{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T13:51:01Z","timestamp":1776779461587,"version":"3.51.2"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81630082"],"award-info":[{"award-number":["81630082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773318"],"award-info":[{"award-number":["81773318"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672089"],"award-info":[{"award-number":["81672089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573039"],"award-info":[{"award-number":["81573039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930089"],"award-info":[{"award-number":["81930089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.01432","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T05:23:42Z","timestamp":1596173022000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Quantitative Proteomic Profile of Psoriatic Epidermis Identifies OAS2 as a Novel Biomarker for Disease Activity"],"prefix":"10.3389","volume":"11","author":[{"given":"Yuan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing-Xi","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue-Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilla","family":"Landeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao-Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Yong","family":"Man","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1056\/NEJMra0804595","article-title":"Psoriasis","volume":"361","author":"Nestle","year":"2009","journal-title":"N Engl J Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/S0140-6736(14)61909-7","article-title":"Psoriasis","volume":"386","author":"Boehncke","year":"2015","journal-title":"Lancet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"16082","DOI":"10.1038\/nrdp.2016.82","article-title":"Psoriasis","volume":"2","author":"Greb","year":"2016","journal-title":"Nat Rev Dis Primers."},{"key":"B4","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/j.0022-202X.2004.23501.x","article-title":"Proteome analysis of skin distinguishes acute guttate from chronic plaque psoriasis","volume":"124","author":"Carlen","year":"2005","journal-title":"J Invest Dermatol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1038\/ng.2467","article-title":"Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity","volume":"44","author":"Tsoi","year":"2012","journal-title":"Nat Genet"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.immuni.2013.11.011","article-title":"S100A8-S100A9 protein complex mediates psoriasis by regulating the expression of complement factor C3","volume":"39","author":"Schonthaler","year":"2013","journal-title":"Immunity."},{"key":"B7","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1186\/1471-2164-14-527","article-title":"Dissecting the psoriasis transcriptome: inflammatory- and cytokine-driven gene expression in lesions from 163 patients","volume":"14","author":"Swindell","year":"2013","journal-title":"BMC Genomics."},{"key":"B8","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.jprot.2013.09.010","article-title":"A proteomics approach to the identification of biomarkers for psoriasis utilising keratome biopsy","volume":"94","author":"Williamson","year":"2013","journal-title":"J Proteomics."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1038\/jid.2014.28","article-title":"Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms","volume":"134","author":"Li","year":"2014","journal-title":"J Invest Dermatol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/ng.2827","article-title":"A large-scale screen for coding variants predisposing to psoriasis","volume":"46","author":"Tang","year":"2014","journal-title":"Nat Genet."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1559-0275-12-1","article-title":"Quantitative tandem mass-spectrometry of skin tissue reveals putative psoriatic arthritis biomarkers","volume":"12","author":"Cretu","year":"2015","journal-title":"Clin Proteomics."},{"key":"B12","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.gpb.2015.04.002","article-title":"Biomarkers of an autoimmune skin disease\u2013psoriasis","volume":"13","author":"Jiang","year":"2015","journal-title":"Genomics Proteomics Bioinformatics."},{"key":"B13","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s13073-015-0208-5","article-title":"Proteogenomic analysis of psoriasis reveals discordant and concordant changes in mRNA and protein abundance","volume":"7","author":"Swindell","year":"2015","journal-title":"Genome Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"6793","DOI":"10.1038\/ncomms7793","article-title":"Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis","volume":"6","author":"Zuo","year":"2015","journal-title":"Nat Commun."},{"key":"B15","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.jprot.2016.03.040","article-title":"Proteomic biomarkers for psoriasis and psoriasis arthritis","volume":"140","author":"Reindl","year":"2016","journal-title":"J Proteomics."},{"key":"B16","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.jpba.2018.03.068","article-title":"Proteomic plasma profile of psoriatic patients","volume":"155","author":"Gegotek","year":"2018","journal-title":"J Pharm Biomed Anal."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e1800003","DOI":"10.1002\/pmic.201800003","article-title":"Quantitative analysis of the global proteome in peripheral blood mononuclear cells from patients with new-onset psoriasis","volume":"18","author":"Li","year":"2018","journal-title":"Proteomics."},{"key":"B18","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.gene.2018.01.033","article-title":"Systems biomarkers in psoriasis: integrative evaluation of computational and experimental data at transcript and protein levels","volume":"647","author":"Sevimoglu","year":"2018","journal-title":"Gene."},{"key":"B19","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/nature13302","article-title":"A draft map of the human proteome","volume":"509","author":"Kim","year":"2014","journal-title":"Nature."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1111\/cea.12979","article-title":"Identification of unique proteomic signatures in allergic and non-allergic skin disease","volume":"47","author":"Wang","year":"2017","journal-title":"Clin Exp Allergy."},{"key":"B21","doi-asserted-by":"publisher","first-page":"E1141","DOI":"10.3390\/ijms20051141","article-title":"Proteomics in psoriasis","volume":"20","author":"Chularojanamontri","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B22","doi-asserted-by":"publisher","first-page":"e12477","DOI":"10.1111\/cpr.12477","article-title":"The role of Sprouty1 in the proliferation, differentiation and apoptosis of epidermal keratinocytes","volume":"51","author":"Wang","year":"2018","journal-title":"Cell Prolif."},{"key":"B23","first-page":"311","article-title":"Inhibition of the hedgehog pathway leads to antifibrotic effects in dermal fibrosis","volume":"22","author":"Cao","year":"2016","journal-title":"Discov Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"150032","DOI":"10.1098\/rsob.150032","article-title":"Analysis of epithelial-mesenchymal transition markers in psoriatic epidermal keratinocytes","volume":"5","author":"Man","year":"2015","journal-title":"Open Biol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"3828","DOI":"10.4049\/jimmunol.1301737","article-title":"Gene expression profiles normalized in psoriatic skin by treatment with brodalumab, a human anti-IL-17 receptor monoclonal antibody","volume":"192","author":"Russell","year":"2014","journal-title":"J Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1951","DOI":"10.1111\/jdv.13091","article-title":"Antiviral gene expression in psoriasis","volume":"29","author":"Raposo","year":"2015","journal-title":"J Eur Acad Dermatol Venereol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1056\/NEJMoa1806382","article-title":"Phase 2 trial of selective tyrosine kinase 2 inhibition in psoriasis","volume":"379","author":"Papp","year":"2018","journal-title":"N Engl J Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1093\/intimm\/dxt062","article-title":"Tyk2 is a therapeutic target for psoriasis-like skin inflammation","volume":"26","author":"Ishizaki","year":"2014","journal-title":"Int Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/j.1600-0625.1999.tb00345.x","article-title":"Enzymatic dissociation of keratinocytes from human skin biopsies for in vitro cell propagation","volume":"8","author":"Hybbinette","year":"1999","journal-title":"Exp Dermatol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1038\/jid.2010.67","article-title":"Evidence for altered Wnt signaling in psoriatic skin","volume":"130","author":"Gudjonsson","year":"2010","journal-title":"J Invest Dermatol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.7150\/ijms.20809","article-title":"IL-36gamma inhibits differentiation and induces inflammation of keratinocyte via Wnt signaling pathway in psoriasis","volume":"14","author":"Wang","year":"2017","journal-title":"Int J Med Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"3965","DOI":"10.1172\/JCI63451","article-title":"Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk","volume":"122","author":"Tortola","year":"2012","journal-title":"J Clin Invest."},{"key":"B33","doi-asserted-by":"publisher","first-page":"eaan2514","DOI":"10.1126\/scitranslmed.aan2514","article-title":"An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target","volume":"9","author":"Mahil","year":"2017","journal-title":"Sci Transl Med"},{"key":"B34","doi-asserted-by":"publisher","first-page":"196","DOI":"10.2340\/00015555-3066","article-title":"The keratinocyte transcriptome in psoriasis: pathways related to immune responses, cell cycle and keratinization","volume":"99","author":"Pasquali","year":"2019","journal-title":"Acta Derm Venereol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.it.2018.02.003","article-title":"Innate antiviral immunity in the skin","volume":"39","author":"Handfield","year":"2018","journal-title":"Trends Immunol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"204ra129","DOI":"10.1126\/scitranslmed.3006245","article-title":"IL-29 is produced by T(H)17 cells and mediates the cutaneous antiviral competence in psoriasis","volume":"5","author":"Wolk","year":"2013","journal-title":"Sci Transl Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/jid.2011.348","article-title":"A subset of methylated CpG sites differentiate psoriatic from normal skin","volume":"132","author":"Roberson","year":"2012","journal-title":"J Invest Dermatol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"32579","DOI":"10.1038\/srep32579","article-title":"Epigenetic regulation of OAS2 shows disease-specific DNA methylation profiles at individual CpG sites","volume":"6","author":"Gu","year":"2016","journal-title":"Sci Rep."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01432\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T05:23:47Z","timestamp":1596173027000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01432\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,31]]},"references-count":38,"alternative-id":["10.3389\/fimmu.2020.01432"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.01432","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,31]]},"article-number":"1432"}}