropoietin on mortality in patients with chronic heart failure","volume":"44","author":"van der Meer","year":"2004","journal-title":"J Am Coll Cardiol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s40620-019-00655-6","article-title":"Aortic stiffness and central systolic pressure are associated with ambulatory orthostatic BP fall in chronic kidney disease","volume":"33","author":"Kirkham","year":"2019","journal-title":"J Nephrol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1373\/clinchem.2003.021956","article-title":"Immediate availability of C-reactive protein and leukocyte count data influenced physicians' decisions to prescribe antimicrobial drugs for new outpatients with acute infections","volume":"50","author":"Takemura","year":"2004","journal-title":"Clin Chem."},{"key":"B34","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1053\/jscd.2003.16","article-title":"C-reactive protein in ischemic stroke and its etiologic subtypes","volume":"12","author":"Eikelboom","year":"2003","journal-title":"J Stroke Cerebrovasc Dis."},{"key":"B35","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s10072-008-0975-5","article-title":"C-reactive protein and aetiological subtypes of cerebral infarction","volume":"29","author":"Terruzzi","year":"2008","journal-title":"Neurol Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1007\/s00415-009-5228-x","article-title":"C-reactive protein in the very early phase of acute ischemic stroke: association with poor outcome and death","volume":"256","author":"den Hertog","year":"2009","journal-title":"J Neurol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1161\/STROKEAHA.113.004562","article-title":"C-reactive protein as a prognostic marker after lacunar stroke: levels of inflammatory markers in the treatment of stroke study","volume":"45","author":"Elkind","year":"2014","journal-title":"Stroke."},{"key":"B38","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1161\/01.CIR.0000053731.05365.5A","article-title":"Coming of age of C-reactive protein: using inflammation markers in cardiology","volume":"107","author":"Yeh","year":"2003","journal-title":"Circulation."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1161\/STROKEAHA.109.553545","article-title":"Lipoprotein-associated phospholipase A2 and C-reactive protein for risk-stratification of patients with TIA","volume":"40","author":"Cucchiara","year":"2009","journal-title":"Stroke."},{"key":"B40","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1161\/01.STR.22.2.155","article-title":"Stroke recurrence within 2 years after ischemic infarction","volume":"22","author":"Hier","year":"1991","journal-title":"Stroke."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2491","DOI":"10.1161\/01.STR.29.12.2491","article-title":"Long-term risk of first recurrent stroke in the perth community stroke study","volume":"29","author":"Hankey","year":"1998","journal-title":"Stroke."},{"key":"B42","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1016\/j.jstrokecerebrovasdis.2013.05.021","article-title":"Predictors of stroke recurrence in patients with recent lacunar stroke and response to interventions according to risk status: secondary prevention of small subcortical strokes trial","volume":"23","author":"Hart","year":"2014","journal-title":"J Stroke Cerebrovasc Dis."},{"key":"B43","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1001\/jama.286.3.327","article-title":"C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus","volume":"286","author":"Pradhan","year":"2001","journal-title":"JAMA."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1131","DOI":"10.2337\/diabetes.51.4.1131","article-title":"Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the insulin resistance atherosclerosis study","volume":"51","author":"Festa","year":"2002","journal-title":"Diabetes."},{"key":"B45","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.bpa.2010.10.005","article-title":"Erythropoietin as neuroprotective and neuroregenerative treatment strategy: comprehensive overview of 12 years of preclinical and clinical research","volume":"24","author":"Sargin","year":"2010","journal-title":"Best Pract Res Clin Anaesthesiol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1002\/ejhf.484","article-title":"High serum erythropoietin levels are related to heart failure development in subjects from the general population with albuminuria: data from PREVEND","volume":"18","author":"Grote Beverborg","year":"2016","journal-title":"Eur J Heart Fail."},{"key":"B47","doi-asserted-by":"publisher","first-page":"10321","DOI":"10.1523\/JNEUROSCI.4014-05.2005","article-title":"A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo","volume":"25","author":"Shih","year":"2005","journal-title":"J Neurosci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1073\/pnas.0505723102","article-title":"Activation of the Keap1\/Nrf2 pathway for neuroprotection by electrophilic [correction of electrophillic] phase II inducers","volume":"103","author":"Satoh","year":"2006","journal-title":"Proc Natl Acad Sci USA."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01403\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T07:28:46Z","timestamp":1594106926000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01403\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,7]]},"references-count":48,"alternative-id":["10.3389\/fimmu.2020.01403"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.01403","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,7]]},"article-number":"1403"}}