{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:03:58Z","timestamp":1790276638918,"version":"4.1.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.01653","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T06:12:16Z","timestamp":1596175936000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Pre-transplant Thymic Function Predicts Is Associated With Patient Death After Kidney Transplantation"],"prefix":"10.3389","volume":"11","author":[{"given":"C\u00e9cile","family":"Courivaud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamal","family":"Bamoulid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Crepin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Gaiffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Laheurte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Saas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Ducloux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3389\/fimmu.2013.00316","article-title":"The effect of age on thymic function","volume":"4","author":"Palmer","year":"2013","journal-title":"Front Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1038\/ki.2011.110","article-title":"Premature aging of circulating T cells in patients with end-stage renal disease","volume":"80","author":"Betjes","year":"2011","journal-title":"Kidney Int."},{"key":"B3","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1093\/ndt\/gfy276","article-title":"Uraemia-induced immune senescence and clinical outcomes in chronic kidney disease patients","volume":"35","author":"Cr\u00e9pin","year":"2020","journal-title":"Nephrol Dial Transplant."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/j.kint.2015.12.044","article-title":"Pre-transplant thymic function predicts acute rejection in ATG-treated renal transplant recipients","volume":"89","author":"Bamoulid","year":"2016","journal-title":"Kidney Int."},{"key":"B5","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1097\/TP.0b013e31825306ff","article-title":"Terminally differentiated CD8+ Temra cells are associated with the risk for acute kidney allograft rejection","volume":"94","author":"Betjes","year":"2012","journal-title":"Transplantation."},{"key":"B6","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1111\/tid.12534","article-title":"Pre-transplant end-stage renal disease-related immune risk profile in kidney transplant recipients predicts post -transplant infections","volume":"18","author":"Crepin","year":"2016","journal-title":"Transpl Infect Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e0150826","DOI":"10.1371\/journal.pone.0150826","article-title":"Expansion of highly differentiated CD28null T cells was also associated with a lower risk for acute rejection","volume":"11","author":"Dedeoglu","year":"2016","journal-title":"PLoS ONE."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1111\/ajt.13759","article-title":"Uremia-associated premature aging of T cells does not predict infectious complications after renal transplantation","volume":"16","author":"Dedeoglu","year":"2016","journal-title":"Am J Transplant."},{"key":"B9","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1681\/ASN.2009090976","article-title":"Prolonged CD4 T cell lymphopenia increases morbidity and mortality after renal transplantation","volume":"21","author":"Ducloux","year":"2010","journal-title":"J Am Soc Nephrol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1182\/blood-2008-02-139154","article-title":"Life after the thymus: CD31+ and CD31- human naive CD4+ T-cell subsets","volume":"113","author":"Kohler","year":"2009","journal-title":"Blood."},{"key":"B11","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1111\/j.1432-2277.2002.tb00187.x","article-title":"Lymphocyte subsets and assessment of cancer risk in renal transplant recipients","volume":"15","author":"Ducloux","year":"2002","journal-title":"Transpl Int."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1111\/ajt.13092","article-title":"ATG-induced accelerated immune senescence: clinical implications in renal transplant recipients","volume":"15","author":"Crepin","year":"2015","journal-title":"Am J Transplant."},{"key":"B13","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1093\/ndt\/gfv362","article-title":"Long-term CD4 lymphopenia is associated with accelerated decline of kidney allograft function","volume":"31","author":"Luque","year":"2016","journal-title":"Nephrol Dial Transplant."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1097\/01.tp.0000181193.98026.3f","article-title":"Long-term kinetic of T-lymphocyte subsets in kidney-transplant recipients: influence of anti-T-cell antibodies and association with posttransplant malignancies","volume":"80","author":"Thibaudin","year":"2005","journal-title":"Transplantation."},{"key":"B15","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.trim.2011.05.003","article-title":"Thymic function, anti-thymocytes globulins, and cancer after renal transplantation","volume":"25","author":"Ducloux","year":"2011","journal-title":"Transpl Immunol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.exger.2014.01.003","article-title":"Naive T cells: the crux of cellular immune aging?","volume":"54","author":"Appay","year":"2014","journal-title":"Exp Gerontol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1007\/s10522-017-9682-z","article-title":"Immunosenescence and cancer","volume":"18","author":"Pawelec","year":"2017","journal-title":"Biogerontology."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1016\/j.exger.2013.09.011","article-title":"Immune senescence and cancer in elderly patients: results from an exploratory study","volume":"48","author":"Falci","year":"2013","journal-title":"Exp Gerontol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1073\/pnas.97.1.274","article-title":"Diversity, functionality, and stability of the T cell repertoire derived in vivo from a single human T cell precursor","volume":"97","author":"Bousso","year":"2000","journal-title":"Proc Natl Acad Sci USA."},{"key":"B20","doi-asserted-by":"crossref","first-page":"379","DOI":"10.4049\/jimmunol.144.1.379","article-title":"Functional consequences of a T cell receptor D beta 2 and J beta 2 gene segment deletion","volume":"144","author":"Woodland","year":"1990","journal-title":"J Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e0214321","DOI":"10.1371\/journal.pone.0214321","article-title":"Pre-transplant CD45RC expression on blood T cells differentiates patients with cancer and rejection after kidney transplantation","volume":"14","author":"Garnier","year":"2019","journal-title":"PLoS ONE."},{"key":"B22","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/ki.2013.538","article-title":"The immune phenotype may relate to cancer development in kidney transplant recipients","volume":"86","author":"Hope","year":"2014","journal-title":"Kidney Int."},{"key":"B23","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/nri2970","article-title":"Harnessing the biology of IL-7 for therapeutic application","volume":"11","author":"Mackall","year":"2011","journal-title":"Nat Rev Immunol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.it.2004.11.002","article-title":"IL-7 and IL-15: therapeutic cytokines for immunodeficiency","volume":"26","author":"Alpdogan","year":"2005","journal-title":"Trends Immunol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"7645","DOI":"10.4049\/jimmunol.0902019","article-title":"IL-7 enhances thymic human T cell development in \u201chuman immune system\u201d Rag2-\/-IL-2Rgammac-\/- mice without affecting peripheral T cell homeostasis","volume":"183","author":"van Lent","year":"2009","journal-title":"J Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1182\/blood-2015-05-645077","article-title":"Administration of interleukin-7 increases CD4 T cells in idiopathic CD4 lymphocytopenia","volume":"127","author":"Sheikh","year":"2016","journal-title":"Blood."},{"key":"B27","doi-asserted-by":"publisher","first-page":"98960","DOI":"10.1172\/jci.insight.98960","article-title":"Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial","volume":"3","author":"Francois","year":"2018","journal-title":"JCI Insight."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1093\/annonc\/mdv173","article-title":"ELYPSE-7: a randomized placebo-controlled phase IIa trial with CYT107 exploring the restoration of CD4+ lymphocyte count in lymphopenic metastatic breast cancer patients","volume":"26","author":"Tr\u00e9dan","year":"2015","journal-title":"Ann Oncol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s11357-011-9341-2","article-title":"Thymic function failure and C-reactive protein levels are independent predictors of all-cause mortality in healthy elderly humans","volume":"35","author":"Ferrando-Mart\u00ednez","year":"2013","journal-title":"Age (Dordr)."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01653\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T03:26:10Z","timestamp":1696476370000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01653\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,31]]},"references-count":29,"alternative-id":["10.3389\/fimmu.2020.01653"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.01653","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,31]]},"article-number":"1653"}}