{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:16:55Z","timestamp":1790227015739,"version":"4.1.0"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.587669","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T06:37:42Z","timestamp":1605076662000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Low Mannose Binding Lectin, but Not L-Ficolin, Is Associated With Spontaneous Clearance of Hepatitis C Virus After Infection"],"prefix":"10.3389","volume":"11","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yundong","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.176","article-title":"Global epidemiology and burden of HCV infection and HCV-related disease","volume":"14","author":"Thrift","year":"2017","journal-title":"Nat Rev Gastro Hepat"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12295","article-title":"Hepatitis C virus infection in China: an emerging public health issue","volume":"22","author":"Qin","year":"2015","journal-title":"J Viral Hepatitis"},{"key":"B3","article-title":"Spontaneous Elimination of Hepatitis C Virus Infection","volume-title":"Current Concepts in Medical Research and Practice","author":"Janiak","year":"2018"},{"key":"B4","doi-asserted-by":"publisher","first-page":"305","DOI":"10.3390\/cells8040305","article-title":"Hepatitis C Virus Genetic Variability, Human Immune Response, and Genome Polymorphisms: Which Is the Interplay","volume":"8","author":"Lapa","year":"2019","journal-title":"CELLS-BASEL"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13401","article-title":"A systematic review and meta-analysis of HCV clearance","volume":"37","author":"Gauthiez","year":"2017","journal-title":"Liver Int"},{"key":"B6","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/imr.12468","article-title":"A journey through the lectin pathway of complement-MBL and beyond","volume":"274","author":"Garred","year":"2016","journal-title":"Immunol Rev"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2012.08.017","article-title":"Ficolins in complement activation","volume":"55","author":"Matsushita","year":"2013","journal-title":"Mol Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1159\/000242419","article-title":"The Genetics of Ficolins","volume":"2","author":"Garred","year":"2010","journal-title":"J Innate Immun"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1042\/BST0361461","article-title":"Mannose-binding lectin genetics: from A to Z","volume":"36","author":"Garred","year":"2008","journal-title":"Biochem Soc Trans"},{"key":"B10","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.virol.2019.02.002","article-title":"Elevated serum activity of MBL and ficolin-2 as biomarkers for progression to hepatocellular carcinoma in chronic HCV infection","volume":"530","author":"Jalal","year":"2019","journal-title":"VIROLOGY"},{"key":"B11","first-page":"89","article-title":"Serum Mannose - Binding Lectin in Egyptian Patients with Chronic Hepatitis C","volume":"24","author":"Yousef","year":"2017","journal-title":"Egypt J Immunol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2017.04.008","article-title":"Cytokine profile in chronic hepatitis C: An observation","volume":"96","author":"Baskic","year":"2017","journal-title":"CYTOKINE"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e6156","DOI":"10.5812\/hepatmon.6156","article-title":"Serum Profile of T Helper 1 and T Helper 2 Cytokines in Hepatitis C Virus Infected Patients","volume":"12","author":"Sofian","year":"2012","journal-title":"Hepat Mon"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2018.10.003","article-title":"Increased risk of group B Streptococcus causing meningitis in infants with mannose-binding lectin deficiency","volume":"25","author":"Chen","year":"2019","journal-title":"Clin Microbiol Infec"},{"key":"B15","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s10875-008-9201-8","article-title":"Mannose-binding Lectin MBL2 Gene Polymorphisms and Outcome of Hepatitis C Virus-infected Patients","volume":"28","author":"Koutsounaki","year":"2008","journal-title":"J Clin Immunol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-015-0364-8","article-title":"Virus-Specific Cellular Response in Hepatitis C Virus Infection","volume":"64","author":"Kazmierczak","year":"2016","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201601200RR","article-title":"Mannan-binding lectin, a serum collectin, suppresses T-cell proliferationvia direct interaction with cell surface calreticulin and inhibition of proximal T-cell receptor signaling","volume":"31","author":"Zhao","year":"2017","journal-title":"FASEB J"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000935","article-title":"Expression of human ficolin-2 in hepatocytes confers resistance to infection by diverse hepatotropic viruses","volume":"68","author":"Jalal","year":"2019","journal-title":"J Med Microbiol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302563","article-title":"Ficolin-2 inhibits hepatitis C virus infection, whereas apolipoprotein E3 mediates viral immune escape","volume":"193","author":"Zhao","year":"2014","journal-title":"J Immunol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi173","article-title":"Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2","volume":"14","author":"Hummelshoj","year":"2005","journal-title":"Hum Mol Genet"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2007.01915.x","article-title":"The impact of FCN2 polymorphisms and haplotypes on the Ficolin-2 serum levels","volume":"65","author":"Munthe-Fog","year":"2007","journal-title":"Scand J Immunol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1080\/09629359890992","article-title":"Circulating Th1 and Th2 cytokines in patients with hepatitis C virus infection","volume":"7","author":"Fan","year":"1998","journal-title":"Mediators Inflammation"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-2940-y","article-title":"Multiplex Cytokine Profiling of Initial Therapeutic Response in Patients with Chronic Hepatitis C Virus Infection","volume":"50","author":"Wright","year":"2005","journal-title":"Digest Dis Sci"},{"key":"B24","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1002\/(SICI)1096-9071(199806)55:2<89::AID-JMV1>3.0.CO;2-J","article-title":"Production of cytokines in patients infected by hepatitis C virus","volume":"55","author":"Cribier","year":"1998","journal-title":"J Med Virol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(97)89432-2","article-title":"Decrease of interferon gamma serum levels in patients with chronic hepatitis C","volume":"51","author":"Malaguarnera","year":"1997","journal-title":"BioMed Pharmacother"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.21855","article-title":"The Impact of IFN-\u03b3 Gene Polymorphisms on Spontaneous Clearance of HCV Infection in Fars Province, Southern of Iran","volume":"30","author":"Sarvari","year":"2016","journal-title":"J Clin Lab Anal"},{"key":"B27","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1186\/1756-0500-5-508","article-title":"Association of IL-10, IL-4, and IL-28B gene polymorphisms with spontaneous clearance of hepatitis C virus in a population from Rio de Janeiro","volume":"5","author":"Ramos","year":"2012","journal-title":"BMC Res Notes"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011163432007","article-title":"Cytokines in alcoholic and nonalcoholic steatohepatitis","volume":"343","author":"Tilg","year":"2000","journal-title":"N\u00a0Engl J Med"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3109\/1547691X.2012.758198","article-title":"Circulating IL-6, IL-17 and vitamin D in hepatocellular carcinoma: potential biomarkers for a more favorable prognosis","volume":"10","author":"Hammad","year":"2013","journal-title":"J Immunotoxicol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000000654","article-title":"Association of HIV, hepatitis C virus and liver fibrosis severity with interleukin-6 and C-reactive protein levels","volume":"29","author":"Shah","year":"2015","journal-title":"AIDS"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2007.02.006","article-title":"IL-10, T cell exhaustion and viral persistence","volume":"15","author":"Blackburn","year":"2007","journal-title":"Trends Microbiol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.587669\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T06:37:45Z","timestamp":1605076665000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.587669\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,11]]},"references-count":31,"alternative-id":["10.3389\/fimmu.2020.587669"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.587669","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,11]]},"article-number":"587669"}}