{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:59:35Z","timestamp":1790492375848,"version":"4.1.0"},"reference-count":56,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.580373","type":"journal-article","created":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T05:33:11Z","timestamp":1604467991000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Systems Biology Methods Applied to Blood and Tissue for a Comprehensive Analysis of Immune Response to Hepatitis B Vaccine in Adults"],"prefix":"10.3389","volume":"11","author":[{"given":"Rym","family":"Ben-Othman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron C.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natallia","family":"Varankovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis M.","family":"Blimkie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin E.","family":"Gill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Novotny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Aevermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibyl","family":"Drissler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey P.","family":"Shannon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"McCann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Marty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordean","family":"Bjornson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel D.","family":"Edgar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Tse Shen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Gladish","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Maclsaac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelly","family":"Amenyogbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Queenie","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Llibre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce","family":"Collin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise","family":"Landais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khoa","family":"Le","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha M.","family":"Reiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne C.","family":"Koff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Havenar-Daughton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manraj","family":"Heran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bippan","family":"Sangha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Walt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mel","family":"Krajden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane","family":"Crotty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devin","family":"Sok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Briney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis R.","family":"Burton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darragh","family":"Duffy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard J.","family":"Foster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William W.","family":"Mohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Kobor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J.","family":"Tebbutt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan R.","family":"Brinkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H.","family":"Scheuermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E. W.","family":"Hancock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias R.","family":"Kollmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Sadarangani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1232910","article-title":"Accelerating next-generation vaccine development for global disease prevention","volume":"340","author":"Koff","year":"2013","journal-title":"Science"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.11.090","article-title":"\u201cIDEAL\u201d vaccines for resource poor settings","author":"Levine","year":"2011","journal-title":"Vaccine"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.immuni.2017.05.007","article-title":"Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches","volume":"46","author":"Pauthner","year":"2017","journal-title":"Immunity"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.10.085","article-title":"Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer","volume":"17","author":"Havenar-Daughton","year":"2016","journal-title":"Cell Rep"},{"key":"B5","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/imr.12512","article-title":"Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem","volume":"275","author":"Havenar-Daughton","year":"2017","journal-title":"Immunol Rev"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.03.002","article-title":"Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli","volume":"40","author":"Duffy","year":"2014","journal-title":"Immunity"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1038\/s41467-019-08794-x","article-title":"Dynamic molecular changes during the first week of human life follow a robust developmental trajectory","volume":"10","author":"Lee","year":"2019","journal-title":"Nat Commun"},{"key":"B8","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1098","article-title":"Ensembl 2018","volume":"46","author":"Zerbino","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2013a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw354","article-title":"MultiQC: summarize analysis results for multiple tools and samples in a single report","volume":"32","author":"Ewels","year":"2016","journal-title":"Bioinformatics"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e229","DOI":"10.7717\/peerj.229","article-title":"Pathway-GPS and SIGORA: identifying relevant pathways based on the over-representation of their gene-pair signatures","volume":"1","author":"Foroushani","year":"2013","journal-title":"PeerJ"},{"key":"B14","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/s13059-016-1066-1","article-title":"Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling","volume":"17","author":"Pidsley","year":"2016","journal-title":"Genome Biol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-293","article-title":"A data-driven approach to preprocessing Illumina 450K methylation array data","volume":"14","author":"Pidsley","year":"2013","journal-title":"BMC Genomics"},{"key":"B16","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/7651_2015_262","article-title":"Adjusting for Cell Type Composition in DNA Methylation Data Using a Regression-Based Approach","volume":"1589","author":"Jones","year":"2017","journal-title":"Methods Mol Biol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxj037","article-title":"Adjusting batch effects in microarray expression data using empirical Bayes methods","volume":"8","author":"Johnson","year":"2007","journal-title":"Biostatistics"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e1187","DOI":"10.1038\/tp.2017.171","article-title":"BECon: a tool for interpreting DNA methylation findings from blood in the context of brain","volume":"7","author":"Edgar","year":"2017","journal-title":"Transl Psychiatry"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M114.047407","article-title":"a Very High-Resolution Quadrupole Time-of-Flight Instrument (QTOF) for Deep Shotgun Proteomics","volume":"14","author":"Beck","year":"2015","journal-title":"Mol Cell Proteomics"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-387","article-title":"The innate immune and systemic response in honey bees to a bacterial pathogen, Paenibacillus larvae","volume":"10","author":"Chan","year":"2009","journal-title":"BMC Genomics"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1021\/ac026117i","article-title":"Stop and go extraction tips for matrix-assisted laser desorption\/ionization, nanoelectrospray, and LC\/MS sample pretreatment in proteomics","volume":"75","author":"Rappsilber","year":"2003","journal-title":"Anal Chem"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200800297","article-title":"Triplex protein quantification based on stable isotope labeling by peptide dimethylation applied to cell and tissue lysates","volume":"8","author":"Boersema","year":"2008","journal-title":"Proteomics"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.RA117.000104","article-title":"A Varroa destructor protein atlas reveals molecular underpinnings of developmental transitions and sexual differentiation","volume":"16","author":"McAfee","year":"2017","journal-title":"Mol Cell Proteomics"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1106","article-title":"The PRIDE database and related tools and resources in 2019: improving support for quantification data","volume":"47","author":"Perez-Riverol","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/ejlt.201500145","article-title":"An automated shotgun lipidomics platform for high throughput, comprehensive, and quantitative analysis of blood plasma intact lipids","volume":"117","author":"Surma","year":"2015","journal-title":"Eur J Lipid Sci Technol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts034","article-title":"The sva package for removing batch effects and other unwanted variation in high-throughput experiments","volume":"28","author":"Leek","year":"2012","journal-title":"Bioinformatics"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2017.12.015","article-title":"High throughput automated analysis of big flow cytometry data","author":"Rahim","year":"2018","journal-title":"Methods"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu677","article-title":"flowDensity: reproducing manual gating of flow cytometry data by automated density-based cell population identification","volume":"31","author":"Malek","year":"2015","journal-title":"Bioinformatics"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts300","article-title":"flowPeaks: a fast unsupervised clustering for flow cytometry data via K-means and density peak finding","volume":"28","author":"Ge","year":"2012","journal-title":"Bioinformatics"},{"key":"B30","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nprot.2016.015","article-title":"Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons","volume":"11","author":"Krishnaswami","year":"2016","journal-title":"Nat Protoc"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1101\/gr.150433.112","article-title":"Genome of the pathogen Porphyromonas gingivalis recovered from a biofilm in a hospital sink using a high-throughput single-cell genomics platform","volume":"23","author":"McLean","year":"2013","journal-title":"Genome Res"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.095","article-title":"Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown","volume":"11","author":"Pertea","year":"2016","journal-title":"Nat Protoc"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1142\/9789813207813_0052","article-title":"Production of a Preliminary Quality Control Pipeline for Single Nuclei Rna-Seq and Its Application in the Analysis of Cell Type Diversity of Post-Mortem Human Brain Neocortex","volume":"22","author":"Aevermann","year":"2017","journal-title":"Pac Symp Biocomput"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw777","article-title":"Scater: pre-processing, quality control, normalization and visualization of single-cell RNA-seq data in R","volume":"33","author":"McCarthy","year":"2017","journal-title":"Bioinformatics"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4236","article-title":"SC3: consensus clustering of single-cell RNA-seq data","volume":"14","author":"Kiselev","year":"2017","journal-title":"Nat Methods"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy100","article-title":"Cell type discovery using single-cell transcriptomics: implications for ontological representation","volume":"27","author":"Aevermann","year":"2018","journal-title":"Hum Mol Genet"},{"key":"B38","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/s12859-017-1977-1","article-title":"Cell type discovery and representation in the era of high-content single cell phenotyping","volume":"18","author":"Bakken","year":"2017","journal-title":"BMC Bioinf"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2017.09.019","article-title":"Standardized whole blood stimulation improves immunomonitoring of induced immune responses in multi-center study","volume":"183","author":"Duffy","year":"2017","journal-title":"Clin Immunol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2014.12.004","article-title":"The Milieu Interieur study - an integrative approach for study of human immunological variance","volume":"157","author":"Thomas","year":"2015","journal-title":"Clin Immunol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.08.011","article-title":"Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses","volume":"16","author":"Urrutia","year":"2016","journal-title":"Cell Rep"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1714765115","article-title":"Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges","volume":"115","author":"Piasecka","year":"2018","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/srep23901","article-title":"Clonify: unseeded antibody lineage assignment from next-generation sequencing data","volume":"6","author":"Briney","year":"2016","journal-title":"Sci Rep"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.03487-14","article-title":"Single-molecule arrays for ultrasensitive detection of host immune response to dengue virus infection","volume":"53","author":"Gaylord","year":"2015","journal-title":"J Clin Microbiol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.5b00322","article-title":"Ultrasensitive Detection of Ricin Toxin in Multiple Sample Matrixes Using Single-Domain Antibodies","volume":"87","author":"Gaylord","year":"2015","journal-title":"Anal Chem"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1641","article-title":"Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations","volume":"28","author":"Rissin","year":"2010","journal-title":"Nat Biotechnol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1021\/ac303426b","article-title":"Direct detection of bacterial genomic DNA at sub-femtomolar concentrations using single molecule arrays","volume":"85","author":"Song","year":"2013","journal-title":"Anal Chem"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2017.08.007","article-title":"Long-Term Measurements of Human Inflammatory Cytokines Reveal Complex Baseline Variations between Individuals","volume":"187","author":"Wu","year":"2017","journal-title":"Am J Pathol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.6b02451","article-title":"Incorporation of Slow Off-Rate Modified Aptamers Reagents in Single Molecule Array Assays for Cytokine Detection with Ultrahigh Sensitivity","volume":"88","author":"Wu","year":"2016","journal-title":"Anal Chem"},{"key":"B50","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/alzrt163","article-title":"Plasma tau levels in Alzheimer\u2019s disease","volume":"5","author":"Zetterberg","year":"2013","journal-title":"Alzheimers Res Ther"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2020.112746","article-title":"Normal human lymph node T follicular helper cells and germinal center B cells accessed via fine needle aspirations","volume":"479","author":"Havenar-Daughton","year":"2020","journal-title":"J Immunol Methods"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.csda.2015.04.004","article-title":"Kernel Generalized Canonical Correlation Analysis","volume":"90","author":"Tenenhaus","year":"2015","journal-title":"Comput Stat Data Anal"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1520112113","article-title":"CXCL13 is a plasma biomarker of germinal center activity","volume":"113","author":"Havenar-Daughton","year":"2016","journal-title":"Proc Natl Acad Sci U.S.A."},{"key":"B54","doi-asserted-by":"publisher","first-page":"797","DOI":"10.4049\/jimmunol.1400749","article-title":"Early lymphoid responses and germinal center formation correlate with lower viral load set points and better prognosis of simian immunodeficiency virus infection","volume":"193","author":"Hong","year":"2014","journal-title":"J Immunol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63039","article-title":"CD4 T follicular helper cell dynamics during SIV infection","volume":"122","author":"Petrovas","year":"2012","journal-title":"J Clin Invest"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2711-0","article-title":"Human germinal centres engage memory and naive B cells after influenza vaccination","volume":"586","author":"Turner","year":"2020","journal-title":"Nature"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.580373\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T05:33:12Z","timestamp":1604467992000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.580373\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,4]]},"references-count":56,"alternative-id":["10.3389\/fimmu.2020.580373"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.580373","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,4]]},"article-number":"580373"}}