{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T12:24:48Z","timestamp":1780662288101,"version":"3.54.1"},"reference-count":102,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.01489","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T05:33:41Z","timestamp":1596087221000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Helminth Sensing at the Intestinal Epithelial Barrier\u2014A Taste of Things to Come"],"prefix":"10.3389","volume":"11","author":[{"given":"Aduragbemi A.","family":"Faniyi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Wijanarko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Tollitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Worthington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1097\/MOG.0000000000000025","article-title":"Global progress towards eliminating gastrointestinal helminth infections","volume":"30","author":"McCarty","year":"2014","journal-title":"Curr Opin Gastroenterol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e64","DOI":"10.1016\/S1473-3099(16)30535-7","article-title":"A call to strengthen the global strategy against schistosomiasis and soil-transmitted helminthiasis: the time is now","volume":"17","author":"Lo","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"B3","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.4049\/jimmunol.160.7.3453","article-title":"A critical role for IL-13 in resistance to intestinal nematode infection","volume":"160","author":"Bancroft","year":"1998","journal-title":"J Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S1074-7613(00)80477-X","article-title":"IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis","volume":"8","author":"Urban","year":"1998","journal-title":"Immunity"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1084\/jem.189.10.1565","article-title":"Simultaneous disruption of interleukin. (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses","volume":"189","author":"McKenzie","year":"1999","journal-title":"J Exp Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1002\/1521-4141(200007)30:7andlt;2083::AID-IMMU2083andgt;3.0.CO;2-3","article-title":"Gastrointestinal nematode expulsion in IL-4 knockout mice is IL-13 dependent","volume":"30","author":"Bancroft","year":"2020","journal-title":"Eur J Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.4049\/jimmunol.164.4.2046","article-title":"Stat6 signaling promotes protective immunity against Trichinella spiralis through a mast cell- and T cell-dependent mechanism","volume":"164","author":"Urban","year":"2020","journal-title":"J Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1086\/425014","article-title":"T helper cell type 2 responsiveness predicts future susceptibility to gastrointestinal nematodes in humans","volume":"190","author":"Jackson","year":"2004","journal-title":"J Infect Dis"},{"key":"B9","doi-asserted-by":"publisher","first-page":"a016337","DOI":"10.1101\/cshperspect.a016337","article-title":"Group 2 innate lymphoid cells in health and disease","volume":"7","author":"Kim","year":"2015","journal-title":"Cold Spring Harb Perspect Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"623","DOI":"10.3389\/fimmu.2019.00623","article-title":"ILC2s-trailblazers in the host response against intestinal helminths","volume":"10","author":"Bouchery","year":"2019","journal-title":"Front Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1172\/JCI124606","article-title":"Epithelial cell-derived cytokines: more than just signaling the alarm","volume":"129","author":"Roan","year":"2019","journal-title":"J Clin Invest"},{"key":"B12","doi-asserted-by":"publisher","first-page":"6631","DOI":"10.1073\/pnas.93.13.6631","article-title":"Taste receptor-like cells in the rat gut identified by expression of alpha-gustducin","volume":"93","author":"H\u00f6fer","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"B13","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1002\/cne.21768","article-title":"Murine intestinal cells expressing Trpm5 are mostly brush cells and express markers of neuronal and inflammatory cells","volume":"509","author":"Bezen\u00e7on","year":"2008","journal-title":"J Comp Neurol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1053\/j.gastro.2009.06.072","article-title":"DCAMKL-1 expression identifies Tuft cells rather than stem cells in the adult mouse intestinal epithelium","volume":"137","author":"Gerbe","year":"2009","journal-title":"Gastroenterology."},{"key":"B15","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1083\/jcb.201010127","article-title":"Distinct ATOH1 and Neurog3 requirements define tuft cells as a new secretory cell type in the intestinal epithelium","volume":"192","author":"Gerbe","year":"2011","journal-title":"J Cell Biol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/ncb2384","article-title":"Single-molecule transcript counting of stem-cell markers in the mouse intestine","volume":"14","author":"Itzkovitz","year":"2011","journal-title":"Nat Cell Biol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s00418-011-0831-1","article-title":"Gastric tuft cells express DCLK1 and are expanded in hyperplasia","volume":"136","author":"Saqui-Salces","year":"2011","journal-title":"Histochem Cell Biol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.ydbio.2011.12.009","article-title":"Origin of the brush cell lineage in the mouse intestinal epithelium","volume":"362","author":"Bjerknes","year":"2012","journal-title":"Dev Biol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/nature16527","article-title":"Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites","volume":"529","author":"Gerbe","year":"2016","journal-title":"Nature"},{"key":"B20","doi-asserted-by":"publisher","first-page":"e0189340","DOI":"10.1371\/journal.pone.0189340","article-title":"Skn-1a\/Pou2f3 functions as a master regulator to generate Trpm5-expressing chemosensory cells in mice","volume":"12","author":"Yamashita","year":"2017","journal-title":"PLoS ONE"},{"key":"B21","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.pt.2016.04.016","article-title":"Tuft cells: a new flavor in innate epithelial immunity","volume":"32","author":"Grencis","year":"2016","journal-title":"Trends Parasitol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1053\/j.gastro.2010.01.045","article-title":"Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection","volume":"138","author":"Hasnain","year":"2010","journal-title":"Gastroenterology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1084\/jem.20102057","article-title":"Muc5ac: a critical component mediating the rejection of enteric nematodes","volume":"208","author":"Hasnain","year":"2011","journal-title":"J Exp Med"},{"key":"B24","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nature16161","article-title":"Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit","volume":"529","author":"von Moltke","year":"2016","journal-title":"Nature"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1016\/j.cell.2018.10.008","article-title":"T helper cell cytokines modulate intestinal stem cell renewal and differentiation","volume":"175","author":"Biton","year":"","journal-title":"Cell. ("},{"key":"B26","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/s41590-018-0297-6","article-title":"IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3","volume":"20","author":"Zhu","year":"2019","journal-title":"Nat Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1126\/science.aaf1648","article-title":"Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut","volume":"351","author":"Howitt","year":"2016","journal-title":"Science"},{"key":"B28","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature24489","article-title":"A single-cell survey of the small intestinal epithelium","volume":"551","author":"Haber","year":"2017","journal-title":"Nature"},{"key":"B29","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/s41586-018-0393-7","article-title":"A revised airway epithelial hierarchy includes CFTR-expressing ionocytes","volume":"560","author":"Montoro","year":"2018","journal-title":"Nature"},{"key":"B30","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/s41577-019-0176-x","article-title":"Regulation of immune responses by tuft cells","volume":"19","author":"Schneider","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.cell.2018.05.014","article-title":"A metabolite-triggered tuft cell-ILC2 circuit drives small intestinal remodeling","volume":"174","author":"Schneider","year":"2018","journal-title":"Cell."},{"key":"B32","doi-asserted-by":"publisher","first-page":"5564","DOI":"10.1073\/pnas.1812901116","article-title":"Infection by the parasitic helminth Trichinella spiralis activates a Tas2r-mediated signaling pathway in intestinal tuft cells","volume":"116","author":"Luo","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"B33","doi-asserted-by":"publisher","first-page":"5552","DOI":"10.1073\/pnas.1720758115","article-title":"Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine","volume":"115","author":"Lei","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"key":"B34","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.immuni.2018.06.016","article-title":"Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit","volume":"49","author":"Nadjsombati","year":"2018","journal-title":"Immunity."},{"key":"B35","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.immuni.2015.09.012","article-title":"The intestinal microbiota contributes to the ability of helminths to modulate allergic inflammation","volume":"43","author":"Zaiss","year":"2015","journal-title":"Immunity"},{"key":"B36","doi-asserted-by":"publisher","first-page":"17466","DOI":"10.1038\/s41598-019-53997-3","article-title":"Distribution pattern and molecular signature of cholinergic tuft cells in human gastro-intestinal and pancreatic-biliary tract","volume":"9","author":"Sch\u00fctz","year":"2019","journal-title":"Sci Rep"},{"key":"B37","doi-asserted-by":"publisher","first-page":"9478","DOI":"10.1073\/pnas.1019418108","article-title":"Cholinergic chemosensory cells in the trachea regulate breathing","volume":"108","author":"Krasteva","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"B38","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.immuni.2020.03.005","article-title":"Chemosensory cell-derived acetylcholine drives tracheal mucociliary clearance in response to virulence-associated formyl peptides","volume":"52","author":"Perniss","year":"2000","journal-title":"Immunity."},{"key":"B39","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/s41467-019-13850-7","article-title":"Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche","volume":"11","author":"Middelhoff","year":"2020","journal-title":"Nat Commun"},{"key":"B40","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/mi.2015.32","article-title":"New developments in goblet cell mucus secretion and function","volume":"8","author":"Birchenough","year":"2015","journal-title":"Mucosal Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.3389\/fimmu.2017.01085","article-title":"Expression and function of the cholinergic system in immune cells","volume":"8","author":"Fujii","year":"2017","journal-title":"Front Immunol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.immuni.2020.02.005","article-title":"Tuft-cell-derived leukotrienes drive rapid anti-helminth immunity in the small intestine but are dispensable for anti-protist immunity","volume":"52","author":"McGinty","year":"2000","journal-title":"Immunity."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1172\/JCI73434","article-title":"Long-lived intestinal tuft cells serve as colon cancer-initiating cells","volume":"124","author":"Westphalen","year":"2014","journal-title":"J Clin Invest"},{"key":"B44","doi-asserted-by":"publisher","first-page":"eaax7224","DOI":"10.1126\/sciimmunol.aax7224","article-title":"Airway brush cells generate cysteinyl leukotrienes through the ATP sensor P2Y2","volume":"5","author":"Ualiyeva","year":"2020","journal-title":"Sci Immunol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"23","DOI":"10.4049\/immunohorizons.1900099","article-title":"The taste receptor TAS1R3 regulates small intestinal tuft cell Homeostasis","volume":"4","author":"Howitt","year":"2020","journal-title":"Immunohorizons."},{"key":"B46","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1210\/en.2014-1710","article-title":"An analysis of cosecretion and coexpression of gut hormones from male rat proximal and distal small intestine","volume":"156","author":"Svendsen","year":"2015","journal-title":"Endocrinology"},{"key":"B47","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1530\/JOE-15-0247","article-title":"GLP1- and GIP-producing cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness","volume":"228","author":"Svendsen","year":"2016","journal-title":"J Endocrinol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1002\/cphy.c170047","article-title":"Distribution and stimulus secretion coupling of enteroendocrine cells along the intestinal tract","volume":"8","author":"Adriaenssens","year":"2018","journal-title":"Compr Physiol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s00441-019-03099-3","article-title":"Quantitation and chemical coding of enteroendocrine cell populations in the human jejunum","volume":"379","author":"Fazio Coles","year":"2020","journal-title":"Cell Tissue"},{"key":"B50","doi-asserted-by":"publisher","first-page":"e93487","DOI":"10.1172\/jci.insight.93487","article-title":"Optimized multiplex immunofluorescence single-cell analysis reveals tuft cell heterogeneity","volume":"2","author":"McKinley","year":"2017","journal-title":"JCI Insight."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1038\/s41598-017-01520-x","article-title":"The intestinal tuft cell nanostructure in 3D","volume":"7","author":"Hoover","year":"2017","journal-title":"Sci Rep"},{"key":"B52","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.yexcr.2018.05.011","article-title":"Tuft cells: distribution and connections with nerves and endocrine cells in mouse intestine","volume":"369","author":"Cheng","year":"2018","journal-title":"Exp Cell Res"},{"key":"B53","doi-asserted-by":"publisher","first-page":"26599","DOI":"10.1073\/pnas.1801888117","article-title":"Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion","volume":"116","author":"van Es","year":"2019","journal-title":"Proc Natl Acad Sci USA."},{"key":"B54","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/nrendo.2013.136","article-title":"The endocrinology of food intake","volume":"9","author":"Begg","year":"2013","journal-title":"Nat Rev Endocrinol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1038\/s41574-019-0168-8","article-title":"Function and mechanisms of enteroendocrine cells and gut hormones in metabolism","volume":"15","author":"Gribble","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/mi.2017.73","article-title":"Enteroendocrine cells-sensory sentinels of the intestinal environment and orchestrators of mucosal immunity","volume":"11","author":"Worthington","year":"2017","journal-title":"Mucosal Immunol"},{"key":"B57","first-page":"13","article-title":"The calcitonin secreting C cells and their relationship to the APUD cell series","volume":"45","author":"Pearse","year":"1969","journal-title":"J Endocrinol."},{"key":"B58","first-page":"23","article-title":"An experimental investigation into the possible origin of pancreatic islet cells from rhombencephalic neurectoderm","volume":"52","author":"Andrew","year":"1979","journal-title":"J Embryol Exp Morphol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/S0016-5085(83)80148-6","article-title":"Gut and pancreatic amine precursor uptake and decarboxylation cells are not neural crest derivatives","volume":"84","author":"Andrew","year":"1983","journal-title":"Gastroenterology"},{"key":"B60","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.stem.2016.11.001","article-title":"Induced quiescence of Lgr5+ stem cells in intestinal organoids enables differentiation of hormone-producing enteroendocrine cells","volume":"20","author":"Basak","year":"2017","journal-title":"Cell Stem Cell."},{"key":"B61","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1126\/science.1065718","article-title":"Requirement of Math1 for secretory cell lineage commitment in the mouse intestine","volume":"294","author":"Yang","year":"2001","journal-title":"Science"},{"key":"B62","doi-asserted-by":"publisher","first-page":"2478","DOI":"10.1053\/j.gastro.2007.03.047","article-title":"Intestine-specific ablation of mouse atonal homolog 1. (Math1) reveals a role in cellular homeostasis","volume":"132","author":"Shroyer","year":"2007","journal-title":"Gastroenterology"},{"key":"B63","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.mce.2009.12.009","article-title":"Gut endocrine cell development","volume":"323","author":"May","year":"2010","journal-title":"Mol Cell Endocrinol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/j.1463-1326.2011.01438.x","article-title":"Basic helix-loop-helix transcription factors and enteroendocrine cell differentiation","volume":"1","author":"Li","year":"","journal-title":"Diabetes Obes Metab. ("},{"key":"B65","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.1007\/s00018-012-0984-7","article-title":"The intestinal epithelium tuft cells: specification and function","volume":"69","author":"Gerbe","year":"2012","journal-title":"CMLS"},{"key":"B66","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/aja.1001410407","article-title":"Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine V. Unitarian theory of the origin of the four epithelial cell types","volume":"141","author":"Cheng","year":"1974","journal-title":"Am J Anatomy"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1038\/nature06196","article-title":"Identification of stem cells in small intestine and colon by marker gene Lgr5","volume":"449","author":"Barker","year":"2007","journal-title":"Nature."},{"key":"B68","doi-asserted-by":"publisher","first-page":"5782","DOI":"10.1210\/en.2012-1595","article-title":"A major lineage of enteroendocrine cells coexpress CCK, secretin, GIP, GLP-1, PYY, and neurotensin but not somatostatin","volume":"153","author":"Egerod","year":"2012","journal-title":"Endocrinology"},{"key":"B69","doi-asserted-by":"publisher","first-page":"3054","DOI":"10.1210\/en.2011-2170","article-title":"Overlap of endocrine hormone expression in the mouse intestine revealed by transcriptional profiling and flow cytometry","volume":"153","author":"Habib","year":"2012","journal-title":"Endocrinology"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1016\/j.cell.2018.12.029","article-title":"Identification of enteroendocrine regulators by real-time single-cell differentiation mapping","volume":"176","author":"Gehart","year":"2019","journal-title":"Cell."},{"key":"B71","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/s41556-018-0143-y","article-title":"Enteroendocrine cells switch hormone expression along the crypt-to-villus BMP signalling gradient","volume":"20","author":"Beumer","year":"2018","journal-title":"Nat Cell Biol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/0304-4017(90)90023-5","article-title":"Effects of multiple dose infections with ascaris-suum on blood gastrointestinal hormone levels in pigs","volume":"37","author":"Yang","year":"1990","journal-title":"Vet Parasitol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1079\/BJN19980008","article-title":"Elevation of feed intake in parasite-infected lambs by central administration of a cholecystokinin receptor antagonist","volume":"79","author":"Dynes","year":"1998","journal-title":"Br J Nutr"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1016\/S0020-7519(98)00112-X","article-title":"Infection of sheep with adult and larval Ostertagia circumcincta: gastrin","volume":"28","author":"Scott","year":"1998","journal-title":"Int J Parasitol"},{"key":"B75","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1111\/j.1365-2761.2005.00674.x","article-title":"Changes in the neuromodulators of the diffuse endocrine system of the alimentary canal of farmed rainbow trout, Oncorhynchus mykiss. (Walbaum), naturally infected with Eubothrium crassum. (Cestoda)","volume":"28","author":"Bosi","year":"2005","journal-title":"J Fish Dis"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1416","DOI":"10.1645\/GE-1214.1","article-title":"Histopathology and ultrastructure of Platichthys flesus naturally infected with Anisakis simplex s.l. larvae","volume":"93","author":"Dezfuli","year":"2007","journal-title":"(Nematoda: anisakidae). J Parasitol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/j.vetpar.2009.03.010","article-title":"Associations between blood gastrin, ghrelin, leptin, pepsinogen and Ostertagia ostertagi antibody concentrations and voluntary feed intake in calves exposed to a trickle infection with O. ostertagi","volume":"162","author":"Forbes","year":"2009","journal-title":"Vet Parasitol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1136\/gut.2005.081752","article-title":"Immune control of food intake: enteroendocrine cells are regulated by CD4(+) T lymphocytes during small intestinal inflammation","volume":"55","author":"McDermott","year":"2006","journal-title":"Gut"},{"key":"B79","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1136\/gut.2006.103226","article-title":"CD4(+) T cell-mediated immunological control of enterochromaffin cell hyperplasia and 5-hydroxytryptamine production in enteric infection","volume":"56","author":"Wang","year":"2007","journal-title":"Gut"},{"key":"B80","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1136\/gut.2007.129296","article-title":"Enterochromaffin cell and 5-hydroxytryptamine responses to the same infectious agent differ in Th1 and Th2 dominant environments","volume":"57","author":"Motomura","year":"2008","journal-title":"Gut"},{"key":"B81","doi-asserted-by":"publisher","first-page":"e1003122","DOI":"10.1371\/journal.ppat.1003122","article-title":"Adaptive immunity alters distinct host feeding pathways during nematode induced inflammation, a novel mechanism in parasite expulsion","volume":"9","author":"Worthington","year":"2013","journal-title":"PLoS Pathog"},{"key":"B82","doi-asserted-by":"publisher","first-page":"4296","DOI":"10.4049\/jimmunol.178.7.4296","article-title":"Activation of enteroendocrine cells via TLRs induces hormone, chemokine, and defensin secretion","volume":"178","author":"Palazzo","year":"2007","journal-title":"J Immunol"},{"key":"B83","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S0002-9610(03)00210-1","article-title":"Interactions between the enteric nervous system and the immune system: role of neuropeptides and nutrition","volume":"186","author":"Genton","year":"2003","journal-title":"Am J Surgery"},{"key":"B84","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1042\/BST20150090","article-title":"The intestinal immunoendocrine axis: novel cross-talk between enteroendocrine cells and the immune system during infection and inflammatory disease","volume":"43","author":"Worthington","year":"2015","journal-title":"Biochem Soc Transact"},{"key":"B85","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.2337\/db14-1577","article-title":"GLP-1 receptor. (GLP-1R) agonists modulate enteric immune responses through the intestinal intraepithelial lymphocyte. (IEL) GLP-1R","volume":"64","author":"Yusta","year":"2015","journal-title":"Diabetes"},{"key":"B86","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s00441-005-0140-x","article-title":"Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine","volume":"324","author":"Karaki","year":"2006","journal-title":"Cell Tissue Res"},{"key":"B87","doi-asserted-by":"publisher","first-page":"3552","DOI":"10.1210\/en.2013-1142","article-title":"GPR41\/FFAR3 and GPR43\/FFAR2 as cosensors for short-chain fatty acids in enteroendocrine cells vs FFAR3 in enteric neurons and FFAR2 in enteric leukocytes","volume":"154","author":"Nohr","year":"2013","journal-title":"Endocrinology"},{"key":"B88","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.molmet.2016.05.011","article-title":"How gut microbes talk to organs: the role of endocrine and nervous routes","volume":"5","author":"Cani","year":"2016","journal-title":"Mol Metab"},{"key":"B89","doi-asserted-by":"publisher","first-page":"111222","DOI":"10.1016\/j.molbiopara.2019.111222","article-title":"Helminth-microbiota cross-talk - A journey through the vertebrate digestive system","volume":"233","author":"Cortes","year":"2019","journal-title":"Mol Biochem Parasitol"},{"key":"B90","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.pt.2018.10.007","article-title":"Helminth microbiomes - a hidden treasure trove?","volume":"35","author":"Jenkins","year":"2019","journal-title":"Trends Parasitol"},{"key":"B91","doi-asserted-by":"publisher","first-page":"e0125495","DOI":"10.1371\/journal.pone.0125495","article-title":"Chronic trichuris muris infection decreases diversity of the intestinal microbiota and concomitantly increases the abundance of lactobacilli","volume":"10","author":"Holm","year":"2015","journal-title":"PLoS ONE"},{"key":"B92","doi-asserted-by":"publisher","first-page":"e0125945","DOI":"10.1371\/journal.pone.0125945","article-title":"Chronic trichuris muris infection in C57BL\/6 mice causes significant changes in host microbiota and metabolome: effects reversed by pathogen clearance","volume":"10","author":"Houlden","year":"2015","journal-title":"PLoS ONE"},{"key":"B93","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.cell.2004.07.002","article-title":"Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis","volume":"118","author":"Rakoff-Nahoum","year":"2004","journal-title":"Cell"},{"key":"B94","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1126\/science.aaf3229","article-title":"Helminth infection promotes colonization resistance via type 2 immunity","volume":"352","author":"Ramanan","year":"2016","journal-title":"Science"},{"key":"B95","doi-asserted-by":"publisher","first-page":"e0227561","DOI":"10.1371\/journal.pone.0227561","article-title":"Parasites modulate the gut-microbiome in insects: a proof-of-concept study","volume":"15","author":"Fredensborg","year":"2020","journal-title":"PLoS ONE."},{"key":"B96","doi-asserted-by":"publisher","first-page":"312","DOI":"10.3389\/fmicb.2020.00312","article-title":"Dietary inulin and trichuris suis infection promote beneficial bacteria throughout the porcine gut","volume":"11","author":"Stolzenbach","year":"2020","journal-title":"Front Microbiol"},{"key":"B97","doi-asserted-by":"publisher","first-page":"2557","DOI":"10.3389\/fimmu.2018.02557","article-title":"Mucosal barrier and Th2 immune responses are enhanced by dietary inulin in pigs infected with Trichuris suis","volume":"9","author":"Myhill","year":"2018","journal-title":"Front Immunol"},{"key":"B98","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s10735-010-9302-6","article-title":"Characterization of basal pseudopod-like processes in ileal and colonic PYY cells","volume":"42","author":"Boh\u00f3rquez","year":"2011","journal-title":"J Mol Histol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"eaat5236","DOI":"10.1126\/science.aat5236","article-title":"A gut-brain neural circuit for nutrient sensory transduction","volume":"361","author":"Kaelberer","year":"2018","journal-title":"Science."},{"key":"B100","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1146\/annurev-neuro-091619-022657","article-title":"Neuropod cells: emerging biology of the gut-brain sensory transduction","volume":"43","author":"Kaelberer","year":"2020","journal-title":"Annu Rev Neurosci"},{"key":"B101","doi-asserted-by":"publisher","first-page":"230","DOI":"10.3389\/fphar.2018.00230","article-title":"Commentary: Neuronal regulation of type 2 innate lymphoid cells via neuromedin U","volume":"9","author":"Jowett","year":"2018","journal-title":"Front Pharmacol"},{"key":"B102","doi-asserted-by":"publisher","first-page":"849","DOI":"10.3389\/fphys.2017.00849","article-title":"Members of bitter taste receptor cluster Tas2r143\/Tas2r135\/Tas2r126 are expressed in the epithelium of murine airways and other non-gustatory tissues","volume":"8","author":"Liu","year":"2017","journal-title":"Front Physiol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01489\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T01:50:56Z","timestamp":1696470656000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01489\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,30]]},"references-count":102,"alternative-id":["10.3389\/fimmu.2020.01489"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.01489","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,30]]},"article-number":"1489"}}