{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T10:36:44Z","timestamp":1782988604869,"version":"3.54.5"},"reference-count":83,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.569727","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T13:24:55Z","timestamp":1602163495000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":59,"title":["Alterations of Gut Microbiome and Metabolite Profiling in Mice Infected by Schistosoma japonicum"],"prefix":"10.3389","volume":"11","author":[{"given":"Yue","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiansong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyue","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minzhao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyun","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyue","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.3389\/fmicb.2017.02248","article-title":"Comparative analysis of proteome-wide lysine acetylation in juvenile and adult Schistosoma japonicum","volume":"8","author":"Li","year":"2017","journal-title":"Front Microbiol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"e807","DOI":"10.1371\/journal.pntd.0000807","article-title":"Metabolic changes reveal the development of schistosomiasis in mice","volume":"4","author":"Wu","year":"2010","journal-title":"PLoS Negl Trop Dis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e0003993","DOI":"10.1371\/journal.pntd.0003993","article-title":"Comparative analysis of transcriptional profiles of adult Schistosoma japonicum from different laboratory animals and the natural host, water buffalo","volume":"9","author":"Liu","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"B4","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s13071-016-1962-y","article-title":"Characterization of Schistosoma japonicum CP1412 protein as a novel member of the ribonuclease T2 molecule family with immune regulatory function","volume":"10","author":"Ke","year":"2017","journal-title":"Parasit Vectors."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e0179565","DOI":"10.1371\/journal.pone.0179565","article-title":"Schistosoma japonicum infection downregulates house dust mite-induced allergic airway inflammation in mice","volume":"12","author":"Qiu","year":"2017","journal-title":"PLoS ONE."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.molbiopara.2005.10.010","article-title":"System level metabolic effects of a Schistosoma japonicum infection in the Syrian hamster","volume":"146","author":"Wang","year":"2006","journal-title":"Mol Biochem Parasitol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e0182196","DOI":"10.1371\/journal.pone.0182196","article-title":"Diagnosis of coinfection by schistosomiasis and viral hepatitis B or C using 1H NMR-based metabonomics","volume":"12","author":"Gouveia","year":"2017","journal-title":"PLoS ONE."},{"key":"B8","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/msb4100190","article-title":"Probiotic modulation of symbiotic gut microbial-host metabolic interactions in a humanized microbiome mouse model","volume":"4","author":"Martin","year":"2008","journal-title":"Mol Syst Biol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"22525","DOI":"10.1038\/srep22525","article-title":"Integrated metabolomics and metagenomics analysis of plasma and urine identified microbial metabolites associated with coronary heart disease","volume":"6","author":"Feng","year":"2016","journal-title":"Sci Rep"},{"key":"B10","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jgr.2015.04.006","article-title":"A UPLC\/MS-based metabolomics investigation of the protective effect of ginsenosides Rg1 and Rg2 in mice with Alzheimer's disease","volume":"40","author":"Li","year":"2016","journal-title":"J Ginseng Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.drudis.2016.11.020","article-title":"UPLC-MS for metabolomics: a giant step forward in support of pharmaceutical research","volume":"22","author":"Nassar","year":"2017","journal-title":"Drug Discov Today"},{"key":"B12","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.chom.2009.01.004","article-title":"Host-parasite interactions revealed by Plasmodium falciparum metabolomics","volume":"5","author":"Olszewski","year":"2009","journal-title":"Cell Host Microbe"},{"key":"B13","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/1741-7007-11-67","article-title":"Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum","volume":"11","author":"MacRae","year":"2013","journal-title":"BMC Biol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s11306-017-1174-2","article-title":"Lipid response patterns in acute phase paediatric Plasmodium falciparum malaria","volume":"13","author":"Orikiiriza","year":"2017","journal-title":"Metabolomics"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e1004689","DOI":"10.1371\/journal.ppat.1004689","article-title":"Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose","volume":"11","author":"Creek","year":"2015","journal-title":"PLoS Pathog"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e0004200","DOI":"10.1371\/journal.pntd.0004200","article-title":"Discovery of infection associated metabolic markers in human african trypanosomiasis","volume":"9","author":"Lamour","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"B17","doi-asserted-by":"publisher","first-page":"e0005140","DOI":"10.1371\/journal.pntd.0005140","article-title":"Metabolomics identifies multiple candidate biomarkers to diagnose and stage human african trypanosomiasis","volume":"10","author":"Vincent","year":"2016","journal-title":"PLoS Negl Trop Dis."},{"key":"B18","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1111\/mmi.13010","article-title":"The intracellular parasite Toxoplasma gondii depends on the synthesis of long-chain and very long-chain unsaturated fatty acids not supplied by the host cell","volume":"97","author":"Ramakrishnan","year":"2015","journal-title":"Mol Microbiol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1186\/s13071-017-2282-6","article-title":"Profiling of the perturbed metabolomic state of mouse spleen during acute and chronic toxoplasmosis","volume":"10","author":"Chen","year":"2017","journal-title":"Parasit Vectors"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.3389\/fmicb.2017.02612","article-title":"Serum metabolic profiling of oocyst-induced Toxoplasma gondii acute and chronic infections in mice using mass-spectrometry","volume":"8","author":"Zhou","year":"2017","journal-title":"Front Microbiol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"11311","DOI":"10.1038\/s41598-017-11532-2","article-title":"High throughput data analyses of the immune characteristics of Microtus fortis infected with Schistosoma japonicum","volume":"7","author":"Hu","year":"2017","journal-title":"Sci Rep"},{"key":"B22","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.chom.2011.09.001","article-title":"Lessons from studying insect symbioses","volume":"10","author":"Douglas","year":"2011","journal-title":"Cell Host Microbe"},{"key":"B23","doi-asserted-by":"publisher","first-page":"9345","DOI":"10.1073\/pnas.1606631113","article-title":"Early gut colonizers shape parasite susceptibility and microbiota composition in honey bee workers","volume":"113","author":"Schwarz","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"B24","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s41572-018-0013-8","article-title":"Schistosomiasis","volume":"4","author":"McManus","year":"2018","journal-title":"Nat Rev Dis Primers"},{"key":"B25","doi-asserted-by":"publisher","first-page":"352","DOI":"10.3389\/fmicb.2019.00352","article-title":"Alterations of the Mice Gut Microbiome via Schistosoma japonicum Ova-Induced Granuloma","volume":"10","author":"Zhao","year":"2019","journal-title":"Front Microbiol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"B27","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/nbt.2170","article-title":"FLASH assembly of TALENs for high-throughput genome editing","volume":"30","author":"Reyon","year":"2012","journal-title":"Nat Biotechnol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/nmeth.f.303","article-title":"QIIME allows analysis of high-throughput community sequencing data","volume":"7","author":"Caporaso","year":"2010","journal-title":"Nat Methods"},{"key":"B29","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/nmeth.2604","article-title":"UPARSE: highly accurate OTU sequences from microbial amplicon reads","volume":"10","author":"Edgar","year":"2013","journal-title":"Nat Methods"},{"key":"B30","doi-asserted-by":"publisher","first-page":"5261","DOI":"10.1128\/AEM.00062-07","article-title":"Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy","volume":"73","author":"Wang","year":"2007","journal-title":"Appl Environ Microbiol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e30619","DOI":"10.1371\/journal.pone.0030619","article-title":"NGS QC Toolkit: a toolkit for quality control of next generation sequencing data","volume":"7","author":"Patel","year":"2012","journal-title":"PLoS ONE."},{"key":"B32","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1093\/bioinformatics\/btp698","article-title":"Fast and accurate long-read alignment with Burrows-Wheeler transform","volume":"26","author":"Li","year":"2010","journal-title":"Bioinformatics"},{"key":"B33","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/2047-217X-1-18","article-title":"SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler","volume":"1","author":"Luo","year":"2012","journal-title":"Gigascience"},{"key":"B34","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/1471-2105-11-119","article-title":"Prodigal: prokaryotic gene recognition and translation initiation site identification","volume":"11","author":"Hyatt","year":"2010","journal-title":"BMC Bioinform"},{"key":"B35","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/nprot.2012.135","article-title":"Global metabolic profiling of animal and human tissues via UPLC-MS","volume":"8","author":"Want","year":"2013","journal-title":"Nat Protoc"},{"key":"B36","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1038\/nprot.2011.319","article-title":"Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst","volume":"6","author":"Xia","year":"2011","journal-title":"Nature Protocols"},{"key":"B37","doi-asserted-by":"publisher","first-page":"W486","DOI":"10.1093\/nar\/gky310","article-title":"MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis","volume":"46","author":"Chong","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"D801","DOI":"10.1093\/nar\/gks1065","article-title":"HMDB 3.0\u2013the human metabolome database in 2013","volume":"41","author":"Wishart","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"B39","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/nbt.2348","article-title":"An accelerated workflow for untargeted metabolomics using the METLIN database","volume":"30","author":"Tautenhahn","year":"2012","journal-title":"Nat Biotechnol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s12879-016-2146-2","article-title":"Gut microbiota disturbance during helminth infection: can it affect cognition and behaviour of children?","volume":"17","author":"Guernier","year":"2017","journal-title":"BMC Infect Dis"},{"key":"B41","doi-asserted-by":"publisher","first-page":"12072","DOI":"10.1038\/s41598-018-30412-x","article-title":"Schistosoma mansoni infection is associated with quantitative and qualitative modifications of the mammalian intestinal microbiota","volume":"8","author":"Jenkins","year":"2018","journal-title":"Sci Rep"},{"key":"B42","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1111\/j.1574-6976.2011.00270.x","article-title":"The host selects mucosal and luminal associations of coevolved gut microorganisms: a novel concept","volume":"35","author":"Van den Abbeele","year":"2011","journal-title":"FEMS Microbiol Rev."},{"key":"B43","doi-asserted-by":"publisher","first-page":"e1003000","DOI":"10.1371\/journal.ppat.1003000","article-title":"Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon","volume":"8","author":"Broadhurst","year":"2012","journal-title":"PLoS Pathog"},{"key":"B44","doi-asserted-by":"publisher","first-page":"e1004014","DOI":"10.1371\/journal.ppat.1004014","article-title":"Wormholes in host defense: how helminths manipulate host tissues to survive and reproduce","volume":"10","author":"Boyett","year":"2014","journal-title":"PLoS Pathog"},{"key":"B45","doi-asserted-by":"publisher","first-page":"e2880","DOI":"10.1371\/journal.pntd.0002880","article-title":"Helminth colonization is associated with increased diversity of the gut microbiota","volume":"8","author":"Lee","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1098\/rstb.2014.0296","article-title":"Suppression of inflammation by helminths: a role for the gut microbiota?","volume":"370","author":"Giacomin","year":"2015","journal-title":"Philos Trans R Soc Lond B Biol Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2976","DOI":"10.3389\/fmicb.2018.02976","article-title":"Bacteroides fragilis prevents Clostridium difficile infection in a mouse model by restoring gut barrier and microbiome regulation","volume":"9","author":"Deng","year":"2018","journal-title":"Front Microbiol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"e0146162","DOI":"10.1371\/journal.pone.0146162","article-title":"Pglyrp-regulated gut microflora Prevotella falsenii, Parabacteroides distasonis and Bacteroides eggerthii enhance and Alistipes finegoldii attenuates colitis in mice","volume":"11","author":"Dziarski","year":"2016","journal-title":"PLoS ONE."},{"key":"B49","doi-asserted-by":"publisher","first-page":"E1306","DOI":"10.1073\/pnas.1518189113","article-title":"Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice","volume":"113","author":"Li","year":"2016","journal-title":"Proc Natl Acad Sci USA."},{"key":"B50","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s40168-017-0264-8","article-title":"Chemical and pathogen-induced inflammation disrupt the murine intestinal microbiome","volume":"5","author":"Borton","year":"2017","journal-title":"Microbiome"},{"key":"B51","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.3389\/fmicb.2017.02222","article-title":"Gut Microbial dysbiosis is associated with altered hepatic functions and serum metabolites in chronic hepatitis B patients","volume":"8","author":"Wang","year":"2017","journal-title":"Front Microbiol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"322","DOI":"10.3389\/fmicb.2019.00322","article-title":"Dynamic change of gut microbiota during porcine epidemic diarrhea virus infection in suckling piglets","volume":"10","author":"Huang","year":"2019","journal-title":"Front Microbiol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1111\/pai.13096","article-title":"Gut microbial-derived butyrate is inversely associated with IgE responses to allergens in childhood asthma","volume":"30","author":"Chiu","year":"2019","journal-title":"Pediatr Allergy Immunol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"e0125945","DOI":"10.1371\/journal.pone.0125945","article-title":"Chronic trichuris muris infection in C57BL\/6 mice causes significant changes in host microbiota and metabolome: effects reversed by pathogen clearance","volume":"10","author":"Houlden","year":"2015","journal-title":"PLoS ONE."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.3389\/fmicb.2018.01736","article-title":"Dietary L-tryptophan modulates the structural and functional composition of the intestinal microbiome in weaned piglets","volume":"9","author":"Liang","year":"2018","journal-title":"Front Microbiol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1007\/s10482-016-0737-y","article-title":"A reduction in the butyrate producing species Roseburia spp. and Faecalibacterium prausnitzii is associated with chronic kidney disease progression","volume":"109","author":"Jiang","year":"2016","journal-title":"Antonie Van Leeuwenhoek"},{"key":"B57","doi-asserted-by":"publisher","first-page":"2870","DOI":"10.1038\/s41598-017-02989-2","article-title":"Alteration of the gut microbiota in Chinese population with chronic kidney disease","volume":"7","author":"Jiang","year":"2017","journal-title":"Sci Rep"},{"key":"B58","doi-asserted-by":"publisher","first-page":"776","DOI":"10.3389\/fmicb.2017.00776","article-title":"Dysbiosis of intestinal microbiota and decreased antimicrobial peptide level in paneth cells during hypertriglyceridemia-related acute necrotizing pancreatitis in rats","volume":"8","author":"Huang","year":"2017","journal-title":"Front Microbiol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"4254","DOI":"10.3748\/wjg.v24.i37.4254","article-title":"VSL#3 can prevent ulcerative colitis-associated carcinogenesis in mice","volume":"24","author":"Wang","year":"2018","journal-title":"World J Gastroenterol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1038\/s41591-018-0202-8","article-title":"Precision identification of diverse bloodstream pathogens in the gut microbiome","volume":"24","author":"Tamburini","year":"2018","journal-title":"Nat Med"},{"key":"B61","doi-asserted-by":"publisher","first-page":"e0208171","DOI":"10.1371\/journal.pone.0208171","article-title":"Gut microbiota signatures in cystic fibrosis: Loss of host CFTR function drives the microbiota enterophenotype","volume":"13","author":"Vernocchi","year":"2018","journal-title":"PLoS ONE."},{"key":"B62","doi-asserted-by":"publisher","first-page":"25945","DOI":"10.1038\/srep25945","article-title":"Gut microbiota composition and Clostridium difficile infection in hospitalized elderly individuals: a metagenomic study","volume":"6","author":"Milani","year":"2016","journal-title":"Sci Rep"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.3389\/fmicb.2018.01230","article-title":"Time series analysis of the microbiota of children suffering from acute infectious diarrhea and their recovery after treatment","volume":"9","author":"Dinleyici","year":"2018","journal-title":"Front Microbiol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"845","DOI":"10.3389\/fgene.2019.00845","article-title":"Genome-wide analysis of alternative splicing provides insights into stress response of the pacific white shrimp Litopenaeus vanname","volume":"10","author":"Zhang","year":"2019","journal-title":"Front Genet"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1007\/s11745-001-0812-7","article-title":"Polyunsaturated fatty acids, inflammation, and immunity","volume":"36","author":"Calder","year":"2001","journal-title":"Lipids"},{"key":"B66","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.plipres.2013.04.006","article-title":"Checks and balances in membrane phospholipid class and acyl chain homeostasis, the yeast perspective","volume":"52","author":"de Kroon","year":"2013","journal-title":"Prog Lipid Res"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.5588\/ijtld.17.0874","article-title":"Serum antiphospholipid antibody levels as biomarkers for diagnosis of pulmonary tuberculosis patients","volume":"22","author":"Takenami","year":"2018","journal-title":"Int J Tuberc Lung Dis"},{"key":"B68","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3389\/fmicb.2019.00086","article-title":"Overproduction of phospholipids by the kennedy pathway leads to hypervirulence in Candida albicans","volume":"10","author":"Tams","year":"2019","journal-title":"Front Microbiol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"e0181432","DOI":"10.1371\/journal.pone.018143","article-title":"The Trypanosoma brucei dihydroxyacetonephosphate acyltransferase TbDAT is dispensable for normal growth but important for synthesis of ether glycerophospholipids","volume":"12","author":"Zufferey","year":"2017","journal-title":"PLoS ONE."},{"key":"B70","doi-asserted-by":"publisher","first-page":"e0006452","DOI":"10.1371\/journal.pntd.0006452","article-title":"Metabolite profiling for biomarkers in Schistosoma haematobium infection and associated bladder pathologies","volume":"12","author":"Adebayo","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"key":"B71","doi-asserted-by":"publisher","first-page":"e100017","DOI":"10.1371\/journal.pone.0100017","article-title":"Plasma metabolomic profiling to reveal antipyretic mechanism of Shuang-huang-lian injection on yeast-induced pyrexia rats","volume":"9","author":"Gao","year":"2014","journal-title":"PLoS ONE."},{"key":"B72","doi-asserted-by":"publisher","first-page":"920","DOI":"10.3389\/fimmu.2018.00920","article-title":"Lysophosphatidylcholine promotes phagosome maturation and regulates inflammatory mediator production through the protein kinase a-phosphatidylinositol 3 kinase-p38 mitogen-activated protein kinase signaling pathway during Mycobacterium tuberculosis infection in mouse macrophages","volume":"9","author":"Lee","year":"2018","journal-title":"Front Immunol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"4464","DOI":"10.1128\/AAC.02708-15","article-title":"Efficacy of lysophosphatidylcholine in combination with antimicrobial agents against Acinetobacter baumannii in experimental murine peritoneal sepsis and pneumonia models","volume":"60","author":"Parra Millan","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"B74","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/nm989","article-title":"Therapeutic effects of lysophosphatidylcholine in experimental sepsis","volume":"10","author":"Yan","year":"2004","journal-title":"Nat Med"},{"key":"B75","doi-asserted-by":"publisher","first-page":"4401","DOI":"10.4049\/jimmunol.0902814","article-title":"Lysophosphatidylcholine increases neutrophil bactericidal activity by enhancement of azurophil granule-phagosome fusion via glycine.GlyR alpha 2\/TRPM2\/p38 MAPK signaling","volume":"184","author":"Hong","year":"2010","journal-title":"J Immunol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1177\/2049936117714920","article-title":"Antimicrobial effects of lysophosphatidylcholine on methicillin-resistant Staphylococcus aureus","volume":"4","author":"Miyazaki","year":"2017","journal-title":"Ther Adv Infect Dis"},{"key":"B77","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1164\/rccm.201701-0071OC","article-title":"Associations of nasopharyngeal metabolome and microbiome with severity among infants with bronchiolitis. A multiomic analysis","volume":"196","author":"Stewart","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"B78","doi-asserted-by":"publisher","first-page":"440","DOI":"10.3389\/fmicb.2019.00440","article-title":"Comparative metabonomic investigations of Schistosoma japonicum from SCID mice and BALB\/c mice: clues to developmental abnormality of schistosome in the immunodeficient host","volume":"10","author":"Liu","year":"2019","journal-title":"Front Microbiol"},{"key":"B79","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/nature13475","article-title":"Sphingolipid metabolites in inflammatory disease","volume":"510","author":"Maceyka","year":"2014","journal-title":"Nature"},{"key":"B80","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1159\/000447831","article-title":"Ischemia\/reperfusion injury alters sphingolipid metabolism in the gut","volume":"39","author":"Hoehn","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"B81","doi-asserted-by":"publisher","first-page":"e87180","DOI":"10.1371\/journal.pone.0087180","article-title":"Limited brain metabolism changes differentiate between the progression and clearance of rabies virus","volume":"9","author":"Schutsky","year":"2014","journal-title":"PLoS ONE."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1099\/mic.0.000080","article-title":"Carnitine in bacterial physiology and metabolism","volume":"161","author":"Meadows","year":"2015","journal-title":"Microbiology"},{"key":"B83","doi-asserted-by":"publisher","first-page":"378","DOI":"10.3389\/fimmu.2017.00378","article-title":"Sphingolipids are dual specific drug targets for the management of pulmonary infections: perspective","volume":"8","author":"Sharma","year":"2017","journal-title":"Front Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.569727\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T13:25:03Z","timestamp":1602163503000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.569727\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,8]]},"references-count":83,"alternative-id":["10.3389\/fimmu.2020.569727"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.569727","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,8]]},"article-number":"569727"}}