{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:39:57Z","timestamp":1793320797797,"version":"4.5.0"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2014-07054"],"award-info":[{"award-number":["2014-07054"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2017-01343"],"award-info":[{"award-number":["2017-01343"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007436","name":"Familjen Erling-Perssons Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007436","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008550","name":"Diabetesfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008550","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004973","name":"Barndiabetesfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004973","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012529","name":"Insamlingsstiftelsen Diabetes Wellness Network Sverige","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012529","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.01916","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T11:24:52Z","timestamp":1598268292000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Increased Plasma Levels of the Co-stimulatory Proteins CDCP1 and SLAMF1 in Patients With Autoimmune Endocrine Diseases"],"prefix":"10.3389","volume":"11","author":[{"given":"Louise","family":"Magnusson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Espes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaura","family":"Casas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per-Ola","family":"Carlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/0167-5699(89)90245-4","article-title":"The mosaic of autoimmunity","volume":"10","author":"Shoenfeld","year":"1989","journal-title":"Immunol Today"},{"key":"B2","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.autrev.2012.02.002","article-title":"Common mechanisms of autoimmune diseases (the autoimmune tautology)","volume":"11","author":"Anaya","year":"2012","journal-title":"Autoimmun rev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"4882","DOI":"10.1210\/jc.2009-1368","article-title":"Clinical, immunological, and genetic features of autoimmune primary adrenal insufficiency: observations from a norwegian registry","volume":"94","author":"Erichsen","year":"2009","journal-title":"J Clin Endocrinol Metab."},{"key":"B4","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1210\/jc.2016-2522","article-title":"Clinical and immunological characteristics of autoimmune addison disease: a nationwide Swedish multicenter study","volume":"102","author":"Dalin","year":"2017","journal-title":"J Clin Endocrinol Metab."},{"key":"B5","doi-asserted-by":"publisher","first-page":"183.e1","DOI":"10.1016\/j.amjmed.2009.06.030","article-title":"Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease","volume":"123","author":"Boelaert","year":"2010","journal-title":"Am J Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.2337\/diacare.25.8.1346","article-title":"Thyroid autoimmunity in children and adolescents with type 1 diabetes: a multicenter survey","volume":"25","author":"Kordonouri","year":"2002","journal-title":"Diabetes Care"},{"key":"B7","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1159\/000023446","article-title":"Thyroid autoimmunity in children and adolescents with type 1 diabetes mellitus. Effect of age, gender and HLA type","volume":"52","author":"Holl","year":"1999","journal-title":"Horm Res"},{"key":"B8","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.mce.2012.09.004","article-title":"Induction of CXCL10 chemokine in adrenocortical cells by stimulation through toll-like receptor 3","volume":"365","author":"Bratland","year":"2013","journal-title":"Mol Cell Endocrinol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1210\/jc.2004-1062","article-title":"Elevated serum interferon-gamma-inducible chemokine-10\/CXC chemokine ligand-10 in autoimmune primary adrenal insufficiency and in vitro expression in human adrenal cells primary cultures after stimulation with proinflammatory cytokines","volume":"90","author":"Rotondi","year":"2005","journal-title":"J Clin Endocrinol Metab."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e0174840","DOI":"10.1371\/journal.pone.0174840","article-title":"Increased inflammation is associated with islet autoimmunity and type 1 diabetes in the diabetes autoimmunity study in the young (DAISY)","volume":"12","author":"Waugh","year":"2017","journal-title":"PloS ONE"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1007\/s00125-002-0879-5","article-title":"Serum concentrations of the interferon-gamma-inducible chemokine IP-10\/CXCL10 are augmented in both newly diagnosed type I diabetes mellitus patients and subjects at risk of developing the disease","volume":"45","author":"Nicoletti","year":"2002","journal-title":"Diabetologia"},{"key":"B12","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1159\/000078438","article-title":"Th1 and Th2 serum cytokine profiles characterize patients with hashimoto's thyroiditis (Th1) and Graves' disease (Th2)","volume":"11","author":"Phenekos","year":"2004","journal-title":"Neuroimmunomodulation"},{"key":"B13","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1530\/eje.1.01847","article-title":"Increase of interferon-gamma inducible alpha chemokine CXCL10 but not beta chemokine CCL2 serum levels in chronic autoimmune thyroiditis","volume":"152","author":"Antonelli","year":"2005","journal-title":"Eur J Endocrinol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S0002-9440(10)64171-5","article-title":"Expression of IP-10\/CXCL10 and MIG\/CXCL9 in the thyroid and increased levels of IP-10\/CXCL10 in the serum of patients with recent-onset Graves' disease","volume":"161","author":"Romagnani","year":"2002","journal-title":"Am J Pathol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.4049\/jimmunol.1000788","article-title":"IL-17 immunity in human type 1 diabetes","volume":"185","author":"Honkanen","year":"2010","journal-title":"J Immunol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s12020-015-0569-y","article-title":"The possible role of CD4(+)CD25(high)Foxp3(+)\/CD4(+)IL-17A(+) cell imbalance in the autoimmunity of patients with hashimoto thyroiditis","volume":"50","author":"Xue","year":"2015","journal-title":"Endocrine"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e102","DOI":"10.1093\/nar\/gkr424","article-title":"Homogeneous antibody-based proximity extension assays provide sensitive and specific detection of low-abundant proteins in human blood","volume":"39","author":"Lundberg","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e95192","DOI":"10.1371\/journal.pone.0095192","article-title":"Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability","volume":"9","author":"Assarsson","year":"2014","journal-title":"PloS ONE"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.3389\/fimmu.2017.01994","article-title":"Equal pro-inflammatory profiles of CCLs, CXCLs, and matrix metalloproteinases in the extracellular microenvironment in vivo in human dense breast tissue and breast cancer","volume":"8","author":"Abrahamsson","year":"2017","journal-title":"Front Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1038\/s41598-018-38304-w","article-title":"Inflammatory and anti-inflammatory markers in plasma: from late pregnancy to early postpartum","volume":"9","author":"Brann","year":"2019","journal-title":"Sci Rep."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.cell.2018.06.045","article-title":"Stereotypic immune system development in newborn children","volume":"174","author":"Olin","year":"2018","journal-title":"Cell"},{"key":"B22","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jim.2015.06.009","article-title":"The effects of age and gender on plasma levels of 63 cytokines","volume":"425","author":"Larsson","year":"2015","journal-title":"J Immunol Methods"},{"key":"B23","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.ebiom.2018.03.019","article-title":"GABA regulates release of inflammatory cytokines from peripheral blood mononuclear cells and CD4(+) T cells and is immunosuppressive in type 1 diabetes","volume":"30","author":"Bhandage","year":"2018","journal-title":"EBioMedicine"},{"key":"B24","doi-asserted-by":"publisher","first-page":"4264","DOI":"10.1210\/jc.2017-01324","article-title":"Visceral fat and novel biomarkers of cardiovascular disease in patients with addison's disease: a case-control study","volume":"102","author":"Bergthorsdottir","year":"2017","journal-title":"J Clin Endocrinol Metab."},{"key":"B25","doi-asserted-by":"publisher","first-page":"288","DOI":"10.3389\/fimmu.2020.00288","article-title":"Mass cytometry studies of patients with autoimmune endocrine diseases reveal distinct disease-specific alterations in immune cell subsets","volume":"11","author":"Magnusson","year":"2020","journal-title":"Front Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"6125","DOI":"10.4049\/jimmunol.173.10.6125","article-title":"Expression and characterization of a novel CD6 ligand in cells derived from joint and epithelial tissues","volume":"173","author":"Saifullah","year":"2004","journal-title":"J Immunol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"E6912","DOI":"10.1073\/pnas.1704008114","article-title":"CD318 is a ligand for CD6","volume":"114","author":"Enyindah-Asonye","year":"2017","journal-title":"Proc Natl Acad Sci USA."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1111\/j.1349-7006.2011.02052.x","article-title":"Roles of CUB domain-containing protein 1 signaling in cancer invasion and metastasis","volume":"102","author":"Uekita","year":"2011","journal-title":"Cancer Sci"},{"key":"B29","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1002\/iub.198","article-title":"The cell surface glycoprotein CDCP1 in cancer\u2013insights, opportunities, and challenges","volume":"61","author":"Wortmann","year":"2009","journal-title":"IUBMB Life"},{"key":"B30","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1111\/j.1365-2249.2010.04235.x","article-title":"CD6 synergistic co-stimulation promoting proinflammatory response is modulated without interfering with the activated leucocyte cell adhesion molecule interaction","volume":"162","author":"Nair","year":"2010","journal-title":"Clin Exp Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1210\/er.2017-00191","article-title":"Obesity in type 1 diabetes: pathophysiology, clinical impact, and mechanisms","volume":"39","author":"Corbin","year":"2018","journal-title":"Endocr Rev."},{"key":"B32","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.jdiacomp.2015.11.016","article-title":"Obesity and glycemic control in patients with diabetes mellitus: analysis of physician electronic health records in the US from 2009\u20132011","volume":"30","author":"Bae","year":"2016","journal-title":"J Diabetes Complications"},{"key":"B33","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/376260a0","article-title":"A novel receptor involved in T-cell activation","volume":"376","author":"Cocks","year":"1995","journal-title":"Nature"},{"key":"B34","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1084\/jem.185.6.993","article-title":"Soluble and membrane-bound forms of signaling lymphocytic activation molecule (SLAM) induce proliferation and Ig synthesis by activated human B lymphocytes","volume":"185","author":"Punnonen","year":"1997","journal-title":"J Exp Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1182\/blood.V99.3.957","article-title":"Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150\/SAP binding and CD150-mediated costimulation","volume":"99","author":"Howie","year":"2002","journal-title":"Blood"},{"key":"B36","doi-asserted-by":"publisher","first-page":"e0186073","DOI":"10.1371\/journal.pone.0186073","article-title":"Expression patterns of signaling lymphocytic activation molecule family members in peripheral blood mononuclear cell subsets in patients with systemic lupus erythematosus","volume":"12","author":"Karampetsou","year":"2017","journal-title":"PloS ONE"},{"key":"B37","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.4049\/jimmunol.159.6.2986","article-title":"Increased expression of signaling lymphocytic activation molecule in patients with rheumatoid arthritis and its role in the regulation of cytokine production in rheumatoid synovium","volume":"159","author":"Isomaki","year":"1997","journal-title":"J Immunol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1210\/jc.2016-2322","article-title":"Expression and function of the costimulatory receptor SLAMF1 is altered in lymphocytes from patients with autoimmune thyroiditis","volume":"102","author":"Vitales-Noyola","year":"2017","journal-title":"J Clin Endocrinol Metab."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1038\/s41467-018-03750-7","article-title":"IL-21 drives expansion and plasma cell differentiation of autoreactive CD11c(hi)T-bet(+) B cells in SLE","volume":"9","author":"Wang","year":"2018","journal-title":"Nat Commun."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1136\/annrheumdis-2012-202893","article-title":"Circulating plasmablasts\/plasmacells as a source of anticitrullinated protein antibodies in patients with rheumatoid arthritis","volume":"72","author":"Kerkman","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"B41","doi-asserted-by":"publisher","first-page":"e626","DOI":"10.1016\/j.lpm.2012.09.010","article-title":"Autoimmune addison's disease","volume":"41","author":"Napier","year":"2012","journal-title":"Presse Med"},{"key":"B42","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1055\/s-0033-1351291","article-title":"Altered chemokine Th1\/Th2 balance in addison's disease: relationship with hydrocortisone dosing and quality of life","volume":"46","author":"Ekman","year":"2014","journal-title":"Horm Metab Res"},{"key":"B43","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1089\/jir.2014.0171","article-title":"Peripheral blood cells from patients with autoimmune addison's disease poorly respond to interferons in vitro, despite elevated serum levels of interferon-inducible chemokines","volume":"35","author":"Edvardsen","year":"2015","journal-title":"J Interferon Cytokine Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.4049\/jimmunol.164.4.1768","article-title":"Inhibition of Th1 immune response by glucocorticoids: dexamethasone selectively inhibits IL-12-induced Stat4 phosphorylation in T lymphocytes","volume":"164","author":"Franchimont","year":"2000","journal-title":"J Immunol."},{"key":"B45","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.4049\/jimmunol.156.7.2406","article-title":"Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro","volume":"156","author":"Ramirez","year":"1996","journal-title":"J Immunol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1002\/eji.1830270933","article-title":"Glucocorticoids inhibit human antigen-specific and enhance total IgE and IgG4 production due to differential effects on T and B cells in vitro","volume":"27","author":"Akdis","year":"1997","journal-title":"Eur J Immunol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"2909","DOI":"10.1210\/jcem.86.7.7636","article-title":"Clinical review 130: addison's disease 2001","volume":"86","author":"Ten","year":"2001","journal-title":"J Clin Endocrinol Metab."},{"key":"B48","doi-asserted-by":"publisher","first-page":"eaaw7756","DOI":"10.1126\/sciadv.aaw7756","article-title":"Cytokine release and gastrointestinal symptoms after gluten challenge in celiac disease","volume":"5","author":"Goel","year":"2019","journal-title":"Sci Adv"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1136\/bmj.316.7139.1236","article-title":"What's wrong with bonferroni adjustments","volume":"316","author":"Perneger","year":"1998","journal-title":"BMJ."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01916\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T06:30:06Z","timestamp":1696573806000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01916\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,24]]},"references-count":49,"alternative-id":["10.3389\/fimmu.2020.01916"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.01916","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,24]]},"article-number":"1916"}}