{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:57:32Z","timestamp":1791089852015,"version":"4.1.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003825","name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011019","name":"Nemzeti Kutat\u00e1si Fejleszt\u00e9si \u00e9s Innov\u00e1ci\u00f3s Hivatal","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.565458","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T06:12:12Z","timestamp":1601359932000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Activated Human Memory B Lymphocytes Use CR4 (CD11c\/CD18) for Adhesion, Migration, and Proliferation"],"prefix":"10.3389","volume":"11","author":[{"given":"Zsuzsa","family":"Nagy-Bal\u00f3","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rich\u00e1rd","family":"Kiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Menge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba","family":"B\u00f6d\u00f6r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zsuzsa","family":"Bajtay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Erdei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.semcdb.2017.11.025","article-title":"Non-identical twins: different faces of CR3 and CR4 in myeloid and lymphoid cells of mice and men","volume":"85","author":"Erdei","year":"2019","journal-title":"Semin Cell Dev Biol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/jlb.51.2.109","article-title":"Macrophage cytoskeleton association with CR3 and CR4 regulates receptor mobility and phagocytosis of iC3b-opsonized erythrocytes","volume":"51","author":"Ross","year":"1992","journal-title":"J Leukoc Biol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1091\/mbc.10.4.861","article-title":"Specific activation of leukocyte \u03b22 integrins lymphocyte function\u2013associated antigen-1 and Mac-1 by chemokines mediated by distinct pathways via the \u03b1 subunit cytoplasmic domains","volume":"10","author":"Weber","year":"1999","journal-title":"Mol Biol Cell."},{"key":"B4","doi-asserted-by":"crossref","first-page":"4582","DOI":"10.4049\/jimmunol.152.9.4582","article-title":"The leukocyte integrin p150, 95 (CD11c\/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain","volume":"152","author":"Bilsland","year":"1994","journal-title":"J Immunol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.imlet.2017.05.014","article-title":"The role of CR3 (CD11b\/CD18) and CR4 (CD11c\/CD18) in complement-mediated phagocytosis and podosome formation by human phagocytes","volume":"189","author":"Luk\u00e1csi","year":"2017","journal-title":"Immunol Lett."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e0163120","DOI":"10.1371\/journal.pone.0163120","article-title":"CD11c\/CD18 dominates adhesion of human monocytes, macrophages and dendritic cells over CD11b\/CD18","volume":"11","author":"S\u00e1ndor","year":"2016","journal-title":"PLoS ONE."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1084\/jem.174.6.1313","article-title":"Regulated expression and function of CD11c\/CD18 integrin on human B lymphocytes. Relation between attachment to fibrinogen and triggering of proliferation through CD11c\/CD18","volume":"174","author":"Postigo","year":"1991","journal-title":"J Exp Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.imlet.2017.05.016","article-title":"Functional studies of chronic lymphocytic leukemia B cells expressing \u03b2 2 -integrin type complement receptors CR3 and CR4","volume":"189","author":"Uzonyi","year":"2017","journal-title":"Immunol Lett."},{"key":"B9","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/nyas.12137","article-title":"Human B-1 cells take the stage","volume":"1285","author":"Rothstein","year":"2013","journal-title":"Ann N Y Acad Sci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1182\/blood.V76.1.123.bloodjournal761123","article-title":"Characteristics of CD11c+CD5+ chronic B-cell leukemias and the identification of novel peripheral blood B-cell subsets with chronic lymphoid leukemia immunophenotypes","volume":"76","author":"Wormsley","year":"1990","journal-title":"Blood."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1182\/blood-2011-01-331462","article-title":"Toll-like receptor 7 (TLR7)\u2013driven accumulation of a novel CD11c+ B-cell population is important for the development of autoimmunity","volume":"118","author":"Rubtsov","year":"2011","journal-title":"Blood."},{"key":"B12","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.jaci.2005.03.021","article-title":"CD11b-mediated migratory property of peripheral blood B cells","volume":"116","author":"Kawai","year":"2005","journal-title":"J Allergy Clin Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3389\/fimmu.2020.00032","article-title":"CD11c+ B cells are mainly memory cells, precursors of antibody secreting cells in healthy donors","volume":"11","author":"Golinski","year":"2020","journal-title":"Front Immunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"391","DOI":"10.3109\/08923973.2010.522195","article-title":"Catechin inhibits adhesion and migration of peripheral blood B cells by blocking CD11b","volume":"33","author":"Kawai","year":"2011","journal-title":"Immunopharmacol Immunotoxicol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1189\/jlb.0107050","article-title":"Fibrinogen is localized on dark zone follicular dendritic cells in vivo and enhances the proliferation and survival of a centroblastic cell line in vitro","volume":"82","author":"Lefevre","year":"2007","journal-title":"J Leukoc Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1084\/jem.20072682","article-title":"Discriminating gene expression profiles of memory B cell subpopulations","volume":"205","author":"Ehrhardt","year":"2008","journal-title":"J Exp Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/BF00919970","article-title":"CR3 (CD11b\/CD18) expressed by cytotoxic T cells and natural killer cells is upregulated in a manner similar to neutrophil CR3 following stimulation with various activating agents","volume":"13","author":"Muto","year":"1993","journal-title":"J Clin Immunol."},{"key":"B18","first-page":"226","article-title":"5.2.6.2. Effects of phorbol esters on integrin affinity and avidity","volume-title":"Integrin-Ligand Interaction.","author":"Gimond","year":"1997"},{"key":"B19","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/imr.12640","article-title":"Generation of memory B cells and their reactivation","volume":"283","author":"Inoue","year":"2018","journal-title":"Immunol Rev."},{"key":"B20","doi-asserted-by":"publisher","first-page":"E546","DOI":"10.1073\/pnas.1416276112","article-title":"Functional capacities of human IgM memory B cells in early inflammatory responses and secondary germinal center reactions","volume":"112","author":"Seifert","year":"2015","journal-title":"Proc Natl Acad Sci USA."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1038\/ni.1814","article-title":"Multiple layers of B cell memory with different effector functions","volume":"10","author":"Dogan","year":"2009","journal-title":"Nat Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/ni.3095","article-title":"Class-switched memory B cells remodel BCRs within secondary germinal centers","volume":"16","author":"McHeyzer-Williams","year":"2015","journal-title":"Nat Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3389\/fimmu.2016.00225","article-title":"How follicular dendritic cells shape the B-cell antigenome","volume":"7","author":"Kranich","year":"2016","journal-title":"Front Immunol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1084\/jem.173.6.1297","article-title":"Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen 1\/intercellular adhesion molecule 1 and very late antigen 4\/vascular cell adhesion molecule 1 pathways","volume":"173","author":"Koopman","year":"1991","journal-title":"J Exp Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/S1074-7613(04)00105-0","article-title":"LFA-1\/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation","volume":"20","author":"Carrasco","year":"2004","journal-title":"Immunity."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.1242\/jcs.017905","article-title":"Regulation of integrin activation through the B-cell receptor","volume":"121","author":"Arana","year":"2008","journal-title":"J Cell Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1084\/jem.20011866","article-title":"The B cell antigen receptor controls integrin activity through Btk and PLC\u03b32","volume":"198","author":"Spaargaren","year":"2003","journal-title":"J Exp Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.immuni.2016.09.001","article-title":"Germinal center b cell dynamics","volume":"45","author":"Mesin","year":"2016","journal-title":"Immunity."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2018.01313","article-title":"Cell cycle-associated CXCR4 expression in germinal center B cells and its implications on affinity maturation","volume":"9","author":"Weber","year":"2018","journal-title":"Front Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"4781","DOI":"10.4049\/jimmunol.1501191","article-title":"Phenotypic and morphological properties of germinal center dark zone Cxcl12-expressing reticular cells","volume":"195","author":"Rodda","year":"2015","journal-title":"J Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1084\/jem.194.1.45","article-title":"A coordinated change in chemokine responsiveness guides plasma cell movements","volume":"194","author":"Hargreaves","year":"2001","journal-title":"J Exp Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/j.1365-2249.1992.tb05842.x","article-title":"Hodgkin's cells express a novel pattern of adhesion molecules","volume":"90","author":"Ellis","year":"1992","journal-title":"Clin Exp Immunol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1093\/annonc\/2.suppl_2.107","article-title":"Expression of myelomonocytic antigens is associated with unfavourable clinicoprognostic factors in B-cell chronic lymphocytic leukaemia","volume":"2","author":"Pinto","year":"1991","journal-title":"Ann Oncol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/0145-2126(95)00064-X","article-title":"Myelomonocytic antigens in B-cell chronic lymphocytic leukemia","volume":"19","author":"T\u00e0ssies","year":"1995","journal-title":"Leuk Res."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.565458\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T14:54:27Z","timestamp":1696776867000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.565458\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,29]]},"references-count":34,"alternative-id":["10.3389\/fimmu.2020.565458"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.565458","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,29]]},"article-number":"565458"}}