{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:20:37Z","timestamp":1792070437543,"version":"4.4.0"},"reference-count":100,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T00:00:00Z","timestamp":1603324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31900627"],"award-info":[{"award-number":["31900627"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.582657","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T01:40:26Z","timestamp":1603330826000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":99,"title":["Phenotypes, Functions, and Clinical Relevance of Regulatory B Cells in Cancer"],"prefix":"10.3389","volume":"11","author":[{"given":"Jin","family":"Shang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufa","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/imr.12821","article-title":"Impaired B-cell tolerance checkpoints promote the development of autoimmune diseases and pathogenic autoantibodies","volume":"292","author":"Meffre","year":"2019","journal-title":"Immunol Rev"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-078071","article-title":"B lymphocytes: how they develop and function","volume":"112","author":"LeBien","year":"2008","journal-title":"Blood"},{"key":"B3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/978-981-15-3532-1_8","article-title":"Regulatory B Cells","volume-title":"B cells in immunity and tolerance Advances in Experimental Medicine and Biology","author":"Luman Wang","year":"2020"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1919329117","article-title":"Optimizing immunization protocols to elicit broadly neutralizing antibodies","volume":"117","author":"Sprenger","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007974","article-title":"Humoral immunity prevents clinical malaria during Plasmodium relapses without eliminating gametocytes","volume":"15","author":"Joyner","year":"2019","journal-title":"PLoS Path"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03163","article-title":"VH1-69 Utilizing Antibodies Are Capable of Mediating Non-neutralizing Fc-Mediated Effector Functions Against the Transmitted\/Founder gp120","volume":"9","author":"Smith","year":"2018","journal-title":"Front Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav8152","article-title":"The regulatory B cell-mediated peripheral tolerance maintained by mast cell IL-5 suppresses oxazolone-induced contact hypersensitivity","volume":"5","author":"Kim","year":"2019","journal-title":"Sci Adv"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12134","article-title":"Treatment of ongoing autoimmune encephalomyelitis with activated B-cell progenitors maturing into regulatory B cells","volume":"7","author":"Korniotis","year":"2016","journal-title":"Nat Commun"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/art.39820","article-title":"The Regulatory B Cell Compartment Expands Transiently During Childhood and Is Contracted in Children With Autoimmunity","volume":"69","author":"Kalampokis","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517695892","article-title":"Thymosin-alpha1 expands deficient IL-10-producing regulatory B cell subsets in relapsing-remitting multiple sclerosis patients","volume":"24","author":"Giacomini","year":"2018","journal-title":"Mult Scler"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/251550a0","article-title":"B-cell suppression of delayed hypersensitivity reactions","volume":"251","author":"Katz","year":"1974","journal-title":"Nature"},{"key":"B12","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.113.6.1716","article-title":"Specific suppression of delayed hypersensitivity: the possible presence of a suppressor B cell in the regulation of delayed hypersensitivity","volume":"113","author":"Neta","year":"1974","journal-title":"J Immunol"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(82)90093-4","article-title":"Feedback suppression of the immune response in vivo. III. Lyt-1+ B cells are suppressor-inducer cells","volume":"68","author":"Shimamura","year":"1982","journal-title":"Cell Immunol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/0008-8749(84)90242-9","article-title":"Feedback suppression of the immune response in vivo","volume":"83","author":"Shimamura","year":"1984","journal-title":"III. Lyt-1+ B Cells are suppressor-inducer Cells Cell Immunol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(02)00274-1","article-title":"Chronic intestinal inflammatory condition generates IL-10-producing regulatory B cell subset characterized by CD1d upregulation","volume":"16","author":"Mizoguchi","year":"2002","journal-title":"Immunity"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.01.010","article-title":"Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity","volume":"46","author":"Zhivaki","year":"2017","journal-title":"Immunity"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.07.006","article-title":"Role of regulatory B cells in immune tolerance to allergens and beyond","volume":"138","author":"van de Veen","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1186\/s12974-018-1334-y","article-title":"Restoration of regulatory B cell deficiency following alemtuzumab therapy in patients with relapsing multiple sclerosis","volume":"15","author":"Kim","year":"2018","journal-title":"J Neuroinflamm"},{"key":"B19","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/s41419-017-0152-y","article-title":"Regulatory B cells: the cutting edge of immune tolerance in kidney transplantation","volume":"9","author":"Peng","year":"2018","journal-title":"Cell Death Dis"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxz068","article-title":"Heterogeneous subsets of B-lineage regulatory cells (Breg cells)","volume":"32","author":"Baba","year":"2020","journal-title":"Int Immunol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2017.35","article-title":"B cell regulation in cancer and anti-tumor immunity","volume":"14","author":"Sarvaria","year":"2017","journal-title":"Cell Mol Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxv034","article-title":"Regulatory B cells in anti-tumor immunity","volume":"27","author":"Zhang","year":"2015","journal-title":"Int Immunol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.12.007","article-title":"Regulatory B cells in inflammatory diseases and tumor","volume":"67","author":"Cai","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/215471","article-title":"The roles of regulatory B cells in cancer","volume":"2014","author":"He","year":"2014","journal-title":"J Immunol Res"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.10.007","article-title":"B regulatory cells in cancer","volume":"34","author":"Balkwill","year":"2013","journal-title":"Trends Immunol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-019-00257-1","article-title":"Function of innate lymphoid cells in the immune-related disorders","volume":"32","author":"Dzopalic","year":"2019","journal-title":"Hum Cell"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.04.005","article-title":"Regulatory B cells: origin, phenotype, and function","volume":"42","author":"Rosser","year":"2015","journal-title":"Immunity"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.11.018","article-title":"Human CD19(+)CD25(high) B regulatory cells suppress proliferation of CD4(+) T cells and enhance Foxp3 and CTLA-4 expression in T-regulatory cells","volume":"11","author":"Kessel","year":"2012","journal-title":"Autoimmun Rev"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134591","article-title":"Regulatory B Cell Function Is Suppressed by Smoking and Obesity in H. pylori-Infected Subjects and Is Correlated with Elevated Risk of Gastric Cancer","volume":"10","author":"Li","year":"2015","journal-title":"PLoS One"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-3450","article-title":"Interleukin 21-induced granzyme B-expressing B cells infiltrate tumors and regulate T cells","volume":"73","author":"Lindner","year":"2013","journal-title":"Cancer Res"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2015.1075112","article-title":"PD-L1 mediated the differentiation of tumor-infiltrating CD19(+) B lymphocytes and T cells in Invasive breast cancer","volume":"5","author":"Guan","year":"2016","journal-title":"OncoImmunology"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/srep12255","article-title":"Regulatory B cells preferentially accumulate in tumor-draining lymph nodes and promote tumor growth","volume":"5","author":"Ganti","year":"2015","journal-title":"Sci Rep"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.03.017","article-title":"A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses","volume":"28","author":"Yanaba","year":"2008","journal-title":"Immunity"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102500","article-title":"Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo","volume":"188","author":"Maseda","year":"2012","journal-title":"J Immunol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400336","article-title":"A novel mechanism of B cell-mediated immune suppression through CD73 expression and adenosine production","volume":"193","author":"Kaku","year":"2014","journal-title":"J Immunol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6519427","article-title":"Role of Regulatory B Cells in the Progression of Cervical Cancer","volume":"2019","author":"Chen","year":"2019","journal-title":"Mediators Inflamm"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.5588","article-title":"CD19+CD24hiCD38hiBregs involved in downregulate helper T cells and upregulate regulatory T cells in gastric cancer","volume":"6","author":"Wang","year":"2015","journal-title":"Oncotarget"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2019.111652","article-title":"Characterization of intratumoral and circulating IL-10-producing B cells in gastric cancer","volume":"384","author":"Hu","year":"2019","journal-title":"Exp Cell Res"},{"key":"B39","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/s40425-018-0451-6","article-title":"Tumor-derived exosomal HMGB1 fosters hepatocellular carcinoma immune evasion by promoting TIM-1(+) regulatory B cell expansion","volume":"6","author":"Ye","year":"2018","journal-title":"J Immunother Cancer"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-1408","article-title":"PD-1hi Identifies a Novel Regulatory B-cell Population in Human Hepatoma That Promotes Disease Progression","volume":"6","author":"Xiao","year":"2016","journal-title":"Cancer Discov"},{"key":"B41","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.molimm.2020.01.008","article-title":"PD-L1(+) regulatory B cells act as a T cell suppressor in a PD-L1-dependent manner in melanoma patients with bone metastasis","volume":"119","author":"Wu","year":"2020","journal-title":"Mol Immunol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1413520","article-title":"A novel MDSC-induced PD-1(-)PD-L1(+) B-cell subset in breast tumor microenvironment possesses immuno-suppressive properties","volume":"7","author":"Shen","year":"2018","journal-title":"OncoImmunology"},{"key":"B43","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1053\/j.gastro.2017.09.045","article-title":"MicroRNAs 15A and 16-1 Activate Signaling Pathways That Mediate Chemotaxis of Immune Regulatory B cells to Colorectal Tumors","volume":"154","author":"Liu","year":"2018","journal-title":"Gastroenterology"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1172\/JCI59266","article-title":"Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice","volume":"121","author":"Horikawa","year":"2011","journal-title":"J Clin Invest"},{"key":"B45","doi-asserted-by":"publisher","first-page":"e547","DOI":"10.1038\/bcj.2017.24","article-title":"Regulatory B cell-myeloma cell interaction confers immunosuppression and promotes their survival in the bone marrow milieu","volume":"7","author":"Zhang","year":"2017","journal-title":"Blood Cancer J"},{"key":"B46","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.oraloncology.2015.11.003","article-title":"CD19(+)IL-10(+) regulatory B cells affect survival of tongue squamous cell carcinoma patients and induce resting CD4(+) T cells to CD4(+)Foxp3(+) regulatory T cells","volume":"53","author":"Zhou","year":"2016","journal-title":"Oral Oncol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-020-02535-6","article-title":"Adenosine-producing regulatory B cells in head and neck cancer","volume":"69","author":"Jeske","year":"2020","journal-title":"Cancer Immunol Immunother"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.09.026","article-title":"Regulatory B cells accelerate hepatocellular carcinoma progression via CD40\/CD154 signaling pathway","volume":"355","author":"Shao","year":"2014","journal-title":"Cancer Lett"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.915556","article-title":"The Role of Regulatory B Cells in Patients with Acute Myeloid Leukemia","volume":"25","author":"Lv","year":"2019","journal-title":"Med Sci Monit"},{"key":"B50","doi-asserted-by":"publisher","first-page":"13083","DOI":"10.1038\/s41598-019-49581-4","article-title":"Increased regulatory B cells are involved in immune evasion in patients with gastric cancer","volume":"9","author":"Murakami","year":"2019","journal-title":"Sci Rep"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300606","article-title":"Inhibition of breast cancer metastasis by resveratrol-mediated inactivation of tumor-evoked regulatory B cells","volume":"191","author":"Lee-Chang","year":"2013","journal-title":"J Immunol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0668-3","article-title":"BTK signaling drives CD1d(hi)CD5(+) regulatory B-cell differentiation to promote pancreatic carcinogenesis","volume":"38","author":"Das","year":"2019","journal-title":"Oncogene"},{"key":"B53","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.intimp.2017.05.018","article-title":"Colorectal tumors are enriched with regulatory plasmablasts with capacity in suppressing T cell inflammation","volume":"49","author":"Mao","year":"2017","journal-title":"Int Immunopharmacol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.jaci.2016.06.033","article-title":"Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases","volume":"138","author":"Akdis","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-04-571125","article-title":"Regulatory B cells are enriched within the IgM memory and transitional subsets in healthy donors but are deficient in chronic GVHD","volume":"124","author":"Khoder","year":"2014","journal-title":"Blood"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2019.101323","article-title":"IL-10-producing regulatory B cells and plasmocytes: Molecular mechanisms and disease relevance","volume":"44","author":"Cerqueira","year":"2019","journal-title":"Semin Immunol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.106111","article-title":"The role of B regulatory (B10) cells in inflammatory disorders and their potential as therapeutic targets","volume":"78","author":"Wu","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103139","article-title":"IL-10-producing regulatory B cells in the pathogenesis of chronic hepatitis B virus infection","volume":"189","author":"Das","year":"2012","journal-title":"J Immunol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900185","article-title":"Nonredundant roles for B cell-derived IL-10 in immune counter-regulation","volume":"183","author":"Madan","year":"2009","journal-title":"J Immunol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3766","article-title":"Inhibitory effects of B cells on antitumor immunity","volume":"66","author":"Inoue","year":"2006","journal-title":"Cancer Res"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2012.04.003","article-title":"Crosstalk between TGF-beta signaling and the microRNA machinery","volume":"33","author":"Butz","year":"2012","journal-title":"Trends Pharmacol Sci"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.2.1081","article-title":"Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice","volume":"167","author":"Tian","year":"2001","journal-title":"J Immunol"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1038\/nature12979","article-title":"IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases","volume":"507","author":"Shen","year":"2014","journal-title":"Nature"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2015.07.013","article-title":"Interleukin 35: Critical regulator of immunity and lymphocyte-mediated diseases","volume":"26","author":"Egwuagu","year":"2015","journal-title":"Cytokine Growth Factor Rev"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/ni1572","article-title":"The Foxp3+ regulatory T cell: a jack of all trades, master of regulation","volume":"9","author":"Tang","year":"2008","journal-title":"Nat Immunol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.11.009","article-title":"CD19(+)CD24(hi)CD38(hi) B cells exhibit regulatory capacity in healthy individuals but are functionally impaired in systemic Lupus Erythematosus patients","volume":"32","author":"Blair","year":"2010","journal-title":"Immunity"},{"key":"B67","doi-asserted-by":"publisher","first-page":"173ra23","DOI":"10.1126\/scitranslmed.3005407","article-title":"CD19+CD24hiCD38hi B cells maintain regulatory T cells while limiting TH1 and TH17 differentiation","volume":"5","author":"Flores-Borja","year":"2013","journal-title":"Sci Transl Med"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2009.00782.x","article-title":"Molecular mechanism and function of CD40\/CD40L engagement in the immune system","volume":"229","author":"Elgueta","year":"2009","journal-title":"Immunol Rev"},{"key":"B69","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.it.2007.10.004","article-title":"The \u2018short\u2019 history of regulatory B cells","volume":"29","author":"Mauri","year":"2008","journal-title":"Trends Immunol"},{"key":"B70","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1158\/2326-6066.CIR-16-0304","article-title":"Differentiated State of Initiating Tumor Cells Is Key to Distinctive Immune Responses Seen in H-Ras(G12V)-Induced Squamous Tumors","volume":"5","author":"Podolsky","year":"2017","journal-title":"Cancer Immunol Res"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830260332","article-title":"Activated B cells express functional Fas ligand","volume":"26","author":"Hahne","year":"1996","journal-title":"Eur J Immunol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1128\/iai.70.2.812-819.2002","article-title":"Fas ligand-expressing B-1a lymphocytes mediate CD4(+)-T-cell apoptosis during schistosomal infection: induction by interleukin 4 (IL-4) and IL-10","volume":"70","author":"Lundy","year":"2002","journal-title":"Infect Immun"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2017.04.016","article-title":"TLR4 supports the expansion of FasL(+)CD5(+)CD1d(hi) regulatory B cells, which decreases in contact hypersensitivity","volume":"87","author":"Wang","year":"2017","journal-title":"Mol Immunol"},{"key":"B74","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1002\/JLB.MR0618-226R","article-title":"The multiple faces of CD5","volume":"105","author":"Burgueno-Bucio","year":"2019","journal-title":"J Leukocyte Biol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.04.003","article-title":"CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote Cancer","volume":"44","author":"Zhang","year":"2016","journal-title":"Immunity"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxw007","article-title":"Mammary-tumor-educated B cells acquire LAP\/TGF-beta and PD-L1 expression and suppress anti-tumor immune responses","volume":"28","author":"Zhang","year":"2016","journal-title":"Int Immunol"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-4538-0","article-title":"Regulatory B cells contribute to the impaired antitumor immunity in ovarian cancer patients","volume":"37","author":"Wei","year":"2016","journal-title":"Tumour Biol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2014.10.005","article-title":"Glioma cell-derived placental growth factor induces regulatory B cells","volume":"57","author":"Han","year":"2014","journal-title":"Int J Biochem Cell Biol"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-19-0240","article-title":"Myeloid-Derived Suppressive Cells Promote B cell-Mediated Immunosuppression via Transfer of PD-L1 in Glioblastoma","volume":"7","author":"Lee-Chang","year":"2019","journal-title":"Cancer Immunol Res"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-4316","article-title":"Tumor-evoked regulatory B cells promote breast cancer metastasis by converting resting CD4(+) T cells to T-regulatory cells","volume":"71","author":"Olkhanud","year":"2011","journal-title":"Cancer Res"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-3077","article-title":"Immunosuppressive and Prometastatic Functions of Myeloid-Derived Suppressive Cells Rely upon Education from Tumor-Associated B Cells","volume":"75","author":"Bodogai","year":"2015","journal-title":"Cancer Res"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201920","article-title":"Cancer-produced metabolites of 5-lipoxygenase induce tumor-evoked regulatory B cells via peroxisome proliferator-activated receptor alpha","volume":"190","author":"Wejksza","year":"2013","journal-title":"J Immunol"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01680","article-title":"The New Era of Cancer Immunotherapy: Targeting Myeloid-Derived Suppressor Cells to Overcome Immune Evasion","volume":"11","author":"De Cicco","year":"2020","journal-title":"Front Immunol"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01526","article-title":"Myeloid-Derived Suppressor Cells in Colorectal Cancer","volume":"11","author":"Sieminska","year":"2020","journal-title":"Front Immunol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900500","article-title":"Functional Diversity of Myeloid-Derived Suppressor Cells: The Multitasking Hydra of Cancer","volume":"203","author":"Jayakumar","year":"2019","journal-title":"J Immunol"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1038\/nri2506","article-title":"Myeloid-derived suppressor cells as regulators of the immune system","volume":"9","author":"Gabrilovich","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.1.284","article-title":"Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression","volume":"176","author":"Bunt","year":"2006","journal-title":"J Immunol"},{"key":"B88","article-title":"The Role of NK Cells in Cancer","volume-title":"Cancer Immunology","author":"Vladimir J","year":"2020"},{"key":"B89","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.cyto.2019.02.001","article-title":"The role of cytokines in the regulation of NK cells in the tumor environment","volume":"117","author":"Konjevic","year":"2019","journal-title":"Cytokine"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01945","article-title":"Molecular Regulation of NK Cell Maturation","volume":"11","author":"Bi","year":"2020","journal-title":"Front Immunol"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-15-0843","article-title":"IL35-Producing B Cells Promote the Development of Pancreatic Neoplasia","volume":"6","author":"Pylayeva-Gupta","year":"2016","journal-title":"Cancer Discov"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310814","article-title":"Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma","volume":"66","author":"Garnelo","year":"2017","journal-title":"Gut"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1038\/nrc4000","article-title":"MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road","volume":"15","author":"Caunt","year":"2015","journal-title":"Nat Rev Cancer"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412690","article-title":"Improved overall survival in melanoma with combined dabrafenib and trametinib","volume":"372","author":"Robert","year":"2015","journal-title":"N Engl J Med"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408868","article-title":"Combined vemurafenib and cobimetinib in BRAF-mutated melanoma","volume":"371","author":"Larkin","year":"2014","journal-title":"N Engl J Med"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0224600","article-title":"MEK inhibition suppresses B regulatory cells and augments anti-tumor immunity","volume":"14","author":"Yarchoan","year":"2019","journal-title":"PLoS One"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.3109\/08820139.2015.1043668","article-title":"Protective Effects of Total Glucosides of Paeony on N-nitrosodiethylamine-induced Hepatocellular Carcinoma in Rats via Down-regulation of Regulatory B Cells","volume":"44","author":"Song","year":"2015","journal-title":"Immunol Invest"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.04.030","article-title":"Lipid mediator lipoxin A4 inhibits tumor growth by targeting IL-10-producing regulatory B (Breg) cells","volume":"364","author":"Wang","year":"2015","journal-title":"Cancer Lett"},{"key":"B99","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.abb.2009.01.018","article-title":"Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms","volume":"486","author":"Athar","year":"2009","journal-title":"Arch Biochem Biophys"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01913","article-title":"In vitro-Induced Human IL-10(+) B Cells Do Not Show a Subset-Defining Marker Signature and Plastically Co-express IL-10 With Pro-Inflammatory Cytokines","volume":"9","author":"Lighaam","year":"2018","journal-title":"Front Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.582657\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T05:37:49Z","timestamp":1696916269000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.582657\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,22]]},"references-count":100,"alternative-id":["10.3389\/fimmu.2020.582657"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.582657","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,22]]},"article-number":"582657"}}