{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:38:00Z","timestamp":1789472280217,"version":"build-2803163510"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.02015","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T05:42:55Z","timestamp":1601012575000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Trichinella spiralis Thioredoxin Peroxidase 2 Regulates Protective Th2 Immune Response in Mice by Directly Inducing Alternatively Activated Macrophages"],"prefix":"10.3389","volume":"11","author":[{"given":"Qi-Wang","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nian-Zhang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Tao","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin-Ju","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Asekhaen","family":"Ohiolei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Yu","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Bin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Zhong","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Xin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Quan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.vetpar.2007.07.002","article-title":"World distribution of Trichinella spp. infections in animals and humans.","volume":"149","author":"Pozio","year":"2007","journal-title":"Vet Parasitol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1895\/wormbook.1.124.1","article-title":"Biology and genome of Trichinella spiralis.","volume":"23","author":"Mitreva","year":"2006","journal-title":"Wormbook."},{"key":"B3","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s12026-012-8287-5","article-title":"Trichinella spiralis: shaping the immune response.","volume":"52","author":"Ilic","year":"2012","journal-title":"Immunol Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1586\/1744666X.2013.811187","article-title":"Trichinella spiralis immunomodulation: an interactive multifactorial process.","volume":"9","author":"Ashour","year":"2013","journal-title":"Expert Rev Clin Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1098\/rstb.1997.0123","article-title":"Th2-mediated host protective immunity to intestinal nematode infections.","volume":"352","author":"Grencis","year":"1997","journal-title":"Philos Trans R Soc Lond B Biol Sci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/2790627","article-title":"Macrophage activation and functions during helminth infection: recent advances from the laboratory mouse.","volume":"2018","author":"Rolot","year":"2018","journal-title":"J Immunol Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines.","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1126\/science.8456300","article-title":"Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.","volume":"259","author":"Dalton","year":"1993","journal-title":"Science."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00514","article-title":"Innate activation of IFN-\u03b3-iNOS axis during infection with salmonella represses the ability of T cells to produce IL-2.","volume":"11","author":"Yadav","year":"2020","journal-title":"Front Immunol."},{"key":"B10","doi-asserted-by":"crossref","DOI":"10.1189\/jlb.71.4.597","article-title":"Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages.","volume":"71","author":"Raes","year":"2002","journal-title":"J Leukoc Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1189\/jlb.0406249","article-title":"Biochemical and functional characterization of three activated macrophage populations.","volume":"80","author":"Edwards","year":"2006","journal-title":"J Leukoc Biol."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2172-3-7","article-title":"IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotype.","volume":"3","author":"Loke","year":"2002","journal-title":"BMC Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2810","DOI":"10.1007\/s10620-011-1689-8","article-title":"The protective effect of the recombinant 53-kDa protein of Trichinella spiralis on experimental colitis in mice.","volume":"56","author":"Du","year":"2011","journal-title":"Dig Dis Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s11010-011-1046-4","article-title":"Regulation of cytokine expression in murine macrophages stimulated by excretory\/secretory products from Trichinella spiralis in vitro.","volume":"360","author":"Bai","year":"2012","journal-title":"Mol Cell Biochem."},{"key":"B15","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1111\/j.1365-3024.2010.01201.x","article-title":"Peroxiredoxin: a central player in immune modulation.","volume":"32","author":"Robinson","year":"2010","journal-title":"Parasite Immunol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"7017","DOI":"10.1073\/pnas.91.15.7017","article-title":"Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes.","volume":"91","author":"Chae","year":"1994","journal-title":"Proc Natl Acad Sci USA."},{"key":"B17","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.vetpar.2016.05.027","article-title":"Cloning and characterization of thioredoxin peroxidases from Trichinella spiralis.","volume":"231","author":"Zhang","year":"2016","journal-title":"Vet Parasitol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1128\/IAI.73.1.166-173.2005","article-title":"Thioredoxin peroxidase secreted by Fasciola hepatica induces the alternative activation of macrophages.","volume":"73","author":"Donnelly","year":"2005","journal-title":"Infect Immun."},{"key":"B19","doi-asserted-by":"publisher","first-page":"4022","DOI":"10.1096\/fj.08-106278","article-title":"Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages.","volume":"22","author":"Donnelly","year":"2008","journal-title":"FASEB J."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1017\/S0031182007002855","article-title":"Identification of stage-specifically expressed genes of Trichinella spiralis by suppression subtractive hybridization.","volume":"134","author":"Liu","year":"2007","journal-title":"Parasitology."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-481-4_4","article-title":"Collecting resident or thioglycollate-elicited peritoneal macrophages.","volume":"1031","author":"Schneider","year":"2013","journal-title":"Methods Mol Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/978-1-4939-6625-7_23","article-title":"Isolation and differentiation of murine macrophages.","volume":"1527","author":"Rios","year":"2017","journal-title":"Methods Mol Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/978-1-62703-481-4_10","article-title":"Measuring T cell function in innate immune models.","volume":"1031","author":"Barker","year":"2013","journal-title":"Methods Mol Biol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/978-1-4939-6625-7_25","article-title":"Isolation of immune cells for adoptive transfer.","volume":"1527","author":"Barhoumi","year":"2017","journal-title":"Methods Mol Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method.","volume":"25","author":"Livak","year":"2001","journal-title":"Methods."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001633","article-title":"Stable T-bet+GATA-3+ Th1\/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation.","volume":"11","author":"Peine","year":"2013","journal-title":"PLoS Biol."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00603","article-title":"TH1\/TH2 paradigm extended: macrophage polarization as an unappreciated pathogen-driven escape mechanism?","volume":"5","author":"Muraille","year":"2014","journal-title":"Front Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/nri2992","article-title":"Diversity and dialogue in immunity to helminths.","volume":"11","author":"Allen","year":"2011","journal-title":"Nat Rev Immunol."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00011","article-title":"Trichinella spiralis excretory-secretory products induce tolerogenic properties in human dendritic cells via Toll-like receptors 2 and 4.","volume":"9","author":"Ilic","year":"2018","journal-title":"Front Immunol."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43057-1","article-title":"Adoptive transfer of Trichinella spiralis-activated macrophages can ameliorate both Th1- and Th2-activated inflammation in murine models.","volume":"9","author":"Kang","year":"2019","journal-title":"Sci Rep."},{"key":"B31","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/nature05746","article-title":"Chitin induces tissue accumulation of innate immune cells associated with allergy.","volume":"447","author":"Reese","year":"2007","journal-title":"Nature."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01930","article-title":"Chemokine-induced macrophage polarization in inflammatory conditions.","volume":"9","author":"Ruytinx","year":"2018","journal-title":"Front Immunol."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02790","article-title":"Arginase-1 is responsible for IL-13-mediated susceptibility to Trypanosoma cruzi infection.","volume":"9","author":"Abad Dar","year":"2018","journal-title":"Front Immunol."},{"key":"B34","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1002\/(SICI)1521-4141(200004)30:4<1127::AID-IMMU1127>3.0.CO;2-#","article-title":"Antigen-presenting cells recruited by Brugia malayi induce Th2 differentiation of na\u00efve CD4(+) T cells.","volume":"30","author":"Loke","year":"2000","journal-title":"Eur J Immunol."},{"key":"B35","first-page":"466","article-title":"A role for CD4+ but not CD8+ T cells in immunity to Schistosoma mansoni induced by 20 krad-irradiated and Ro 11-3128-terminated infections.","volume":"67","author":"Vignali","year":"1989","journal-title":"Immunology."},{"key":"B36","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.4049\/jimmunol.140.9.3206","article-title":"The role of L3T4+ and Lyt-2+ T cells in the IgE response and immunity to Nippostrongylus brasiliensis.","volume":"140","author":"Katona","year":"1988","journal-title":"J Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/s1074-7613(01)00186-8","article-title":"Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter.","volume":"15","author":"Mohrs","year":"2001","journal-title":"Immunity."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.4049\/jimmunol.164.4.2046","article-title":"Stat6 signaling promotes protective immunity against Trichinella spiralis through a mast cell- and T cell-dependent mechanism.","volume":"164","author":"Urban","year":"2000","journal-title":"J Immunol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.exppara.2010.10.004","article-title":"Trichinella spiralis: infection reduces airway allergic inflammation in mice.","volume":"127","author":"Park","year":"2011","journal-title":"Exp Parasitol."},{"key":"B40","first-page":"329","article-title":"Host protective immunity to Trichinella spiralis in mice: activation of Th cell subsets and lymphokine secretion in mice expressing different response phenotypes.","volume":"74","author":"Grencis","year":"1991","journal-title":"Immunology."},{"key":"B41","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1126\/science.1154315","article-title":"Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc.","volume":"320","author":"Anthony","year":"2008","journal-title":"Science."},{"key":"B42","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.jaci.2011.05.012","article-title":"Regulatory B-cell induction by helminths: implications for allergic disease.","volume":"128","author":"Hussaarts","year":"2011","journal-title":"J Allergy Clin Immunol."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02280","article-title":"Ascaris lumbricoides cystatin prevents development of allergic airway inflammation in a mouse model.","volume":"10","author":"Coronado","year":"2019","journal-title":"Front Immunol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.02015\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T06:45:24Z","timestamp":1696747524000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.02015\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,25]]},"references-count":43,"alternative-id":["10.3389\/fimmu.2020.02015"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.02015","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,25]]},"article-number":"2015"}}