{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:32:40Z","timestamp":1787668360065,"version":"build-2736575974"},"reference-count":82,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.02191","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T12:11:11Z","timestamp":1600431071000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Human Chondrocyte Activation by Toxins From Premolis semirufa, an Amazon Rainforest Moth Caterpillar: Identifying an Osteoarthritis Signature"],"prefix":"10.3389","volume":"11","author":[{"given":"Isadora M.","family":"Villas-Boas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselle","family":"Pidde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Lichtenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Tung Ching","family":"Ching","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e1cio de Loiola Meirelles","family":"Junqueira-de-Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"DeOcesano-Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo","family":"Madureira Trufen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Marisa","family":"Chudzinski-Tavassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00e1tia Luciano Pereira","family":"Morais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise V.","family":"Tambourgi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"347","DOI":"10.4269\/ajtmh.2005.72.347","article-title":"The evolving global epidemiology, syndromic classification, management, and prevention of caterpillar envenoming","volume":"72","author":"Diaz","year":"2005","journal-title":"Am J Trop Med Hyg."},{"key":"B2","first-page":"1","article-title":"Efeitos danosos da lagarta \u201cPararama\u201d. (Premolis semirufa) a seringueiros no Estado do Par\u00e1","volume":"8","author":"Rodrigues","year":"1976","journal-title":"Bol FCAP"},{"key":"B3","first-page":"988","article-title":"Pararama: doen\u00e7a dos seringais","volume-title":"Doen\u00e7as Infecciosas e Parasit\u00e1rias.","author":"Dias","year":"1991"},{"key":"B4","first-page":"61","article-title":"Experimental arthritis induced by bristles from a \u201cLepidoptera\u201d, \u201cPremolis semirufa\u201d: histopathological study in rats","volume":"35","author":"Costa","year":"1995","journal-title":"Rev Bras Reumatol."},{"key":"B5","first-page":"132","article-title":"Pararamosis: uma reumatose ocupacional","volume":"21","author":"Costa","year":"1981","journal-title":"Rev Bras Reumatol."},{"key":"B6","first-page":"9","article-title":"Pararama, a disease caused by moth larvae: experimental findings","volume":"7","author":"Dias","year":"1973","journal-title":"PAHO Bull."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e1531","DOI":"10.1371\/journal.pntd.0001531","article-title":"Premolis semirufa (Walker, 1856) envenomation, disease affecting rubber tappers of the amazon: searching for caterpillar-bristles toxic components","volume":"6","author":"Villas-Boas","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e71938","DOI":"10.1371\/journal.pone.0071938","article-title":"Characterization of phenotypes of immune cells and cytokines associated with chronic exposure to Premolis semirufa caterpillar bristles extract","volume":"8","author":"Villas-Boas","year":"2013","journal-title":"PLoS ONE."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e0118615","DOI":"10.1371\/journal.pone.0118615","article-title":"A serine protease isolated from the bristles of the amazonic caterpillar, Premolis semirufa, is a potent complement system activator","volume":"10","author":"Villas-Boas","year":"2015","journal-title":"PLoS ONE."},{"key":"B10","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1038\/ncprheum0727","article-title":"Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?","volume":"4","author":"Murphy","year":"2008","journal-title":"Nat Clin Pract Rheumatol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"4","DOI":"10.4172\/2167-7921.1000233","article-title":"Efficacy of oral collagen in joint pain - osteoarthritis and rheumatoid arthritis","volume":"6","author":"Woo","year":"2017","journal-title":"J Arthritis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2174\/1874347101911010001","article-title":"Comparison between major types of arthritis based on diagnostic ultrasonography","volume":"11","author":"Roy","year":"2019","journal-title":"Open Med Imaging J."},{"key":"B13","doi-asserted-by":"publisher","first-page":"S69","DOI":"10.1097\/01.blo.0000144970.05107.7e","article-title":"The mechanobiology of articular cartilage development and degeneration","volume":"427","author":"Carter","year":"2004","journal-title":"Clin Orthop Relat Res."},{"key":"B14","first-page":"603","article-title":"Perspectives on chondrocyte mechanobiology and osteoarthritis","volume":"43","author":"Buckwalter","year":"2006","journal-title":"Biorheology."},{"key":"B15","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3389\/fbioe.2018.00018","article-title":"Recent insights into the contribution of the changing hypertrophic chondrocyte phenotype in the development and progression of osteoarthritis","volume":"6","author":"Ripmeester","year":"2018","journal-title":"Front Bioeng Biotechnol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/ar2592","article-title":"Cartilage homeostasis in health and rheumatic diseases","volume":"11","author":"Goldring","year":"2009","journal-title":"Arthritis Res Ther."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1002\/art.30364","article-title":"Osteoarthritic synovial tissue inhibition of proteoglycan production in human osteoarthritic knee cartilage: establishment and characterization of a long-term cartilage-synovium coculture","volume":"63","author":"Beekhuizen","year":"2011","journal-title":"Arthritis Rheum."},{"key":"B18","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1097\/BOR.0b013e328349c2b1","article-title":"Inflammation in osteoarthritis","volume":"23","author":"Goldring","year":"2011","journal-title":"Curr Opin Rheumatol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.imlet.2006.04.011","article-title":"Molecular and cellular basis of rheumatoid joint destruction","volume":"106","author":"Karouzakis","year":"2006","journal-title":"Immunol Lett."},{"key":"B20","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.jbspin.2010.08.017","article-title":"Cell and cytokine imbalances in rheumatoid synovitis","volume":"78","author":"Boissier","year":"2011","journal-title":"Jt Bone Spine."},{"key":"B21","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/nrd1109","article-title":"Therapeutic strategies for rheumatoid arthritis","volume":"2","author":"Smolen","year":"2003","journal-title":"Nat Rev Drug Discov."},{"key":"B22","first-page":"690","article-title":"Catalogue of the Arctiadae (Arctianae) and Agaristidae in the collection of the British Museum","volume-title":"Catalogue of the Lepidoptera Phalaenae in the British Museum","author":"Hampson","year":"1901"},{"key":"B23","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J Immunol Methods."},{"key":"B24","doi-asserted-by":"publisher","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat Methods."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"e108","DOI":"10.1093\/nar\/gkt214","article-title":"The subread aligner: fast, accurate and scalable read mapping by seed-and-vote","volume":"41","author":"Liao","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/S0945-053X(02)00028-8","article-title":"Response of young, aged and osteoarthritic human articular chondrocytes to inflammatory cytokines: molecular and cellular aspects","volume":"21","author":"Dozin","year":"2002","journal-title":"Matrix Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1159\/000252832","article-title":"Disease activity and cytokine production in mitogen-stimulated peripheral blood mononuclear cells from patients with rheumatoid arthritis","volume":"19","author":"Uppal","year":"2010","journal-title":"Med Princ Pract."},{"key":"B30","doi-asserted-by":"crossref","first-page":"5418","DOI":"10.4049\/jimmunol.154.10.5418","article-title":"Neutrophil accumulation and activation by homologous IL-8 in rabbits. IL-8 induces destruction of cartilage and production of IL-1 and IL-1 receptor antagonist in vivo","volume":"154","author":"Matsukawa","year":"1995","journal-title":"J Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"4406","DOI":"10.4049\/jimmunol.171.8.4406","article-title":"IL-8\/CXCL8 and growth-related oncogene alpha\/CXCL1 induce chondrocyte hypertrophic differentiation","volume":"171","author":"Merz","year":"2003","journal-title":"J Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.biocel.2008.07.018","article-title":"Monocyte chemoattractant protein-1: a key mediator in inflammatory processes","volume":"41","author":"Melgarejo","year":"2009","journal-title":"Int J Biochem Cell Biol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1007\/s00264-012-1724-1","article-title":"Osteoarthritis synovial fluid activates pro-inflammatory cytokines in primary human chondrocytes","volume":"37","author":"Hoff","year":"2013","journal-title":"Int Orthop."},{"key":"B34","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0090-6980(96)00094-9","article-title":"Effects of misoprostol and prostaglandin E2 on proteoglycan biosynthesis and loss in unloaded and loaded articular cartilage explants","volume":"52","author":"Torzilli","year":"1996","journal-title":"Prostaglandins."},{"key":"B35","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0223-5234(01)01197-7","article-title":"Cyclooxygenase inhibitors - Current status and future prospects","volume":"36","author":"Dannhardt","year":"2001","journal-title":"Eur J Med Chem."},{"key":"B36","doi-asserted-by":"publisher","first-page":"19819","DOI":"10.1074\/jbc.M002079200","article-title":"Impaired bone resorption to prostaglandin E2 in prostaglandin E receptor EP4-knockout mice","volume":"275","author":"Miyaura","year":"2000","journal-title":"J Biol Chem."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1016\/j.joca.2008.03.009","article-title":"Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes","volume":"16","author":"Chabane","year":"2008","journal-title":"Osteoarthr Cartil."},{"key":"B38","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.matbio.2015.04.004","article-title":"Tumor angiogenesis: MMP-mediated induction of intravasation- and metastasis-sustaining neovasculature","author":"Deryugina","year":"2015","journal-title":"Matrix Biol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.matbio.2015.01.004","article-title":"Matrix metalloproteinases in liver injury, repair and fibrosis","author":"Duarte","year":"2015","journal-title":"Matrix Biol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.matbio.2015.03.004","article-title":"Membrane-type matrix metalloproteinases: their functions and regulations","author":"Itoh","year":"2015","journal-title":"Matrix Biol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.matbio.2015.03.002","article-title":"Matrix remodeling by MMPs during wound repair","author":"Rohani","year":"2015","journal-title":"Matrix Biol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1136\/ard.2004.022434","article-title":"MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis","volume":"64","author":"Tchetverikov","year":"2005","journal-title":"Ann Rheum Dis."},{"key":"B43","doi-asserted-by":"crossref","first-page":"499","DOI":"10.4049\/jimmunol.144.2.499","article-title":"IL-6 production by human articular chondrocytes. Modulation of its synthesis by cytokines, growth factors, and hormones in vitro","volume":"144","author":"Guerne","year":"1990","journal-title":"J Immunol."},{"key":"B44","doi-asserted-by":"crossref","first-page":"466","DOI":"10.4049\/jimmunol.148.2.466","article-title":"Cartilage and joint inflammation. Regulation of IL-8 expression by human articular chondrocytes","volume":"148","author":"Lotz","year":"1992","journal-title":"J Immunol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1172\/JCI115885","article-title":"Monocyte chemoattractant protein-1 (MCP-1) expression in human articular cartilage. Induction by peptide regulatory factors and differential effects of dexamethasone and retinoic acid","volume":"90","author":"Villiger","year":"1992","journal-title":"J Clin Invest"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1002\/1529-0131(200107)44:7<1633::AID-ART286>3.0.CO;2-Z","article-title":"Production of the chemokine RANTES by articular chondrocytes and role in cartilage degradation","volume":"44","author":"Alaaeddine","year":"2001","journal-title":"Arthritis Rheum."},{"key":"B47","doi-asserted-by":"publisher","first-page":"987","DOI":"10.2460\/ajvr.2002.63.987","article-title":"Evaluation of the influence of prostaglandin E2 on recombinant equine interleukin-1beta-stimulated matrix metalloproteinases 1, 3, and 13 and tissue inhibitor of matrix metalloproteinase 1 expression in equine chondrocyte cultures","volume":"63","author":"Tung","year":"2002","journal-title":"Am J Vet Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"S53","DOI":"10.1097\/01.blo.0000143805.64755.4f","article-title":"Chemokines in cartilage degradation","volume":"427","author":"Borz\u00ec","year":"2004","journal-title":"Clin Orthop Relat Res."},{"key":"B49","first-page":"1007","article-title":"Inhibition of extracellular matrix-degrading endopeptidases: problems, comments, and hypotheses","volume":"379","author":"Baici","year":"1998","journal-title":"Biol Chem."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1002\/1529-0131(199810)41:10<1760::AID-ART8>3.0.CO;2-M","article-title":"The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint","volume":"41","author":"Cawston","year":"1998","journal-title":"Arthritis Rheum."},{"key":"B51","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.cytogfr.2003.10.005","article-title":"IL-6, RANKL, TNF-alpha\/IL-1: interrelations in bone resorption pathophysiology","volume":"15","author":"Kwan Tat","year":"2004","journal-title":"Cytokine Growth Factor Rev."},{"key":"B52","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1002\/art.22299","article-title":"Restoration of the extracellular matrix in human osteoarthritic articular cartilage by overexpression of the transcription factor SOX9","volume":"56","author":"Cucchiarini","year":"2007","journal-title":"Arthritis Rheum."},{"key":"B53","first-page":"433","article-title":"Terminal complement complex in synovial tissue from patients affected by rheumatoid arthritis, osteoarthritis and acute joint trauma","volume":"10","author":"Corvetta","year":"1992","journal-title":"Clin Exp Rheumatol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/BF00302666","article-title":"Expression of the components and regulatory proteins of the classical pathway of complement in normal and diseased synovium","volume":"14","author":"Gulati","year":"1994","journal-title":"Rheumatol Int."},{"key":"B55","first-page":"648","article-title":"Synthesis of classical pathway complement components by chondrocytes","volume":"88","author":"Bradley","year":"1996","journal-title":"Immunology."},{"key":"B56","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1002\/art.1780400318","article-title":"CR1, CD35 in synovial fluid from patients with inflammatory joint diseases","volume":"40","author":"Sadallah","year":"1997","journal-title":"Arthritis Rheum."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1038\/nm.2543","article-title":"Identification of a central role for complement in osteoarthritis","volume":"17","author":"Wang","year":"2011","journal-title":"Nat Med."},{"key":"B58","doi-asserted-by":"publisher","first-page":"2753","DOI":"10.1016\/j.molimm.2009.04.027","article-title":"The role of the anaphylatoxins in health and disease","volume":"46","author":"Klos","year":"2009","journal-title":"Mol Immunol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/sj.bjp.0707332","article-title":"Function, structure and therapeutic potential of complement C5a receptors","volume":"152","author":"Monk","year":"2007","journal-title":"Br J Pharmacol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"2328","DOI":"10.1073\/pnas.0408835103","article-title":"Drusen complement components C3a and C5a promote choroidal neovascularization","volume":"103","author":"Nozaki","year":"2006","journal-title":"Proc Natl Acad Sci USA."},{"key":"B61","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.joca.2007.09.003","article-title":"The potential role of vascular endothelial growth factor (VEGF) in cartilage: how the angiogenic factor could be involved in the pathogenesis of osteoarthritis?","volume":"16","author":"Murata","year":"2008","journal-title":"Osteoarthr Cartil"},{"key":"B62","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1172\/JCI119526","article-title":"Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints","volume":"100","author":"Lark","year":"1997","journal-title":"J Clin Invest."},{"key":"B63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.csm.2004.08.007","article-title":"Basic science of articular cartilage and osteoarthritis","volume":"24","author":"Pearle","year":"2005","journal-title":"Clin Sports Med."},{"key":"B64","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.berh.2008.02.001","article-title":"Cartilage in normal and osteoarthritis conditions","volume":"22","author":"Martel-Pelletier","year":"2008","journal-title":"Best Pract Res Clin Rheumatol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s00402-009-0981-y","article-title":"Changes in content and synthesis of collagen types and proteoglycans in osteoarthritis of the knee joint and comparison of quantitative analysis with Photoshop-based image analysis","volume":"130","author":"Lahm","year":"2010","journal-title":"Arch Orthop Trauma Surg."},{"key":"B66","doi-asserted-by":"publisher","first-page":"ii78","DOI":"10.1136\/ard.61.suppl_2.ii78","article-title":"Type II collagen degradation and its regulation in articular cartilage in osteoarthritis","volume":"61","author":"Poole","year":"2002","journal-title":"Ann Rheum Dis."},{"key":"B67","doi-asserted-by":"publisher","first-page":"R165","DOI":"10.1186\/ar3124","article-title":"High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1\u03b2 in osteoarthritic synoviocytes","volume":"12","author":"Garc\u00eda-Arnandis","year":"2010","journal-title":"Arthritis Res Ther."},{"key":"B68","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1111\/j.1365-2796.2003.01303.x","article-title":"HMGB1 is a potent trigger of arthritis","volume":"255","author":"Andersson","year":"2004","journal-title":"J Intern Med."},{"key":"B69","doi-asserted-by":"publisher","first-page":"21893","DOI":"10.1074\/jbc.274.31.21893","article-title":"Antisense inhibition of hyaluronan synthase-2 in human articular chondrocytes inhibits proteoglycan retention and matrix assembly","volume":"274","author":"Nishida","year":"1999","journal-title":"J Biol Chem."},{"key":"B70","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.bbrc.2013.05.052","article-title":"Chondrogenic capacity and alterations in hyaluronan synthesis of cultured human osteoarthritic chondrocytes","volume":"435","author":"Ono","year":"2013","journal-title":"Biochem Biophys Res Commun."},{"key":"B71","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1096\/fasebj.6.3.1740236","article-title":"Proteoglycans: many forms and many functions","volume":"6","author":"Hardingham","year":"1992","journal-title":"FASEB J."},{"key":"B72","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1083\/jcb.120.3.825","article-title":"Hyaluronan receptor-directed assembly of chondrocyte pericellular matrix","volume":"120","author":"Knudson","year":"1993","journal-title":"J Cell Biol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"d637","DOI":"10.2741\/A308","article-title":"CD44 isoform-cytoskeleton interaction in oncogenic signaling and tumor progression","volume":"3","author":"Bourguignon","year":"1998","journal-title":"Front Biosci."},{"key":"B74","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1016\/0955-0674(94)90100-7","article-title":"Hyaluronate receptors: key players in growth, differentiation, migration and tumor progression","volume":"6","author":"Sherman","year":"1994","journal-title":"Curr Opin Cell Biol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/jcp.1041520118","article-title":"The proto-oncogene c-myc is involved in cell differentiation as well as cell proliferation: studies on growth plate chondrocytes in situ","volume":"152","author":"Farquharson","year":"1992","journal-title":"J Cell Physiol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/S0006-291X(05)81108-8","article-title":"Detection of mRNA for the transforming growth factor beta family in human articular chondrocytes by the polymerase chain reaction","volume":"180","author":"Frazer","year":"1991","journal-title":"Biochem Biophys Res Commun."},{"key":"B77","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1242\/dev.114.4.907","article-title":"Transforming growth factor-beta 1, -beta 2 and -beta 3 in cartilage and bone cells during endochondral ossification in the chick","volume":"114","author":"Thorp","year":"1992","journal-title":"Development."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.joca.2016.01.001","article-title":"Evidence for enhanced collagen type III deposition focally in the territorial matrix of osteoarthritic hip articular cartilage","volume":"24","author":"Hosseininia","year":"2016","journal-title":"Osteoarthr Cartil."},{"key":"B79","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/S0945-053X(97)90026-3","article-title":"The AP-1 site and MMP gene regulation: what is all the fuss about?","volume":"15","author":"Benbow","year":"1997","journal-title":"Matrix Biol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1023\/A:1026028303196","article-title":"Regulation of matrix metalloproteinases: an overview","volume":"253","author":"Chakraborti","year":"2003","journal-title":"Mol Cell Biochem."},{"key":"B81","doi-asserted-by":"publisher","first-page":"48","DOI":"10.4161\/19336918.2014.987587","article-title":"Tenascin-C: form versus function","volume":"9","author":"Giblin","year":"2015","journal-title":"Cell Adh Migr."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.2460\/ajvr.69.12.1569","article-title":"Examination of synovial fluid hyaluronan quantity and quality in stifle joints of dogs with osteoarthritis","volume":"69","author":"Venable","year":"2008","journal-title":"Am J Vet Res."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.02191\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T14:40:54Z","timestamp":1696689654000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.02191\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,18]]},"references-count":82,"alternative-id":["10.3389\/fimmu.2020.02191"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.02191","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,18]]},"article-number":"2191"}}