{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T16:56:43Z","timestamp":1776013003745,"version":"3.50.1"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005366","name":"Universitetet i Oslo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005366","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.01921","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T04:21:20Z","timestamp":1598502080000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Commentary: Gut Antibody Deficiency in a Mouse Model of CVID Results in Spontaneous Development of a Gluten-Sensitive Enteropathy"],"prefix":"10.3389","volume":"11","author":[{"given":"Silje F.","family":"J\u00f8rgensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00f8rre","family":"Fevang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e5l","family":"Aukrust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1146\/annurev-immunol-030409-101314","article-title":"Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis","volume":"28","author":"Fagarasan","year":"2010","journal-title":"Annu Rev Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.coi.2012.03.005","article-title":"IgA synthesis: a form of functional immune adaptation extending beyond gut","volume":"24","author":"Sutherland","year":"2012","journal-title":"Curr Opin Immunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"5475","DOI":"10.4049\/jimmunol.170.11.5475","article-title":"Isolated lymphoid follicle formation is inducible and dependent upon lymphotoxin-sufficient B lymphocytes, lymphotoxin \u03b2 receptor, and TNF receptor I function","volume":"170","author":"Lorenz","year":"2003","journal-title":"J Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.immuni.2014.05.016","article-title":"Foxp3+ T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis","volume":"41","author":"Kawamoto","year":"2014","journal-title":"Immunity."},{"key":"B5","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1126\/science.1217718","article-title":"The inhibitory receptor PD-1 regulates IgA selection and bacterial composition in the gut","volume":"336","author":"Kawamoto","year":"2012","journal-title":"Science."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1073\/pnas.0307317101","article-title":"Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut","volume":"101","author":"Suzuki","year":"2004","journal-title":"Proc Natl Acad Sci USA."},{"key":"B7","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/ni.1991","article-title":"Mice carrying a knock-in mutation of Aicda resulting in a defect in somatic hypermutation have impaired gut homeostasis and compromised mucosal defense","volume":"12","author":"Wei","year":"2011","journal-title":"Nat Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2484","DOI":"10.3389\/fimmu.2019.02484","article-title":"Gut antibody deficiency in a mouse model of CVID results in spontaneous development of a gluten-sensitive enteropathy","volume":"10","author":"Mohammed","year":"2019","journal-title":"Front Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s10875-018-0574-z","article-title":"Autoimmunity and inflammation in CVID: a possible crosstalk between immune activation, gut microbiota, and epigenetic modifications","volume":"39","author":"Jorgensen","year":"2019","journal-title":"J Clin Immunol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1038\/nm.2505","article-title":"Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut","volume":"17","author":"Shulzhenko","year":"2011","journal-title":"Nat Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1038\/mi.2016.18","article-title":"Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation","volume":"9","author":"Jorgensen","year":"2016","journal-title":"Mucosal Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"14","DOI":"10.18176\/jiaci.0388","article-title":"Common variable immunodeficiency: epidemiology, pathogenesis, clinical manifestations, diagnosis, classification, and management","volume":"30","author":"Yazdani","year":"2020","journal-title":"J Investig Allergol Clin Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/s41586-020-2265-1","article-title":"Whole-genome sequencing of a sporadic primary immunodeficiency cohort","volume":"583","author":"Thaventhiran","year":"2020","journal-title":"Nature."},{"key":"B14","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1007\/s10875-013-9892-3","article-title":"The role of HLA DQ2 and DQ8 in dissecting celiac-like disease in common variable immunodeficiency","volume":"33","author":"Venhoff","year":"2013","journal-title":"J Clin Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1309\/ajcpeiilh2c0wfye","article-title":"The significance of duodenal mucosal atrophy in patients with common variable immunodeficiency: a clinical and histopathologic study","volume":"138","author":"Biagi","year":"2012","journal-title":"Am J Clin Pathol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1038\/ajg.2010.214","article-title":"The enteropathy associated with common variable immunodeficiency: the delineated frontiers with celiac disease","volume":"105","author":"Malamut","year":"2010","journal-title":"Am J Gastroenterol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1038\/ajg.2016.329","article-title":"A Cross-sectional study of the prevalence of gastrointestinal symptoms and pathology in patients with common variable immunodeficiency","volume":"111","author":"Jorgensen","year":"2016","journal-title":"Am J Gastroenterol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01921\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T04:21:22Z","timestamp":1598502082000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.01921\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,27]]},"references-count":17,"alternative-id":["10.3389\/fimmu.2020.01921"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.01921","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,27]]},"article-number":"1921"}}