{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:46:56Z","timestamp":1783633616385,"version":"3.55.0"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700570"],"award-info":[{"award-number":["81700570"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.02111","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T05:39:04Z","timestamp":1603345144000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Role of Innate Immunity in Pediatric Post-transplant Idiopathic Liver Fibrosis"],"prefix":"10.3389","volume":"11","author":[{"given":"Yue","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoqiao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxiang","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1002\/hep.28681","article-title":"Five-year histological and serological follow-up of operationally tolerant pediatric liver transplant recipients enrolled in WISP-R","volume":"65","author":"Feng","year":"2017","journal-title":"Hepatology."},{"key":"B2","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1111\/ajt.14126","article-title":"OPTN\/SRTR 2015 annual data report: liver","volume":"17","author":"Kim","year":"2017","journal-title":"Am J Transplant."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1111\/ajt.14626","article-title":"Long-term outcome of liver transplantation in childhood: a study of 20-year survivors","volume":"18","author":"Martinelli","year":"2018","journal-title":"Am J Transplant."},{"key":"B4","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1002\/hep.22686","article-title":"Graft fibrosis after pediatric liver transplantation: ten years of follow-up","volume":"49","author":"Scheenstra","year":"2009","journal-title":"Hepatology."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1002\/lt.24616","article-title":"Late graft hepatitis and fibrosis in pediatric liver allograft recipients: current concepts and future developments","volume":"22","author":"Kelly","year":"2016","journal-title":"Liver Transpl."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1111\/j.1600-6143.2008.02341.x","article-title":"Donor HLA-C genotype has a profound impact on the clinical outcome following liver transplantation","volume":"8","author":"Hanvesakul","year":"2008","journal-title":"Am J Transplant."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2986","DOI":"10.1111\/j.1600-6143.2012.04210.x","article-title":"Novel histologic scoring system for long-term allograft fibrosis after liver transplantation in children","volume":"12","author":"Venturi","year":"2012","journal-title":"Am J Transplant."},{"key":"B8","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1111\/j.1872-034X.2012.01003.x","article-title":"Non-inflammatory centrilobular sinusoidal fibrosis in pediatric liver transplant recipients under tacrolimus withdrawal","volume":"42","author":"Egawa","year":"2012","journal-title":"Hepatol Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1002\/lt.21549","article-title":"Graft histology characteristics in long-term survivors of pediatric liver transplantation","volume":"14","author":"Ekong","year":"2008","journal-title":"Liver Transpl."},{"key":"B10","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1002\/lt.21444","article-title":"Interface hepatitis is associated with a high incidence of late graft fibrosis in a group of tightly monitored pediatric orthotopic liver transplantation patients","volume":"14","author":"Herzog","year":"2008","journal-title":"Liver Transpl."},{"key":"B11","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1002\/lt.20358","article-title":"Long-term outcome of pediatric liver transplantation for biliary atresia: a 10-year follow-up in a single center","volume":"11","author":"Fouquet","year":"2005","journal-title":"Liver Transpl."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1097\/PAS.0b013e31817a8e96","article-title":"Significance of central perivenulitis in pediatric liver transplantation","volume":"32","author":"Abraham","year":"2008","journal-title":"Am J Surg Pathol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1002\/lt.23534","article-title":"Progressive graft fibrosis and donor-specific human leukocyte antigen antibodies in pediatric late liver allografts","volume":"18","author":"Miyagawa-Hayashino","year":"2012","journal-title":"Liver Transpl."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1097\/TP.0000000000000185","article-title":"Association of anti-human leukocyte antigen and anti-angiotensin II type 1 receptor antibodies with liver allograft fibrosis after immunosuppression withdrawal","volume":"98","author":"Ohe","year":"2014","journal-title":"Transplantation."},{"key":"B15","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1111\/ajt.13476","article-title":"Proposed diagnostic criteria for chronic antibody-mediated rejection in liver allografts","volume":"16","author":"O'Leary","year":"2016","journal-title":"Am J Transplant."},{"key":"B16","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1111\/j.1399-3046.2012.01781.x","article-title":"Humoral immunity is involved in the development of pericentral fibrosis after pediatric live donor liver transplantation","volume":"16","author":"Yamada","year":"2012","journal-title":"Pediatr Transplant."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.3389\/fimmu.2018.02401","article-title":"Innate immune cells in immune tolerance after liver transplantation","volume":"9","author":"Huang","year":"2018","journal-title":"Front Immunol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"S112","DOI":"10.1111\/j.1440-1746.2007.05274.x","article-title":"Innate immunity and alcoholic liver fibrosis","volume":"23","author":"Jeong","year":"2008","journal-title":"J Gastroenterol Hepatol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1038\/nm1663","article-title":"TLR4 enhances TGF-beta signaling and hepatic fibrosis","volume":"13","author":"Seki","year":"2007","journal-title":"Nat Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1002\/lt.23793","article-title":"Role of toll-like receptors in liver transplantation","volume":"20","author":"Howell","year":"2014","journal-title":"Liver Transpl."},{"key":"B21","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1097\/01.tp.0000276960.35313.bf","article-title":"Association between toll-like receptor polymorphisms and the outcome of liver transplantation for chronic hepatitis C virus","volume":"84","author":"Eid","year":"2007","journal-title":"Transplantation."},{"key":"B22","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/j.dld.2012.11.010","article-title":"Gut-liver axis and fibrosis in nonalcoholic fatty liver disease: an input for novel therapies","volume":"45","author":"Frasinariu","year":"2013","journal-title":"Dig Liver Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1053\/j.gastro.2010.03.052","article-title":"Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice","volume":"139","author":"Miura","year":"2010","journal-title":"Gastroenterology."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.jhep.2009.06.020","article-title":"Toll-like receptor activated human and murine hepatic stellate cells are potent regulators of hepatitis C virus replication","volume":"51","author":"Wang","year":"2009","journal-title":"J Hepatol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1053\/j.gastro.2005.10.055","article-title":"Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners","volume":"130","author":"Radaeva","year":"2006","journal-title":"Gastroenterology."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1002\/hep.510230538","article-title":"Interferon gamma decreases hepatic stellate cell activation and extracellular matrix deposition in rat liver fibrosis","volume":"23","author":"Baroni","year":"1996","journal-title":"Hepatology."},{"key":"B27","first-page":"660","article-title":"Interferon gamma inhibits lipocyte activation and extracellular matrix mRNA expression during experimental liver injury: implications for treatment of hepatic fibrosis","volume":"42","author":"Rockey","year":"1994","journal-title":"J Invest Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1002\/hep.1840380415","article-title":"Interferon alfa down-regulates collagen gene transcription and suppresses experimental hepatic fibrosis in mice","volume":"38","author":"Inagaki","year":"2003","journal-title":"Hepatology."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1002\/hep.21440","article-title":"Impact of disease severity on outcome of antiviral therapy for chronic hepatitis C: lessons from the HALT-C trial","volume":"44","author":"Everson","year":"2006","journal-title":"Hepatology."},{"key":"B30","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0168-8278(95)80420-X","article-title":"Improvement of liver fibrosis in chronic hepatitis C patients treated with natural interferon alpha","volume":"22","author":"Hiramatsu","year":"1995","journal-title":"J Hepatol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1053\/j.gastro.2007.03.041","article-title":"Efficacy of antiviral therapy on hepatitis C recurrence after liver transplantation: a randomized controlled study","volume":"132","author":"Carrion","year":"2007","journal-title":"Gastroenterology."},{"key":"B32","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1002\/hep.20073","article-title":"Effect of peginterferon alfa-2a on liver histology in chronic hepatitis C: a meta-analysis of individual patient data","volume":"39","author":"Camma","year":"2004","journal-title":"Hepatology."},{"key":"B33","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1002\/hep.21344","article-title":"STAT1 contributes to dsRNA inhibition of liver regeneration after partial hepatectomy in mice","volume":"44","author":"Sun","year":"2006","journal-title":"Hepatology."},{"key":"B34","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1111\/eci.12669","article-title":"Intrahepatic NK cells function suppressed in advanced liver fibrosis","volume":"46","author":"Li","year":"2016","journal-title":"Eur J Clin Invest."},{"key":"B35","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1002\/path.4733","article-title":"Enhanced protection from fibrosis and inflammation in the combined absence of IL-13 and IFN-\u03b3","volume":"239","author":"Ramalingam","year":"2016","journal-title":"J Pathol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2674","DOI":"10.3389\/fimmu.2019.02674","article-title":"Macrophage coordination of the interferon lambda immune response","volume":"10","author":"Read","year":"2019","journal-title":"Front Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.1002\/hep.29395","article-title":"Interferon lambda 4 rs368234815 TT>\u03b4G variant is associated with liver damage in patients with nonalcoholic fatty liver disease","volume":"66","author":"Petta","year":"2017","journal-title":"Hepatology."},{"key":"B38","doi-asserted-by":"publisher","first-page":"e0150606","DOI":"10.1371\/journal.pone.0150606","article-title":"A protocol for the comprehensive flow cytometric analysis of immune cells in normal and inflamed murine non-lymphoid tissues","volume":"11","author":"Mueller","year":"2016","journal-title":"PLoS ONE."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1002\/hep.24189","article-title":"Interferon-\u03b2 and interferon-\u03bb signaling is not affected by interferon-induced refractoriness to interferon-\u03b1 in vivo","volume":"53","author":"Makowska","year":"2011","journal-title":"Hepatology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.immuni.2008.06.017","article-title":"Plasmacytoid dendritic cells mediate oral tolerance","volume":"29","author":"Goubier","year":"2008","journal-title":"Immunity."},{"key":"B41","doi-asserted-by":"publisher","first-page":"3213","DOI":"10.1172\/JCI37581","article-title":"In liver fibrosis, dendritic cells govern hepatic inflammation in mice via TNF-alpha","volume":"119","author":"Connolly","year":"2009","journal-title":"J Clin Invest."},{"key":"B42","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1002\/hep.26267","article-title":"Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice","volume":"58","author":"Henning","year":"2013","journal-title":"Hepatology."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1016\/0140-6736(92)91875-9","article-title":"Donor dendritic cells after liver and heart allotransplantation under short-term immunosuppression","volume":"339","author":"Demetris","year":"1992","journal-title":"Lancet."},{"key":"B44","doi-asserted-by":"publisher","first-page":"3951","DOI":"10.1182\/blood-2004-10-3927","article-title":"Cyclosporin A and tacrolimus, but not rapamycin, inhibit MHC-restricted antigen presentation pathways in dendritic cells","volume":"105","author":"Lee","year":"2005","journal-title":"Blood."},{"key":"B45","doi-asserted-by":"publisher","first-page":"44544","DOI":"10.1038\/srep44544","article-title":"Activated hepatic stellate cells impair NK cell anti-fibrosis capacity through a TGF-beta-dependent emperipolesis in HBV cirrhotic patients","volume":"7","author":"Shi","year":"2017","journal-title":"Sci Rep."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1002\/hep.21419","article-title":"STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity","volume":"44","author":"Jeong","year":"2006","journal-title":"Hepatology."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2094","DOI":"10.1111\/j.1600-6143.2005.00995.x","article-title":"IFN-gamma, produced by NK cells that infiltrate liver allografts early after transplantation, links the innate and adaptive immune responses","volume":"5","author":"Obara","year":"2005","journal-title":"Am J Transplant."},{"key":"B48","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1038\/cmi.2017.72","article-title":"Liver-resident NK cells and their potential functions","volume":"14","author":"Peng","year":"2017","journal-title":"Cell Mol Immunol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1084\/jem.20051600","article-title":"Functionally distinct NKT cell subsets and subtypes","volume":"202","author":"Seino","year":"2005","journal-title":"J Exp Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1038\/nri3328","article-title":"Recognition of CD1d-restricted antigens by natural killer T cells","volume":"12","author":"Rossjohn","year":"2012","journal-title":"Nat Rev Immunol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"2082","DOI":"10.3389\/fimmu.2018.02082","article-title":"Complex network of NKT cell subsets controls immune homeostasis in liver and gut","volume":"9","author":"Marrero","year":"2018","journal-title":"Front Immunol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1002\/hep.22813","article-title":"Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride","volume":"49","author":"Park","year":"2009","journal-title":"Hepatology."},{"key":"B53","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1177\/0192623311427570","article-title":"Neutrophils and intravascular immunity in the liver during infection and sterile inflammation","volume":"40","author":"McDonald","year":"2012","journal-title":"Toxicol Pathol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/nri3024","article-title":"Neutrophils in the activation and regulation of innate and adaptive immunity","volume":"11","author":"Mantovani","year":"2011","journal-title":"Nat Rev Immunol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1182\/blood-2010-06-287243","article-title":"Human neutrophils interact with both 6-sulfo LacNAc+ DC and NK cells to amplify NK-derived IFN{gamma}: role of CD18, ICAM-1, and ICAM-3","volume":"117","author":"Costantini","year":"2011","journal-title":"Blood."},{"key":"B56","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1002\/hep.27129","article-title":"Soluble CD163, a macrophage activation marker, is independently associated with fibrosis in patients with chronic viral hepatitis B and C","volume":"60","author":"Kazankov","year":"2014","journal-title":"Hepatology."},{"key":"B57","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1172\/JCI200522675","article-title":"Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair","volume":"115","author":"Duffield","year":"2005","journal-title":"J Clin Invest."},{"key":"B58","doi-asserted-by":"publisher","first-page":"5226","DOI":"10.4049\/jimmunol.1202909","article-title":"Chemokine receptor CXCR6-dependent hepatic NK T Cell accumulation promotes inflammation and liver fibrosis","volume":"190","author":"Wehr","year":"2013","journal-title":"J Immunol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1002\/hep.26429","article-title":"Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice","volume":"58","author":"Pradere","year":"2013","journal-title":"Hepatology."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1053\/j.gastro.2007.02.033","article-title":"Gene expression profiles during hepatic stellate cell activation in culture and in vivo","volume":"132","author":"De Minicis","year":"2007","journal-title":"Gastroenterology"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.jhep.2012.12.014","article-title":"Progression of liver fibrosis in post-transplant hepatitis C: mechanisms, assessment and treatment","volume":"58","author":"Berenguer","year":"2013","journal-title":"J Hepatol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/j.1365-2559.2011.03742.x","article-title":"Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy: potential role in mesangial matrix expansion","volume":"58","author":"Ikezumi","year":"2011","journal-title":"Histopathology."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1007\/s00467-014-3023-0","article-title":"Alternatively activated macrophages in the pathogenesis of chronic kidney allograft injury","volume":"30","author":"Ikezumi","year":"2015","journal-title":"Pediatr Nephrol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3389\/fimmu.2019.00052","article-title":"Immune status in children before liver transplantation-a cross-sectional analysis within the chilssfree multicentre cohort study","volume":"10","author":"Mohring","year":"2019","journal-title":"Front Immunol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1002\/hep.21152","article-title":"Progressive histological damage in liver allografts following pediatric liver transplantation","volume":"43","author":"Evans","year":"2006"},{"key":"B66","doi-asserted-by":"publisher","first-page":"e526","DOI":"10.1038\/cddis.2013.56","article-title":"Effect of FK506 in reducing scar formation by inducing fibroblast apoptosis after sciatic nerve injury in rats","volume":"4","author":"Que","year":"2013","journal-title":"Cell Death Dis."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/j.bbrc.2017.06.181","article-title":"Tacrolimus induces fibroblasts apoptosis and reduces epidural fibrosis by regulating miR-429 and its target of RhoE","volume":"490","author":"Li","year":"2017","journal-title":"Biochem Biophys Res Commun."},{"key":"B68","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1182\/blood-2010-11-317396","article-title":"Calcineurin-dependent negative regulation of CD94\/NKG2A expression on naive CD8+ T cells","volume":"118","author":"Cho","year":"2011","journal-title":"Blood."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1189\/jlb.0310148","article-title":"FK506 causes cellular and functional defects in human natural killer cells","volume":"88","author":"Kim","year":"2010","journal-title":"J Leukoc Biol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.02111\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T05:39:06Z","timestamp":1603345146000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.02111\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,22]]},"references-count":69,"alternative-id":["10.3389\/fimmu.2020.02111"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.02111","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,22]]},"article-number":"2111"}}