{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:09:12Z","timestamp":1790744952048,"version":"4.1.0"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.558036","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T05:55:26Z","timestamp":1602827726000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":46,"title":["The Novel Omega-6 Fatty Acid Docosapentaenoic Acid Positively Modulates Brain Innate Immune Response for Resolving Neuroinflammation at Early and Late Stages of Humanized APOE-Based Alzheimer's Disease Models"],"prefix":"10.3389","volume":"11","author":[{"given":"Qiu-Lan","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cansheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Morselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trent","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Pelligrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengqi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mychica","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Denver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Relampagos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin","family":"Caoili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Teter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally A.","family":"Frautschy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.brainresbull.2011.10.004","article-title":"Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases","volume":"87","author":"Smith","year":"2012","journal-title":"Brain Res Bull."},{"key":"B2","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer's disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N Engl J Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 associated with the risk of Alzheimer's disease","volume":"368","author":"Jonsson","year":"2013","journal-title":"N Engl J Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"13320","DOI":"10.1523\/JNEUROSCI.1224-13.2013","article-title":"CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing","volume":"33","author":"Malik","year":"2013","journal-title":"J Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"222 e9","DOI":"10.1016\/j.neurobiolaging.2016.07.028","article-title":"TYROBP genetic variants in early-onset Alzheimer's disease","volume":"48","author":"Pottier","year":"2016","journal-title":"Neurobiol Aging."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A unique microglia type associated with restricting development of Alzheimer's Disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell."},{"key":"B7","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.mrfmmm.2008.10.011","article-title":"Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases","volume":"667","author":"Migliore","year":"2009","journal-title":"Mutat Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"853","DOI":"10.3233\/JAD-160488","article-title":"Inflammation antiinflammatory agents, and Alzheimer's disease: the last 22 years","volume":"54","author":"McGeer","year":"2016","journal-title":"J Alzheimers Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"5709","DOI":"10.1523\/JNEUROSCI.20-15-05709.2000","article-title":"Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease","volume":"20","author":"Lim","year":"2000","journal-title":"J Neurosci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1212\/WNL.48.3.626","article-title":"Risk of Alzheimer's disease and duration of NSAID use","volume":"48","author":"Stewart","year":"1997","journal-title":"Neurology."},{"key":"B11","first-page":"655","article-title":"Selective COX-2 inhibitors: a review of their structure-activity relationships","volume":"10","author":"Zarghi","year":"2011","journal-title":"Iran J Pharm Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s40266-015-0239-z","article-title":"Non-steroidal anti-inflammatory drugs as a treatment for Alzheimer's disease: a systematic review and meta-analysis of treatment effect","volume":"32","author":"Miguel-Alvarez","year":"2015","journal-title":"Drugs Aging."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1093\/ajcn\/87.6.1616","article-title":"Effects of docosahexaenoic acid-rich n-3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study","volume":"87","author":"Vedin","year":"2008","journal-title":"Am J Clin Nutr."},{"key":"B14","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.alit.2014.08.003","article-title":"Role of omega-3 fatty acids and their metabolites in asthma and allergic diseases","volume":"64","author":"Miyata","year":"2015","journal-title":"Allergol Int."},{"key":"B15","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.ejphar.2015.08.050","article-title":"EPA- and DHA-derived resolvins' actions in inflammatory bowel disease","volume":"785","author":"Schwanke","year":"2016","journal-title":"Eur J Pharmacol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"79","DOI":"10.2147\/JIR.S102221","article-title":"Protective effect of soybean oil- or fish oil-rich diets on allergic airway inflammation","volume":"9","author":"Navarro-Xavier","year":"2016","journal-title":"J Inflamm Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/0140-6736(93)91705-Q","article-title":"Apolipoprotein E polymorphism and Alzheimer's disease","volume":"342","author":"Poirier","year":"1993","journal-title":"Lancet."},{"key":"B18","doi-asserted-by":"publisher","first-page":"41774","DOI":"10.1074\/jbc.M112.407957","article-title":"APOE4-specific changes in Abeta accumulation in a new transgenic mouse model of Alzheimer disease","volume":"287","author":"Youmans","year":"2012","journal-title":"J Biol Chem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1750-1326-8-2","article-title":"Neuron loss in the 5XFAD mouse model of Alzheimer's disease correlates with intraneuronal Abeta42 accumulation and Caspase-3 activation","volume":"8","author":"Eimer","year":"2013","journal-title":"Mol Neurodegener."},{"key":"B20","doi-asserted-by":"publisher","first-page":"810981","DOI":"10.4061\/2011\/810981","article-title":"Introducing human APOE into Abeta transgenic mouse models","volume":"2011","author":"Tai","year":"2011","journal-title":"Int J Alzheimer's Dis."},{"key":"B21","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1093\/hmg\/9.3.353","article-title":"Altered cholesterol metabolism in human apolipoprotein E4 knock-in mice","volume":"9","author":"Hamanaka","year":"2000","journal-title":"Human Mol Gen."},{"key":"B22","doi-asserted-by":"publisher","first-page":"3032","DOI":"10.1523\/JNEUROSCI.4225-04.2005","article-title":"A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model","volume":"25","author":"Lim","year":"2005","journal-title":"J Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1046\/j.1471-4159.2000.0752563.x","article-title":"Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration","volume":"75","author":"Moriguchi","year":"2000","journal-title":"J Neurochem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.neuron.2004.08.013","article-title":"Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model","volume":"43","author":"Calon","year":"2004","journal-title":"Neuron."},{"key":"B25","first-page":"379","article-title":"Antibody to caspase-cleaved actin detects apoptosis in differentiated neuroblastoma and plaque-associated neurons and microglia in Alzheimer's disease","volume":"152","author":"Yang","year":"1998","journal-title":"Am J Pathol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics."},{"key":"B27","doi-asserted-by":"publisher","first-page":"R29","DOI":"10.1186\/gb-2014-15-2-r29","article-title":"voom: Precision weights unlock linear model analysis tools for RNA-seq read counts","volume":"15","author":"Law","year":"2014","journal-title":"Genome Biol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/s41467-017-00769-0","article-title":"Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner","volume":"8","author":"Deczkowska","year":"2017","journal-title":"Nat Commun."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2","DOI":"10.12688\/f1000research.9005.2","article-title":"RNA-seq analysis is easy as 1-2-3 with limma, Glimma and edgeR","volume":"5","author":"Law","year":"2016","journal-title":"F1000Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"4820","DOI":"10.1038\/s41598-019-41315-w","article-title":"Novel data transformations for RNA-seq differential expression analysis","volume":"9","author":"Zhang","year":"2019","journal-title":"Sci Rep."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e0190152","DOI":"10.1371\/journal.pone.0190152","article-title":"RNA-Seq differential expression analysis: An extended review and a software tool","volume":"12","author":"Costa-Silva","year":"2017","journal-title":"PLoS ONE."},{"key":"B32","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.lfs.2018.04.049","article-title":"Omega-3 and omega-6 polyunsaturated fatty acids: dietary sources, metabolism, and significance - A review","volume":"203","author":"Saini","year":"2018","journal-title":"Life Sci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3390\/ijms19020532","article-title":"The differential effects of eicosapentaenoic acid and docosahexaenoic acid on cardiometabolic risk factors: a systematic review","volume":"19","author":"Innes","year":"2018","journal-title":"Int J Mol Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1001\/archneur.63.10.1402","article-title":"Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial","volume":"63","author":"Freund-Levi","year":"2006","journal-title":"Arch Neurol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3233\/JAD-132081","article-title":"Alzheimer's disease: evidence for the expression of interleukin-33 and its receptor ST2 in the brain","volume":"40","author":"Xiong","year":"2014","journal-title":"J Alzheimers Dis."},{"key":"B36","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s00406-004-0558-2","article-title":"Pattern of interleukin-6 receptor complex immunoreactivity between cortical regions of rapid autopsy normal and Alzheimer's disease brain","volume":"255","author":"Hampel","year":"2005","journal-title":"Eur Arch Psychiatry Clin Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1016\/j.neurobiolaging.2008.10.012","article-title":"Soluble TNF receptors are associated with Abeta metabolism and conversion to dementia in subjects with mild cognitive impairment","volume":"31","author":"Buchhave","year":"2010","journal-title":"Neurobiol Aging."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1523\/JNEUROSCI.4580-03.2004","article-title":"Tumor necrosis factor death receptor signaling cascade is required for amyloid-beta protein-induced neuron death","volume":"24","author":"Li","year":"2004","journal-title":"J Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.immuni.2014.03.011","article-title":"Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function","volume":"40","author":"Shouval","year":"2014","journal-title":"Immunity."},{"key":"B40","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/1742-2094-9-179","article-title":"Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study","volume":"9","author":"Cribbs","year":"2012","journal-title":"J Neuroinflammation."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1016\/j.neurobiolaging.2012.09.012","article-title":"Neuroinflammatory phenotype in early Alzheimer's disease","volume":"34","author":"Sudduth","year":"2013","journal-title":"Neurobiol Aging."},{"key":"B42","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1159\/000474940","article-title":"Serum interleukin-10 levels correlate with cerebrospinal fluid amyloid beta deposition in alzheimer disease patients","volume":"17","author":"D'Anna","year":"2017","journal-title":"Neurodegener Dis."},{"key":"B43","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.neuron.2014.12.068","article-title":"Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology","volume":"85","author":"Guillot-Sestier","year":"2015","journal-title":"Neuron."},{"key":"B44","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0047-6374(02)00188-4","article-title":"Preliminary studies on Alzheimer's disease using cDNA microarrays","volume":"124","author":"Wang","year":"2003","journal-title":"Mech Ageing Dev."},{"key":"B45","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1007\/s11745-010-3406-3","article-title":"Docosahexaenoic acid (DHA) and docosapentaenoic acid (DPAn-6) algal oils reduce inflammatory mediators in human peripheral mononuclear cells in vitro and paw edema in vivo","volume":"45","author":"Nauroth","year":"2010","journal-title":"Lipids"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/0361-9230(89)90018-X","article-title":"Further studies on the identification of microglia in mixed brain cell cultures","volume":"22","author":"Glenn","year":"1989","journal-title":"Brain Res Bull."},{"key":"B47","first-page":"109","article-title":"Characterisation of ramified microglial cells: detailed morphology, morphological plasticity and proliferative capability","volume":"1992","author":"Glenn","year":"1992","journal-title":"J Anat."},{"key":"B48","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.it.2007.01.005","article-title":"Astrocytes are active players in cerebral innate immunity","volume":"28","author":"Farina","year":"2007","journal-title":"Trends Immunol."},{"key":"B49","first-page":"1003","article-title":"Neuroinflammation induces neurodegeneration","volume":"1","author":"Kempuraj","year":"2016","journal-title":"J Neurol Neurosurg Spine."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/bj3260001","article-title":"Caspases: the executioners of apoptosis","volume":"326","author":"Cohen","year":"1997","journal-title":"Biochem J."},{"key":"B51","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.tins.2011.09.001","article-title":"Caspase-6 and neurodegeneration","volume":"34","author":"Graham","year":"2011","journal-title":"Trends Neurosci."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1724","DOI":"10.1212\/WNL.0000000000000417","article-title":"Pituitary adenylate cyclase-activating polypeptide is reduced in Alzheimer disease","volume":"82","author":"Han","year":"2014","journal-title":"Neurology."},{"key":"B53","doi-asserted-by":"publisher","first-page":"10800","DOI":"10.1523\/JNEUROSCI.23-34-10800.2003","article-title":"Brain-derived neurotrophic factor-induced gene expression reveals novel actions of VGF in hippocampal synaptic plasticity","volume":"23","author":"Alder","year":"2003","journal-title":"J Neurosci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1002\/pmic.200300470","article-title":"A panel of cerebrospinal fluid potential biomarkers for the diagnosis of Alzheimer's disease","volume":"3","author":"Carrette","year":"2003","journal-title":"Proteomics."},{"key":"B55","doi-asserted-by":"publisher","first-page":"801","DOI":"10.2174\/138620705774962391","article-title":"Identification of novel biomarker candidates by differential peptidomics analysis of cerebrospinal fluid in Alzheimer's disease","volume":"8","author":"Selle","year":"2005","journal-title":"Comb Chem High Throughput Screen."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1016\/j.neurobiolaging.2012.12.026","article-title":"A preliminary study of the whole-genome expression profile of sporadic and monogenic early-onset Alzheimer's disease","volume":"34","author":"Antonell","year":"2013","journal-title":"Neurobiol Aging."},{"key":"B57","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1002\/prca.201400178","article-title":"Development and evaluation of a multiplexed mass spectrometry based assay for measuring candidate peptide biomarkers in Alzheimer's Disease Neuroimaging Initiative (ADNI) CSF","volume":"9","author":"Spellman","year":"2015","journal-title":"Proteomics Clin Appl."},{"key":"B58","doi-asserted-by":"publisher","first-page":"e26540","DOI":"10.1371\/journal.pone.0026540","article-title":"Peptide fingerprinting of Alzheimer's disease in cerebrospinal fluid: identification and prospective evaluation of new synaptic biomarkers","volume":"6","author":"Jahn","year":"2011","journal-title":"PLoS ONE."},{"key":"B59","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1021\/pr501076j","article-title":"An integrated workflow for multiplex CSF proteomics and peptidomics-identification of candidate cerebrospinal fluid biomarkers of Alzheimer's disease","volume":"14","author":"Holtta","year":"2015","journal-title":"J Proteome Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"e0135365","DOI":"10.1371\/journal.pone.0135365","article-title":"High resolution discovery proteomics reveals candidate disease progression markers of alzheimer's disease in human cerebrospinal fluid","volume":"10","author":"Hendrickson","year":"2015","journal-title":"PLoS ONE."},{"key":"B61","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13195-017-0335-x","article-title":"Synaptic proteins in CSF as potential novel biomarkers for prognosis in prodromal Alzheimer's disease","volume":"10","author":"Duits","year":"2018","journal-title":"Alzheimers Res Ther."},{"key":"B62","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1002\/prca.201700131","article-title":"A parallel reaction monitoring mass spectrometric method for analysis of potential CSF biomarkers for alzheimer's disease","volume":"12","author":"Brinkmalm","year":"2018","journal-title":"Proteomics Clin Appl."},{"key":"B63","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/S0896-6273(00)80782-5","article-title":"Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp","volume":"23","author":"O'Brien","year":"1999","journal-title":"Neuron."},{"key":"B64","doi-asserted-by":"publisher","first-page":"23798","DOI":"10.7554\/eLife.23798","article-title":"NPTX2 and cognitive dysfunction in Alzheimer's Disease","volume":"6","author":"Xiao","year":"2017","journal-title":"Elife."},{"key":"B65","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.jand.2012.03.029","article-title":"Effect of dietary linoleic acid on markers of inflammation in healthy persons: a systematic review of randomized controlled trials","volume":"112","author":"Johnson","year":"2012","journal-title":"J Acad Nutr Diet."},{"key":"B66","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.plefa.2008.09.019","article-title":"Too much linoleic acid promotes inflammation-doesn't it?","volume":"79","author":"Fritsche","year":"2008","journal-title":"Prostagl Leukotri Essent Fatty Acids."},{"key":"B67","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1002\/art.10803","article-title":"Methotrexate pneumonitis after initiation of infliximab therapy for rheumatoid arthritis","volume":"47","author":"Kramer","year":"2002","journal-title":"Arthr Rheum."},{"key":"B68","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.jpsychires.2016.10.021","article-title":"Bipolar disorder moderates associations between linoleic acid and markers of inflammation","volume":"85","author":"Chang","year":"2016","journal-title":"J Psychiatr Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1079\/PNS2002166","article-title":"Dietary modification of inflammation with lipids","volume":"61","author":"Calder","year":"2002","journal-title":"Proc Nutr Soc."},{"key":"B70","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1038\/s41591-020-0815-6","article-title":"Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation","volume":"26","author":"Johnson","year":"2020","journal-title":"Nat Med."},{"key":"B71","first-page":"141","article-title":"Brain interleukin-1 beta in Alzheimer's disease and vascular dementia","volume":"16","author":"Cacabelos","year":"1994","journal-title":"Methods Find Exp Clin Pharmacol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1172\/JCI77983","article-title":"TREM2 sustains microglial expansion during aging and response to demyelination","volume":"125","author":"Poliani","year":"2015","journal-title":"J Clin Invest."},{"key":"B73","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1084\/jem.20142322","article-title":"TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models","volume":"212","author":"Jay","year":"2015","journal-title":"J Exp Med."},{"key":"B74","doi-asserted-by":"publisher","first-page":"4283","DOI":"10.1523\/JNEUROSCI.4814-07.2008","article-title":"Dynamics of the microglial\/amyloid interaction indicate a role in plaque maintenance","volume":"28","author":"Bolmont","year":"2008","journal-title":"J Neurosci."},{"key":"B75","doi-asserted-by":"publisher","first-page":"2274","DOI":"10.1002\/glia.23074","article-title":"Microglia contributes to plaque growth by cell death due to uptake of amyloid beta in the brain of Alzheimer's disease mouse model","volume":"64","author":"Baik","year":"2016","journal-title":"Glia."},{"key":"B76","doi-asserted-by":"publisher","first-page":"8354","DOI":"10.1523\/JNEUROSCI.0616-08.2008","article-title":"Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice","volume":"28","author":"Hickman","year":"2008","journal-title":"J Neurosci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"e60921","DOI":"10.1371\/journal.pone.0060921","article-title":"Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology","volume":"8","author":"Krabbe","year":"2013","journal-title":"PLoS ONE."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.558036\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T05:55:30Z","timestamp":1602827730000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.558036\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,16]]},"references-count":77,"alternative-id":["10.3389\/fimmu.2020.558036"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.558036","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,16]]},"article-number":"558036"}}