{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T12:43:19Z","timestamp":1776948199564,"version":"3.51.4"},"reference-count":71,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.559342","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T04:21:33Z","timestamp":1601007693000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer\u2019s Disease Brain"],"prefix":"10.3389","volume":"11","author":[{"given":"Olena","family":"Korvatska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kostantin","family":"Kiianitsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Ratushny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Matsushita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal","family":"Beeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Ming","family":"Chien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Ichi","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael O.","family":"Dorschner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Dirk","family":"Keene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo K.","family":"Bammler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas D.","family":"Bird","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy H.","family":"Raskind","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-017-0184-x","article-title":"Late onset Alzheimer\u2019s disease genetics implicates microglial pathways in disease risk.","volume":"12","author":"Efthymiou","year":"2017","journal-title":"Mol Neurodegener."},{"key":"B2","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 associated with the risk of Alzheimer\u2019s disease.","volume":"368","author":"Jonsson","year":"2013","journal-title":"N Eng J Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer\u2019s disease.","volume":"368","author":"Guerreiro","year":"2012","journal-title":"N Engl J Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1086\/342259","article-title":"Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype.","volume":"71","author":"Paloneva","year":"2002","journal-title":"Am J Hum Genet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2419 e23","DOI":"10.1016\/j.neurobiolaging.2014.04.010","article-title":"Homozygous TREM2 mutation in a family with atypical frontotemporal dementia.","volume":"35","author":"Le Ber","year":"2014","journal-title":"Neurobiol Aging."},{"key":"B6","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/s41582-018-0072-1","article-title":"TREM2 \u2013 a key player in microglial biology and Alzheimer disease.","volume":"14","author":"Ulland","year":"2018","journal-title":"Nat Rev Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1007\/s00109-007-0191-4","article-title":"Transcript profiles of dendritic cells of PLoSL patients link demyelinating CNS disorders with abnormalities in pathways of actin bundling and immune response.","volume":"85","author":"Kiialainen","year":"2007","journal-title":"J Mol Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1084\/jem.20041611","article-title":"Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2.","volume":"201","author":"Takahashi","year":"2005","journal-title":"J Exp Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.neuron.2018.01.031","article-title":"TREM2 Is a receptor for beta-amyloid that mediates microglial function.","volume":"97","author":"Zhao","year":"2018","journal-title":"Neuron."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1772","DOI":"10.1523\/jneurosci.2459-16.2017","article-title":"TREM2 promotes microglial survival by activating Wnt\/beta-catenin pathway.","volume":"37","author":"Zheng","year":"2017","journal-title":"J Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.4049\/jimmunol.177.4.2051","article-title":"Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12.","volume":"177","author":"Hamerman","year":"2006","journal-title":"J Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1089\/neu.2016.4401","article-title":"Triggering R receptor expressed on myeloid cells 2 deficiency alters acute macrophage distribution and improves recovery after traumatic brain injury.","volume":"34","author":"Saber","year":"2017","journal-title":"J Neurotrauma."},{"key":"B13","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1523\/jneurosci.2110-16.2017","article-title":"Disease progression-dependent efects of TREM2 deficiency in a mouse model of Alzheimer\u2019s disease.","volume":"37","author":"Jay","year":"2017","journal-title":"J Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1093\/hmg\/ddx366","article-title":"Behavioral and transcriptomic analysis of TREM2-null mice: not all knockout mice are created equal.","volume":"27","author":"Kang","year":"2018","journal-title":"Hum Mol Genet."},{"key":"B15","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1084\/jem.20141732","article-title":"TREM-2 promotes macrophage survival and lung disease after respiratory viral infection.","volume":"212","author":"Wu","year":"2015","journal-title":"J Exp Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1084\/jem.20160844","article-title":"Soluble TREM2 induces inflammatory responses and enhances microglial survival.","volume":"214","author":"Zhong","year":"2017","journal-title":"J Exp Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.neuron.2016.06.015","article-title":"TREM2 binds to apolipoproteins, including APOE and CLU\/APOJ, and thereby facilitates uptake of amyloid-beta by microglia.","volume":"91","author":"Yeh","year":"2016","journal-title":"Neuron."},{"key":"B18","doi-asserted-by":"publisher","first-page":"26043","DOI":"10.1074\/jbc.m115.679043","article-title":"Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2).","volume":"290","author":"Atagi","year":"2015","journal-title":"J Biol Chem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"26033","DOI":"10.1074\/jbc.m115.677286","article-title":"The triggering receptor expressed on myeloid cells 2 Binds apolipoprotein E.","volume":"290","author":"Bailey","year":"2015","journal-title":"J Biol Chem."},{"key":"B20","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.neuron.2019.12.007","article-title":"TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge.","volume":"105","author":"Nugent","year":"2020","journal-title":"Neuron."},{"key":"B21","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1001\/jamaneurol.2015.0979","article-title":"R47H variant of TREM2 associated with Alzheimer disease in a large late-onset family: clinical, genetic, and neuropathological study.","volume":"72","author":"Korvatska","year":"2015","journal-title":"JAMA Neurol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1111\/j.1468-1331.2010.03311.x","article-title":"Nasu-Hakola disease with a splicing mutation of TREM2 in a Japanese family.","volume":"18","author":"Numasawa","year":"2011","journal-title":"Eur J Neurol."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-9-68","article-title":"LC3, an autophagosome marker, is expressed on oligodendrocytes in Nasu-Hakola disease brains.","volume":"9","author":"Satoh","year":"2014","journal-title":"Orphanet J Rare Dis."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system.","volume":"8","author":"Ran","year":"2013","journal-title":"Nat Protoc."},{"key":"B25","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s00011-007-6115-5","article-title":"Optimized THP-1 differentiation is required for the detection of responses to weak stimuli.","volume":"56","author":"Park","year":"2007","journal-title":"Inflamm Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.jim.2013.11.006","article-title":"Reduced PMA enhances the responsiveness of transfected THP-1 macrophages to polarizing stimuli.","volume":"402","author":"Maess","year":"2014","journal-title":"J Immunol Methods."},{"key":"B27","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.","volume":"25","author":"Livak","year":"2001","journal-title":"Methods."},{"key":"B28","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1214\/07-aoas101","article-title":"On testing the significance of sets of genes.","volume":"1","author":"Efron","year":"2007","journal-title":"Ann Appl Stat."},{"key":"B29","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The molecular signatures database (MSigDB) hallmark gene set collection.","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"B30","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/j.chom.2015.11.002","article-title":"Meta- and orthogonal integration of influenza \u201cOMICs\u201d data defines a role for UBR4 in virus budding.","volume":"18","author":"Tripathi","year":"2015","journal-title":"Cell Host Microbe."},{"key":"B31","doi-asserted-by":"publisher","first-page":"D362","DOI":"10.1093\/nar\/gkw937","article-title":"The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible.","volume":"45","author":"Szklarczyk","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal3222","article-title":"An environment-dependent transcriptional network specifies human microglia identity.","volume":"356","author":"Gosselin","year":"2017","journal-title":"Science."},{"key":"B33","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s00401-019-02048-2","article-title":"Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer\u2019s disease patient brain samples.","volume":"138","author":"Prokop","year":"2019","journal-title":"Acta Neuropathol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1158\/0008-5472.can-15-0262","article-title":"Evaluating robustness and sensitivity of the nanostring technologies ncounter platform to enable multiplexed gene expression analysis of clinical samples.","volume":"75","author":"Veldman-Jones","year":"2015","journal-title":"Cancer Res."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/srep12393","article-title":"Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer\u2019s disease.","volume":"5","author":"Li","year":"2015","journal-title":"Sci Rep."},{"key":"B36","doi-asserted-by":"publisher","first-page":"D852","DOI":"10.1093\/nar\/gkn732","article-title":"INTERFEROME: the database of interferon regulated genes.","volume":"37","author":"Samarajiwa","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1084\/jem.20161596","article-title":"Type I interferon-mediated monogenic autoinflammation: the type I interferonopathies, a conceptual overview.","volume":"213","author":"Rodero","year":"2016","journal-title":"J Exp Med."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2019-000336","article-title":"Type I interferons in host defence and inflammatory diseases.","volume":"6","author":"Crow","year":"2019","journal-title":"Lupus Sci Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1073\/pnas.0308512100","article-title":"Incipient Alzheimer\u2019s disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses.","volume":"101","author":"Blalock","year":"2004","journal-title":"Proc Natl Acad Sci USA."},{"key":"B40","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.bbr.2016.05.007","article-title":"Transcriptional signatures of brain aging and Alzheimer\u2019s disease: what are our rodent models telling us?","author":"Hargis","year":"2017","journal-title":"Behav Brain Res."},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-7-51","article-title":"Transcriptome meta-analysis reveals a central role for sex steroids in the degeneration of hippocampal neurons in Alzheimer\u2019s disease.","volume":"7","author":"Winkler","year":"2013","journal-title":"BMC Syst Biol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1007\/s11481-012-9409-5","article-title":"Common transcriptional signatures in brain tissue from patients with HIV-associated neurocognitive disorders, Alzheimer\u2019s disease, and multiple sclerosis.","volume":"7","author":"Borjabad","year":"2012","journal-title":"J Neuroimmune Pharmacol."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-014-0093-y","article-title":"Integrated multi-cohort transcriptional meta-analysis of neurodegenerative diseases.","volume":"2","author":"Li","year":"2014","journal-title":"Acta Neuropathol Commun."},{"key":"B44","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.intimp.2014.08.002","article-title":"THP-1 cell line: an in vitro cell model for immune modulation approach.","volume":"23","author":"Chanput","year":"2014","journal-title":"Int Immunopharmacol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"3520","DOI":"10.4049\/jimmunol.177.6.3520","article-title":"Cutting edge: TREM-2 attenuates macrophage activation.","volume":"177","author":"Turnbull","year":"2006","journal-title":"J Immunol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"992","DOI":"10.15252\/emmm.201606370","article-title":"TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance.","volume":"8","author":"Xiang","year":"2016","journal-title":"EMBO Mol Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"8459","DOI":"10.1073\/pnas.0603082103","article-title":"Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus.","volume":"103","author":"Gitlin","year":"2006","journal-title":"Proc Natl Acad Sci USA."},{"key":"B48","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.immuni.2005.04.010","article-title":"Cell type-specific involvement of RIG-I in antiviral response.","volume":"23","author":"Kato","year":"2005","journal-title":"Immunity."},{"key":"B49","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1084\/jem.20030027","article-title":"DAP12\/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features.","volume":"198","author":"Paloneva","year":"2003","journal-title":"J Exp Med."},{"key":"B50","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1136\/jnnp.74.6.825-a","article-title":"An Italian family affected by Nasu-Hakola disease with a novel genetic mutation in the TREM2 gene.","volume":"74","author":"Soragna","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"B51","doi-asserted-by":"publisher","first-page":"E194","DOI":"10.1002\/humu.20836","article-title":"Mutations in TREM2 lead to pure early-onset dementia without bone cysts.","volume":"29","author":"Chouery","year":"2008","journal-title":"Hum Mut."},{"key":"B52","doi-asserted-by":"publisher","first-page":"2890 e1","DOI":"10.1016\/j.neurobiolaging.2013.06.005","article-title":"Novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family.","volume":"34","author":"Guerreiro","year":"2013","journal-title":"Neurobiol Aging."},{"key":"B53","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1001\/jamaneurol.2013.579","article-title":"Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement.","volume":"70","author":"Guerreiro","year":"2013","journal-title":"JAMA Neurol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/j.jmb.2017.04.004","article-title":"TREM2-ligand interactions in health and disease.","volume":"429","author":"Kober","year":"2017","journal-title":"J Mol Biol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.jalz.2016.07.004","article-title":"Alzheimer\u2019s disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation.","volume":"13","author":"Song","year":"2017","journal-title":"Alzheimers Dement."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.cell.2015.01.049","article-title":"TREM2 lipid sensing sustains the microglial response in an Alzheimer\u2019s disease model.","volume":"160","author":"Wang","year":"2015","journal-title":"Cell."},{"key":"B57","doi-asserted-by":"publisher","first-page":"89","DOI":"10.2147\/rrbc.s58057","article-title":"The TREM2-DAP12 signaling pathway in Nasu-Hakola disease: a molecular genetics perspective.","volume":"5","author":"Xing","year":"2015","journal-title":"Res Rep Biochem."},{"key":"B58","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/nri3850","article-title":"Aicardi-Goutieres syndrome and the type I interferonopathies.","volume":"15","author":"Crow","year":"2015","journal-title":"Nat Rev Immunol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s10875-016-0359-1","article-title":"Assessment of Type I interferon signaling in pediatric inflammatory disease.","volume":"37","author":"Rice","year":"2017","journal-title":"J Clin Immunol."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.08007","article-title":"Genome-wide DNA hypomethylation and RNA:DNA hybrid accumulation in Aicardi-Goutieres syndrome.","volume":"4","author":"Lim","year":"2015","journal-title":"Elife."},{"key":"B61","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1126\/science.1252945","article-title":"Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function.","volume":"346","author":"Baruch","year":"2014","journal-title":"Science."},{"key":"B62","doi-asserted-by":"publisher","first-page":"E89","DOI":"10.1073\/pnas.1216922110","article-title":"p53 cooperates with DNA methylation and a suicidal interferon response to maintain epigenetic silencing of repeats and noncoding RNAs.","volume":"110","author":"Leonova","year":"2013","journal-title":"Proc Natl Acad Sci USA."},{"key":"B63","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.cmet.2019.02.014","article-title":"LINE1 derepression in aged wild-type and SIRT6-deficient mice drives inflammation.","volume":"29","author":"Simon","year":"2019","journal-title":"Cell Metab."},{"key":"B64","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.mad.2018.02.002","article-title":"The epigenetic alterations of endogenous retroelements in aging.","volume":"174","author":"Cardelli","year":"2018","journal-title":"Mech Ageing Dev."},{"key":"B65","doi-asserted-by":"publisher","first-page":"25982","DOI":"10.1073\/pnas.1822164116","article-title":"Endogenous retroviruses are associated with hippocampus-based memory impairment.","volume":"116","author":"Sankowski","year":"2019","journal-title":"Proc Natl Acad Sci USA."},{"key":"B66","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/j.neuron.2020.02.034","article-title":"Alzheimer\u2019s risk factors age, APOE genotype, and sex drive distinct molecular pathways.","volume":"106","author":"Zhao","year":"2020","journal-title":"Neuron."},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2018.03.003","article-title":"Senescent human hematopoietic progenitors show elevated expression of transposable elements and inflammatory genes.","volume":"62","author":"Capone","year":"2018","journal-title":"Exp Hematol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.celrep.2015.03.069","article-title":"DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function.","volume":"11","author":"Yu","year":"2015","journal-title":"Cell Rep."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1080\/15384047.2015.1056419","article-title":"Type 1 interferons contribute to the clearance of senescent cell.","volume":"16","author":"Katlinskaya","year":"2015","journal-title":"Cancer Biol Ther."},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1101\/499319","article-title":"TREM2 R47H exacerbates immune response in Alzheimer\u2019s disease brain.","author":"Korvatska","year":"2018","journal-title":"BioRxiv"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1101\/068940","article-title":"Gene expression markers of tumor infiltrating leukocytes.","volume":"5","author":"Danaher","year":"2017","journal-title":"J Immunother Cancer."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.559342\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T04:21:36Z","timestamp":1601007696000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.559342\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,25]]},"references-count":71,"alternative-id":["10.3389\/fimmu.2020.559342"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.559342","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,25]]},"article-number":"559342"}}