{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:44:26Z","timestamp":1789875866559,"version":"4.0.1"},"reference-count":119,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.01810","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T15:03:01Z","timestamp":1597158181000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":51,"title":["NLR and Intestinal Dysbiosis-Associated Inflammatory Illness: Drivers or Dampers?"],"prefix":"10.3389","volume":"11","author":[{"given":"Jefferson","family":"Elias-Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jefferson Ant\u00f4nio","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00cdtalo Sousa","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhefferson Barbosa","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Martins da Costa","family":"Manso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Santana","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita C\u00e1ssia","family":"Tostes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Carlos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"116","DOI":"10.3390\/medsci6040116","article-title":"Microbiota in the gastrointestinal tract","volume":"6","author":"Dieterich","year":"2018","journal-title":"Med Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1038\/nrg.2017.63","article-title":"Human genetic variation and the gut microbiome in disease","volume":"18","author":"Hall","year":"2017","journal-title":"Nat Rev Genet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/nrmicro3552","article-title":"Gut biogeography of the bacterial microbiota","volume":"14","author":"Donaldson","year":"2016","journal-title":"Nat Rev Microbiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/nrmicro.2016.83","article-title":"Metagenome-wide association studies: fine-mining the microbiome","volume":"14","author":"Wang","year":"2016","journal-title":"Nat Rev Microbiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/nm.3914","article-title":"The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment","volume":"21","author":"Zhang","year":"2015","journal-title":"Nat Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1038\/ncomms2266","article-title":"Symptomatic atherosclerosis is associated with an altered gut metagenome","volume":"3","author":"Karlsson","year":"2012","journal-title":"Nat Commun."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/gut.53.1.1","article-title":"Dysbiosis in inflammatory bowel disease","volume":"53","author":"Tamboli","year":"2004","journal-title":"Gut."},{"key":"B8","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s11154-015-9309-0","article-title":"The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity","volume":"16","author":"Tai","year":"2015","journal-title":"Rev Endocr Metab Disord."},{"key":"B9","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nature11450","article-title":"A metagenome-wide association study of gut microbiota in type 2 diabetes","volume":"490","author":"Qin","year":"2012","journal-title":"Nature."},{"key":"B10","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1038\/s41579-019-0256-8","article-title":"Diet\u2013microbiota interactions and personalized nutrition","volume":"17","author":"Kolodziejczyk","year":"2019","journal-title":"Nat Rev Microbiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1152\/advan.00058.2013","article-title":"Pattern recognition receptors in innate immunity, host defense, and immunopathology","volume":"37","author":"Suresh","year":"2013","journal-title":"Adv Physiol Educ."},{"key":"B13","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1093\/intimm\/dxp017","article-title":"The roles of TLRs, RLRs and NLRs in pathogen recognition","volume":"21","author":"Kawai","year":"2009","journal-title":"Int Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.3389\/fimmu.2017.01882","article-title":"Gut microbiota dysbiosis drives and implies novel therapeutic strategies for diabetes mellitus and related metabolic diseases","volume":"8","author":"Li","year":"2017","journal-title":"Front Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"489821","DOI":"10.1155\/2015\/489821","article-title":"How the intricate interaction among toll-like receptors, microbiota, and intestinal immunity can influence gastrointestinal pathology","volume":"2015","author":"Frosali","year":"2015","journal-title":"J Immunol Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00394-017-1445-8","article-title":"Gut microbiota functions : metabolism of nutrients and other food components","volume":"57","author":"Rowland","year":"2018","journal-title":"Eur J Nutr."},{"key":"B17","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nature11551","article-title":"Reciprocal interactions of the intestinal microbiota and immune system","volume":"489","author":"Maynard","year":"2012","journal-title":"Nature."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2018.01830","article-title":"Aspects of gut microbiota and immune system interactions in infectious diseases, immunopathology, and cancer","volume":"9","author":"Lazar","year":"2018","journal-title":"Front Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3328","DOI":"10.3389\/fmicb.2018.03328","article-title":"Intestinal microbiota as a host defense mechanism to infectious threats","volume":"9","author":"Iacob","year":"2019","journal-title":"Front Microbiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1539595","DOI":"10.1080\/21688370.2018.1539595","article-title":"Role of gut microbiota in intestinal wound healing and barrier function","volume":"6","author":"Alam","year":"2018","journal-title":"Tissue Barriers."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2872","DOI":"10.1038\/s41467-018-05336-9","article-title":"Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism","volume":"9","author":"Zarrinpar","year":"2018","journal-title":"Nat Commun."},{"key":"B22","doi-asserted-by":"publisher","first-page":"137","DOI":"10.4168\/aair.2020.12.1.137","article-title":"Antibiotics-induced dysbiosis of intestinal microbiota aggravates atopic dermatitis in mice by altered short-chain fatty acids","volume":"12","author":"Kim","year":"2020","journal-title":"Allergy Asthma Immunol Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.humic.2016.09.001","article-title":"Diet influence on the gut microbiota and dysbiosis related to nutritional disorders","volume":"1","author":"Alou","year":"2016","journal-title":"Hum Microbiome J."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.3389\/fmicb.2018.02013","article-title":"Effects of psychological, environmental and physical stressors on the gut microbiota","volume":"9","author":"Karl","year":"2018","journal-title":"Front Microbiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/s41577-019-0198-4","article-title":"The intestinal microbiota fuelling metabolic inflammation","volume":"20","author":"Tilg","year":"2020","journal-title":"Nat Rev Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/nrgastro.2016.85","article-title":"The role of the gut microbiota in NAFLD","volume":"13","author":"Leung","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"12918","DOI":"10.1038\/s41598-019-49452-y","article-title":"Defining dysbiosis for a cluster of chronic diseases","volume":"9","author":"Wilkins","year":"2019","journal-title":"Sci Rep."},{"key":"B28","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/nrgastro.2012.152","article-title":"The gut microbiota in IBD","volume":"9","author":"Manichanh","year":"2012","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.ijmm.2016.02.010","article-title":"Dysbiosis in intestinal inflammation: cause or consequence","volume":"306","author":"Butt\u00f3","year":"2016","journal-title":"Int J Med Microbiol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"26191","DOI":"10.3402\/mehd.v26.26191","article-title":"Dysbiosis of the gut microbiota in disease","volume":"26","author":"Carding","year":"2015","journal-title":"Microb Ecol Health Dis."},{"key":"B31","first-page":"1500","article-title":"Fecal microbiota in early rheumatoid arthritis","volume":"35","author":"Vaahtovuo","year":"2008","journal-title":"J Rheumatol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1093\/rheumatology\/keq088","article-title":"Distinct bacterial colonization patterns of Escherichia coli subtypes associate with rheumatoid factor status in early inflammatory arthritis","volume":"49","author":"Newkirk","year":"2010","journal-title":"Rheumatology."},{"key":"B33","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1002\/art.40003","article-title":"Evidence of the immune relevance of prevotella copri, a gut microbe, in patients with rheumatoid arthritis","volume":"69","author":"Pianta","year":"2017","journal-title":"Arthritis Rheumatol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/nrgastro.2017.88","article-title":"Gut microbiota and IBD: causation or correlation?","volume":"14","author":"Ni","year":"2017","journal-title":"Nat Publ Gr."},{"key":"B35","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S2468-1253(19)30333-4","article-title":"The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990-2017: a systematic analysis for the Global burden of disease study 2017","volume":"5","year":"2020","journal-title":"Lancet Gastroenterol Hepatol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"493012","DOI":"10.1155\/2015\/493012","article-title":"Inflammatory bowel disease : an overview of immune mechanisms and biological treatments","volume":"2015","author":"Mattos","year":"2015","journal-title":"Mediators Inflamm."},{"key":"B37","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.ijpara.2016.11.010","article-title":"Giardia duodenalis induces pathogenic dysbiosis of human intestinal microbiota biofilms","volume":"47","author":"Beatty","year":"2017","journal-title":"Int J Parasitol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"G824","DOI":"10.1152\/ajpgi.00070.2014","article-title":"Enteric dysbiosis promotes antibiotic-resistant bacterial infection: systemic dissemination of resistant and commensal bacteria through epithelial transcytosis","volume":"307","author":"Yu","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1136\/gutjnl-2013-304739","article-title":"Colonic mucosa-associated diffusely adherent afaC+ Escherichia coli expressing lpfA and pks are increased in inflammatory bowel disease and colon cancer","volume":"63","author":"Prorok-Hamon","year":"2014","journal-title":"Gut."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1136\/gutjnl-2014-306890","article-title":"Pathobiont hypnotises enterocytes to promote tumour development","volume":"63","author":"Chassaing","year":"2014","journal-title":"Gut."},{"key":"B41","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1007\/s12275-012-1362-8","article-title":"Microbial fingerprinting detects unique bacterial communities in the faecal microbiota of rats with experimentally-induced colitis","volume":"50","author":"Samanta","year":"2012","journal-title":"J Microbiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1002\/ibd.21462","article-title":"Microbial ecology of the murine gut associated with the development of dextran sodium sulfate-induced colitis","volume":"17","author":"Nagalingam","year":"2011","journal-title":"Inflamm Bowel Dis."},{"key":"B43","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1136\/gut.52.2.237","article-title":"Alterations of the dominant faecal bacterial groups in patients with Crohn's disease of the colon","volume":"52","author":"Seksik","year":"2003","journal-title":"Gut."},{"key":"B44","doi-asserted-by":"publisher","first-page":"e51","DOI":"10.1097\/MD.0000000000000051","article-title":"Characteristics of fecal and mucosa-associated microbiota in Chinese patients with inflammatory bowel disease","volume":"93","author":"Chen","year":"2014","journal-title":"Medicine."},{"key":"B45","doi-asserted-by":"publisher","first-page":"18880","DOI":"10.1038\/s41598-019-55290-9","article-title":"Differences in the intestinal microbiome of healthy children and patients with newly diagnosed Crohn's disease","volume":"9","author":"Kowalska-Duplaga","year":"2019","journal-title":"Sci Rep."},{"key":"B46","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2180-11-7","article-title":"High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease","volume":"11","author":"Walker","year":"2011","journal-title":"BMC Microbiol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"3562","DOI":"10.3748\/wjg.v19.i23.3562","article-title":"Virulence factors of Enterococcus strains isolated from patients with inflammatory bowel disease","volume":"19","author":"Golinska","year":"2013","journal-title":"World J Gastroenterol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/IM9.0000000000000011","article-title":"Dysbiosis of gut microbiota contributes to the development of diabetes mellitus","volume":"1","author":"Lu","year":"2019","journal-title":"Infect microbes Dis."},{"key":"B49","doi-asserted-by":"publisher","first-page":"850","DOI":"10.4239\/wjd.v6.i6.850","article-title":"Diabetes mellitus: the epidemic of the century","volume":"6","author":"Kharroubi","year":"2015","journal-title":"World J Diabetes."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/nrdp.2017.16","article-title":"Type 1 diabetes mellitus","volume":"3","author":"Katsarou","year":"2017","journal-title":"Nat Rev Dis Prim."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1038\/nature07336","article-title":"Innate immunity and intestinal microbiota in the development of Type 1 diabetes","volume":"455","author":"Wen","year":"2008","journal-title":"Nature."},{"key":"B52","doi-asserted-by":"publisher","first-page":"590","DOI":"10.4049\/jimmunol.1601519","article-title":"The influence of the microbiome on type 1 diabetes","volume":"198","author":"Paun","year":"2017","journal-title":"J Immunol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s13099-019-0332-7","article-title":"Is there any association between gut microbiota and type 1 diabetes?","volume":"11","author":"Jamshidi","year":"2019","journal-title":"Gut Pathog."},{"key":"B54","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1099\/mic.0.000412","article-title":"The intestinal proteome of diabetic and control children is enriched with different microbial and host proteins","volume":"163","author":"Pinto","year":"2017","journal-title":"Microbiology."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.2337\/db12-0526","article-title":"Fecal microbiota composition differs between children with beta-cell autoimmunity and those without","volume":"62","author":"de Goffau","year":"2013","journal-title":"Diabetes."},{"key":"B56","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1007\/s11892-018-1057-6","article-title":"Altered gut microbiota in type 2 diabetes: just a coincidence?","volume":"18","author":"Sircana","year":"2018","journal-title":"Curr Diab Rep."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1876","DOI":"10.1016\/j.bbadis.2018.09.032","article-title":"Diabetic gut microbiota dysbiosis as an inflammaging and immunosenescence condition that fosters progression of retinopathy and nephropathy","volume":"1865","author":"Fernandes","year":"2019","journal-title":"Biochim Biophys Acta Mol Basis Dis."},{"key":"B58","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1159\/000447690","article-title":"Association of intestinal microbiota with metabolic markers and dietary habits in patients with type 2 diabetes","volume":"94","author":"Yamaguchi","year":"2016","journal-title":"Digestion."},{"key":"B59","doi-asserted-by":"publisher","first-page":"63","DOI":"10.2220\/biomedres.36.63","article-title":"Bifidobacterium species lower serum glucose, increase expressions of insulin signaling proteins, and improve adipokine profile in diabetic mice","volume":"36","author":"Le","year":"2015","journal-title":"Biomed Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.bbrc.2018.05.105","article-title":"Sterilized bifidobacteria suppressed fat accumulation and blood glucose level","volume":"501","author":"Kikuchi","year":"2018","journal-title":"Biochem Biophys Res Commun."},{"key":"B61","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/mi.2016.42","article-title":"Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice","volume":"10","author":"Yang","year":"2017","journal-title":"Mucosal Immunol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"479","DOI":"10.3389\/fimmu.2013.00479","article-title":"Debug your bugs - how NLRs shape intestinal host-microbe interactions","volume":"4","author":"Lipinski","year":"2013","journal-title":"Front Immunol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/j.1600-065X.2012.01146.x","article-title":"PAMPs and DAMPs: signal 0s that spur autophagy and immunity","volume":"249","author":"Daolin","year":"2012","journal-title":"Immunol Rev."},{"key":"B64","doi-asserted-by":"publisher","first-page":"41702","DOI":"10.1074\/jbc.M307198200","article-title":"Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2","volume":"278","author":"Girardin","year":"2003","journal-title":"J Biol Chem."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1126\/science.1084677","article-title":"Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan","volume":"300","author":"Girardin","year":"2003","journal-title":"Science."},{"key":"B66","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1038\/ni945","article-title":"An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid","volume":"4","author":"Chamaillard","year":"2003","journal-title":"Nat Immunol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"5509","DOI":"10.1074\/jbc.C200673200","article-title":"Host recognition of bacterial muramyl dipeptide mediated through NOD2: implications for Crohn's disease","volume":"278","author":"Inohara","year":"2003","journal-title":"J Biol Chem."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1136\/gut.2010.216259","article-title":"Nod2 is essential for temporal development of intestinal microbial communities","volume":"60","author":"Rehman","year":"2011","journal-title":"Gut."},{"key":"B69","doi-asserted-by":"publisher","first-page":"15813","DOI":"10.1073\/pnas.0907722106","article-title":"Nod2 is required for the regulation of commensal microbiota in the intestine","volume":"106","author":"Petnicki-Ocwieja","year":"2009","journal-title":"Proc Natl Acad Sci USA."},{"key":"B70","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1172\/JCI62236","article-title":"NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer","volume":"123","author":"Couturier-Maillard","year":"2013","journal-title":"J Clin Invest."},{"key":"B71","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1146\/annurev-physiol-021113-170324","article-title":"Inflammasomes and metabolic disease","volume":"76","author":"Henao-Mejia","year":"2014","journal-title":"Annu Rev Physiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1016\/j.cell.2015.10.048","article-title":"Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling","volume":"163","author":"Levy","year":"2015","journal-title":"Cell."},{"key":"B73","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.cell.2011.04.022","article-title":"NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis","volume":"145","author":"Elinav","year":"2011","journal-title":"Cell."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/j.cell.2014.01.026","article-title":"NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion","volume":"156","author":"Wlodarska","year":"2014","journal-title":"Cell."},{"key":"B75","doi-asserted-by":"publisher","first-page":"e0175336","DOI":"10.1371\/journal.pone.0175336","article-title":"Impact of human monocyte and macrophage polarization on NLR expression and NLRP3 inflammasome activation","volume":"12","author":"Awad","year":"2017","journal-title":"PLoS ONE."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-017-01917-2","article-title":"Remodelling of the gut microbiota by hyperactive NLRP3 induces regulatory T cells to maintain homeostasis","volume":"8","author":"Yao","year":"2017","journal-title":"Nat Commun."},{"key":"B77","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/nature10809","article-title":"Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity","volume":"482","author":"Henao-Mejia","year":"2012","journal-title":"Nature."},{"key":"B78","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1155\/2017\/6817349","article-title":"Genesis and maintenance of attentional biases: the role of the locus coeruleus-noradrenaline system","volume":"1","author":"Ehlers","year":"2017","journal-title":"Neural Plast."},{"key":"B79","doi-asserted-by":"publisher","first-page":"39914","DOI":"10.1074\/jbc.M502820200","article-title":"The CATERPILLER protein Monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor \u03b1-, and Mycobacterium tuberculosis-induced pro-inflammatory signals","volume":"280","author":"Williams","year":"2005","journal-title":"J Biol Chem."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.4049\/jimmunol.178.3.1256","article-title":"Cutting edge: monarch-1 suppresses non-canonical NF-\u03baB activation and p52-dependent chemokine expression in monocytes","volume":"178","author":"Lich","year":"2007","journal-title":"J Immunol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1016\/j.immuni.2012.03.012","article-title":"NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-\u03baB signaling","volume":"36","author":"Allen","year":"2012","journal-title":"Immunity."},{"key":"B82","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.ccr.2011.10.022","article-title":"The NOD-Like receptor NLRP12 attenuates colon inflammation and tumorigenesis","volume":"20","author":"Zaki","year":"2011","journal-title":"Cancer Cell."},{"key":"B83","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.immuni.2012.07.006","article-title":"The NLRP12 inflammasome recognizes yersinia pestis","volume":"37","author":"Vladimer","year":"2012","journal-title":"Immunity."},{"key":"B84","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/ni.3690","article-title":"NLRP12 attenuates colon inflammation by maintaining colonic microbial diversity and promoting protective commensal bacterial growth","volume":"18","author":"Chen","year":"2017","journal-title":"Nat Immunol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1084\/jem.20150744","article-title":"Gut microbiota translocation to the pancreatic lymph nodes triggers NOD2 activation and contributes to T1D onset","volume":"213","author":"Costa","year":"2016","journal-title":"J Exp Med."},{"key":"B86","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.jaut.2017.05.007","article-title":"Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) modulates T1DM susceptibility by gut microbiota","volume":"82","author":"Li","year":"2017","journal-title":"J Autoimmun."},{"key":"B87","doi-asserted-by":"publisher","first-page":"11318","DOI":"10.1073\/pnas.1513509112","article-title":"NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets","volume":"112","author":"Hu","year":"2015","journal-title":"Proc Natl Acad Sci USA."},{"key":"B88","doi-asserted-by":"publisher","first-page":"164","DOI":"10.3389\/fimmu.2017.00164","article-title":"Mitochondrial DNA activates the NLRP3 inflammasome and predisposes to type 1 diabetes in murine model","volume":"8","author":"Carlos","year":"2017","journal-title":"Front Immunol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"583","DOI":"10.3109\/08916930903540432","article-title":"Two SNPs in NLRP3 gene are involved in the predisposition to type-1 diabetes and celiac disease in a pediatric population from northeast Brazil","volume":"43","author":"Pontillo","year":"2010","journal-title":"Autoimmunity."},{"key":"B90","doi-asserted-by":"publisher","first-page":"959","DOI":"10.3390\/cells9040959","article-title":"The DNA sensor AIM2 protects against streptozotocin-induced type 1 diabetes by regulating intestinal homeostasis via the IL-18 pathway","volume":"9","author":"Leite","year":"2020","journal-title":"Cells."},{"key":"B91","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/1741-7015-11-46","article-title":"Gut microbiota in children with type 1 diabetes differs from that in healthy children: a case-control study","volume":"11","author":"Murri","year":"2013","journal-title":"BMC Med."},{"key":"B92","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1099\/mic.0.082610-0","article-title":"Streptozotocin-induced type-1-diabetes disease onset in Sprague-Dawley rats is associated with an altered intestinal microbiota composition and decreased diversity","volume":"161","author":"Patterson","year":"2015","journal-title":"Microbiology."},{"key":"B93","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/nature07725","article-title":"AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC","volume":"458","author":"Hornung","year":"2009","journal-title":"Nature."},{"key":"B94","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/ni.1864","article-title":"The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses","volume":"11","author":"Rathinam","year":"2010","journal-title":"Nat Immunol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1002\/eji.201545839","article-title":"AIM2 inflammasome in infection, cancer, and autoimmunity: role in DNA sensing, inflammation, and innate immunity","volume":"46","author":"Man","year":"2016","journal-title":"Eur J Immunol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"e0171521","DOI":"10.1371\/journal.pone.0171521","article-title":"Gut dysbiosis is associated with metabolism and systemic inflammation in patients with ischemic stroke","volume":"12","author":"Yamashiro","year":"2017","journal-title":"PLoS ONE."},{"key":"B97","doi-asserted-by":"publisher","first-page":"3","DOI":"10.23736\/S0026-4806.18.05589-1","article-title":"Effects of chronic exercise on gut microbiota and intestinal barrier in human with type 2 diabetes","volume":"110","author":"Pasini","year":"2019","journal-title":"Minerva Med."},{"key":"B98","doi-asserted-by":"publisher","first-page":"e47713","DOI":"10.1371\/journal.pone.0047713","article-title":"High fat diet-induced gut microbiota exacerbates inflammation and obesity in mice via the TLR4 signaling pathway","volume":"7","author":"Kim","year":"2012","journal-title":"PLoS ONE."},{"key":"B99","doi-asserted-by":"publisher","first-page":"3015","DOI":"10.1172\/JCI28898","article-title":"TLR4 links innate immunity and fatty acid-induced insulin resistance","volume":"116","author":"Shi","year":"2006","journal-title":"J Clin Invest."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes."},{"key":"B101","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1007\/s00125-007-0654-8","article-title":"C3H\/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet","volume":"50","author":"Poggi","year":"2007","journal-title":"Diabetologia."},{"key":"B102","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.molmet.2013.06.005","article-title":"Metabolic endotoxemia directly increases the proliferation of adipocyte precursors at the onset of metabolic diseases through a CD14-dependent mechanism","volume":"2","author":"Luche","year":"2013","journal-title":"Mol Metab."},{"key":"B103","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1007\/s11938-017-0151-1","article-title":"Diabetes mellitus and the Cclon","volume":"15","author":"Piper","year":"2017","journal-title":"Curr Treat Options Gastroenterol."},{"key":"B104","doi-asserted-by":"publisher","first-page":"438","DOI":"10.2337\/db15-0792","article-title":"Pancreatic \u03b2-cell adaptive plasticity in obesity increases insulin production but adversely affects secretory function","volume":"65","author":"Alarcon","year":"2016","journal-title":"Diabetes."},{"key":"B105","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/j.molmet.2017.04.010","article-title":"The dynamic plasticity of insulin production in \u03b2-cells","volume":"6","author":"Boland","year":"2017","journal-title":"Mol Metab."},{"key":"B106","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s12933-019-0870-9","article-title":"Inflammatory cytokines in type 2 diabetes mellitus as facilitators of hypercoagulation and abnormal clot formation","volume":"18","author":"Randeria","year":"2019","journal-title":"Cardiovasc Diabetol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1172\/JCI117936","article-title":"Increased adipose tissue expression of tumor necrosis factor-\u03b1 in human obesity and insulin resistance","volume":"95","author":"Hotamisligil","year":"1995","journal-title":"J Clin Invest."},{"key":"B108","doi-asserted-by":"publisher","first-page":"110713","DOI":"10.1016\/j.exger.2019.110713","article-title":"Glycemic control and comprehensive metabolic risk factors control in older adults with type 2 diabetes","volume":"127","author":"Yan","year":"2019","journal-title":"Exp Gerontol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.canep.2019.04.009","article-title":"Type 2 diabetes, obesity, and breast cancer risk among Japanese women of the atomic bomb survivor cohort","volume":"60","author":"Maskarinec","year":"2019","journal-title":"Cancer Epidemiol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"100210","DOI":"10.1016\/j.jcte.2019.100210","article-title":"Association between obesity phenotypes of insulin resistance and risk of type 2 diabetes in African Americans: the Jackson heart study","volume":"19","author":"Lee","year":"2020","journal-title":"J Clin Transl Endocrinol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1007\/s00125-014-3224-x","article-title":"Myokines in insulin resistance and type 2 diabetes","volume":"57","author":"Eckardt","year":"2014","journal-title":"Diabetologia."},{"key":"B112","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1126\/science.271.5249.665","article-title":"IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance","volume":"271","author":"Hotamisligil","year":"1996","journal-title":"Science."},{"key":"B113","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.2337\/db11-0004","article-title":"NOD1 activators link innate immunity to insulin resistance","volume":"60","author":"Schertzer","year":"2011","journal-title":"Diabetes."},{"key":"B114","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.ebiom.2018.03.004","article-title":"Inflammatory cytokine profiles in visceral and subcutaneous adipose tissues of obese patients undergoing bariatric surgery reveal lack of correlation with obesity or diabetes","volume":"30","author":"Rakotoarivelo","year":"2018","journal-title":"EBioMedicine."},{"key":"B115","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.1016\/S1098-3597(06)80039-6","article-title":"Adipose tissue dysfunction in obesity and lipodystrophy","volume":"8","author":"Garg","year":"2006","journal-title":"Clin Cornerstone."},{"key":"B116","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/j.imbio.2018.07.003","article-title":"Absence of NOD2 receptor predisposes to intestinal inflammation by a deregulation in the immune response in hosts that are unable to control gut dysbiosis","volume":"223","author":"de Souza","year":"2018","journal-title":"Immunobiology."},{"key":"B117","doi-asserted-by":"publisher","first-page":"259","DOI":"10.15252\/emmm.201404169","article-title":"Defective NOD 2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance","volume":"7","author":"Denou","year":"2015","journal-title":"EMBO Mol Med."},{"key":"B118","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1126\/science.1198719","article-title":"Diet drives convergence in gut microbiome functions across mammalian phylogeny and within humans","volume":"332","author":"Muegge","year":"2011","journal-title":"Science."},{"key":"B119","doi-asserted-by":"publisher","first-page":"e0179696","DOI":"10.1371\/journal.pone.0179696","article-title":"The short chain fatty acid receptor GPR43 regulates inflammatory signals in adipose tissue M2-type macrophages","volume":"12","author":"Nakajima","year":"2017","journal-title":"PLoS ONE."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01810\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T15:03:05Z","timestamp":1597158185000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01810\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,11]]},"references-count":119,"alternative-id":["10.3389\/fimmu.2020.01810"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.01810","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,11]]},"article-number":"1810"}}