{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T22:55:32Z","timestamp":1791327332942,"version":"4.3.1"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.571884","type":"journal-article","created":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T14:14:06Z","timestamp":1602857646000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["\u201cAge Related Differences in the Biology of Chronic Graft-Versus-Host Disease After Hematopoietic Stem Cell Transplantation\u201d"],"prefix":"10.3389","volume":"11","author":[{"given":"Geoff D. E.","family":"Cuvelier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibyl","family":"Drissler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Kariminia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayeh","family":"Abdossamadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Rozmus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Chanoine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mostafavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan R.","family":"Brinkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk R.","family":"Schultz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2017.11.004","article-title":"Influence of Age on Acute and Chronic GVHD in Children Undergoing HLA-Identical Sibling Bone Marrow Transplantation for Acute Leukemia: Implications for Prophylaxis","volume":"24","author":"Qayed","year":"2018","journal-title":"Biol Blood Marrow Transplant"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2007.10.009","article-title":"Elevated Numbers of Immature\/Transitional CD21- B Lymphocytes and Deficiency of Memory CD27+ B Cells Identify Patients With Active Chronic Graft-Versus-Host Disease","volume":"14","author":"Greinix","year":"2008","journal-title":"Biol Blood Marrow Transplant"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.170928","article-title":"CD56bright NK regulatory cells in filgrastim primed donor blood or marrow products regulate chronic GvHD: CBMTG randomized 0601 study results","volume":"102","author":"Kariminia","year":"2017","journal-title":"Haematologica"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-09-668251","article-title":"Heterogeneity of chronic graft-versus-host disease biomarkers: the only consistent association is with CXCL10 and CXCR3+ NK cells","volume":"127","author":"Kariminia","year":"2016","journal-title":"Blood"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.65.9615","article-title":"Biomarker Panel for Chronic Graft-Versus-Host Disease","volume":"34","author":"Yu","year":"2016","journal-title":"J Clin Oncol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-018-0092-x","article-title":"Biomarkers in Chronic Graft-Versus-Host Disease: Quo Vadis","volume":"53","author":"Wolff","year":"2018","journal-title":"Bone Marrow Transplant"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000216","article-title":"Benefits and challenges with diagnosing chronic and late acute GvHD in children using the NIH consensus criteria","volume":"134","author":"Cuvelier","year":"2019","journal-title":"Blood"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003186","article-title":"Immune Profile Differences Between Chronic GVHD and Late Acute GVHD: Results of the ABLE\/PBMTC 1202 Studies","volume":"135","author":"Schultz","year":"2020","journal-title":"Blood"},{"key":"B9","volume-title":"Review of methods for determining pubertal status and age of onset of puberty in cohort and longitudinal studies","author":"Baird","year":"2017"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00147","article-title":"Review of the Literature on Current Changes in the Timing of Pubertal Development and the Incomplete Forms of Early Puberty","volume":"7","author":"Farello","year":"2019","journal-title":"Front Pediatr"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00302","article-title":"Gender Disparity Impacts on Thymus Aging and LHRH Receptor Antagonist-Induced Thymic Reconstitution Following Chemotherapeutic Damage","volume":"11","author":"Hun","year":"2020","journal-title":"Front Immunol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.11.015","article-title":"Anti-Thymocyte Globulin Prophylaxis Induces a Decrease in Naive Th Cells to Inhibit the Onset of Chronic Graft-versus-Host Disease: Results From the Canadian Bone Marrow Transplant Group (CBMTG) 0801 Study","volume":"26","author":"Naeije","year":"2020","journal-title":"Biol Blood Marrow Transplant"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80501-1","article-title":"Clinical longitudinal standards for height and height velocity for North American children","volume":"107","author":"Tanner","year":"1985","journal-title":"J Pediatr"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1101\/2020.04.23.058545","article-title":"flowCut \u2014 An R package for precise and accurate automated removal of outlier events and flagging of files based on time versus fluorescence analysis","author":"Meskas","year":"2020","journal-title":"bioRxiv"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu677","article-title":"flowDensity: reproducing manual gating of flow cytometry data by automated density-based cell population identification","volume":"31","author":"Malek","year":"2015","journal-title":"Bioinformatics"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt770","article-title":"Enhanced flowType\/RchyOptimyx: a BioConductor pipeline for discovery in high-dimensional cytometry data","volume":"30","author":"O\u2019Neill","year":"2014","journal-title":"Bioinformatics"},{"key":"B17","volume-title":"R: A language and environment for statistical computing","year":"2019"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2018.11.007","article-title":"Comprehensive B Cell Phenotyping Profile for Chronic Graft-Versus-Host Disease Diagnosis","volume":"25","author":"Rozmus","year":"2019","journal-title":"Biol Blood Marrow Transplant"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12224","article-title":"Subsets of human natural killer cells and their regulatory effects","volume":"141","author":"Fu","year":"2014","journal-title":"Immunology"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00606","article-title":"Regulatory Functions of Natural Killer Cells in Multiple Sclerosis","volume":"7","author":"Gross","year":"2016","journal-title":"Front Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-08-106286","article-title":"Biomarkers in Newly Diagnosed Pediatric Extensive Chronic Graft-versus-Host Disease","volume":"111","author":"Fujii","year":"2008","journal-title":"Blood"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344423","article-title":"PD-1 Regulates Extrathymic Regulatory T-cell Differentiation","volume":"44","author":"Chen","year":"2014","journal-title":"Eur J Immunol"},{"key":"B23","article-title":"Requirement for B Cells in T Cell Priming to Minor Histocompatibility Antigens and Development of Graft-Versus-Host Disease","volume":"16","author":"Schultz","year":"1995","journal-title":"Bone Marrow Transplant"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2006.12.441","article-title":"Altered Toll-like Receptor 9 Responses in Circulating B Cells at the Onset of Extensive Chronic Graft-Versus-Host Disease","volume":"13","author":"She","year":"2007","journal-title":"Biol Blood Marrow Transplant"},{"key":"B25","doi-asserted-by":"publisher","first-page":"9999","DOI":"10.1073\/pnas.1822001116","article-title":"PD-1(+) regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer. 1","volume":"116","author":"Kamada","year":"2019","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0211-0","article-title":"B cell checkpoints in autoimmune rheumatic diseases","volume":"15","author":"Rubin","year":"2019","journal-title":"Nat Rev Rheumatol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/imr.12821","article-title":"Impaired B-cell tolerance checkpoints promote the development of autoimmune diseases and pathogenic autoantibodies","volume":"292","author":"Meffre","year":"2019","journal-title":"Immunol Rev"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102176","article-title":"Altered B Cell Homeostasis Is Associated With Type I Diabetes and Carriers of the PTPN22 Allelic Variant","volume":"188","author":"Habib","year":"2012","journal-title":"J Immunol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01372","article-title":"CD19 + CD24 hi CD38 hi B Cells Are Expanded in Juvenile Dermatomyositis and Exhibit a Pro-Inflammatory Phenotype After Activation Through Toll-Like Receptor 7 and Interferon-\u03b1","volume":"9","author":"Piper","year":"2018","journal-title":"Front Immunol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050630","article-title":"RNA-associated Autoantigens Activate B Cells by Combined B Cell Antigen receptor\/Toll-like Receptor 7 Engagement","volume":"202","author":"Lau","year":"2005","journal-title":"J Exp Med"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/416603a","article-title":"Chromatin-IgG Complexes Activate B Cells by Dual Engagement of IgM and Toll-like Receptors","volume":"416","author":"Leadbetter","year":"2002","journal-title":"Nature"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2011.01.016","article-title":"Toll-like Receptor Driven B Cell Activation in the Induction of Systemic Autoimmunity","volume":"23","author":"Green","year":"2011","journal-title":"Semin Immunol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302519","article-title":"A Role for Intrathymic B Cells in the Generation of Natural Regulatory T Cells","volume":"193","author":"Walters","year":"2014","journal-title":"J Immunol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01897","article-title":"Human Innate Lymphoid Cells: Their Functional and Cellular Interactions in Decidua","volume":"9","author":"Vacca","year":"2018","journal-title":"Front Immunol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100789","article-title":"Unexpected role for granzyme K in CD56bright NK cell-mediated immunoregulation of multiple sclerosis","volume":"187","author":"Jiang","year":"2011","journal-title":"J Immunol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1257","article-title":"Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease","volume":"106","author":"Zorn","year":"2005","journal-title":"Blood"},{"key":"B37","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1016\/j.exphem.2005.05.001","article-title":"Numbers of Foxp3-expressing CD4+CD25high T cells do not correlate with the establishment of long-term tolerance after allogeneic stem cell transplantation","volume":"33","author":"Meignin","year":"2005","journal-title":"Exp Hematol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-06-2073","article-title":"Chronic graft-versus-host disease is associated with increased numbers of peripheral blood CD4+CD25high regulatory T cells","volume":"103","author":"Clark","year":"2004","journal-title":"Blood"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1608873113","article-title":"Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model","volume":"113","author":"Zhang","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-741629","article-title":"PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy","volume":"129","author":"Asano","year":"2017","journal-title":"Blood"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401936","article-title":"PD-1 Upregulated on Regulatory T Cells During Chronic Virus Infection Enhances the Suppression of CD8+ T Cell Immune Response via the Interaction With PD-L1 Expressed on CD8+ T Cells","volume":"194","author":"Park","year":"2015","journal-title":"J Immunol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"386165","DOI":"10.1155\/2015\/386165","article-title":"Bone Marrow Cells in Acute Lymphoblastic Leukemia Create a Proinflammatory Microenvironment Influencing Normal Hematopoietic Differentiation Fates","volume":"2015","author":"Vilchis-Ordo\u00f1ez","year":"2015","journal-title":"BioMed Res Int"},{"key":"B43","doi-asserted-by":"publisher","first-page":"393","DOI":"10.2478\/v10181-011-0059-y","article-title":"Influence of Bestatin, an Inhibitor of Aminopeptidases, on T and B Lymphocyte Subsets in Mice","volume":"14","author":"Lis","year":"2011","journal-title":"Pol J Vet Sci"},{"key":"B44","article-title":"Partial Review of Immunotherapeutic Pharmacology in Stem Cell Transplantation","volume":"14","author":"Bierman","year":"2000","journal-title":"Vivo"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.1996.tb00176.x","article-title":"Estrogen blocks early T cell development in the thymus","volume":"36","author":"Rijhsinghani","year":"1996","journal-title":"Am J Reprod Immunol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(94)90212-7","article-title":"The thymus in pregnancy: the interplay of neural, endocrine and immune influences","volume":"15","author":"Clarke","year":"1994","journal-title":"Immunol Today"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4470","article-title":"Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury","volume":"24","author":"Velardi","year":"2018","journal-title":"Nat Med"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/s004310050006","article-title":"Pubertal development and growth after total-body irradiation and bone marrow transplantation for haematological malignancies","volume":"159","author":"Bakker","year":"2000","journal-title":"Eur J Pediatr"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-09-599159","article-title":"CD24(hi)CD27+ and Plasmablast-Like Regulatory B Cells in Human Chronic Graft-Versus-Host Disease","volume":"125","author":"de Masson","year":"2015","journal-title":"Blood"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.571884\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T14:14:09Z","timestamp":1602857649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.571884\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,16]]},"references-count":49,"alternative-id":["10.3389\/fimmu.2020.571884"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.571884","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,16]]},"article-number":"571884"}}