{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:14:27Z","timestamp":1784740467106,"version":"3.55.0"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.577015","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T06:05:35Z","timestamp":1601445935000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":52,"title":["Tenascin-C in Osteoarthritis and Rheumatoid Arthritis"],"prefix":"10.3389","volume":"11","author":[{"given":"Masahiro","family":"Hasegawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshimichi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Sudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000479","article-title":"Epidemiology of osteoarthritis: literature update","volume":"30","author":"Vina","year":"2018","journal-title":"Curr Opin Rheumatol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2016.01.006","article-title":"Risk factors and burden of osteoarthritis","volume":"59","author":"Palazzo","year":"2016","journal-title":"Ann Phys Rehabil Med"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60826-4","article-title":"Rheumatoid arthritis","volume":"376","author":"Scott","year":"2010","journal-title":"Lancet"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.132","article-title":"The case for periodontitis in the pathogenesis of rheumatoid arthritis","volume":"13","author":"Potempa","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00283","article-title":"Tenascin-C and mechanotransduction in the development and diseases of cardiovascular system","volume":"5","author":"Imanaka-Yoshida","year":"2014","journal-title":"Front Physiol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.98.6.1926","article-title":"Chick myotendinous antigen. I. A monoclonal antibody as a marker for tendon and muscle morphogenesis","volume":"98","author":"Chiquet","year":"1984","journal-title":"J Cell Biol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.98.6.1937","article-title":"Chick myotendinous antigen. II. A novel extracellular glycoprotein complex consisting of large disulfide-linked subunits","volume":"98","author":"Chiquet","year":"1984","journal-title":"J Cell Biol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"48","DOI":"10.4161\/19336918.2014.987587","article-title":"Tenascin-C: Form versus function","volume":"9","author":"Giblin","year":"2015","journal-title":"Cell Adh. Migr"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2015.06.003","article-title":"Tenascin-C: Its functions as an integrin ligand","volume":"65","author":"Tucker","year":"2015","journal-title":"Int J Biochem Cell Biol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1080\/19336918.2015.1008332","article-title":"Tenascin-C and integrins in cancer","volume":"9","author":"Yoshida","year":"2015","journal-title":"Cell Adh Migr"},{"key":"B12","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/978-94-007-7893-1_3","article-title":"Basic components of connective tissues and extracellular matrix: elastin, fibrillin, fibulins, fibrinogen, fibronectin, laminin, tenascins and thrombospondins","volume":"802","author":"Halper","year":"2014","journal-title":"Adv Exp Med Biol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90158-4","article-title":"Tenascin interferes with fibronectin action","volume":"53","author":"Chiquet-Ehrismann","year":"1988","journal-title":"Cell"},{"key":"B14","article-title":"Interference of tenascin-C with syndecan-4 binding to fibronectin blocks cell adhesion and stimulates tumor cell proliferation","volume":"61","author":"Huang","year":"2001","journal-title":"Cancer Res"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-08-0759","article-title":"Coregulation of fibronectin signaling and matrix contraction by tenascin-C and syndecan-4","volume":"15","author":"Midwood","year":"2004","journal-title":"Mol Biol Cell"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-012-4710-7","article-title":"Effects of mechanical strain on human mesenchymal stem cells and ligament fibroblasts in a textured poly(l-lactide) scaffold for ligament tissue engineering","volume":"23","author":"Kreja","year":"2012","journal-title":"J Mater Sci Mater Med"},{"key":"B17","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.matbio.2018.05.005","article-title":"Cartilage diseases","author":"Krishnan","year":"2018","journal-title":"Matrix Biol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-014-3137-5","article-title":"Role of integrins and their ligands in osteoarthritic cartilage","volume":"35","author":"Tian","year":"2015","journal-title":"Rheumatol Int"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2016.10.005","article-title":"Articular cartilage and joint development from embryogenesis to adulthood","volume":"62","author":"Decker","year":"2017","journal-title":"Semin Cell Dev Biol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03191-5","article-title":"Mechanisms of synovial joint and articular cartilage development","volume":"76","author":"Chijimatsu","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"B21","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.ydbio.2008.01.012","article-title":"A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis","volume":"316","author":"Koyama","year":"2008","journal-title":"Dev Biol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ydbio.2017.04.006","article-title":"Cell origin, volume and arrangement are drivers of articular cartilage formation, morphogenesis and response to injury in mouse limbs","volume":"426","author":"Decker","year":"2017","journal-title":"Dev Biol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.105.6.2569","article-title":"Tenascin is associated with chondrogenic and osteogenic differentiation in vivo and promotes chondrogenesis in vitro","volume":"105","author":"Mackie","year":"1987","journal-title":"J Cell Biol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370706","article-title":"Tenascin distribution in articular cartilage from normal subjects and from patients with osteoarthritis and rheumatoid arthritis","volume":"37","author":"Chevalier","year":"1994","journal-title":"Arthritis Rheumatol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s13104-020-4906-8","article-title":"Tenascin-C expression controls the maturation of articular cartilage in mice","volume":"13","author":"Gruber","year":"2020","journal-title":"BMC Res Notes"},{"key":"B26","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s13018-017-0534-y","article-title":"The use of mesenchymal stem cells for cartilage repair and regeneration: a systematic review","volume":"12","author":"Goldberg","year":"2017","journal-title":"J Orthop Surg Res"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/jor.22794","article-title":"Effect of tenascin-C on the repair of full-thickness osteochondral defects of articular cartilage in rabbits","volume":"33","author":"Ikemura","year":"2015","journal-title":"J Orthop Res"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1177\/0363546509357915","article-title":"Autologous chondrocyte implantation: a long-term follow-up","volume":"38","author":"Peterson","year":"2010","journal-title":"Am J Sports Med"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1007\/s00776-010-1513-x","article-title":"Distribution and role of tenascin-C in human osteoarthritic cartilage","volume":"15","author":"Nakoshi","year":"2010","journal-title":"J Orthop Sci"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2009.08.013","article-title":"Deficiency of tenascin-C delays articular cartilage repair in mice","volume":"18","author":"Okamura","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jos.2019.03.013","article-title":"Tenascin-C promotes the repair of cartilage defects in mice","volume":"25","author":"Unno","year":"2020","journal-title":"J Orthop Sci"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2067-8","article-title":"Tenascin-C fragments are endogenous inducers of cartilage matrix degradation","volume":"32","author":"Sofat","year":"2012","journal-title":"Rheumatol Int"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1177\/1947603520912300","article-title":"TNIIIA2, The Peptide of Tenascin-C, as a Candidate for Preventing Articular Cartilage Degeneration","author":"Hattori","year":"2020","journal-title":"Cartilage"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-12-164","article-title":"Tenascin-C induces inflammatory mediators and matrix degradation in osteoarthritic cartilage","volume":"12","author":"Patel","year":"2011","journal-title":"BMC Musculoskelet Disord"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1987","article-title":"Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease","volume":"15","author":"Midwood","year":"2009","journal-title":"Nat Med"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1177\/1947603516681134","article-title":"Tenascin-C Prevents Articular cartilage degeneration in murine osteoarthritis models","volume":"9","author":"Matsui","year":"2018","journal-title":"Cartilage"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900725","article-title":"Alpha9 integrin and its ligands constitute critical joint microenvironments for development of autoimmune arthritis","volume":"182","author":"Kanayama","year":"2009","journal-title":"J Immunol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.intimp.2018.02.022","article-title":"Amelioration of collagen antibody induced arthritis in mice by an antibody directed against the fibronectin type III repeats of tenascin-C: Targeting fibronectin type III repeats of tenascin-C in rheumatoid arthritis","volume":"58","author":"Mehta","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Lancet"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.02.012","article-title":"The role of synovitis in osteoarthritis pathogenesis","volume":"51","author":"Scanzello","year":"2012","journal-title":"Bone"},{"key":"B41","article-title":"Subtyping of osteoarthritic synoviopathy","volume":"20","author":"Oehler","year":"2002","journal-title":"Clin Exp Rheumatol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02508.x","article-title":"Synovitis score: discrimination between chronic low-grade and high-grade synovitis","volume":"49","author":"Krenn","year":"2006","journal-title":"Histopathology"},{"key":"B43","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s13018-016-0346-5","article-title":"Animal models of osteoarthritis: classification, update, and measurement of outcomes","volume":"11","author":"Kuyinu","year":"2016","journal-title":"J Orthop Surg Res"},{"key":"B44","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1136\/ard.16.4.494","article-title":"Radiological assessment of osteoarthrosis","volume":"16","author":"Kellgren","year":"1957","journal-title":"Ann Rheum Dis"},{"key":"B45","article-title":"Tenascin-C concentration in synovial fluid correlates with radiographic progression of knee osteoarthritis","volume":"31","author":"Hasegawa","year":"2004","journal-title":"J Rheumatol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.10.016","article-title":"Tenascin-C levels in synovial fluid are elevated after injury to the human and canine joint and correlate with markers of inflammation and matrix degradation","volume":"21","author":"Chockalingam","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"B47","article-title":"Regulation of tenascin-C expression by tumor necrosis factor-alpha in cultured human osteoarthritis chondrocytes","volume":"35","author":"Nakoshi","year":"2008","journal-title":"J Rheumatol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90294-8","article-title":"Two contrary functions of tenascin: dissection of the active sites by recombinant tenascin fragments","volume":"59","author":"Spring","year":"1989","journal-title":"Cell"},{"key":"B49","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1369\/0022155418757443","article-title":"Internal Affairs: Tenascin-C as a Clinically Relevant, Endogenous Driver of Innate Immunity","volume":"66","author":"Marzeda","year":"2018","journal-title":"J Histochem Cytochem"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.057471","article-title":"Toll-like receptor 4 induced FcgammaR expression potentiates early onset of joint inflammation and cartilage destruction during immune complex arthritis: Toll-like receptor 4 largely regulates FcgammaR expression by interleukin 10","volume":"66","author":"van Lent","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1002\/art.34492","article-title":"The growing array of innate inflammatory ignition switches in osteoarthritis","volume":"64","author":"Liu-Bryan","year":"2012","journal-title":"Arthritis Rheumatol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201600772R","article-title":"Soluble CD14 acts as a DAMP in human macrophages: origin and involvement in inflammatory cytokine\/chemokine production","volume":"31","author":"L\u00e9v\u00eaque","year":"2017","journal-title":"FASEB J"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1002\/art.23288","article-title":"Absence of posttraumatic arthritis following intraarticular fracture in the MRL\/MpJ mouse","volume":"58","author":"Ward","year":"2008","journal-title":"Arthritis Rheumatol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"pii: E2657","DOI":"10.3390\/ijms19092657","article-title":"Comparative Transcriptomics Identifies Novel Genes and Pathways Involved in Post-Traumatic Osteoarthritis Development and Progression","volume":"19","author":"Sebastian","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B55","doi-asserted-by":"publisher","first-page":"vi5","DOI":"10.1093\/rheumatology\/kes279","article-title":"ACR\/EULAR 2010 rheumatoid arthritis classification criteria","volume":"51","author":"Kay","year":"2012","journal-title":"Rheumatol (Oxford)"},{"key":"B56","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1111\/j.1600-065X.2008.00626.x","article-title":"Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics","volume":"223","author":"Feldmann","year":"2008","journal-title":"Immunol Rev"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.154252","article-title":"Biomarkers and personalised medicine in rheumatoid arthritis: a proposal for interactions between academia, industry and regulatory bodies","volume":"70","author":"Miossec","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket371","article-title":"\u03b19\u03b21 integrin acts as a critical intrinsic regulator of human rheumatoid arthritis","volume":"53","author":"Asano","year":"2014","journal-title":"Rheumatol (Oxford)"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20366","article-title":"Expression of large tenascin-C splice variants in synovial fluid of patients with rheumatoid arthritis","volume":"25","author":"Hasegawa","year":"2007","journal-title":"J Orthop Res"},{"key":"B60","doi-asserted-by":"publisher","first-page":"R260","DOI":"10.1186\/ar4105","article-title":"Raised circulating tenascin-C in rheumatoid arthritis","volume":"14","author":"Page","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208495","article-title":"Identification of an immunodominant peptide from citrullinated tenascin-C as a major target for autoantibodies in rheumatoid arthritis","volume":"75","author":"Schwenzer","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1002\/art.40227","article-title":"Association of distinct fine specificities of anti-citrullinated peptide antibodies with elevated immune responses to Prevotella intermedia in a Subgroup of patients with rheumatoid arthritis and periodontitis","volume":"69","author":"Schwenzer","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1038\/s41467-017-01718-7","article-title":"Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers","volume":"8","author":"Zuliani-Alvarez","year":"2017","journal-title":"Nat Commun"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214294","article-title":"Targeting early changes in the synovial microenvironment: a new class of immunomodulatory therapy","volume":"78","author":"Aungier","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1002\/ar.22985","article-title":"Tenascin-C in development and disease of blood vessels","volume":"297","author":"Imanaka-Yoshida","year":"2014","journal-title":"Anat Rec (Hoboken)"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1177\/1533033818821106","article-title":"Prognostic Role of Tenascin-C for Cancer Outcome: A Meta-Analysis","volume":"18","author":"Ming","year":"2019","journal-title":"Technol Cancer Res Treat"},{"key":"B67","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s13223-018-0300-7","article-title":"Characterization of tenascin-C as a novel biomarker for asthma: utility of tenascin-C in combination with periostin or immunoglobulin E","volume":"14","author":"Yasuda","year":"2018","journal-title":"Allergy Asthma Clin Immunol"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1475705","article-title":"Tenascin-C Is Increased in Inflammatory Bowel Disease and Is Associated with response to Infliximab Therapy","volume":"2019","author":"Ning","year":"2019","journal-title":"BioMed Res Int"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.577015\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T06:05:37Z","timestamp":1601445937000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.577015\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,30]]},"references-count":68,"alternative-id":["10.3389\/fimmu.2020.577015"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.577015","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,30]]},"article-number":"577015"}}