{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:54:01Z","timestamp":1753890841757,"version":"3.41.2"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.565862","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T05:41:51Z","timestamp":1602135711000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Early Protein Markers of Necrotizing Enterocolitis in Plasma of Preterm Pigs Exposed to Antibiotics"],"prefix":"10.3389","volume":"11","author":[{"given":"Yan-Nan","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tik","family":"Muk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Stensballe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duc Ninh","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per Torp","family":"Sangild","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping-Ping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1056\/NEJMra1005408","article-title":"Necrotizing enterocolitis","volume":"364","author":"Neu","year":"2011","journal-title":"N Engl J Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1542\/peds.2004-0569","article-title":"Neurodevelopmental and growth outcomes of extremely low birth weight infants after necrotizing enterocolitis","volume":"115","author":"Hintz","year":"2005","journal-title":"Pediatrics."},{"key":"B3","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/j.clp.2015.04.014","article-title":"Immunologic and hematological abnormalities in necrotizing enterocolitis","volume":"42","author":"Maheshwari","year":"2015","journal-title":"Clin Perinatol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.3233\/NPM-16915130","article-title":"Necrotizing enterocolitis in premature infants and newborns","volume":"9","author":"M\u00fcller","year":"2016","journal-title":"J Neonatal Perinatal Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/pr.2015.235","article-title":"Metabolomic and proteomic analysis of serum from preterm infants with necrotising entercolitis and late-onset sepsis","volume":"79","author":"Stewart","year":"2015","journal-title":"Pediatr Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"G323","DOI":"10.1152\/ajpgi.00392.2015","article-title":"Enteral but not parenteral antibiotics enhance gut function and prevent necrotizing enterocolitis in formula-fed newborn preterm pigs","volume":"310","author":"Birck","year":"2016","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s10020-018-0002-0","article-title":"Neonatal intestinal dysbiosis in necrotizing enterocolitis","volume":"24","author":"Denning","year":"2018","journal-title":"Mol Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/jp.2008.31","article-title":"Prophylactic antibiotics in the prevention of catheter-associated bloodstream bacterial infection in preterm neonates: a systematic review","volume":"28","author":"Lodha","year":"2008","journal-title":"J Perinatol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s40168-016-0216-8","article-title":"Temporal bacterial and metabolic development of the preterm gut reveals specific signatures in health and disease","volume":"4","author":"Stewart","year":"2016","journal-title":"Microbiome."},{"key":"B10","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.jpeds.2018.07.036","article-title":"Early antibiotic exposure and adverse outcomes in preterm, very low birth weight infants","volume":"203","author":"Cantey","year":"2018","journal-title":"J Pediatr."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1858","DOI":"10.1093\/jac\/dkx088","article-title":"Antibiotic exposure in neonates and early adverse outcomes: a systematic review and meta-analysis","volume":"72","author":"Esaiassen","year":"2017","journal-title":"J Antimicrob Chemother."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2020.06.032","article-title":"Early use of antibiotics is associated with a lower incidence of necrotizing enterocolitis in preterm, very low birth weight infants: The NEOMUNE-NeoNutriNet cohort study","author":"Li","year":"","journal-title":"J Pediatr"},{"key":"B13","doi-asserted-by":"publisher","first-page":"CD000405","DOI":"10.1002\/14651858.CD000405","article-title":"Enteral antibiotics for preventing necrotizing enterocolitis in low birthweight or preterm infants","volume":"2001","author":"Bury","year":"2001","journal-title":"Cochrane Database Syst Rev."},{"key":"B14","doi-asserted-by":"publisher","first-page":"G59","DOI":"10.1152\/ajpgi.00213.2013","article-title":"Antibiotics modulate intestinal immunity and prevent necrotizing enterocolitis in preterm neonatal piglets","volume":"306","author":"Jensen","year":"2014","journal-title":"Am J Physiol Gastrointest Liver Physiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1093\/dnares\/dsy001","article-title":"Early microbial colonization affects DNA methylation of genes related to intestinal immunity and metabolism in preterm pigs","volume":"25","author":"Pan","year":"2018","journal-title":"DNA Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1177\/1753425915615195","article-title":"Oral antibiotics increase blood neutrophil maturation and reduce bacteremia and necrotizing enterocolitis in the immediate postnatal period of preterm pigs","volume":"22","author":"Nguyen","year":"2016","journal-title":"Innate Immun."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2992","DOI":"10.1074\/mcp.M112.025585","article-title":"Quantitative assessment of in-solution digestion efficiency identifies optimal protocols for unbiased protein analysis","volume":"12","author":"Le\u00f3n","year":"2013","journal-title":"Mol Cell Proteomics."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat Biotechnol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat Methods."},{"volume-title":"R. A Language and Environment for Statistical Computing","year":"2013","author":"R","key":"B20"},{"volume-title":"R Studio: Integrated Development for R","year":"2012","key":"B21"},{"key":"B22","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1471-2199-7-33","article-title":"Selection of housekeeping genes for gene expression studies in human reticulocytes using real-time PCR","volume":"7","author":"Silver","year":"2006","journal-title":"BMC Mol Biol."},{"key":"B23","unstructured":"PinheiroJ\n            BatesD\n            DebRoyS\n            SarkarD\n            TeamRC\n          24302486nlme: Linear and Nonlinear Mixed Effects Models2019"},{"key":"B24","first-page":"251","article-title":"Multiple testing procedures: R multtest package and applications to genomics","author":"Pollard","year":"2005","journal-title":"Bioinformatics and Computational Biology Solutions Using R and Bioconductor"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.12688\/f1000research.9090.1","article-title":"AutoAnnotate: a Cytoscape app for summarizing networks with semantic annotations","volume":"5","author":"Kucera","year":"2016","journal-title":"F1000Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"B27","doi-asserted-by":"publisher","first-page":"e0172987","DOI":"10.1371\/journal.pone.0172987","article-title":"Changes in plasma protein levels as an early indication of a bloodstream infection","volume":"12","author":"Kuusela","year":"2017","journal-title":"PLoS ONE."},{"key":"B28","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3109\/15513815.2012.721477","article-title":"Systemic inflammation associated with severe intestinal injury in extremely low gestational age newborns","volume":"32","author":"Martin","year":"2013","journal-title":"Fetal Pediatr Pathol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/nrm3904","article-title":"Remodelling the extracellular matrix in development and disease","volume":"15","author":"Bonnans","year":"2014","journal-title":"Nat Rev Mol Cell Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1203\/01.PDR.0000072326.23442.C3","article-title":"Matrix metalloproteinases in necrotising enterocolitis","volume":"54","author":"Pender","year":"2003","journal-title":"Pediatr Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e969100","DOI":"10.4161\/21688362.2014.969100","article-title":"Epithelial adhesion molecules and the regulation of intestinal homeostasis during neutrophil transepithelial migration","volume":"3","author":"Sumagin","year":"2014","journal-title":"Tissue Barr."},{"key":"B32","first-page":"180","article-title":"Modulation of matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 in sepsis","volume":"3","author":"Maitra","year":"2010","journal-title":"Int J Clin Exp Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"R158","DOI":"10.1186\/cc8211","article-title":"Matrix metalloproteinase-9,\u221210, and tissue inhibitor of matrix metalloproteinases-1 blood levels as biomarkers of severity and mortality in sepsis","volume":"13","author":"Lorente","year":"2009","journal-title":"Crit Care."},{"key":"B34","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/978-3-319-09665-0_15","article-title":"HDL in infectious diseases and sepsis","volume-title":"High Density Lipoproteins: From Biological Understanding to Clinical Exploitation.","author":"Pirillo","year":"2015"},{"key":"B35","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1080\/00365540902767056","article-title":"Diagnostic values of lipid and lipoprotein levels in late onset neonatal sepsis","volume":"41","author":"Yildiz","year":"2009","journal-title":"Scand J Infect Dis."},{"key":"B36","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/978-3-319-07320-0_5","article-title":"Inflammation, infection, cancer and all that\u2026the role of paraoxonases","volume":"824","author":"Devarajan","year":"2014","journal-title":"Adv Exp Med Biol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1016\/j.clinbiochem.2017.04.016","article-title":"Paraoxonases and infectious diseases","volume":"50","author":"Camps","year":"2017","journal-title":"Clin Biochem."},{"key":"B38","doi-asserted-by":"publisher","first-page":"2330","DOI":"10.1002\/jcp.25767","article-title":"PCSK9 at the crossroad of cholesterol metabolism and immune function during infections","volume":"232","author":"Paciullo","year":"2017","journal-title":"J Cell Physiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"19891","DOI":"10.1074\/jbc.M001462200","article-title":"The expression and localization of plasma platelet-activating factor acetylhydrolase in endotoxemic rats","volume":"275","author":"Howard","year":"2000","journal-title":"J Biol Chem."},{"key":"B40","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1016\/S0022-3476(05)80661-4","article-title":"Role of platelet activating factor and tumor necrosis factor-alpha in neonatal necrotizing enterocolitis","volume":"116","author":"Caplan","year":"1990","journal-title":"J Pediatr."},{"key":"B41","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1053\/j.sempedsurg.2005.05.002","article-title":"The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis","volume":"14","author":"Caplan","year":"2005","journal-title":"Semin Pediatr Surg."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e169","DOI":"10.1097\/MPG.0000000000001215","article-title":"Coagulation gene expression profiling in infants with necrotizing enterocolitis","volume":"63","author":"Giuliani","year":"2016","journal-title":"J Pediatric Gastroenterol Nutr."},{"key":"B43","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1055\/s-0035-1556730","article-title":"Coagulopathy of acute sepsis","volume":"41","author":"Semeraro","year":"2015","journal-title":"Semin Thromb Hemost."},{"key":"B44","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1097\/MOH.0b013e328309ec97","article-title":"Regulation of coagulation by protein S","volume":"15","author":"Castoldi","year":"2008","journal-title":"Curr Opin Hematol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1097\/PCC.0b013e3181c59032","article-title":"Study of protein C. protein S, and antithrombin III in newborns with sepsis","volume":"11","author":"El Beshlawy","year":"2010","journal-title":"Pediatr Crit Care Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1097\/CCM.0000000000002947","article-title":"Decrease in histidine-rich glycoprotein as a novel biomarker to predict sepsis among systemic inflammatory response syndrome","volume":"46","author":"Kosuke","year":"2018","journal-title":"Crit Care Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.jpeds.2016.09.016","article-title":"Blood level of inter-alpha inhibitor proteins distinguishes necrotizing enterocolitis from spontaneous intestinal perforation","volume":"180","author":"Shah","year":"2017","journal-title":"J Pediatr."},{"key":"B48","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ejphar.2011.04.036","article-title":"Development of non-antibiotic macrolide that corrects inflammation-driven immune dysfunction in models of inflammatory bowel diseases and arthritis","volume":"665","author":"Mencarelli","year":"2011","journal-title":"Eur J Pharmacol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.beem.2015.09.001","article-title":"Corticosteroid-binding globulin: modulating mechanisms of bioavailability of cortisol and its clinical implications","volume":"29","author":"Bae","year":"2015","journal-title":"Best Pract Res Clin Endocrinol Metab."},{"key":"B50","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.3389\/fimmu.2019.02651","article-title":"Rapid proteome changes in plasma and cerebrospinal fluid following bacterial infection in preterm newborn pigs","volume":"10","author":"Muk","year":"2019","journal-title":"Front Immunol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.565862\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T05:41:55Z","timestamp":1602135715000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.565862\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,8]]},"references-count":50,"alternative-id":["10.3389\/fimmu.2020.565862"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.565862","relation":{},"ISSN":["1664-3224"],"issn-type":[{"type":"electronic","value":"1664-3224"}],"subject":[],"published":{"date-parts":[[2020,10,8]]},"article-number":"565862"}}