{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:51:17Z","timestamp":1787068277223,"version":"build-2736575974"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.574212","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T03:02:01Z","timestamp":1599620521000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Influence of Experimental Autoimmune Prostatitis on Sexual Function and the Anti-inflammatory Efficacy of Celecoxib in a Rat Model"],"prefix":"10.3389","volume":"11","author":[{"given":"Yadong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuikui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingkuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangzhou","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.eururo.2015.08.061","article-title":"Contemporary management of chronic prostatitis\/chronic pelvic pain syndrome.","volume":"69","author":"Magistro","year":"2016","journal-title":"Eur Urol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1046\/j.1464-410x.2001.02259.x","article-title":"Fears, sexual disturbances and personality features in men with prostatitis: a population-based cross-sectional study in Finland.","volume":"88","author":"Mehik","year":"2001","journal-title":"BJU Int."},{"key":"B3","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.urology.2005.04.050","article-title":"Quality of life and psychological factors in chronic prostatitis\/chronic pelvic pain syndrome.","volume":"66","author":"Ku","year":"2005","journal-title":"Urology."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153054","article-title":"Erectile dysfunction in chronic prostatitis\/chronic pelvic pain syndrome: outcomes from a multi-center study and risk factor analysis in a single center.","volume":"11","author":"Zhang","year":"2016","journal-title":"PLoS One."},{"key":"B5","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/j.urology.2010.01.061","article-title":"Prevalence of premature ejaculation and its correlation with chronic prostatitis in Chinese men.","volume":"76","author":"Liang","year":"2010","journal-title":"Urology."},{"key":"B6","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.jpsychores.2014.09.012","article-title":"Assessing psychological factors, social aspects and psychiatric co-morbidity associated with chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS) in men\u2013a systematic review.","volume":"77","author":"Riegel","year":"2014","journal-title":"J Psychosom Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1007\/s00345-013-1121-4","article-title":"Understanding chronic prostatitis\/chronic pelvic pain syndrome (CP\/CPPS).","volume":"31","author":"Nickel","year":"2013","journal-title":"World J Urol."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00898","article-title":"Immunological mechanisms underlying chronic pelvic pain and prostate inflammation in chronic pelvic pain syndrome.","volume":"8","author":"Breser","year":"2017","journal-title":"Front Immunol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1600-0897.1985.tb00260.x","article-title":"Experimental autoimmunity to rat male accessory glands (MAG).","volume":"7","author":"Depiante-Depaoli","year":"1985","journal-title":"Am J Reprod Immunol Microbiol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/s0022-5347(17)32871-9","article-title":"Development of a mouse model for nonbacterial prostatitis.","volume":"152","author":"Keetch","year":"1994","journal-title":"J Urol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1006\/clin.1997.4427","article-title":"Inflammatory cells and MHC class II antigens expression in prostate during time-course experimental autoimmune prostatitis development.","volume":"85","author":"Donadio","year":"1997","journal-title":"Clin Immunol Immunopathol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1006\/clim.2002.5281","article-title":"Prostatein or steroid binding protein (PSBP) induces experimental autoimmune prostatitis (EAP) in NOD mice.","volume":"105","author":"Rivero","year":"2002","journal-title":"Clin Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.biopha.2017.05.004","article-title":"Establishment of a rat model of chronic Prostatitis\/Chronic Pelvic Pain Syndrome (CP\/CPPS) induced by immunization with a novel peptide T2.","volume":"91","author":"Ihsan","year":"2017","journal-title":"Biomed Pharmacother."},{"key":"B14","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1111\/j.1365-3083.2007.01971.x","article-title":"Autoimmune prostatitis: state of the art.","volume":"66","author":"Motrich","year":"2007","journal-title":"Scand J Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"R1268","DOI":"10.1152\/ajpregu.00836.2007","article-title":"Experimental autoimmune prostatitis induces chronic pelvic pain.","volume":"294","author":"Rudick","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.phrs.2015.11.012","article-title":"In vitro pharmacological evaluation of multitarget agents for thromboxane prostanoid receptor antagonism and COX-2 inhibition.","volume":"103","author":"Hoxha","year":"2016","journal-title":"Pharmacol Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1590\/s0100-879x2009005000021","article-title":"Celecoxib reduces symptoms in men with difficult chronic pelvic pain syndrome (Category IIIA).","volume":"42","author":"Zhao","year":"2009","journal-title":"Braz J Med Biol Res."},{"key":"B18","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1001\/jama.2010.1913","article-title":"Management of chronic prostatitis\/chronic pelvic pain syndrome: a systematic review and network meta-analysis.","volume":"305","author":"Anothaisintawee","year":"2011","journal-title":"JAMA."},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1515\/jcim-2019-0016","article-title":"Celecoxib, ibuprofen, and indomethacin alleviate depression-like behavior induced by interferon-alfa in mice.","volume":"17","author":"Mesripour","year":"2019","journal-title":"J Complement Integr Med."},{"key":"B20","first-page":"205","article-title":"Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce suicidal ideation and depression.","volume":"28","author":"Lehrer","year":"2019","journal-title":"Discov Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.neubiorev.2006.01.001","article-title":"Serotonin and the neurobiology of the ejaculatory threshold.","volume":"30","author":"de Jong","year":"2006","journal-title":"Neurosci Biobehav Rev."},{"key":"B22","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.eururo.2013.08.018","article-title":"Results from a prospective observational study of men with premature ejaculation treated with dapoxetine or alternative care: the PAUSE study.","volume":"65","author":"Mirone","year":"2014","journal-title":"Eur Urol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.biopsych.2008.07.014","article-title":"Vaccination as a novel approach for treating depressive behavior.","volume":"65","author":"Lewitus","year":"2009","journal-title":"Biol Psychiatry."},{"key":"B24","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0022-5347(05)66153-8","article-title":"Cell relationship in a Wistar rat model of spontaneous prostatitis.","volume":"166","author":"Keith","year":"2001","journal-title":"J Urol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.yexmp.2004.02.004","article-title":"Matrix metalloproteinases in the pathogenesis of estradiol-induced nonbacterial prostatitis in the lateral prostate lobe of the Wistar rat.","volume":"77","author":"Wilson","year":"2004","journal-title":"Exp Mol Pathol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.urology.2005.06.070","article-title":"Evaluation of two techniques of partial urethral obstruction in the male rat model of bladder outlet obstruction.","volume":"66","author":"Melman","year":"2005","journal-title":"Urology."},{"key":"B27","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1002\/pros.22580","article-title":"Evidences of the inflammasome pathway in chronic prostatitis and chronic pelvic pain syndrome in an animal model.","volume":"73","author":"Chen","year":"2013","journal-title":"Prostate."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1016\/j.juro.2009.07.067","article-title":"T-cell recognition of prostatic peptides in men with chronic prostatitis\/chronic pelvic pain syndrome.","volume":"182","author":"Kouiavskaia","year":"2009","journal-title":"J Urol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jinf.2005.11.007","article-title":"Chlamydia trachomatis occurrence and its impact on sperm quality in chronic prostatitis patients.","volume":"53","author":"Motrich","year":"2006","journal-title":"J Infect."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1016\/j.biopha.2018.10.010","article-title":"Experimental rodent models of chronic prostatitis and evaluation criteria.","volume":"108","author":"Wang","year":"2018","journal-title":"Biomed Pharmacother."},{"key":"B31","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.2147\/NDT.S211288","article-title":"Microglial activation and neurobiological alterations in experimental autoimmune prostatitis-induced depressive-like behavior in mice.","volume":"15","author":"Du","year":"2019","journal-title":"Neuropsychiatr Dis Treat."},{"key":"B32","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/0149-7634(81)90005-1","article-title":"Acute and chronic stress effects on open field activity in the rat: implications for a model of depression.","volume":"5","author":"Katz","year":"1981","journal-title":"Neurosci Biobehav Rev."},{"key":"B33","doi-asserted-by":"publisher","first-page":"S14","DOI":"10.1038\/sj.ijir.3901330","article-title":"Psychopharmacology of male rat sexual behavior: modeling human sexual dysfunctions.","volume":"18","author":"Olivier","year":"2006","journal-title":"Int J Impot Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.mehy.2004.10.020","article-title":"Male reproductive physiology as a sexually selected handicap? Erectile dysfunction is correlated with general health and health prognosis and may have evolved as a marker of poor phenotypic quality.","volume":"65","author":"Cellerino","year":"2005","journal-title":"Med Hypotheses."},{"key":"B35","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0022-5347(05)67497-6","article-title":"IL-1beta and TNF-alpha in prostatic secretions are indicators in the evaluation of men with chronic prostatitis.","volume":"164","author":"Nadler","year":"2000","journal-title":"J Urol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/s0090-4295(98)00390-2","article-title":"Elevated levels of proinflammatory cytokines in the semen of patients with chronic prostatitis\/chronic pelvic pain syndrome.","volume":"52","author":"Alexander","year":"1998","journal-title":"Urology."},{"key":"B37","doi-asserted-by":"publisher","first-page":"521","DOI":"10.3109\/21681805.2013.769460","article-title":"Assessing chronic pelvic pain syndrome patients: blood plasma factors and cortisol saliva.","volume":"47","author":"Lundh","year":"2013","journal-title":"Scand J Urol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.jad.2011.02.024","article-title":"Association of the C(-1019)G 5-HT1A promoter polymorphism with exposure to stressors preceding hospitalization for bipolar depression.","volume":"132","author":"Benedetti","year":"2011","journal-title":"J Affect Disord."},{"key":"B39","first-page":"681","article-title":"Central regulation of ejaculation and the therapeutic role of serotonergic agents in premature ejaculation.","volume":"10","author":"Patel","year":"2009","journal-title":"Curr Opin Investig Drugs."},{"key":"B40","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/s0304-3959(02)00026-x","article-title":"Expression of 5-HT1A receptor mRNA in rat lumbar spinal dorsal horn neurons after peripheral inflammation.","volume":"98","author":"Zhang","year":"2002","journal-title":"Pain."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pneurobio.2008.01.004","article-title":"Neurotransmitter, peptide and cytokine processes in relation to depressive disorder: comorbidity between depression and neurodegenerative disorders.","volume":"85","author":"Anisman","year":"2008","journal-title":"Prog Neurobiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"2121","DOI":"10.1038\/sj.npp.130102","article-title":"The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters.","volume":"31","author":"Zhu","year":"2006","journal-title":"Neuropsychopharmacology."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.574212\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T03:02:03Z","timestamp":1599620523000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.574212\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,9]]},"references-count":42,"alternative-id":["10.3389\/fimmu.2020.574212"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.574212","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,9]]},"article-number":"574212"}}