{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:23:27Z","timestamp":1791829407166,"version":"4.3.4"},"reference-count":119,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.02098","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T01:39:15Z","timestamp":1599010755000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["\u03b23-Adrenoceptors as Putative Regulator of Immune Tolerance in Cancer and Pregnancy"],"prefix":"10.3389","volume":"11","author":[{"given":"Maura","family":"Calvani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Dabraio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Subbiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Buonvicino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"De Gregorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ciullini Mannurita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Pini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Nardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Favre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Filippi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/nm.3160","article-title":"Fetomaternal immune cross-talk and its consequences for maternal and offspring\u2019s health.","volume":"19","author":"Arck","year":"2013","journal-title":"Nat Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"325","DOI":"10.4049\/jimmunol.1800058","article-title":"Immune cells at the fetomaternal interface: how the microenvironment modulates immune cells to foster fetal development.","volume":"201","author":"Schumacher","year":"2018","journal-title":"J Immunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"977","DOI":"10.4049\/jimmunol.179.2.977","article-title":"Cross-talk between myeloid-derived suppressor cells and macrophages subverts tumor immunity toward a type 2 response.","volume":"179","author":"Sinha","year":"2007","journal-title":"J Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1189\/jlb.3A0414-210R","article-title":"Cross-talk among myeloid-derived suppressor cells, macrophages, and tumor cells impacts the inflammatory milieu of solid tumors.","volume":"96","author":"Beury","year":"2014","journal-title":"J Leukoc Biol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1189\/jlb.0708446","article-title":"Inflammation enhances myeloid-derived suppressor cell cross-talk by signaling through Toll-like receptor 4.","volume":"85","author":"Bunt","year":"2009","journal-title":"J Leukoc Biol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"240","DOI":"10.4049\/jimmunol.182.1.240","article-title":"Cancer-expanded myeloid-derived suppressor cells induce anergy of NK cells through membrane-bound TGF-beta 1.","volume":"182","author":"Li","year":"2009","journal-title":"J Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.critrevonc.2007.07.004","article-title":"The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages.","volume":"66","author":"Allavena","year":"2008","journal-title":"Crit Rev Oncol Hematol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"11438","DOI":"10.1158\/0008-5472.CAN-07-1882","article-title":"Amino-biphosphonate-mediated MMP-9 inhibition breaks the tumor-bone marrow axis responsible for myeloid-derived suppressor cell expansion and macrophage infiltration in tumor stroma.","volume":"67","author":"Melani","year":"2007","journal-title":"Cancer Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1073\/pnas.0437939100","article-title":"IL-1 is required for tumor invasiveness and angiogenesis.","volume":"100","author":"Voronov","year":"2003","journal-title":"Proc Natl Acad Sci USA."},{"key":"B10","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.ccr.2007.12.004","article-title":"Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis.","volume":"13","author":"Yang","year":"2008","journal-title":"Cancer Cell."},{"key":"B11","doi-asserted-by":"publisher","first-page":"10019","DOI":"10.1158\/0008-5472.CAN-07-2354","article-title":"Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression.","volume":"67","author":"Bunt","year":"2007","journal-title":"Cancer Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"284","DOI":"10.4049\/jimmunol.176.1.284","article-title":"Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression.","volume":"176","author":"Bunt","year":"2006","journal-title":"J Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"3367","DOI":"10.1172\/JCI35213","article-title":"Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice.","volume":"118","author":"Kujawski","year":"2008","journal-title":"J Clin Invest."},{"key":"B14","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/ni1037","article-title":"Regulatory T cells mediate maternal tolerance to the fetus.","volume":"5","author":"Aluvihare","year":"2004","journal-title":"Nat Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s00281-006-0023-6","article-title":"Regulatory T cells in pregnancy.","volume":"28","author":"Zenclussen","year":"2006","journal-title":"Springer Semin Immunopathol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1034\/j.1600-0897.2003.00080.x","article-title":"Cytokines, implantation and early abortion: re-examining the Th1\/Th2 paradigm leads to question the single pathway, single therapy concept.","volume":"50","author":"Chaouat","year":"2003","journal-title":"Am J Reprod Immunol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.smim.2003.12.007","article-title":"Regualtory T cells and organ transplantation.","volume":"16","author":"Waldmann","year":"2004","journal-title":"Semin Immunol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/j.bbrc.2004.12.106","article-title":"Critical role of heme oxygenase-1 in Foxp3-mediated immune suppression.","volume":"327","author":"Choi","year":"2005","journal-title":"Biochem Biophys Res Commun."},{"key":"B19","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1093\/molehr\/gah044","article-title":"Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases.","volume":"10","author":"Sasaki","year":"2004","journal-title":"Mol Hum Reprod."},{"key":"B20","doi-asserted-by":"publisher","first-page":"S47","DOI":"10.1016\/j.placenta.2005.11.008","article-title":"Differential distribution of CD4(+) CD25(bright) and CD8(+) CD28(-) T-cells in decidua and maternal blood during human pregnancy.","author":"Tilburgs","year":"2006","journal-title":"Placenta."},{"key":"B21","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/j.1600-0897.2010.00982.x","article-title":"Regulation of costimulatory signal in maternal-fetal immune tolerance.","volume":"66","author":"Jin","year":"2011","journal-title":"Am J Reprod Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1177\/1933719109349962","article-title":"The immunomodulatory roles of macrophages at the maternal-fetal interface.","volume":"17","author":"Nagamatsu","year":"2010","journal-title":"Reprod Sci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1093\/molehr\/gah246","article-title":"IDO expression on decidual and peripheral blood dendritic cells and monocytes\/macrophages after treatment with CTLA-4 or interferon-gamma increase in normal pregnancy but decrease in spontaneous abortion.","volume":"11","author":"Miwa","year":"2005","journal-title":"Mol Hum Reprod."},{"key":"B24","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/nature11462","article-title":"Pregnancy imprints regulatory memory that sustains anergy to fetal antigen.","volume":"490","author":"Rowe","year":"2012","journal-title":"Nature."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1126\/science.1164511","article-title":"Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero.","volume":"322","author":"Mold","year":"2008","journal-title":"Science."},{"key":"B26","doi-asserted-by":"publisher","first-page":"4715","DOI":"10.1182\/blood-2004-10-4051","article-title":"Ontogeny of CD4+CD25+ regulatory\/suppressor T cells in human fetuses.","volume":"105","author":"Darrasse-J\u00e8ze","year":"2005","journal-title":"Blood."},{"key":"B27","doi-asserted-by":"publisher","first-page":"5741","DOI":"10.4049\/jimmunol.176.10.5741","article-title":"Regulation of T cell responses in the developing human fetus.","volume":"176","author":"Micha\u00eblsson","year":"2006","journal-title":"J Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1093\/intimm\/10.12.1969","article-title":"Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic\/suppressive state.","volume":"10","author":"Takahashi","year":"1998","journal-title":"Int Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/nature06306","article-title":"The inhibitory cytokine IL-35 contributes to regulatory T-cell function.","volume":"450","author":"Collison","year":"2007","journal-title":"Nature."},{"key":"B30","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.immuni.2007.08.014","article-title":"Granzyme B and perforin are important for regulatory T cell-mediated suppression of tumor clearance.","volume":"27","author":"Cao","year":"2007","journal-title":"Immunity."},{"key":"B31","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.immuni.2004.08.010","article-title":"Role of LAG-3 in regulatory T cells.","volume":"21","author":"Huang","year":"2004","journal-title":"Immunity."},{"key":"B32","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/nri1457","article-title":"IDO expression by dendritic cells: tolerance and tryptophan catabolism.","volume":"4","author":"Mellor","year":"2004","journal-title":"Nat Rev Immunol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1038\/nm934","article-title":"Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase.","volume":"9","author":"Uyttenhove","year":"2003","journal-title":"Nat Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1111\/imm.12218","article-title":"The up side of decidual natural killer cells: new developments in immunology of pregnancy.","volume":"141","author":"Jabrane-Ferrat","year":"2014","journal-title":"Immunology."},{"key":"B35","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1038\/nri.2015.9","article-title":"Natural killer cell memory in infection, inflammation and cancer.","volume":"16","author":"Cerwenka","year":"2016","journal-title":"Nat Rev Immunol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/nri.2016.34","article-title":"Emerging insights into natural killer cells in human peripheral tissues.","volume":"16","author":"Bj\u00f6rkstr\u00f6m","year":"2016","journal-title":"Nat Rev Immunol."},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01397","article-title":"Features of human decidual NK Cells in healthy pregnancy and during viral infection.","volume":"10","author":"Jabrane-Ferrat","year":"2019","journal-title":"Front Immunol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/s0198-8859(99)00049-x","article-title":"The expression of killer cell inhibitory receptors on natural killer cells and activation status of CD4+ and CD8+ T cells in the decidua of normal and abnormal early pregnancies.","volume":"60","author":"Chao","year":"1999","journal-title":"Hum Immunol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1002\/1521-4141(200006)30:63.0.CO;2-M","article-title":"HLA-E is expressed on trophoblast and interacts with CD94\/NKG2 receptors on decidual NK cells.","volume":"30","author":"King","year":"2000","journal-title":"Eur J Immunol."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5738371","article-title":"Lymphocytes in placental tissues: immune regulation and translational possibilities for immunotherapy.","volume":"2017","author":"Erkers","year":"2017","journal-title":"Stem Cells Int."},{"key":"B41","doi-asserted-by":"publisher","first-page":"11918","DOI":"10.1073\/pnas.1001749107","article-title":"Crosstalk between decidual NK and CD14+ myelomonocytic cells results in induction of Tregs and immunosuppression.","volume":"107","author":"Vacca","year":"2010","journal-title":"Proc Natl Acad Sci USA."},{"key":"B42","doi-asserted-by":"publisher","first-page":"2320","DOI":"10.1002\/(sici)1097-0142(19970615)79:123.0.co;2-p","article-title":"The prognostic significance of intratumoral natural killer cells in patients with colorectal carcinoma.","volume":"79","author":"Coca","year":"1997","journal-title":"Cancer."},{"key":"B43","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/(SICI)1097-0142(20000201)88:3<577::AID-CNCR13>3.0.CO;2-V","article-title":"Prognostic value of intratumoral natural killer cells in gastric carcinoma.","volume":"88","author":"Ishigami","year":"2000","journal-title":"Cancer."},{"key":"B44","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/s0169-5002(01)00292-6","article-title":"Prognostic significance of tumor infiltrating natural killer cells subset CD57 in patients with squamous cell lung cancer.","volume":"35","author":"Villegas","year":"2002","journal-title":"Lung Cancer."},{"key":"B45","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.it.2003.09.007","article-title":"NK cells and the tumour microenvironment: implications for NK-cell function and anti-tumour activity.","volume":"24","author":"Albertsson","year":"2003","journal-title":"Trends Immunol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.lungcan.2007.07.022","article-title":"Malignant and non-malignant lung tissue areas are differentially populated by natural killer cells and regulatory T cells in non-small cell lung cancer.","volume":"59","author":"Esendagli","year":"2008","journal-title":"Lung Cancer."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1158\/1078-0432.CCR-11-0641","article-title":"Molecular pathways: beta-adrenergic signaling in cancer.","volume":"18","author":"Cole","year":"2012","journal-title":"Clin Cancer Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1158\/1078-0432.CCR-05-1698","article-title":"Stress hormone-mediated invasion of ovarian cancer cells.","volume":"12","author":"Sood","year":"2006","journal-title":"Clin Cancer Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1172\/JCI63324","article-title":"Behavioral stress accelerates prostate cancer development in mice.","volume":"123","author":"Hassan","year":"2013","journal-title":"J Clin Invest."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061435","article-title":"Effect of chronic restraint stress on human colorectal carcinoma growth in mice.","volume":"8","author":"Lin","year":"2013","journal-title":"PLoS One."},{"key":"B51","first-page":"2227","article-title":"The role of adrenergic receptors in lung cancer.","volume":"8","author":"Huang","year":"2018","journal-title":"Am J Cancer Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1111\/j.1349-7006.2002.tb01313.x","article-title":"Psychosocial stress augments tumor development through beta-adrenergic activation in mice.","volume":"93","author":"Hasegawa","year":"2002","journal-title":"Jpn J Cancer Res."},{"key":"B53","doi-asserted-by":"publisher","first-page":"29919","DOI":"10.1074\/jbc.M611539200","article-title":"Stress hormones regulate interleukin-6 expression by human ovarian carcinoma cells through a Src-dependent mechanism.","volume":"282","author":"Nilsson","year":"2007","journal-title":"J Biol Chem."},{"key":"B54","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.bbi.2008.10.005","article-title":"Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progression.","volume":"23","author":"Yang","year":"2009","journal-title":"Brain Behav Immun."},{"key":"B55","doi-asserted-by":"publisher","first-page":"35462","DOI":"10.1074\/jbc.M110.109579","article-title":"Stress effects on FosB- and interleukin-8 (IL8)-driven ovarian cancer growth and metastasis.","volume":"285","author":"Shahzad","year":"2010","journal-title":"J Biol Chem."},{"key":"B56","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1016\/j.bbi.2010.12.012","article-title":"Stress hormones increase cell proliferation and regulates interleukin-6 secretion in human oral squamous cell carcinoma cells.","volume":"25","author":"Bernab\u00e9","year":"2011","journal-title":"Brain Behav Immun."},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-11-72","article-title":"Stress hormones promote growth of B16-F10 melanoma metastases: an interleukin 6- and glutathione-dependent mechanism.","volume":"11","author":"Valles","year":"2013","journal-title":"J Transl Med."},{"key":"B58","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.jneuroim.2004.03.003","article-title":"Catecholaminergic control of NK cell cytolytic activity regulatory factors in the spleen.","volume":"151","author":"Dokur","year":"2004","journal-title":"J Neuroimmunol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"R537","DOI":"10.1152\/ajpregu.1996.271.3.R537","article-title":"Immobilization increases norepinephrine release and reduces NK cytotoxicity in spleen of conscious rat.","volume":"271","author":"Shimizu","year":"1996","journal-title":"Am J Physiol."},{"key":"B60","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.4049\/jimmunol.160.7.3251","article-title":"In vivo beta-adrenergic stimulation suppresses natural killer activity and compromises resistance to tumor metastasis in rats.","volume":"160","author":"Shakhar","year":"1998","journal-title":"J Immunol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1002\/(sici)1097-0215(19990315)80:63.0.co;2-y","article-title":"Evidence that stress and surgical interventions promote tumor development by suppressing natural killer cell activity.","volume":"80","author":"Ben-Eliyahu","year":"1999","journal-title":"Int J Cancer."},{"key":"B62","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1111\/j.1365-2362.1987.tb01148.x","article-title":"Natural killer cell activity during cortisol and adrenaline infusion in healthy volunteers.","volume":"17","author":"T\u00f8nnesen","year":"1987","journal-title":"Eur J Clin Invest."},{"key":"B63","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1097\/00000542-198710000-00014","article-title":"Natural killer cell activity and lymphocyte function during and after coronary artery bypass grafting in relation to the endocrine stress response.","volume":"67","author":"T\u00f8nnesen","year":"1987","journal-title":"Anesthesiology."},{"key":"B64","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1111\/j.1365-3083.1988.tb02400.x","article-title":"Modulation of natural killer cell activity in peripheral blood by physical exercise.","volume":"27","author":"Pedersen","year":"1988","journal-title":"Scand J Immunol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1152\/jappl.1997.83.5.1492","article-title":"Adrenergic beta 1- and beta 1 + 2-receptor blockade suppress the natural killer cell response to head-up tilt in humans.","volume":"83","author":"Klokker","year":"1997","journal-title":"J Appl Physiol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1152\/jappl.1995.78.4.1442","article-title":"Effect of eccentric exercise on natural killer cell activity.","volume":"78","author":"Palm\u00f8","year":"1995","journal-title":"J Appl Physiol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1002\/eji.201243005","article-title":"Beta2-adrenergic receptor signaling in CD4+ Foxp3+ regulatory T cells enhances their suppressive function in a PKA-dependent manner.","volume":"43","author":"Guereschi","year":"2013","journal-title":"Eur J Immunol."},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159059","article-title":"Induction of suppressor cells and increased tumor growth following chronic psychosocial stress in male mice.","volume":"11","author":"Schmidt","year":"2016","journal-title":"PLoS One."},{"key":"B69","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.cellimm.2011.04.003","article-title":"Psychological stress is associated with altered levels of myeloid-derived suppressor cells in breast cancer patients.","volume":"270","author":"Mundy-Bosse","year":"2011","journal-title":"Cell Immunol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3109\/08923973.2015.1059442","article-title":"Norepinephrine-induced myeloid-derived suppressor cells block T-cell responses via generation of reactive oxygen species.","volume":"37","author":"Liu","year":"2015","journal-title":"Immunopharmacol Immunotoxicol."},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1405205","article-title":"Beta blocker use correlates with better overall survival in metastatic melanoma patients and improves the efficacy of immunotherapies in mice.","volume":"7","author":"Kokolus","year":"2017","journal-title":"Oncoimmunology."},{"key":"B72","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1016\/0002-9378(83)91088-8","article-title":"Fetal catecholamines.","volume":"146","author":"Phillippe","year":"1983","journal-title":"Am J Obstet Gynecol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"H2069","DOI":"10.1152\/ajpheart.00588.2002","article-title":"Catecholamines act via a beta-adrenergic receptor to maintain fetal heart rate and survival.","volume":"284","author":"Portbury","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/374643a0","article-title":"Noradrenaline is essential for mouse fetal development.","volume":"374","author":"Thomas","year":"1995","journal-title":"Nature."},{"key":"B75","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1038\/374640a0","article-title":"Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development.","volume":"374","author":"Zhou","year":"1995","journal-title":"Nature."},{"key":"B76","first-page":"1027","article-title":"Role of fetal catecholamines before and during birth.","volume":"41","author":"Kudo","year":"1989","journal-title":"Nihon Sanka Fujinka Gakkai Zasshi."},{"key":"B77","doi-asserted-by":"publisher","first-page":"2635","DOI":"10.1200\/JCO.2010.33.5422","article-title":"Beta blockers and breast cancer mortality: a population- based study.","volume":"29","author":"Barron","year":"2011","journal-title":"J Clin Oncol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.clbc.2015.07.001","article-title":"\u03b2-blockers reduce breast cancer recurrence and breast cancer death: a meta-analysis.","volume":"15","author":"Childers","year":"2015","journal-title":"Clin Breast Cancer."},{"key":"B79","first-page":"5059","article-title":"Prognostic significance of \u03b22-adrenergic receptor expression in non-small cell lung cancer.","volume":"8","author":"Yazawa","year":"2016","journal-title":"Am J Transl Res."},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.2908","article-title":"Propranolol for off-label treatment of patients with melanoma: results from a cohort study.","volume":"4","author":"De Giorgi","year":"2018","journal-title":"JAMA Oncol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1093\/humrep\/del016","article-title":"Identification of functional alpha2- and beta-adrenergic receptors in mammalian spermatozoa.","volume":"21","author":"Adeoya-Osiguwa","year":"2006","journal-title":"Hum Reprod."},{"key":"B82","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/mrd.20256","article-title":"Expression of beta adrenergic receptors in mouse oocytes and preimplantation embryos.","volume":"71","author":"Cikos","year":"2005","journal-title":"Mol Reprod Dev."},{"key":"B83","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/rda.12233","article-title":"Expression of adrenergic receptors in bovine and rabbit oocytes and preimplantation embryos.","volume":"49","author":"\u00c8iko\u0161","year":"2014","journal-title":"Reprod Domest Anim."},{"key":"B84","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/s0304-3940(97)00511-9","article-title":"Gene expression of catecholamine synthesizing enzymes and beta adrenoceptor subtypes during rat embryogenesis.","volume":"231","author":"Fujinaga","year":"1997","journal-title":"Neurosci Lett."},{"key":"B85","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1002\/mrd.10337","article-title":"Role of adrenergic receptor subtypes in the control of human placental blood vessels.","volume":"66","author":"Resch","year":"2003","journal-title":"Mol Reprod Dev."},{"key":"B86","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1080\/10641950701826554","article-title":"Beta-adrenoceptor subtype expression in human placenta and umbilical arteries in normal and preeclamptic pregnancies.","volume":"27","author":"Hynes","year":"2008","journal-title":"Hypertens Pregnancy."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1210\/jc.2004-0233","article-title":"Beta3-adrenoceptor is the predominant beta-adrenoceptor subtype in human myometrium and its expression is up-regulated in pregnancy.","volume":"90","author":"Rouget","year":"2005","journal-title":"J Clin Endocrinol Metab."},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-7-S1-S14","article-title":"Is the beta3-adrenoceptor (ADRB3) a potential target for uterorelaxant drugs?","author":"Bardou","year":"2007","journal-title":"BMC Pregnancy Childbirth."},{"key":"B89","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1159\/000163851","article-title":"Upregulation of beta3-adrenergic receptor mRNA in human colon cancer: a preliminary study.","volume":"75","author":"Perrone","year":"2008","journal-title":"Oncology."},{"key":"B90","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.bbi.2012.01.013","article-title":"Chronic stress enhances progression of acute lymphoblastic leukemia via \u03b2-adrenergic signaling.","volume":"26","author":"Lamkin","year":"2012","journal-title":"Brain Behav Immun."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1038\/modpathol.2012.108","article-title":"\u03b2-Adrenergic receptor expression in vascular tumors.","volume":"25","author":"Chisholm","year":"2012","journal-title":"Mod Pathol."},{"key":"B92","first-page":"669","article-title":"An association between the Trp64Arg polymorphism in the beta3-adrenergic receptor gene and endometrial cancer and obesity.","volume":"23","author":"Babol","year":"","journal-title":"J Exp Clin Cancer Res."},{"key":"B93","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1186\/bcr304","article-title":"Possible association of beta2- and beta3-adrenergic receptor gene polymorphisms with susceptibility to breast cancer.","volume":"3","author":"Huang","year":"2001","journal-title":"Breast Cancer Res."},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1126\/science.1236361","article-title":"Autonomic nerve development contributes to prostate cancer progression.","volume":"341","author":"Magnon","year":"2013","journal-title":"Science."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1007\/s00109-013-1073-6","article-title":"Functional involvement of \u03b23-adrenergic receptors in melanoma growth and vascularization.","volume":"91","author":"Dal Monte","year":"2013","journal-title":"J Mol Med (Berl)."},{"key":"B96","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1007\/s00210-015-1165-7","article-title":"Role of host \u03b21- and \u03b22-adrenergic receptors in a murine model of B16 melanoma: functional involvement of \u03b23-adrenergic receptors.","volume":"388","author":"Sereni","year":"2015","journal-title":"Naunyn Schmiedebergs Arch Pharmacol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/s00210-014-0969-1","article-title":"\u03b23-adrenergic receptor activity modulates melanoma cell proliferation and survival through nitric oxide signaling.","volume":"387","author":"Dal Monte","year":"2014","journal-title":"Naunyn Schmiedebergs Arch Pharmacol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"4615","DOI":"10.18632\/oncotarget.2652","article-title":"Norepinephrine promotes tumor microenvironment reactivity through \u03b23-adrenoreceptors during melanoma progression.","volume":"6","author":"Calvani","year":"2015","journal-title":"Oncotarget."},{"key":"B99","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1161\/hh1901.098042","article-title":"Upregulation of functional beta (3)-adrenergic receptor in the failing canine myocardium.","volume":"89","author":"Cheng","year":"2001","journal-title":"Circ Res."},{"key":"B100","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1161\/01.cir.103.12.1649","article-title":"Upregulation of beta (3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium.","volume":"103","author":"Moniotte","year":"2001","journal-title":"Circulation."},{"key":"B101","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1161\/01.CIR.0000139331.85766.AF","article-title":"Endothelial beta3-adrenoceptors mediate vasorelaxation of human coronary microarteries through nitric oxide and endothelium-dependent hyperpolarization.","volume":"110","author":"Dessy","year":"2004","journal-title":"Circulation."},{"key":"B102","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1167\/iovs.10-5536","article-title":"Role of the adrenergic system in a mouse model of oxygen-induced retinopathy: antiangiogenic effects of beta-adrenoreceptor blockade.","volume":"52","author":"Ristori","year":"2011","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B103","doi-asserted-by":"publisher","first-page":"2968","DOI":"10.1167\/iovs.12-9691","article-title":"Propranolol inhibition of \u03b2-adrenergic receptor does not suppress pathologic neovascularization in oxygen-induced retinopathy.","volume":"53","author":"Chen","year":"2012","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B104","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s00210-012-0828-x","article-title":"Beta3-adrenergic receptors modulate vascular endothelial growth factor release in response to hypoxia through the nitric oxide pathway in mouse retinal explants.","volume":"386","author":"Dal Monte","year":"2013","journal-title":"Naunyn Schmiedebergs Arch Pharmacol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1111\/bph.14660","article-title":"\u03b2(3)-Adrenoceptor as a potential immuno-suppressor agent in melanoma.","volume":"176","author":"Calvani","year":"2019","journal-title":"Br J Pharmacol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.diff.2009.06.002","article-title":"Hypoxia and pluripotency in embryonic and embryonal carcinoma stem cell biology.","volume":"78","author":"Silv\u00e1n","year":"2009","journal-title":"Differentiation."},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00020","article-title":"Similarities between embryo development and cancer process suggest new strategies for research and therapy of tumors: a new point of view.","volume":"7","author":"Manzo","year":"2019","journal-title":"Front Cell Dev Biol."},{"key":"B108","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1067\/mob.2001.111935","article-title":"Evaluation of respiratory gases and acid-base gradients in human fetal fluids and uteroplacental tissue between 7 and 16 weeks\u2019 gestation.","volume":"184","author":"Jauniaux","year":"2001","journal-title":"Am J Obstet Gynecol."},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6816508","article-title":"\u03b23-adrenoreceptors control mitochondrial dormancy in melanoma and embryonic stem cells.","volume":"2018","author":"Calvani","year":"2018","journal-title":"Oxid Med Cell Longev."},{"key":"B110","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1002\/mrd.22017","article-title":"Glycolysis in preimplantation development is partially controlled by the Warburg Effect.","volume":"79","author":"Redel","year":"2012","journal-title":"Mol Reprod Dev."},{"key":"B111","doi-asserted-by":"publisher","first-page":"21280","DOI":"10.1074\/jbc.M115.656629","article-title":"Warburg-like glycolysis and lactate shuttle in mouse decidua during early pregnancy.","volume":"290","author":"Zuo","year":"2015","journal-title":"J Biol Chem."},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00004","article-title":"Hypoxia-modified cancer cell metabolism.","volume":"7","author":"Al Tameemi","year":"2019","journal-title":"Front Cell Dev Biol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1080\/09553002.2019.1589653","article-title":"The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression.","volume":"95","author":"Vaupel","year":"2019","journal-title":"Int J Radiat Biol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1042\/BST20120352","article-title":"Parallels between embryo and cancer cell metabolism.","volume":"41","author":"Smith","year":"2013","journal-title":"Biochem Soc Trans."},{"key":"B115","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/s41388-019-0993-1","article-title":"\u03b23-adrenoreceptor blockade reduces tumor growth and increases neuronal differentiation in neuroblastoma via SK2\/S1P(2) modulation.","volume":"39","author":"Bruno","year":"2020","journal-title":"Oncogene."},{"key":"B116","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1177\/0023677217738268","article-title":"On determining sample size in experiments involving laboratory animals.","volume":"52","author":"Festing","year":"2018","journal-title":"Lab Anim"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02087","article-title":"Decidual-placental immune landscape during syngeneic murine pregnancy.","volume":"9","author":"Li","year":"2018","journal-title":"Front Immunol."},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1038\/s41377-019-0181-7","article-title":"Non-invasive determination of murine placental and foetal functional parameters with multispectral optoacoustic tomography.","volume":"8","author":"Basak","year":"2019","journal-title":"Light Sci Appl."},{"key":"B119","doi-asserted-by":"publisher","first-page":"5520","DOI":"10.1096\/fj.201700047RR","article-title":"Photoacoustic imaging for in vivo quantification of placental oxygenation in mice.","volume":"31","author":"Yamaleyeva","year":"2017","journal-title":"FASEB J."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.02098\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T14:51:36Z","timestamp":1696603896000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.02098\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,2]]},"references-count":119,"alternative-id":["10.3389\/fimmu.2020.02098"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.02098","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,2]]},"article-number":"2098"}}