{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T19:42:44Z","timestamp":1769456564474,"version":"3.49.0"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["UBACyT 20020130100774BA"],"award-info":[{"award-number":["UBACyT 20020130100774BA"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2014\/1049"],"award-info":[{"award-number":["PICT 2014\/1049"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.572178","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T04:43:27Z","timestamp":1600922607000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["IL-10-Dependent and -Independent Mechanisms Are Involved in the Cardiac Pathology Modulation Mediated by Fenofibrate in an Experimental Model of Chagas Heart Disease"],"prefix":"10.3389","volume":"11","author":[{"given":"Jimena","family":"Rada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mart\u00edn","family":"Donato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico N.","family":"Penas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catalina","family":"Alba Soto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1gata C.","family":"Cevey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azul V.","family":"Pieralisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Gelpi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerardo A.","family":"Mirkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora B.","family":"Goren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1590\/S0074-02762009000900031","article-title":"Innate immunity and regulatory T-cells in human chagas disease: what must be understood?","volume":"104","author":"Sathler-Avelar","year":"2009","journal-title":"Mem Inst Oswaldo Cruz."},{"key":"B2","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/nm.4023","article-title":"Killer lymphocytes use granulysin, perforin and granzymes to kill intracellular parasites.","volume":"22","author":"Dotiwala","year":"2016","journal-title":"Nat Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.imbio.2016.08.007","article-title":"MIF-driven activation of macrophages induces killing of intracellular Trypanosoma cruzi dependent on endogenous production of tumor necrosis factor, nitric oxide and reactive oxygen species.","volume":"222","author":"Cutrullis","year":"2017","journal-title":"Immunobiology."},{"key":"B4","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1111\/j.1365-2567.2007.02677.x","article-title":"B cells modulate T cells so as to favour T helper type 1 and CD8 + T-cell responses in the acute phase of Trypanosoma cruzi infection.","volume":"122","author":"Cardillo","year":"2007","journal-title":"Immunology."},{"key":"B5","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.coi.2009.07.006","article-title":"CD8+ T cells in Trypanosoma cruzi infection.","volume":"21","author":"Padilla","year":"2009","journal-title":"Curr Opin Immunol."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007410","article-title":"Highly competent, non-exhausted CD8+ T cells continue to tightly control pathogen load throughout chronic Trypanosoma cruzi infection.","volume":"14","author":"Pack","year":"2018","journal-title":"PLoS Pathog."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2019.105168","article-title":"Immunity and vaccine development efforts against Trypanosoma cruzi.","volume":"200","author":"Rios","year":"2019","journal-title":"Acta Trop."},{"key":"B8","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1086\/314889","article-title":"Parasite persistence correlates with disease severity and localization in chronic chagas\u2019 disease.","volume":"180","author":"Zhang","year":"1999","journal-title":"J Infect Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/S0020-7519(01)00158-8","article-title":"Parasite persistence in the aetiology of Chagas disease.","volume":"31","author":"Tarleton","year":"2001","journal-title":"Int. J. Parasitol."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01856","article-title":"Correlation of parasite burden, kDNA integration, autoreactive antibodies, and cytokine pattern in the pathophysiology of chagas disease.","volume":"10","author":"Wesley","year":"2019","journal-title":"Front Microbiol."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01242-20","article-title":"In Vivo analysis of Trypanosoma cruzi persistence foci at single-cell resolution.","volume":"11","author":"Ward","year":"2020","journal-title":"MBio."},{"key":"B12","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/j.pt.2019.08.006","article-title":"Understanding CD8+ T cell immunity to trypanosoma cruzi and how to improve it.","volume":"35","author":"Acosta Rodr\u00edguez","year":"2019","journal-title":"Trends Parasitol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"82","DOI":"10.15420\/ecr.2018.30.2","article-title":"Chagas disease and heart failure: an expanding issue worldwide.","volume":"14","author":"Martinez","year":"2019","journal-title":"Eur Cardiol Rev."},{"key":"B14","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1146\/annurev-pathol-020117-043711","article-title":"Pathology and pathogenesis of chagas heart disease.","volume":"14","author":"Bonney","year":"2019","journal-title":"Annu Rev Pathol Mech Dis."},{"key":"B15","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1161\/CIRCRESAHA.117.310221","article-title":"Inflammatory cardiomyopathic syndromes.","volume":"121","author":"Trachtenberg","year":"2017","journal-title":"Circ Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/S0140-6736(17)31612-4","article-title":"Chagas disease.","volume":"391","author":"P\u00e9rez-Molina","year":"2018","journal-title":"Lancet."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00153-13","article-title":"Matrix metalloproteinases 2 and 9 are differentially expressed in patients with indeterminate and cardiac clinical forms of chagas disease.","volume":"81","author":"Fares","year":"2013","journal-title":"Infect Immun."},{"key":"B18","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/J.TCM.2016.08.003","article-title":"Molecular mechanisms of cardiac electromechanical remodeling during chagas disease: role of TNF and TGF-\u03b2.","volume":"27","author":"Cruz","year":"2017","journal-title":"Trends Cardiovasc Med."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006589","article-title":"Innate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patients.","volume":"12","author":"Pereira","year":"2018","journal-title":"PLoS Negl Trop Dis."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01921","article-title":"New insights into the immunobiology of mononuclear phagocytic cells and their relevance to the pathogenesis of cardiovascular diseases.","volume":"8","author":"Sanmarco","year":"2018","journal-title":"Front Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","article-title":"IL-17 and Th17 Cells.","volume":"27","author":"Korn","year":"2009","journal-title":"Annu Rev Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.it.2017.01.006","article-title":"IL-17 signaling: the yin and the yang.","volume":"38","author":"Amatya","year":"2017","journal-title":"Trends Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1002\/eji.201646710","article-title":"The IL\u201310\/STAT3 axis: Contributions to immune tolerance by thymus and peripherally derived regulatory T-cells.","volume":"47","author":"Schmetterer","year":"2017","journal-title":"Eur J Immunol."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/613864","article-title":"Nuclear control of the inflammatory response in mammals by peroxisome proliferator-activated receptors.","volume":"2013","author":"Mandard","year":"2013","journal-title":"PPAR Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.bj.2019.05.008","article-title":"Regulatory functions of B cells and regulatory plasma cells.","volume":"42","author":"Fillatreau","year":"2019","journal-title":"Biomed J."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1007\/s00296-019-04317-5","article-title":"Interleukin-17 pathways in systemic sclerosis-associated fibrosis.","volume":"39","author":"Ahmed","year":"2019","journal-title":"Rheumatol Int."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-38811-4","article-title":"Interleukin 17A promotes diabetic kidney injury.","volume":"9","author":"Ma","year":"2019","journal-title":"Sci Rep."},{"key":"B28","doi-asserted-by":"publisher","first-page":"389","DOI":"10.21037\/atm.2019.07.100","article-title":"The expression and clinical significance of serum IL-17 in patients with primary biliary cirrhosis.","volume":"7","author":"Sun","year":"2019","journal-title":"Ann Transl Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/J.YJMCC.2018.08.005","article-title":"Interleukin-17 enhances cardiac ventricular remodeling via activating MAPK pathway in ischemic heart failure.","volume":"122","author":"Chang","year":"2018","journal-title":"J Mol Cell Cardiol."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2019.109445","article-title":"Interleukin-10 induces senescence of activated hepatic stellate cells via STAT3-p53 pathway to attenuate liver fibrosis.","volume":"66","author":"Huang","year":"2020","journal-title":"Cell Signal."},{"key":"B31","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1089\/wound.2011.0307","article-title":"Regulation of macrophage polarization and wound healing.","volume":"1","author":"Ferrante","year":"2012","journal-title":"Adv Wound Care."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.117.006040","article-title":"Interleukin 10 treatment ameliorates high-fat diet-induced inflammatory atrial remodeling and fibrillation.","volume":"11","author":"Kondo","year":"2018","journal-title":"Circ Arrhythm Electrophysiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/j.imbio.2015.01.013","article-title":"The adult murine heart has a sparse, phagocytically active macrophage population that expands through monocyte recruitment and adopts an \u201cM2\u201d phenotype in response to Th2 immunologic challenge.","volume":"220","author":"Mylonas","year":"2015","journal-title":"Immunobiology."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-017-0622-5","article-title":"IL-10 improves cardiac remodeling after myocardial infarction by stimulating M2 macrophage polarization and fibroblast activation.","volume":"112","author":"Jung","year":"2017","journal-title":"Basic Res Cardiol."},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/FIMMU.2019.01257","article-title":"Betulinic acid derivative BA5, attenuates inflammation and fibrosis in experimental chronic chagas disease cardiomyopathy by inducing IL-10 and M2 polarization.","volume":"10","author":"Meira","year":"2019","journal-title":"Front Immunol."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079445","article-title":"IL-10 inhibits the NF-\u03baB and ERK\/MAPK-mediated production of pro-inflammatory mediators by up-regulation of SOCS-3 in Trypanosoma cruzi-infected cardiomyocytes.","volume":"8","author":"Hovsepian","year":"2013","journal-title":"PLoS One."},{"key":"B37","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1210\/er.2018-00064","article-title":"Molecular actions of PPAR\u03b1 in lipid metabolism and inflammation.","volume":"39","author":"Bougarne","year":"2018","journal-title":"Endocr Rev."},{"key":"B38","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.ijpddr.2017.10.003","article-title":"Treatment with Fenofibrate plus a low dose of Benznidazole attenuates cardiac dysfunction in experimental chagas disease.","volume":"7","author":"Cevey","year":"2017","journal-title":"Int J Parasitol Drugs Drug Resist."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1172\/JCI118861","article-title":"Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4+Th1-like responses.","volume":"98","author":"Berg","year":"1996","journal-title":"J Clin Invest."},{"key":"B40","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/0001-706X(93)90075-M","article-title":"In vivo macrophage function in experimental infection with Trypanosoma cruzi subpopulations.","volume":"55","author":"Celentano","year":"1993","journal-title":"Acta Trop."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1590\/S0074-02762009000700021","article-title":"A new consensus for Trypanosoma cruzi intraspecific nomenclature: second revision meeting recommends TcI to TcVI.","volume":"9","author":"Zingales","year":"2009","journal-title":"Mem Inst Oswaldo Cruz."},{"key":"B42","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1128\/JCM.18.2.327-330.1983","article-title":"Direct micromethod for diagnosis of acute and congenital Chagas\u2019 disease.","volume":"18","author":"Feilij","year":"1983","journal-title":"J Clin Microbiol."},{"key":"B43","first-page":"119","article-title":"Observations on immunity to superinfections in mice experimentally inoculated with Trypanosoma cruzi and subjected to treatment.","volume":"4","author":"Brener","year":"1962","journal-title":"Rev Inst Med Trop Sao Paulo."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1161\/01.CIR.58.6.1072","article-title":"Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.","volume":"78","author":"Sahn","year":"1978","journal-title":"Circulation."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1006\/2000.1215","article-title":"CTGF expression is induced by TGF-in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis.","volume":"32","author":"Chen","year":"2000","journal-title":"J Mol Cell Cardiol."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2015.1100356","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).","volume":"12","author":"Klionsky","year":"2016","journal-title":"Autophagy."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02791","article-title":"Disease tolerance and pathogen resistance genes may underlie trypanosoma cruzi persistence and differential progression to chagas disease cardiomyopathy.","volume":"9","author":"Chevillard","year":"2018","journal-title":"Front Immunol."},{"key":"B48","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s40588-018-0081-2","article-title":"Pathogenesis of chronic chagas disease: macrophages, mitochondria, and oxidative stress.","volume":"5","author":"Lopez","year":"2018","journal-title":"Curr Clin Microbiol Rep."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1056\/NEJMoa1507574","article-title":"Randomized trial of benznidazole for chronic Chagas\u2019 cardiomyopathy.","volume":"373","author":"Morillo","year":"2015","journal-title":"N Engl J Med."},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004343","article-title":"The BENEFIT trial: where do we go from here?","volume":"10","author":"Pecoul","year":"2016","journal-title":"PLoS Negl Trop Dis."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.4269\/ajtmh.16-0761","article-title":"Experimental and clinical treatment of chagas disease: a review.","volume":"97","author":"Sales Junior","year":"2017","journal-title":"Am J Trop Med Hyg."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065820","article-title":"Analysis of the dynamics of infiltrating CD4+ T cell subsets in the heart during experimental trypanosoma cruzi infection.","volume":"8","author":"Sanoja","year":"2013","journal-title":"PLoS One."},{"key":"B53","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1590\/0074-0276140033","article-title":"Severity of chronic experimental Chagas\u2019 heart disease parallels tumour necrosis factor and nitric oxide levels in the serum: models of mild and severe disease.","volume":"109","author":"Pereira","year":"2014","journal-title":"Mem Inst Oswaldo Cruz."},{"key":"B54","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1007\/s00395-009-0776-x","article-title":"Changes in cellular contractility and cytokines profile during Trypanosoma cruzi infection in mice.","volume":"104","author":"Roman-Campos","year":"2009","journal-title":"Basic Res Cardiol."},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/683230","article-title":"Chagas disease cardiomyopathy: Immunopathology and genetics.","volume":"2014","author":"Cunha-Neto","year":"2014","journal-title":"Mediators Inflamm."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/914326","article-title":"Myocardial gene expression of T-bet, GATA-3, Ror-\u03b3 t, FoxP3, and hallmark cytokines in chronic Chagas disease cardiomyopathy: An essentially unopposed T-Type response.","volume":"2014","author":"Nogueira","year":"2014","journal-title":"Mediators Inflamm."},{"key":"B57","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.ijcard.2015.07.040","article-title":"Inflammatory and cardiac biomarkers are differentially expressed in clinical stages of Chagas disease.","volume":"199","author":"Keating","year":"2015","journal-title":"Int J Cardiol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1159\/000491699","article-title":"Dysregulated network of immune, endocrine and metabolic markers is associated to more severe human chronic chagas cardiomyopathy.","volume":"25","author":"Gonz\u00e1lez","year":"2018","journal-title":"Neuroimmunomodulation."},{"key":"B59","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/J.CYTO.2012.04.035","article-title":"Genetic susceptibility to chronic Chagas disease: an overview of single nucleotide polymorphisms of cytokine genes.","volume":"59","author":"Vasconcelos","year":"2012","journal-title":"Cytokine."},{"key":"B60","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.ijpara.2010.12.002","article-title":"Modulation of inflammatory response and parasitism by 15-Deoxy-\u0394(12,14) prostaglandin J(2) in Trypanosoma cruzi-infected cardiomyocytes.","volume":"41","author":"Hovsepian","year":"2011","journal-title":"Int J Parasitol."},{"key":"B61","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.bbadis.2012.08.007","article-title":"PPAR\u03b3 ligand treatment inhibits cardiac inflammatory mediators induced by infection with different lethality strains of Trypanosoma cruzi.","volume":"1832","author":"Penas","year":"2013","journal-title":"Biochim Biophys Acta Mol Basis Dis."},{"key":"B62","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.bbadis.2014.12.019","article-title":"Treatment in vitro with PPAR\u03b1 and PPAR\u03b3 ligands drives M1-to-M2 polarization of macrophages from T. cruzi-infected mice.","volume":"1852","author":"Penas","year":"2015","journal-title":"Biochim Biophys Acta."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01738","article-title":"Treatment with a new peroxisome proliferator-activated receptor gamma agonist, pyridinecarboxylic acid derivative, increases angiogenesis and reduces inflammatory mediators in the heart of trypanosoma cruzi-infected mice.","volume":"8","author":"Penas","year":"2017","journal-title":"Front Immunol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"5283","DOI":"10.1128\/IAI.72.9.5283-5291.2004","article-title":"Monocytes from patients with indeterminate and cardiac forms of Chagas\u2019 disease display distinct phenotypic and functional characteristics associated with morbidity.","volume":"72","author":"Souza","year":"2004","journal-title":"Infect Immun."},{"key":"B65","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1086\/596061","article-title":"Functional IL\u221210 gene polymorphism is associated with chagas disease cardiomyopathy.","volume":"199","author":"Costa","year":"2009","journal-title":"J Infect Dis."},{"key":"B66","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nrneph.2016.48","article-title":"TGF-\u03b2: The master regulator of fibrosis.","volume":"12","author":"Meng","year":"2016","journal-title":"Nat Rev Nephrol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/J.MAM.2018.07.001","article-title":"Cardiac fibrosis: cell biological mechanisms, molecular pathways and therapeutic opportunities.","volume":"65","author":"Frangogiannis","year":"2019","journal-title":"Mol Aspects Med."},{"key":"B68","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1161\/hc3401.093154","article-title":"Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor.","volume":"104","author":"Sivasubramanian","year":"2001","journal-title":"Circulation."},{"key":"B69","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1111\/j.1365-2567.2008.02826.x","article-title":"The immunomodulatory glycan LNFPIII initiates alternative activation of murine macrophages in vivo.","volume":"125","author":"Atochina","year":"2008","journal-title":"Immunology."},{"key":"B70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.exppara.2017.03.008","article-title":"Dual genetic absence of STAT6 and IL-10 does not abrogate anti-hyperglycemic effects of Schistosoma mansoni in streptozotocin-treated diabetic mice.","volume":"177","author":"Osada","year":"2017","journal-title":"Exp Parasitol."},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PNTD.0007602","article-title":"TGF-\u03b2 inhibitor therapy decreases fibrosis and stimulates cardiac improvement in a pre-clinical study of chronic Chagas\u2019 heart disease.","volume":"13","author":"Ferreira","year":"2019","journal-title":"PLoS Negl Trop Dis."},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1111\/sji.12650","article-title":"Alternative Th17 and CD4 + CD25 + FoxP3 + cell frequencies increase and correlate with worse cardiac function in Chagas cardiomyopathy.","volume":"87","author":"Almeida","year":"2018","journal-title":"Scand J Immunol."},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172833","article-title":"The role of interleukin 17-mediated immune response in Chagas disease: high level is correlated with better left ventricular function.","volume":"12","author":"Sousa","year":"2017","journal-title":"PLoS One."},{"key":"B74","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1053\/J.GASTRO.2007.03.113","article-title":"Fenofibrate represses interleukin-17 and interferon-\u03b3 expression and improves colitis in interleukin-10\u2013deficient mice.","volume":"133","author":"Lee","year":"2007","journal-title":"Gastroenterology."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/145654","article-title":"Fenofibrate inhibited the differentiation of T helper 17 cells In Vitro.","volume":"2012","author":"Zhou","year":"2012","journal-title":"PPAR Res."},{"key":"B76","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/J.YEXCR.2018.12.005","article-title":"PPAR\u03b1 suppresses Th17 cell differentiation through IL-6\/STAT3\/ROR\u03b3t pathway in experimental autoimmune myocarditis.","volume":"375","author":"Chang","year":"2019","journal-title":"Exp Cell Res."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/529035","article-title":"Fenofibrate enhances the In Vitro differentiation of regulatory T cells in mice.","volume":"2012","author":"Zhou","year":"2012","journal-title":"PPAR Res."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.572178\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T04:43:33Z","timestamp":1600922613000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.572178\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,24]]},"references-count":77,"alternative-id":["10.3389\/fimmu.2020.572178"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.572178","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,24]]},"article-number":"572178"}}