{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:59:57Z","timestamp":1793048397073,"version":"4.5.0"},"reference-count":92,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK091658, R01 DK098589, R01 DE027301 , R01 AI133623 , T32 DK108736, P01 AI42288"],"award-info":[{"award-number":["R01 DK091658, R01 DK098589, R01 DE027301 , R01 AI133623 , T32 DK108736, P01 AI42288"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.574447","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T05:29:03Z","timestamp":1603344543000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Immunomodulatory Dual-Sized Microparticle System Conditions Human Antigen Presenting Cells Into a Tolerogenic Phenotype In Vitro and Inhibits Type 1 Diabetes-Specific Autoreactive T Cell Responses"],"prefix":"10.3389","volume":"11","author":[{"given":"Maigan A.","family":"Brusko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L.","family":"Posgai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clive H.","family":"Wasserfall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd M.","family":"Brusko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin G.","family":"Keselowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s11892-015-0689-z","article-title":"Molecular Interactions Governing Autoantigen Presentation in Type 1 Diabetes","volume":"15","author":"Nakayama","year":"2015","journal-title":"Curr Diabetes Rep"},{"key":"B2","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/9780470697405.ch7","article-title":"Type 1 diabetes: chronic progressive autoimmune disease","volume":"292","author":"Zhang","year":"2008","journal-title":"Novartis Found Symp"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61309-4","article-title":"Nasal insulin to prevent type 1 diabetes in children with HLA genotypes and autoantibodies conferring increased risk of disease: a double-blind, randomised controlled trial","volume":"372","author":"N\u00e4nt\u00f6-Salonen","year":"2008","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.2928","article-title":"Effects of high-dose oral insulin on immune responses in children at high risk for type 1 diabetes: the Pre-POINT randomized clinical trial","volume":"313","author":"Bonifacio","year":"2015","journal-title":"JAMA"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0523","article-title":"Groups D-aTS: Long-term outcome of individuals treated with oral insulin: diabetes prevention trial-type 1 (DPT-1) oral insulin trial","volume":"34","author":"Vehik","year":"2011","journal-title":"Diabetes Care"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.17070","article-title":"Group WCftTDTOIS: Effect of Oral Insulin on Prevention of Diabetes in Relatives of Patients With Type 1 Diabetes: A Randomized Clinical Trial","volume":"318","author":"Krischer","year":"2017","journal-title":"JAMA"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142318","article-title":"Immune Depletion in Combination with Allogeneic Islets Permanently Restores Tolerance to Self-Antigens in Diabetic NOD Mice","volume":"10","author":"Gagliani","year":"2015","journal-title":"PLoS One"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0236","article-title":"Teplizumab preserves C-peptide in recent-onset type 1 diabetes: two-year results from the randomized, placebo-controlled Prot\u00e9g\u00e9 trial","volume":"62","author":"Hagopian","year":"2013","journal-title":"Diabetes"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.9b00707","article-title":"Anti-CD3 Antibody for the Prevention of Type 1 Diabetes: A Story of Perseverance","volume":"58","author":"Gaglia","year":"2019","journal-title":"Biochemistry"},{"key":"B10","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41435-018-0032-1","article-title":"Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes","volume":"20","author":"Linsley","year":"2019","journal-title":"Genes Immun"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(13)70065-2","article-title":"Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial","volume":"1","author":"Gitelman","year":"2013","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI78492","article-title":"Anti-thymocyte globulin\/G-CSF treatment preserves \u03b2 cell function in patients with established type 1 diabetes","volume":"125","author":"Haller","year":"2015","journal-title":"J Clin Invest"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.2337\/db16-0823","article-title":"Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes","volume":"65","author":"Haller","year":"2016","journal-title":"Diabetes"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-0494","article-title":"Low-Dose Anti-Thymocyte Globulin (ATG) Preserves \u03b2-Cell Function and Improves HbA","volume":"41","author":"Haller","year":"2018","journal-title":"Diabetes Care"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.10.009","article-title":"Immunotherapy for Type 1 Diabetes: Why Do Current Protocols Not Halt the Underlying Disease Process","volume":"25","author":"Kolb","year":"2017","journal-title":"Cell Metab"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2006.09.013","article-title":"Moving towards efficient therapies in type 1 diabetes: to combine or not to combine","volume":"6","author":"Bresson","year":"2007","journal-title":"Autoimmun Rev"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.2337\/db10-0630","article-title":"Antigen-specific immunotherapy for type 1 diabetes: maximizing the potential","volume":"59","author":"Peakman","year":"2010","journal-title":"Diabetes"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04153.x","article-title":"Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN-JDRF Type 1 Diabetes Combination Therapy Assessment Group","volume":"160","author":"Matthews","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"89","DOI":"10.17925\/EE.2016.12.02.89","article-title":"Updates on Immune Therapies in Type 1 Diabetes","volume":"12","author":"Nambam","year":"2016","journal-title":"Eur Endocrinol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.clim.2015.03.023","article-title":"A combination dual-sized microparticle system modulates dendritic cells and prevents type 1 diabetes in prediabetic NOD mice","volume":"160","author":"Lewis","year":"2015","journal-title":"Clin Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b00332","article-title":"Dual-Sized Microparticle System for Generating Suppressive Dendritic Cells Prevents and Reverses Type 1 Diabetes in the Nonobese Diabetic Mouse Model","volume":"5","author":"Lewis","year":"2019","journal-title":"ACS Biomater Sci Eng"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.12.001","article-title":"Dendritic cell subsets and type I diabetes: focus upon DC-based therapy","volume":"5","author":"Lo","year":"2006","journal-title":"Autoimmun Rev"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00148","article-title":"Tolerogenic Dendritic Cells and T-Regulatory Cells at the Clinical Trials Crossroad for the Treatment of Autoimmune Disease; Emphasis on Type 1 Diabetes Therapy","volume":"10","author":"Phillips","year":"2019","journal-title":"Front Immunol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/nm.3044","article-title":"Initiating type I diabetes: new suspects in the lineup","volume":"19","author":"Creusot","year":"2013","journal-title":"Nat Med"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1039\/C3TB21460E","article-title":"Combinatorial delivery of immunosuppressive factors to dendritic cells using dual-sized microspheres","volume":"2","author":"Lewis","year":"2014","journal-title":"J Mater Chem B"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e66","DOI":"10.1038\/cti.2016.6","article-title":"Targeting dendritic cells: a promising strategy to improve vaccine effectiveness","volume":"5","author":"Macri","year":"2016","journal-title":"Clin Transl Immunol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2016.09.002","article-title":"Migration of dendritic cells to the lymph nodes and its enhancement to drive anti-tumor responses","volume":"107","author":"Seyfizadeh","year":"2016","journal-title":"Crit Rev Oncol Hematol"},{"key":"B28","article-title":"Dendritic cell mediated therapy for immunoregulation of type 1 diabetes mellitus","volume":"5","author":"Phillips","year":"2008","journal-title":"Pediatr Endocrinol Rev"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089503","article-title":"Dynamic visualization of dendritic cell-antigen interactions in the skin following transcutaneous immunization","volume":"9","author":"Rattanapak","year":"2014","journal-title":"PLoS One"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2004.09.010","article-title":"DNA-loaded biodegradable microparticles as vaccine delivery systems and their interaction with dendritic cells","volume":"57","author":"Jilek","year":"2005","journal-title":"Adv Drug Deliv Rev"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2003.12.032","article-title":"Characterization of poly(D,L-lactic-co-glycolic acid) based nanoparticulate system for enhanced delivery of antigens to dendritic cells","volume":"22","author":"Elamanchili","year":"2004","journal-title":"Vaccine"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2008.10.011","article-title":"Delivery of rapamycin to dendritic cells using degradable microparticles","volume":"133","author":"Jhunjhunwala","year":"2009","journal-title":"J Control Release"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2016.135","article-title":"Improving the efficacy and safety of biologic drugs with tolerogenic nanoparticles","volume":"11","author":"Kishimoto","year":"2016","journal-title":"Nat Nanotechnol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/polb.22259","article-title":"Biomedical Applications of Biodegradable Polymers","volume":"49","author":"Ulery","year":"2011","journal-title":"J Polym Sci B Polym Phys"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2005.10.032","article-title":"Encapsulation of proteins and peptides into biodegradable poly(D,L-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells","volume":"24","author":"Waeckerle-Men","year":"2006","journal-title":"Vaccine"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1039\/C5TB01754H","article-title":"A cell-based microarray to investigate combinatorial effects of microparticle-encapsulated adjuvants on dendritic cell activation","volume":"4","author":"Acharya","year":"2016","journal-title":"J Mater Chem B"},{"key":"B37","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1146\/annurev-immunol-032713-120257","article-title":"TGF-\u03b2 activation and function in immunity","volume":"32","author":"Travis","year":"2014","journal-title":"Annu Rev Immunol"},{"key":"B38","article-title":"Transforming growth factor beta inhibits the antigen-presenting functions and antitumor activity of dendritic cell vaccines","volume":"63","author":"Kobie","year":"2003","journal-title":"Cancer Res"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.8.5194","article-title":"Cutting edge: Autocrine TGF-beta sustains default tolerogenesis by IDO-competent dendritic cells","volume":"181","author":"Belladonna","year":"2008","journal-title":"J Immunol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/nri2095","article-title":"TGFbeta signalling in control of T-cell-mediated self-reactivity","volume":"7","author":"Rubtsov","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/nmat2357","article-title":"Infection-mimicking materials to program dendritic cells in situ","volume":"8","author":"Ali","year":"2009","journal-title":"Nat Mater"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2008.12.001","article-title":"Modulation of dendritic cells using granulocyte-macrophage colony-stimulating factor (GM-CSF) delays type 1 diabetes by enhancing CD4+CD25+ regulatory T cell function","volume":"131","author":"Cheatem","year":"2009","journal-title":"Clin Immunol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2010.04.001","article-title":"Vitamin D: modulator of the immune system","volume":"10","author":"Baeke","year":"2010","journal-title":"Curr Opin Pharmacol"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803345","article-title":"1,25-dihydroxyvitamin D3 is an autonomous regulator of the transcriptional changes leading to a tolerogenic dendritic cell phenotype","volume":"182","author":"Sz\u00e9les","year":"2009","journal-title":"J Immunol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200839103","article-title":"Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: differential role for PD-L1","volume":"39","author":"Unger","year":"2009","journal-title":"Eur J Immunol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.2013006782","article-title":"Infectious tolerance as candidate therapy for type 1 diabetes: transfer of immunoregulatory properties from human regulatory T cells to other T cells and proinflammatory dendritic cells","volume":"33","author":"Kleijwegt","year":"2013","journal-title":"Crit Rev Immunol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-71029-5_12","article-title":"Induction of tolerogenic dendritic cells by vitamin D receptor agonists","volume":"188","author":"Adorini","year":"2009","journal-title":"Handb Exp Pharmacol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00697","article-title":"Vitamin D in Autoimmunity: Molecular Mechanisms and Therapeutic Potential","volume":"7","author":"Dankers","year":"2016","journal-title":"Front Immunol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.07.015","article-title":"Significant vitamin D deficiency in youth with type 1 diabetes mellitus","volume":"154","author":"Svoren","year":"2009","journal-title":"J Pediatr"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0576","article-title":"Reduced serum vitamin D-binding protein levels are associated with type 1 diabetes","volume":"60","author":"Blanton","year":"2011","journal-title":"Diabetes"},{"key":"B51","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.biomaterials.2017.07.029","article-title":"An antigen-specific semi-therapeutic treatment with local delivery of tolerogenic factors through a dual-sized microparticle system blocks experimental autoimmune encephalomyelitis","volume":"143","author":"Cho","year":"2017","journal-title":"Biomaterials"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/cei.12656","article-title":"Factors impeding the discovery of an intervention-based treatment for type 1 diabetes","volume":"183","author":"von Herrath","year":"2016","journal-title":"Clin Exp Immunol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01313","article-title":"Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing","volume":"8","author":"Yeh","year":"2017","journal-title":"Front Immunol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1002\/cyto.a.21010","article-title":"Interpretation of cellular proliferation data: avoid the panglossian","volume":"79","author":"Roederer","year":"2011","journal-title":"Cytometry A"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.2337\/db17-0106","article-title":"Type 1 Interferons Potentiate Human CD8","volume":"66","author":"Newby","year":"2017","journal-title":"Diabetes"},{"key":"B56","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1111\/cei.12465","article-title":"Generation of beta cell-specific human cytotoxic T cells by lentiviral transduction and their survival in immunodeficient human leucocyte antigen-transgenic mice","volume":"179","author":"Babad","year":"2015","journal-title":"Clin Exp Immunol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-1785","article-title":"Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis","volume":"42","author":"Sharp","year":"2019","journal-title":"Diabetes Care"},{"key":"B58","doi-asserted-by":"publisher","first-page":"4529","DOI":"10.1038\/s41598-018-22574-5","article-title":"Application of a Genetic Risk Score to Racially Diverse Type 1 Diabetes Populations Demonstrates the Need for Diversity in Risk-Modeling","volume":"8","author":"Perry","year":"2018","journal-title":"Sci Rep"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.19.3.1864","article-title":"Telomerase activity is sufficient to allow transformed cells to escape from crisis","volume":"19","author":"Halvorsen","year":"1999","journal-title":"Mol Cell Biol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1288.015","article-title":"Cell-based therapies for diabetes: progress towards a transplantable human beta cell line","volume":"1005","author":"Itkin-Ansari","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102417","article-title":"Innate inflammation drives NK cell activation to impair Treg activity","volume":"108","author":"Dean","year":"2020","journal-title":"J Autoimmun"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2017.05.011","article-title":"Macrophage-specific nanotechnology-driven CD163 overexpression in human macrophages results in an M2 phenotype under inflammatory conditions","volume":"222","author":"Alvarado-Vazquez","year":"2017","journal-title":"Immunobiology"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2019.577079","article-title":"The change of PD1, PDL1 in experimental autoimmune encephalomyelitis treated by 1,25(OH)","volume":"338","author":"Cao","year":"2020","journal-title":"J Neuroimmunol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.337","article-title":"Rapamycin induces ILT3(high)ILT4(high) dendritic cells promoting a new immunoregulatory pathway","volume":"85","author":"Stallone","year":"2014","journal-title":"Kidney Int"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02627","article-title":"Synergistic Effects of Interferon-\u03b3 and Vitamin D","volume":"10","author":"\u0160vajger","year":"2019","journal-title":"Front Immunol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/ni1271","article-title":"The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity","volume":"6","author":"Zhu","year":"2005","journal-title":"Nat Immunol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20062175","article-title":"Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection","volume":"204","author":"Jankovic","year":"2007","journal-title":"J Exp Med"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/nri3307","article-title":"Transcriptional control of effector and memory CD8+ T cell differentiation","volume":"12","author":"Kaech","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/nri3862","article-title":"Molecular and cellular insights into T cell exhaustion","volume":"15","author":"Wherry","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-3274(03)00058-3","article-title":"High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells","volume":"11","author":"Manavalan","year":"2003","journal-title":"Transpl Immunol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-2044","article-title":"Expression of the inhibitory receptor ILT3 on dendritic cells is dispensable for induction of CD4+Foxp3+ regulatory T cells by 1,25-dihydroxyvitamin D3","volume":"106","author":"Penna","year":"2005","journal-title":"Blood"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-04-278739","article-title":"siRNA silencing of PD-L1 and PD-L2 on dendritic cells augments expansion and function of minor histocompatibility antigen-specific CD8+ T cells","volume":"116","author":"Hobo","year":"2010","journal-title":"Blood"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2019.09.008","article-title":"The B7x Immune Checkpoint Pathway: From Discovery to Clinical Trial","volume":"40","author":"John","year":"2019","journal-title":"Trends Pharmacol Sci"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.3.1257","article-title":"Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production","volume":"170","author":"Brown","year":"2003","journal-title":"J Immunol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.06.011","article-title":"Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells","volume":"41","author":"Wu","year":"2014","journal-title":"Immunity"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X657891","article-title":"Overexpression of galectin-9 in islets prolongs grafts survival via downregulation of Th1 responses","volume":"22","author":"Chou","year":"2013","journal-title":"Cell Transplant"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12500","article-title":"Up-regulation of galectin-9 induces cell migration in human dendritic cells infected with dengue virus","volume":"19","author":"Hsu","year":"2015","journal-title":"J Cell Mol Med"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00006","article-title":"TCR Signal Strength Alters T-DC Activation and Interaction Times and Directs the Outcome of Differentiation","volume":"7","author":"van Panhuys","year":"2016","journal-title":"Front Immunol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1801609","article-title":"TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2","volume":"202","author":"Kotov","year":"2019","journal-title":"J Immunol"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2014.09.022","article-title":"The activation status of human macrophages presenting antigen determines the efficiency of Th17 responses","volume":"220","author":"Arnold","year":"2015","journal-title":"Immunobiology"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1038\/nri1457","article-title":"IDO expression by dendritic cells: tolerance and tryptophan catabolism","volume":"4","author":"Mellor","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1111\/xen.12326","article-title":"Human regulatory macrophages are potent in suppression of the xenoimmune response via indoleamine-2,3-dioxygenase-involved mechanism(s)","volume":"24","author":"Guo","year":"2017","journal-title":"Xenotransplantation"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1097\/MOT.0b013e328355a979","article-title":"Regulatory macrophages as therapeutic targets and therapeutic agents in solid organ transplantation","volume":"17","author":"Broichhausen","year":"2012","journal-title":"Curr Opin Organ Transplant"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171491","article-title":"Human monocytes and macrophages regulate immune tolerance via integrin \u03b1v\u03b28-mediated TGF\u03b2 activation","volume":"215","author":"Kelly","year":"2018","journal-title":"J Exp Med"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-1347","article-title":"TGF\u03b21-Mediated SMAD3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer","volume":"6","author":"Park","year":"2016","journal-title":"Cancer Discov"},{"key":"B86","doi-asserted-by":"publisher","first-page":"691","DOI":"10.4049\/jimmunol.165.2.691","article-title":"Activated self-MHC-reactive T cells have the cytokine phenotype of Th3\/T regulatory cell 1 T cells","volume":"165","author":"Kitani","year":"2000","journal-title":"J Immunol"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.2337\/db16-0946","article-title":"In Vivo Enrichment of Diabetogenic T Cells","volume":"66","author":"Thelin","year":"2017","journal-title":"Diabetes"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425535","article-title":"Inhibition of altered peptide ligand-mediated antagonism of human GAD65-responsive CD4+ T cells by non-antagonizable T cells","volume":"34","author":"Gebe","year":"2004","journal-title":"Eur J Immunol"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.88242","article-title":"Tissue distribution and clonal diversity of the T and B cell repertoire in type 1 diabetes","volume":"1","author":"Seay","year":"2016","journal-title":"JCI Insight"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000488","article-title":"Enforcing the checkpoints: harnessing T-cell exhaustion for therapy of T1D","volume":"26","author":"Linsley","year":"2019","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(75)90308-3","article-title":"Comparison of the chemical composition of glomerular and tubular basement membranes obtained from human kidneys of diabetics and non-diabetics","volume":"61","author":"Sato","year":"1975","journal-title":"Clin Chim Acta"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.4172\/1745-7580.1000063","article-title":"Navigating diabetes-related immune epitope data: resources and tools provided by the Immune Epitope Database (IEDB)","volume":"9","author":"Vaughan","year":"2013","journal-title":"Immunome Res"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.574447\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T05:29:10Z","timestamp":1603344550000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.574447\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,22]]},"references-count":92,"alternative-id":["10.3389\/fimmu.2020.574447"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.574447","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,22]]},"article-number":"574447"}}