{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:40:17Z","timestamp":1791632417677,"version":"4.3.4"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.01768","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T14:48:28Z","timestamp":1597330108000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":130,"title":["Tape-Strip Proteomic Profiling of Atopic Dermatitis on Dupilumab Identifies Minimally Invasive Biomarkers"],"prefix":"10.3389","volume":"11","author":[{"given":"Helen","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline M.","family":"Olesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana B.","family":"Pavel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja-Lisa","family":"Clausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianni","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeriel","family":"Estrada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tove","family":"Agner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Guttman-Yassky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jaci.2018.08.022","article-title":"Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis","volume":"143","author":"Guttman-Yassky","year":"2019","journal-title":"J Allergy Clin Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s11882-014-0433-9","article-title":"Skin barrier defects in atopic dermatitis","volume":"14","author":"Agrawal","year":"2014","journal-title":"Curr Allergy Asthma Rep."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1016\/j.jaci.2017.04.004","article-title":"Novel concepts of prevention and treatment of atopic dermatitis through barrier and immune manipulations with implications for the atopic march","volume":"139","author":"Czarnowicki","year":"2017","journal-title":"J Allergy Clin Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1016\/j.jaci.2012.07.012","article-title":"Progressive activation of T(H)2\/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis","volume":"130","author":"Gittler","year":"2012","journal-title":"J Allergy Clin Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/j.1600-065X.2011.01027.x","article-title":"Atopic dermatitis: a disease of altered skin barrier and immune dysregulation","volume":"242","author":"Boguniewicz","year":"2011","journal-title":"Immunol Rev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1016\/j.jaci.2015.03.003","article-title":"RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications","volume":"135","author":"Suarez-Farinas","year":"2015","journal-title":"J Allergy Clin Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.jaci.2010.10.033","article-title":"Comparative proteomic profiling of patients with atopic dermatitis based on history of eczema herpeticum infection and Staphylococcus aureus colonization","volume":"127","author":"Broccardo","year":"2011","journal-title":"J Allergy Clin Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.anai.2018.08.024","article-title":"Atopic dermatitis in African American patients is TH2\/TH22-skewed with TH1\/TH17 attenuation","volume":"122","author":"Sanyal","year":"2018","journal-title":"Ann Allergy Asthma Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/j.jaci.2015.08.015","article-title":"The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization","volume":"136","author":"Noda","year":"2015","journal-title":"J Allergy Clin Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.jaci.2018.02.047","article-title":"Serum from Asian patients with atopic dermatitis is characterized by TH2\/TH22 activation, which is highly correlated with nonlesional skin measures","volume":"142","author":"Wen","year":"2018","journal-title":"J Allergy Clin Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.jaci.2019.01.015","article-title":"Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis","volume":"144","author":"Zhou","year":"2019","journal-title":"J Allergy Clin Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1016\/j.jaci.2014.10.013","article-title":"Dupilumab improves the molecular signature in skin of patients with moderate-to-severe atopic dermatitis","volume":"134","author":"Hamilton","year":"2014","journal-title":"J Allergy Clin Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1056\/NEJMoa1610020","article-title":"Two phase 3 trials of dupilumab versus placebo in atopic dermatitis","volume":"375","author":"Simpson","year":"2016","journal-title":"N Engl J Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1001\/jamadermatol.2019.3336","article-title":"Efficacy and safety of dupilumab in adolescents with uncontrolled moderate to severe atopic dermatitis: a phase 3 randomized clinical trial","volume":"156","author":"Simpson","year":"2019","journal-title":"JAMA Dermatol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1016\/j.jid.2019.03.1160","article-title":"Side-by-side comparison of skin biopsies and skin tape stripping highlights abnormal stratum corneum in atopic dermatitis","volume":"139","author":"Kim","year":"2019","journal-title":"J Invest Dermatol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1016\/j.jaci.2017.10.046","article-title":"Minimally invasive skin tape strip RNA sequencing identifies novel characteristics of the type 2-high atopic dermatitis disease endotype","volume":"141","author":"Dyjack","year":"2018","journal-title":"J Allergy Clin Immunol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1001\/jamadermatol.2019.2983","article-title":"Use of tape strips to detect immune and barrier abnormalities in the skin of children with early-onset atopic dermatitis","volume":"155","author":"Guttman-Yassky","year":"2019","journal-title":"JAMA Dermatol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"eaav2685","DOI":"10.1126\/scitranslmed.aav2685","article-title":"The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype","volume":"11","author":"Leung","year":"2019","journal-title":"Sci Transl Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"e98006","DOI":"10.1172\/jci.insight.98006","article-title":"Lipid abnormalities in atopic skin are driven by type 2 cytokines","volume":"3","author":"Berdyshev","year":"2018","journal-title":"JCI Insight."},{"key":"B20","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1111\/bjd.16994","article-title":"A minimally invasive tool to study immune response and skin barrier in children with atopic dermatitis","volume":"180","author":"Hulshof","year":"2019","journal-title":"Br J Dermatol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1111\/bjd.17088","article-title":"Systemic and stratum corneum biomarkers of severity in infant atopic dermatitis include markers of innate and T helper cell-related immunity and angiogenesis","volume":"180","author":"Mcaleer","year":"2019","journal-title":"Br J Dermatol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1016\/j.jid.2016.03.037","article-title":"Quantitative Proteomic analysis of stratum corneum dysfunction in adult chronic atopic dermatitis","volume":"136","author":"Winget","year":"2016","journal-title":"J Invest Dermatol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/j.jaci.2009.07.057","article-title":"Peeling off the layers: skin taping and a novel proteomics approach to study atopic dermatitis","volume":"124","author":"Broccardo","year":"2009","journal-title":"J Allergy Clin Immunol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1038\/s41598-018-20204-8","article-title":"Measurements of AMPs in stratum corneum of atopic dermatitis and healthy skin-tape stripping technique","volume":"8","author":"Clausen","year":"2018","journal-title":"Sci Rep."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2755","DOI":"10.1194\/jlr.P030338","article-title":"Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients","volume":"53","author":"Janssens","year":"2012","journal-title":"J Lipid Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1111\/j.1600-0625.2011.01259.x","article-title":"Distinct barrier integrity phenotypes in filaggrin-related atopic eczema following sequential tape stripping and lipid profiling","volume":"20","author":"Angelova-Fischer","year":"2011","journal-title":"Exp Dermatol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1159\/000448400","article-title":"Stratum corneum tape stripping: monitoring of inflammatory mediators in atopic dermatitis patients using topical therapy","volume":"170","author":"Koppes","year":"2016","journal-title":"Int Arch Allergy Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.jaad.2019.10.039","article-title":"The proteomic skin profile of moderate-to-severe atopic dermatitis patients shows an inflammatory signature","volume":"82","author":"Pavel","year":"2020","journal-title":"J Am Acad Dermatol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.atherosclerosis.2015.07.023","article-title":"Use of a proximity extension assay proteomics chip to discover new biomarkers for human atherosclerosis","volume":"242","author":"Lind","year":"2015","journal-title":"Atherosclerosis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"8707","DOI":"10.1038\/s41598-017-09207-z","article-title":"The atopic dermatitis blood signature is characterized by increases in inflammatory and cardiovascular risk proteins","volume":"7","author":"Brunner","year":"2017","journal-title":"Sci Rep."},{"key":"B31","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.anai.2019.10.013","article-title":"Increased cardiovascular and atherosclerosis markers in blood of older patients with atopic dermatitis","volume":"124","author":"He","year":"2020","journal-title":"Ann Allergy Asthma Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/j.jaci.2010.12.1124","article-title":"Nonlesional atopic dermatitis skin is characterized by broad terminal differentiation defects and variable immune abnormalities","volume":"127","author":"Suarez-Farinas","year":"2011","journal-title":"J Allergy Clin Immunol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"3574","DOI":"10.4049\/jimmunol.169.7.3574","article-title":"Differential functions of IL-4 receptor types I and II for dendritic cell maturation and IL-12 production and their dependency on GM-CSF","volume":"169","author":"Lutz","year":"2002","journal-title":"J Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1038\/jid.2010.410","article-title":"IL-4 and IL-13 alter plasmacytoid dendritic cell responsiveness to CpG DNA and herpes simplex virus-1","volume":"131","author":"Tel","year":"2011","journal-title":"J Invest Dermatol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1373\/clinchem.2011.173369","article-title":"Role of ST2 in non-ST-elevation acute coronary syndrome in the MERLIN-TIMI 36 trial","volume":"58","author":"Kohli","year":"2012","journal-title":"Clin Chem."},{"key":"B36","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/35006097","article-title":"Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1","volume":"404","author":"Gu","year":"2000","journal-title":"Nature."},{"key":"B37","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1111\/j.1440-1711.2005.01365.x","article-title":"Differential expression of inflammatory chemokines by Th1- and Th2-cell promoting dendritic cells: a role for different mature dendritic cell populations in attracting appropriate effector cells to peripheral sites of inflammation","volume":"83","author":"Lebre","year":"2005","journal-title":"Immunol Cell Biol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1111\/j.1365-2567.2007.02719.x","article-title":"Immunological decision-making: how does the immune system decide to mount a helper T-cell response?","volume":"123","author":"Kaiko","year":"2008","journal-title":"Immunology."},{"key":"B39","doi-asserted-by":"publisher","first-page":"e1003414","DOI":"10.1371\/journal.pcbi.1003414","article-title":"Competition for antigen between Th1 and Th2 responses determines the timing of the immune response switch during Mycobaterium avium subspecies paratuberulosis infection in ruminants","volume":"10","author":"Magombedze","year":"2014","journal-title":"PLoS Comput Biol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.jaad.2019.04.036","article-title":"The blood proteomic signature of early-onset pediatric atopic dermatitis shows systemic inflammation and is distinct from adult long-standing disease","volume":"81","author":"Brunner","year":"2019","journal-title":"J Am Acad Dermatol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.advms.2018.08.017","article-title":"Insulin-like growth factor-binding protein 7 (IGFBP 7) as a new biomarker in coronary heart disease","volume":"64","author":"Lisowska","year":"2019","journal-title":"Adv Med Sci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.atherosclerosis.2019.11.031","article-title":"ALCAM predicts future cardiovascular death in acute coronary syndromes: insights from the PLATO trial","volume":"293","author":"Ueland","year":"2020","journal-title":"Atherosclerosis."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1161\/01.ATV.0000089329.09061.07","article-title":"Serum chitotriosidase activity is increased in subjects with atherosclerosis disease","volume":"23","author":"Artieda","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s12020-010-9334-4","article-title":"Chitotriosidase activity predicts endothelial dysfunction in type-2 diabetes mellitus","volume":"37","author":"Sonmez","year":"2010","journal-title":"Endocrine."},{"key":"B45","doi-asserted-by":"publisher","first-page":"214","DOI":"10.4103\/0971-9784.179588","article-title":"Soluble urokinase plasminogen activation receptor\u2013An emerging new biomarker of cardiovascular disease and critical illness","volume":"19","author":"Cyrille","year":"2016","journal-title":"Ann Card Anaesth."},{"key":"B46","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1111\/j.1365-2796.2010.02252.x","article-title":"Circulating soluble urokinase plasminogen activator receptor predicts cancer, cardiovascular disease, diabetes and mortality in the general population","volume":"268","author":"Eugen-Olsen","year":"2010","journal-title":"J Intern Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1056\/NEJM200006153422406","article-title":"Plasminogen-activator inhibitor type 1 and coronary artery disease","volume":"342","author":"Kohler","year":"2000","journal-title":"N Engl J Med."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1056\/NEJM198512193132501","article-title":"Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction","volume":"313","author":"Hamsten","year":"1985","journal-title":"N Engl J Med."},{"key":"B49","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.ijcard.2014.03.016","article-title":"AXL receptor tyrosine kinase is increased in patients with heart failure","volume":"173","author":"Batlle","year":"2014","journal-title":"Int J Cardiol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01768\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T14:48:30Z","timestamp":1597330110000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01768\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,6]]},"references-count":49,"alternative-id":["10.3389\/fimmu.2020.01768"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.01768","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,6]]},"article-number":"1768"}}