{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:40:37Z","timestamp":1782254437779,"version":"3.54.5"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.561294","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T04:56:18Z","timestamp":1603083378000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Anti-CD20-Mediated B Cell Depletion Is Associated With Bone Preservation in Lymphoma Patients and Bone Mass Increase in Mice"],"prefix":"10.3389","volume":"11","author":[{"given":"Albert","family":"Kolomansky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irit","family":"Kaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Ben-Califa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"Gorodov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zamzam","family":"Awida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ofer","family":"Sadovnic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Liron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Hiram-Bab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard S.","family":"Oster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadav","family":"Sarid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chava","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yankel","family":"Gabet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Mittelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drorit","family":"Neumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"163","DOI":"10.3389\/fonc.2018.00163","article-title":"Past, present, and future of rituximab\u2014the world's first oncology monoclonal antibody therapy","volume":"8","author":"Pierpont","year":"2018","journal-title":"Front Oncol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.4049\/jimmunol.167.5.2625","article-title":"Connection between B lymphocyte and osteoclast differentiation pathways","volume":"167","author":"Manabe","year":"2001","journal-title":"J Immunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.bone.2010.06.011","article-title":"How B cells influence bone biology in health and disease","volume":"47","author":"Horowitz","year":"2010","journal-title":"Bone."},{"key":"B4","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/83210","article-title":"Bipotential B-macrophage progenitors are present in adult bone marrow","volume":"2","author":"Montecino-Rodriguez","year":"2001","journal-title":"Nat Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1359\/jbmr.2001.16.12.2215","article-title":"Generation of bone-resorbing osteoclasts from B220+ cells: its role in accelerated osteoclastogenesis due to estrogen deficiency","volume":"16","author":"Sato","year":"2001","journal-title":"J Bone Miner Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1007\/s00223-018-0401-9","article-title":"Osteoporosis in rheumatic diseases: anti-rheumatic drugs and the skeleton","volume":"102","author":"Dubrovsky","year":"2018","journal-title":"Calcif Tissue Int."},{"key":"B7","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/s00296-010-1560-9","article-title":"Influence of Rituximab on markers of bone remodeling in patients with rheumatoid arthritis: a prospective open-label pilot study","volume":"31","author":"Hein","year":"2011","journal-title":"Rheumatol Int."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e0201527","DOI":"10.1371\/journal.pone.0201527","article-title":"Changes in bone density and bone turnover in patients with rheumatoid arthritis treated with rituximab, results from an exploratory, prospective study","volume":"13","author":"Wheater","year":"2018","journal-title":"PLoS ONE."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1177\/0961203313502861","article-title":"Bone mineral density in systemic lupus erythematosus women one year after rituximab therapy","volume":"22","author":"Mendoza Pinto","year":"2013","journal-title":"Lupus."},{"key":"B10","doi-asserted-by":"publisher","first-page":"3839","DOI":"10.1182\/blood-2006-07-037994","article-title":"B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo","volume":"109","author":"Li","year":"2007","journal-title":"Blood"},{"key":"B11","doi-asserted-by":"publisher","first-page":"29851","DOI":"10.1074\/jbc.M112.377945","article-title":"Receptor activator of nuclear factor kappaB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss","volume":"287","author":"Onal","year":"2012","journal-title":"J Biol Chem."},{"key":"B12","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1038\/emm.2003.51","article-title":"B cells activated in the presence of Th1 cytokines inhibit osteoclastogenesis","volume":"35","author":"Choi","year":"2003","journal-title":"Exp Mol Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1002\/art.39489","article-title":"Production of RANKL by memory B cells: a link between b cells and bone erosion in rheumatoid arthritis","volume":"68","author":"Meednu","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.jaut.2016.09.002","article-title":"Pathogenic conversion of regulatory B10 cells into osteoclast-priming cells in rheumatoid arthritis","volume":"76","author":"Hu","year":"2016","journal-title":"J Autoimmum."},{"key":"B15","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1002\/1521-4141(200107)31:7<2179::aid-immu2179>3.0.co;2-x","article-title":"Osteoclastogenesis is enhanced by activated B cells but suppressed by activated CD8(+) T cells","volume":"31","author":"Choi","year":"2001","journal-title":"Eur J Immunol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"3706","DOI":"10.1182\/blood-2006-08-041384","article-title":"Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells","volume":"109","author":"Zhu","year":"2007","journal-title":"Blood."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.4049\/jimmunol.166.3.1482","article-title":"Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and function","volume":"166","author":"Yun","year":"2001","journal-title":"J Immunol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.1101\/gad.13.18.2412","article-title":"RANK is essential for osteoclast and lymph node development","volume":"13","author":"Dougall","year":"1999","journal-title":"Genes Dev."},{"key":"B19","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1006\/bbrc.1993.1832","article-title":"Osteoblasts release a soluble factor that modulates immunoglobulin secretion by mature B cells","volume":"194","author":"Benayahu","year":"1993","journal-title":"Biochem Biophys Res Commun."},{"key":"B20","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1073\/pnas.0136772100","article-title":"IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells","volume":"100","author":"Toraldo","year":"2003","journal-title":"Proc Natl Acad Sci USA."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1359\/JBMR.040318","article-title":"Characterization of a novel bipotent hematopoietic progenitor population in normal and osteopetrotic mice","volume":"19","author":"Blin-Wakkach","year":"2004","journal-title":"J Bone Miner Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1359\/jbmr.2000.15.8.1477","article-title":"Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts","volume":"15","author":"Takeshita","year":"2000","journal-title":"J Bone Miner Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"8744","DOI":"10.7150\/thno.45845","article-title":"Erythropoietin receptor in B cells plays a role in bone remodeling in mice","volume":"10","author":"Deshet-Unger","year":"2020","journal-title":"Theranostics."},{"key":"B24","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1002\/ajh.23313","article-title":"Follicular lymphoma: 2012 update on diagnosis and management","volume":"87","author":"Freedman","year":"2012","journal-title":"Am J Hematol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.bone.2017.04.008","article-title":"Vertebral and femoral bone mineral density and bone strength in prostate cancer patients assessed in phantomless PET\/CT examinations","volume":"101","author":"Schwaiger","year":"2017","journal-title":"Bone."},{"key":"B26","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/ajg.2013.478","article-title":"Validation of a CT-derived method for osteoporosis screening in IBD patients undergoing contrast-enhanced CT enterography","volume":"109","author":"Weber","year":"2014","journal-title":"Am J Gastroenterol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1371\/journal.pone.0005438","article-title":"Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner","author":"Noh","year":"2009","journal-title":"PLoS ONE."},{"key":"B28","doi-asserted-by":"publisher","first-page":"3964","DOI":"10.1182\/blood-2010-01-263830","article-title":"Frenkel, Krox20\/EGR2 deficiency accelerates cell growth and differentiation in the monocytic lineage and decreases bone mass","volume":"116","author":"Gabet","year":"2010","journal-title":"Blood."},{"key":"B29","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s002239900006","article-title":"A microtomographic system for the nondestructive evaluation of bone architecture","volume":"58","author":"Ruegsegger","year":"1996","journal-title":"Calcif Tissue Int."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1096\/fj.14-259085","article-title":"Erythropoietin directly stimulates osteoclast precursors and induces bone loss","volume":"29","author":"Hiram-Bab","year":"2015","journal-title":"FASEB J."},{"key":"B31","doi-asserted-by":"publisher","first-page":"10169","DOI":"10.1074\/jbc.M116.771816","article-title":"RANKL cytokine enhances TNF-induced osteoclastogenesis independently of TNF receptor associated factor (TRAF) 6 by degrading TRAF3 in osteoclast precursors","volume":"292","author":"Yao","year":"2017","journal-title":"J Biol Chem."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1073\/pnas.97.4.1566","article-title":"RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism","volume":"97","author":"Li","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/S0140-6736(10)60826-4","article-title":"Rheumatoid arthritis","volume":"376","author":"Scott","year":"2010","journal-title":"Lancet."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1080\/10428194.2016.1233543","volume":"58","author":"Svendsen","year":"2017"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1002\/jbmr.2800","article-title":"Activation of mTORC1 in B lymphocytes promotes osteoclast formation via regulation of beta-catenin and RANKL\/OPG","volume":"31","author":"Xu","year":"2016","journal-title":"J Bone Miner Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"421746","DOI":"10.1155\/2015\/421746","article-title":"Biology of bone tissue: structure, function, and factors that influence bone cells","volume":"2015","author":"Florencio-Silva","year":"2015","journal-title":"Biomed Res Int."},{"key":"B37","doi-asserted-by":"publisher","first-page":"24838","DOI":"10.1074\/jbc.M116.742452","article-title":"RANKL (receptor activator of NFkappaB ligand) produced by osteocytes is required for the increase in b cells and bone loss caused by estrogen deficiency in mice","volume":"291","author":"Fujiwara","year":"2016","journal-title":"J Biol Chem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1359\/jbmr.060604","article-title":"RANK Expression as a cell surface marker of human osteoclast precursors in peripheral blood, bone marrow, and giant cell tumors of bone","volume":"21","author":"Atkins","year":"2006","journal-title":"J Bone Miner Res."},{"key":"B39","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1136\/ard.2006.062505","article-title":"Changes in macrophage function after rituximab treatment in patients with rheumatoid arthritis","volume":"66","author":"Toubi","year":"2007","journal-title":"Ann Rheum Dis."},{"key":"B40","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/0167-5699(89)90175-8","article-title":"Interleukin 7\u2014Effects on early events in lymphopoiesis","volume":"10","author":"Henney","year":"1989","journal-title":"Immunol Today."},{"key":"B41","doi-asserted-by":"publisher","first-page":"3104","DOI":"10.1182\/blood-2010-09-307983","article-title":"B-cell depletion reactivates B lymphopoiesis in the BM and rejuvenates the B lineage in aging","volume":"117","author":"Keren","year":"2011","journal-title":"Blood."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e12959","DOI":"10.1111\/acel.12959","article-title":"Depletion of B cells rejuvenates the peripheral B-cell compartment but is insufficient to restore immune competence in aging","volume":"18","author":"Avivi","year":"2019","journal-title":"Aging Cell."},{"key":"B43","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.immuni.2017.07.005","article-title":"Interleukin-7 availability is maintained by a hematopoietic cytokine sink comprising innate lymphoid cells and t cells","volume":"47","author":"Martin","year":"2017","journal-title":"Immunity."},{"key":"B44","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3389\/fimmu.2016.00077","article-title":"B cell development in the bone marrow is regulated by homeostatic feedback exerted by mature b cells","volume":"7","author":"Shahaf","year":"2016","journal-title":"Front Immunol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/nrendo.2013.179","article-title":"The role of estrogen and androgen receptors in bone health and disease. Nature reviews","volume":"9","author":"Manolagas","year":"2013","journal-title":"Endocrinology."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1172\/JCI117424","article-title":"Estrogen deficiency stimulates B lymphopoiesis in mouse bone marrow","volume":"94","author":"Masuzawa","year":"1994","journal-title":"J Clin Invest."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.561294\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T04:56:21Z","timestamp":1603083381000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.561294\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,19]]},"references-count":46,"alternative-id":["10.3389\/fimmu.2020.561294"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.561294","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,19]]},"article-number":"561294"}}