{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:46:35Z","timestamp":1793947595518,"version":"4.8.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.579266","type":"journal-article","created":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T08:04:11Z","timestamp":1602057851000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":38,"title":["Non-Transcriptional and Translational Function of Canonical NF-\u03baB Signaling in Activating ERK1\/2 in IL-1\u03b2-Induced COX-2 Expression in Synovial Fibroblasts"],"prefix":"10.3389","volume":"11","author":[{"given":"Rei","family":"Nakano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Kitanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Namba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanako","family":"Kitanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Suwabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadayoshi","family":"Konno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Sugiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(02)00021-7","article-title":"Roles of IL-1 in the development of rheumatoid arthritis: consideration from mouse models","volume":"13","author":"Iwakura","year":"2002","journal-title":"Cytokine Growth Factor Rev"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.2174\/1574887113666180314102651","article-title":"The Emerging Role of IL-1 Inhibition in Patients Affected by Rheumatoid Arthritis and Diabetes","volume":"13","author":"Ruscitti","year":"2018","journal-title":"Rev Recent Clin Trials"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.4","article-title":"IL-1 pathways in inflammation and human diseases","volume":"6","author":"Gabay","year":"2010","journal-title":"Nat Rev Rheumatol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.9.1.113","article-title":"IL-1 inhibitors: novel agents in the treatment of rheumatoid arthritis","volume":"9","author":"Gabay","year":"2000","journal-title":"Expert Opin Investig Drugs"},{"key":"B5","doi-asserted-by":"publisher","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-\u03baB pathway in inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harbor Pespect Biol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1101\/gad.183434.111","article-title":"NF-\u03baB, the first quarter-century: remarkable progress and outstanding questions","volume":"26","author":"Hayden","year":"2012","journal-title":"Genes Dev"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetimm.2015.10.003","article-title":"Activation of MEK\/ERK pathways through NF-\u03baB activation is involved in interleukin-1\u03b2-induced cyclooxygenease-2 expression in canine dermal fibroblasts","volume":"168","author":"Tsuchiya","year":"2015","journal-title":"Vet Immunol Immunopathol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/srep39914","article-title":"JNK activation is essential for activation of MEK\/ERK signaling in IL-1\u03b2-induced COX-2 expression in synovial fibroblasts","volume":"7","author":"Kitanaka","year":"2017","journal-title":"Sci Rep"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182923","article-title":"ERK2 and JNK1 contribute to TNF-\u03b1-induced IL-8 expression in synovial fibroblasts","volume":"12","author":"Namba","year":"2017","journal-title":"PloS One"},{"key":"B10","doi-asserted-by":"publisher","first-page":"8535","DOI":"10.1038\/s41598-018-26473-7","article-title":"Protein kinase C\u03f5 regulates nuclear translocation of extracellular signal-regulated kinase, which contributes to bradykinin-induced cyclooxygenase-2 expression","volume":"8","author":"Nakano","year":"2018","journal-title":"Sci Rep"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0220262","article-title":"Interleukin-1\u03b2 promotes interleulin-6 expression via ERK1\/2 signaling pathway in canine dermal fibroblasts","volume":"14","author":"Kitanaka","year":"2019","journal-title":"PloS One"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0222869","article-title":"ERK1\/ATF-2 signaling axis contributes to interleukin-1\u03b2-induced MMP-3 expression in dermal fibroblasts","volume":"14","author":"Kitanaka","year":"2019","journal-title":"PloS One"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0229892","article-title":"All-trans retinoic acid induces reprogramming of canine dedifferentiated cells into neuron-like cells","volume":"15","author":"Nakano","year":"2020","journal-title":"PloS One"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1080\/15216540600746393","article-title":"Regulatory mechanisms and functions of MAP kinase signaling pathways","volume":"58","author":"Imajo","year":"2006","journal-title":"IUBMB Life"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-015-1472-2","article-title":"Compromised MAPK signaling in human diseases: an update","volume":"89","author":"Kim","year":"2015","journal-title":"Arch Toxicol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0171-2985(97)80025-3","article-title":"Regulation of NF-\u03baB activation by MAP kinase cascades","volume":"198","author":"Schulze-Osthoff","year":"1997","journal-title":"Immunobiol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/35104560","article-title":"Induction of gadd45\u03b2 by NF-\u03baB downregulates pro-apoptotic JNK signalling","volume":"414","author":"De Smaele","year":"2001","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.70.4.649","article-title":"Phosphatidylinositol 3-kinase and ERK are required for NF-\u03baB activation but not for phagocytosis","volume":"70","author":"Garc\u00eda-Garc\u00eda","year":"2001","journal-title":"J Leukoc Biol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg139","article-title":"Transcriptional activation of the NF-\u03baB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)","volume":"22","author":"Vermeulen","year":"2003","journal-title":"EMBO J"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M307521200","article-title":"Temporal control of NF-\u03baB activation by ERK differentially regulates interleukin-1\u03b2-induced gene expression","volume":"279","author":"Jiang","year":"2004","journal-title":"J Biol Chem"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2007.07.008","article-title":"Roles of ERK and p38 mitogen-activated protein kinases in phorbol ester-induced NF-\u03baB activation and COX-2 expression in human breast epithelial cells","volume":"171","author":"Kim","year":"2008","journal-title":"Chem Biol Interact"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.74.10.1311","article-title":"Evaluation of mRNA expression levels and electrophysiological function of neuron-like cells derived from canine bone marrow stromal cells","volume":"74","author":"Nakano","year":"2013","journal-title":"Am J Vet Res"},{"key":"B23","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1292\/jvms.14-0284","article-title":"Differentiation of canine bone marrow stromal cells into voltage- and glutamate-responsive neuron-like cells by basic fibroblast growth factor","volume":"77","author":"Nakano","year":"2015","journal-title":"J Vet Med Sci"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0141581","article-title":"Fibroblast growth factor receptor-2 contributes to the basic fibroblast growth factor-induced neuronal differentiation in canine bone marrow stromal cells via phosphoinositide 3-kinase\/Akt signaling pathway","volume":"10","author":"Nakano","year":"2015","journal-title":"PloS One"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166707","article-title":"Expression and function of interleukin-1\u03b2-induced neutrophil gelatinase-associated lipocalin in renal tubular cells","volume":"11","author":"Konno","year":"2016","journal-title":"PloS One"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208955","article-title":"NF-\u03baB p65 and p105 implicate in interleukin 1\u03b2-mediated COX-2 expression in melanoma cells","volume":"13","author":"Kitanaka","year":"2018","journal-title":"PloS One"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.69.1.145","article-title":"Cyclooxygeneses: structural, cellular, and molecular biology","volume":"69","author":"Smith","year":"2000","journal-title":"Annu Rev Biochem"},{"key":"B29","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1124\/pr.56.3.3","article-title":"Cyclooxygenese isozymes: the biology of prostaglandin synthesis and inhibition","volume":"56","author":"Simmons","year":"2004","journal-title":"Pharmacol Rev"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)01161-9","article-title":"Regulation of the transcriptional activity of the NF-\u03baB p65 subunit","volume":"64","author":"Vermeulen","year":"2002","journal-title":"Biochem Pharmacol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.tibs.2004.11.009","article-title":"Phosphorylation of NF-\u03baB and I\u03baB proteins: implications in cancer and inflammation","volume":"30","author":"Viatour","year":"2005","journal-title":"Trends Biochem Sci"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209937","article-title":"Post-translational modifications regulating the activity and function of the NF-\u03baB pathway","volume":"25","author":"Perkins","year":"2006","journal-title":"Oncogene"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2010.03.017","article-title":"Posttranslational modifications of NF-\u03baB: another layer of regulation for NF-\u03baB signaling pathway","volume":"22","author":"Huang","year":"2010","journal-title":"Cell Signal"},{"key":"B34","doi-asserted-by":"publisher","first-page":"E12","DOI":"10.3390\/cells5010012","article-title":"The regulation of NF-\u03baB subunits by phosphorylation","volume":"5","author":"Christian","year":"2016","journal-title":"Cells"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13627","article-title":"NFKB1: a suppressor of inflammation, ageing and cancer","volume":"283","author":"Cartwright","year":"2016","journal-title":"FEBS J"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2001.81.2.807","article-title":"Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation","volume":"81","author":"Kyriakis","year":"2001","journal-title":"Physiol Rev"},{"key":"B37","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1152\/physrev.00028.2011","article-title":"Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update","volume":"92","author":"Kyriakis","year":"2012","journal-title":"Physiol Rev"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.2174\/187153006779025711","article-title":"Role of PGE2 and EP receptors in the pathogenesis of rheumatoid arthritis and as a novel therapeutic strategy","volume":"6","author":"Akaogi","year":"2006","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2006.01.016","article-title":"Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases","volume":"119","author":"Park","year":"2006","journal-title":"Clin Immunol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2004.03.008","article-title":"The two NF-\u03baB activation pathways and their role in innate and adaptive immunity","volume":"25","author":"Bonizzi","year":"2004","journal-title":"Trends Immunol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/12.5.423","article-title":"Construction, expression, purification and functional analysis of recombinant NF\u03baB p50\/p65 heterodimer","volume":"12","author":"Chen","year":"1999","journal-title":"Protein Eng"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M004899200","article-title":"Mechanism of I\u03baB\u03b1 binding to NF-\u03baB dimers","volume":"275","author":"Phelps","year":"2000","journal-title":"J Biol Chem"},{"key":"B43","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1172\/JCI11830","article-title":"NF-\u03baB: a key role in inflammatory diseases","volume":"107","author":"Tak","year":"2001","journal-title":"J Clin Invest"},{"key":"B44","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/1476-4598-12-86","article-title":"The complexity of NF-\u03baB signaling in inflammation and cancer","volume":"12","author":"Hoesel","year":"2013","journal-title":"Mol Cancer"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032678","article-title":"Charting the NF-\u03baB pathway interactome map","volume":"7","author":"Tieri","year":"2012","journal-title":"PloS One"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.579266\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T08:04:13Z","timestamp":1602057853000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.579266\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,7]]},"references-count":45,"alternative-id":["10.3389\/fimmu.2020.579266"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.579266","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,7]]},"article-number":"579266"}}