{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T10:48:54Z","timestamp":1783334934141,"version":"3.54.6"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81561128008"],"award-info":[{"award-number":["81561128008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672018"],"award-info":[{"award-number":["81672018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2014CB542502"],"award-info":[{"award-number":["2014CB542502"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.571248","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T06:12:47Z","timestamp":1600927967000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["A Systemic Prime\u2013Intrarectal Pull Strategy Raises Rectum-Resident CD8+ T Cells for Effective Protection in a Murine Model of LM-OVA Infection"],"prefix":"10.3389","volume":"11","author":[{"given":"Qian","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangli","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinci","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuye","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangqing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongquan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanxuan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/mi.2012.96","article-title":"Guarding the perimeter: protection of the mucosa by tissue-resident memory T cells","volume":"6","author":"Cauley","year":"2013","journal-title":"Mucosal Immunol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1016\/S0140-6736(08)61591-3","article-title":"Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial","volume":"372","author":"Buchbinder","year":"2008","journal-title":"Lancet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/S1473-3099(11)70098-6","article-title":"Safety and efficacy of the HVTN 503\/Phambili Study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2b study","volume":"11","author":"Gray","year":"2011","journal-title":"Lancet Infect Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1146\/annurev-med-052912-123749","article-title":"Lessons from the RV144 thai phase III HIV-1 vaccine trial and the search for correlates of protection","volume":"66","author":"Kim","year":"2015","journal-title":"Annu Rev Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"9228","DOI":"10.1128\/JVI.79.14.9228-9235.2005","article-title":"CD8+ T-lymphocyte response to major immunodominant epitopes after vaginal exposure to simian immunodeficiency virus: too late and too little","volume":"79","author":"Reynolds","year":"2005","journal-title":"J Virol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nature08757","article-title":"Targeting early infection to prevent HIV-1 mucosal transmission","volume":"464","author":"Haase","year":"2010","journal-title":"Nature."},{"key":"B7","doi-asserted-by":"publisher","first-page":"19739","DOI":"10.1073\/pnas.1208927109","article-title":"Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen","volume":"109","author":"Ariotti","year":"2012","journal-title":"Proc Natil Acad Sci USA."},{"key":"B8","doi-asserted-by":"publisher","first-page":"eaam6970","DOI":"10.1126\/sciimmunol.aam6970","article-title":"Resident memory CD8(+) T cells in the upper respiratory tract prevent pulmonary influenza virus infection","volume":"2","author":"Pizzolla","year":"2017","journal-title":"Sci Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1126\/science.1254536","article-title":"Resident memory CD8 T cells trigger protective innate and adaptive immune responses","volume":"343","author":"Medzhitov","year":"2000","journal-title":"N Engl J Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"3462","DOI":"10.4049\/jimmunol.1201305","article-title":"The molecular signature of tissue resident memory CD8 T cells isolated from the brain","volume":"189","author":"Wakim","year":"2012","journal-title":"J Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/ni.2568","article-title":"Sensing and alarm function of resident memory CD8(+) T cells","volume":"14","author":"Schenkel","year":"2013","journal-title":"Nat Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1126\/science.1254803","article-title":"T cell memory. skin-resident memory CD8(+) T cells trigger a state of tissue-wide pathogen alert","volume":"346","author":"Ariotti","year":"2014","journal-title":"Science."},{"key":"B13","doi-asserted-by":"publisher","first-page":"ijerph13010030","DOI":"10.3390\/ijerph13010030","article-title":"Characterizing the HIV\/AIDS epidemic in the United States and China","volume":"13","author":"Huang","year":"2015","journal-title":"Int J Environ Res Public Health."},{"key":"B14","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1038\/mi.2016.97","article-title":"The rectal mucosa and condomless receptive anal intercourse in HIV-negative MSM: implications for HIV transmission and prevention","volume":"10","author":"Kelley","year":"2017","journal-title":"Mucosal Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/j.1365-2796.2008.02051.x","article-title":"Antiviral CD8+ T cells in the genital tract control viral replication and delay progression to AIDS after vaginal SIV challenge in rhesus macaques immunized with virulence attenuated SHIV 89","volume":"265","author":"Genesca","year":"2009","journal-title":"J Intern Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"8264","DOI":"10.1128\/JVI.72.10.8264-8272.1998","article-title":"Induction of a mucosal cytotoxic T-lymphocyte response by intrarectal immunization with a replication-deficient recombinant vaccinia virus expressing human immunodeficiency virus 89","volume":"72","author":"Belyakov","year":"1998","journal-title":"J Virol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1038\/nm1201-1320","article-title":"Mucosal AIDS vaccine reduces disease and viral load in gut reservoir and blood after mucosal infection of macaques","volume":"7","author":"Belyakov","year":"2001","journal-title":"Nat Med."},{"key":"B18","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4049\/jimmunol.162.1.254","article-title":"Intranasal immunization with plasmid DNA-lipid complexes elicits mucosal immunity in the female genital and rectal tracts","volume":"162","author":"Klavinskis","year":"1999","journal-title":"J Immunol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"6209","DOI":"10.4049\/jimmunol.172.10.6209","article-title":"Induction of HIV immunity in the genital tract after intranasal delivery of a MVA vector: enhanced immunogenicity after DNA prime-modified vaccinia virus Ankara boost immunization schedule","volume":"172","author":"Gherardi","year":"2004","journal-title":"J Immunol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nature11522","article-title":"A vaccine strategy that protects against genital herpes by establishing local memory T cells","volume":"491","author":"Shin","year":"2012","journal-title":"Nature."},{"key":"B21","doi-asserted-by":"publisher","first-page":"18099","DOI":"10.1038\/srep18099","article-title":"Successive site translocating inoculation potentiates DNA\/recombinant vaccinia vaccination","volume":"5","author":"Ren","year":"2015","journal-title":"Sci Rep."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.4049\/jimmunol.1001142","article-title":"Qualitatively different memory CD8+ T cells are generated after lymphocytic choriomeningitis virus and influenza virus infections","volume":"185","author":"Mueller","year":"2010","journal-title":"J Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/nature17947","article-title":"EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells","volume":"533","author":"Li","year":"2016","journal-title":"Nature."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1016\/j.vaccine.2014.02.056","article-title":"As a genetic adjuvant, CTA improves the immunogenicity of DNA vaccines in an ADP-ribosyltransferase activity- and IL-6-dependent manner","volume":"32","author":"Wan","year":"2014","journal-title":"Vaccine."},{"key":"B25","doi-asserted-by":"publisher","first-page":"4606","DOI":"10.1172\/JCI63287","article-title":"Intravaginal immunization with HPV vectors induces tissue-resident CD8+ T cell responses","volume":"122","author":"Cuburu","year":"2012","journal-title":"J Clin Invest."},{"key":"B26","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1128\/JVI.02380-14","article-title":"Topical herpes simplex virus 2 (HSV-2) vaccination with human papillomavirus vectors expressing gB\/gD ectodomains induces genital-tissue-resident memory CD8+ T cells and reduces genital disease and viral shedding after HSV-2 challenge","volume":"89","author":"Cuburu","year":"2015","journal-title":"J Virol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1084\/jem.175.6.1531","article-title":"CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo","volume":"175","author":"Harty","year":"1992","journal-title":"J Exp Med"},{"key":"B28","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/j.immuni.2014.03.007","article-title":"Oral infection drives a distinct population of intestinal resident memory CD8(+) T cells with enhanced protective function","volume":"40","author":"Sheridan","year":"2014","journal-title":"Immunity."},{"key":"B29","doi-asserted-by":"publisher","first-page":"8874","DOI":"10.1016\/j.vaccine.2007.08.066","article-title":"Mucosal priming with replicative Tiantan vaccinia and systemic boosting with DNA vaccine raised strong mucosal and systemic HIV-specific immune responses","volume":"25","author":"Huang","year":"2007","journal-title":"Vaccine."},{"key":"B30","doi-asserted-by":"publisher","first-page":"S34","DOI":"10.1016\/S0264-410X(02)00169-X","article-title":"Mechanisms of stimulation of the immune response by aluminum adjuvants","volume":"20","author":"HogenEsch","year":"2002","journal-title":"Vaccine."},{"key":"B31","doi-asserted-by":"publisher","first-page":"e00278","DOI":"10.1128\/JVI.00278-17","article-title":"CXCL10\/CXCR3-dependent mobilization of herpes simplex virus-specific CD8(+) TEM and CD8(+) TRM cells within infected tissues allows efficient protection against recurrent herpesvirus infection and disease","volume":"91","author":"Srivastava","year":"2017","journal-title":"J Virol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1084\/jem.20090858","article-title":"Dynamic T cell migration program provides resident memory within intestinal epithelium","volume":"207","author":"Masopust","year":"2010","journal-title":"J Exp Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"S45","DOI":"10.1038\/nm1213","article-title":"Mucosal immunity and vaccines","volume":"11","author":"Holmgren","year":"2005","journal-title":"Nat Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.it.2015.07.002","article-title":"Tissue instruction for migration and retention of TRM cells","volume":"36","author":"Iijima","year":"2015","journal-title":"Trends Immunol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1007\/s00705-003-0006-z","article-title":"Tissue distribution of the Ankara strain of vaccinia virus (MVA) after mucosal or systemic administration","volume":"148","author":"Ramirez","year":"2003","journal-title":"Archiv Virol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e85832","DOI":"10.1172\/jci.insight.85832","article-title":"Vaccine-generated lung tissue-resident memory T cells provide heterosubtypic protection to influenza infection","volume":"1","author":"Zens","year":"2016","journal-title":"JCI Insight."},{"key":"B37","doi-asserted-by":"publisher","first-page":"e1442163","DOI":"10.1080\/2162402X.2018.1442163","article-title":"Vaccination-induced skin-resident memory CD8(+) T cells mediate strong protection against cutaneous melanoma","volume":"7","author":"Galvez-Cancino","year":"2018","journal-title":"Oncoimmunology."},{"key":"B38","doi-asserted-by":"publisher","first-page":"20137","DOI":"10.1038\/srep20137","article-title":"Combined local and systemic immunization is essential for durable T-cell mediated heterosubtypic immunity against influenza A virus","volume":"6","author":"Uddback","year":"2016","journal-title":"Sci Rep."},{"key":"B39","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.3389\/fimmu.2019.02075","article-title":"Mucosal-pull induction of lung-resident memory CD8 T cells in parenteral TB vaccine-primed hosts requires cognate antigens and CD4 T cells","volume":"10","author":"Haddadi","year":"2019","journal-title":"Front Immunol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.3389\/fmicb.2019.01630","article-title":"Influenza vaccine with consensus internal antigens as immunogens provides cross-group protection against influenza a viruses","volume":"10","author":"Xie","year":"2019","journal-title":"Front Microbiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1016\/0264-410X(93)90039-Z","article-title":"Cholera toxin and cholera B subunit as oral\u2014mucosal adjuvant and antigen vector systems","volume":"11","author":"Holmgren","year":"1993","journal-title":"Vaccine."},{"key":"B42","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1615\/CritRevImmunol.2015012295","article-title":"Mechanisms of cholera toxin in the modulation of TH17 responses","volume":"35","author":"Tsai","year":"2015","journal-title":"Critical Rev Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.immuni.2006.01.015","article-title":"Residual antigen presentation after influenza virus infection affects CD8 T cell activation and migration","volume":"24","author":"Zammit","year":"2006","journal-title":"Immunity."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.4049\/jimmunol.1800219","article-title":"A prime-pull-amplify vaccination strategy to maximize induction of circulating and genital-resident intraepithelial CD8(+) memory T cells","volume":"202","author":"Cuburu","year":"2019","journal-title":"J Immunol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.4049\/jimmunol.1201682","article-title":"Cutting edge: intravascular staining redefines lung CD8 T cell responses","volume":"189","author":"Anderson","year":"2012","journal-title":"J Immunol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1038\/mi.2017.89","article-title":"Induction of vaginal-resident HIV-specific CD8 T cells with mucosal prime-boost immunization","volume":"11","author":"Tan","year":"2018","journal-title":"Mucosal Immunol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/s41590-017-0029-3","article-title":"Intravital mucosal imaging of CD8(+) resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory","volume":"19","author":"Beura","year":"2018","journal-title":"Nat Immunol."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.571248\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T03:41:49Z","timestamp":1696736509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.571248\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,24]]},"references-count":47,"alternative-id":["10.3389\/fimmu.2020.571248"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.571248","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,24]]},"article-number":"571248"}}