{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:41:25Z","timestamp":1790790085440,"version":"4.1.0"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.586977","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T08:28:49Z","timestamp":1601454529000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Hypoxia Promotes Syndecan-3 Expression in the Tumor Microenvironment"],"prefix":"10.3389","volume":"11","author":[{"given":"Endika","family":"Prieto-Fern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leire","family":"Egia-Mendikute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Garc\u00eda del R\u00edo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borja","family":"Jimenez-Lasheras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asier","family":"Anto\u00f1ana-Vildosola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asis","family":"Palazon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3904","DOI":"10.1111\/j.1742-4658.2010.07800.x","article-title":"Proteoglycans in health and disease: novel roles for proteoglycans in malignancy and their pharmacological targeting.","volume":"277","author":"Theocharis","year":"2010","journal-title":"FEBS J."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2010.07796.x","article-title":"Proteoglycans in health and disease: emerging concepts and future directions.","volume":"277","author":"Iozzo","year":"2010","journal-title":"FEBS J."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1111\/j.1582-4934.2010.01236.x","article-title":"Proteoglycans in cancer biology, tumour microenvironment and angiogenesis.","volume":"15","author":"Iozzo","year":"2011","journal-title":"J Cell Mol Med."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00069","article-title":"Proteoglycans-biomarkers and targets in cancer therapy.","volume":"9","author":"Nikitovic","year":"2018","journal-title":"Front Endocrinol (Lausanne)."},{"key":"B5","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/febs.13940","article-title":"Syndecans\u2013key regulators of cell signaling and biological functions.","volume":"284","author":"Afratis","year":"2017","journal-title":"FEBS J."},{"key":"B6","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s00441-009-0829-3","article-title":"Syndecans as receptors and organizers of the extracellular matrix.","volume":"339","author":"Xian","year":"2010","journal-title":"Cell Tissue Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1242\/jcs.03432","article-title":"Heparan sulfate proteoglycans at a glance.","volume":"120","author":"Kirkpatrick","year":"2007","journal-title":"J Cell Sci."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a004952","article-title":"Heparan sulfate proteoglycans.","volume":"3","author":"Sarrazin","year":"2011","journal-title":"Cold Spring Harb Perspect Biol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1111\/bph.14397","article-title":"Soluble syndecans: biomarkers for diseases and therapeutic options.","volume":"176","author":"Bertrand","year":"2019","journal-title":"Br J Pharmacol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1146\/annurev-cellbio-100109-104126","article-title":"Transmembrane signaling proteoglycans.","volume":"26","author":"Couchman","year":"2010","journal-title":"Annu Rev Cell Dev Biol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1369\/0022155415568995","article-title":"Syndecan-4 is a major syndecan in primary human endothelial cells in vitro, modulated by inflammatory stimuli and involved in wound healing.","volume":"63","author":"Vuong","year":"2015","journal-title":"J Histochem Cytochem."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2919","DOI":"10.1111\/cas.13722","article-title":"Regulation of antitumor miR-144-5p targets oncogenes: direct regulation of syndecan-3 and its clinical significance.","volume":"109","author":"Yamada","year":"2018","journal-title":"Cancer Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.devcel.2017.08.014","article-title":"Control of cell shape, neurite outgrowth, and migration by a Nogo-A\/HSPG interaction.","volume":"43","author":"Kempf","year":"2017","journal-title":"Dev Cell."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.03031","article-title":"Syndecan-3 in inflammation and angiogenesis.","volume":"10","author":"Arokiasamy","year":"2019","journal-title":"Front Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"19464","DOI":"10.1073\/pnas.0703747104","article-title":"Syndecan-3 is a dendritic cell-specific attachment receptor for HIV-1.","volume":"104","author":"de Witte","year":"2007","journal-title":"Proc Natl Acad Sci USA."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.2-270.v1","article-title":"A novel role for syndecan-3 in angiogenesis.","volume":"2","author":"De Rossi","year":"2013","journal-title":"F1000Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1101\/gad.1214204","article-title":"Essential and separable roles for Syndecan-3 and Syndecan-4 in skeletal muscle development and regeneration.","volume":"18","author":"Cornelison","year":"2004","journal-title":"Genes Dev."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1172\/JCI20631","article-title":"Mice lacking the syndecan-3 gene are resistant to diet-induced obesity.","volume":"114","author":"Strader","year":"2004","journal-title":"J Clin Invest."},{"key":"B19","doi-asserted-by":"publisher","first-page":"4282","DOI":"10.1158\/1078-0432.CCR-04-1386","article-title":"Regulation of fibroblast growth factor-2 activity by human ovarian cancer tumor endothelium.","volume":"11","author":"Whitworth","year":"2005","journal-title":"Clin Cancer Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"5178","DOI":"10.1158\/1078-0432.CCR-03-0103","article-title":"Distribution and clinical significance of heparan sulfate proteoglycans in ovarian cancer.","volume":"10","author":"Davies","year":"2004","journal-title":"Clin Cancer Res."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117404","article-title":"Syndecan-3 and TFPI colocalize on the surface of endothelial-, smooth muscle-, and cancer cells.","volume":"10","author":"Tinholt","year":"2015","journal-title":"PLoS One."},{"key":"B22","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1002\/(SICI)1096-9896(199807)185:3<290::AID-PATH91>3.0.CO;2-I","article-title":"Heparan sulphate proteoglycan expression in human primary liver tumours.","volume":"185","author":"Roskams","year":"1998","journal-title":"J Pathol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1177\/039463200902200308","article-title":"Expression of basic fibroblast growth factor, its receptors and syndecans in bladder cancer.","volume":"22","author":"Marzioni","year":"2009","journal-title":"Int J Immunopathol Pharmacol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"3023","DOI":"10.1111\/jcmm.13213","article-title":"Pleiotrophin, a target of miR-384, promotes proliferation, metastasis and lipogenesis in HBV-related hepatocellular carcinoma.","volume":"21","author":"Bai","year":"2017","journal-title":"J Cell Mol Med."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-34","article-title":"Prognostic significance of the expression of GFRalpha1, GFRalpha3 and syndecan-3, proteins binding ARTEMIN, in mammary carcinoma.","volume":"13","author":"Wu","year":"2013","journal-title":"BMC Cancer."},{"key":"B26","doi-asserted-by":"publisher","first-page":"3907","DOI":"10.3748\/wjg.v23.i21.3907","article-title":"Pleiotrophin and N-syndecan promote perineural invasion and tumor progression in an orthotopic mouse model of pancreatic cancer.","volume":"23","author":"Yao","year":"2017","journal-title":"World J Gastroenterol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"40339","DOI":"10.1074\/jbc.M112.405852","article-title":"Loss of receptor protein tyrosine phosphatase beta\/zeta (RPTPbeta\/zeta) promotes prostate cancer metastasis.","volume":"287","author":"Diamantopoulou","year":"2012","journal-title":"J Biol Chem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"461","DOI":"10.2174\/1568009620666200409130032","article-title":"CircRNA SCARB1 promotes renal cell carcinoma progression via miR-510-5p\/SDC3 axis.","volume":"20","author":"Sun","year":"2020","journal-title":"Curr Cancer Drug Targets."},{"key":"B29","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s11060-005-9010-3","article-title":"Expression of syndecans, a heparan sulfate proteoglycan, in malignant gliomas: participation of nuclear factor-kappaB in upregulation of syndecan-1 expression.","volume":"77","author":"Watanabe","year":"2006","journal-title":"J Neuro Oncol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1053\/j.seminoncol.2015.02.009","article-title":"Immune response regulation in the tumor microenvironment by hypoxia.","volume":"42","author":"Labiano","year":"2015","journal-title":"Semin Oncol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/ncb3330","article-title":"The ever-expanding role of HIF in tumour and stromal biology.","volume":"18","author":"LaGory","year":"2016","journal-title":"Nat Cell Biol."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3390\/cells8091083","article-title":"Improving cancer immunotherapy by targeting the hypoxic tumor microenvironment: new opportunities and challenges.","volume":"8","author":"Noman","year":"2019","journal-title":"Cells."},{"key":"B33","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.immuni.2014.09.008","article-title":"HIF transcription factors, inflammation, and immunity.","volume":"41","author":"Palazon","year":"2014","journal-title":"Immunity."},{"key":"B34","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/nrc3726","article-title":"Hypoxia and the extracellular matrix: drivers of tumour metastasis.","volume":"14","author":"Gilkes","year":"2014","journal-title":"Nat Rev Cancer."},{"key":"B35","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/S0002-9440(10)62038-X","article-title":"Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies.","volume":"167","author":"Lewis","year":"2005","journal-title":"Am J Pathol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"3672","DOI":"10.1172\/JCI84427","article-title":"The impact of hypoxia on tumor-associated macrophages.","volume":"126","author":"Henze","year":"2016","journal-title":"J Clin Invest."},{"key":"B37","doi-asserted-by":"publisher","first-page":"5492","DOI":"10.1158\/0008-5472.CAN-18-1367","article-title":"Diverse functions of macrophages in different tumor microenvironments.","volume":"78","author":"Yang","year":"2018","journal-title":"Cancer Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrc3973","article-title":"Evolving synergistic combinations of targeted immunotherapies to combat cancer.","volume":"15","author":"Melero","year":"2015","journal-title":"Nat Rev Cancer."},{"key":"B39","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41587-020-0546-8","article-title":"Visualizing and interpreting cancer genomics data via the Xena platform.","volume":"38","author":"Goldman","year":"2020","journal-title":"Nat Biotechnol."},{"key":"B40","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.cell.2016.06.017","article-title":"A landscape of pharmacogenomic interactions in cancer.","volume":"166","author":"Iorio","year":"2016","journal-title":"Cell."},{"key":"B41","doi-asserted-by":"publisher","first-page":"6062","DOI":"10.1073\/pnas.0400782101","article-title":"A gene atlas of the mouse and human protein-encoding transcriptomes.","volume":"101","author":"Su","year":"2004","journal-title":"Proc Natl Acad Sci USA."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-632","article-title":"An expression atlas of human primary cells: inference of gene function from coexpression networks.","volume":"14","author":"Mabbott","year":"2013","journal-title":"BMC Genomics."},{"key":"B43","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/s42255-019-0045-8","article-title":"Characterization of hypoxia-associated molecular features to aid hypoxia-targeted therapy.","volume":"1","author":"Ye","year":"2019","journal-title":"Nat Metab."},{"key":"B44","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1126\/science.aad0501","article-title":"Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq.","volume":"352","author":"Tirosh","year":"2016","journal-title":"Science."},{"key":"B45","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1101\/gad.1881410","article-title":"Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis.","volume":"24","author":"Takeda","year":"2010","journal-title":"Genes Dev."},{"key":"B46","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1096\/fj.13-243741","article-title":"HIF-1-PHD2 axis controls expression of syndecan 4 in nucleus pulposus cells.","volume":"28","author":"Fujita","year":"2014","journal-title":"FASEB J."},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-019-1939-2","article-title":"Soluble syndecan-3 binds chemokines, reduces leukocyte migration in vitro and ameliorates disease severity in models of rheumatoid arthritis.","volume":"21","author":"Eustace","year":"2019","journal-title":"Arthritis Res Ther."},{"key":"B48","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/s41573-018-0007-y","article-title":"Approaches to treat immune hot, altered and cold tumours with combination immunotherapies.","volume":"18","author":"Galon","year":"2019","journal-title":"Nat Rev Drug Discov."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-017-0011-9","article-title":"The hypoxic tumour microenvironment.","volume":"7","author":"Petrova","year":"2018","journal-title":"Oncogenesis."}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.586977\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T08:28:51Z","timestamp":1601454531000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fimmu.2020.586977\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,30]]},"references-count":49,"alternative-id":["10.3389\/fimmu.2020.586977"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.586977","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,30]]},"article-number":"586977"}}