{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T02:34:05Z","timestamp":1792550045670,"version":"4.5.0"},"reference-count":234,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T00:00:00Z","timestamp":1603411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2020.590261","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T02:44:47Z","timestamp":1603421087000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":159,"title":["Involvement of Neural Transient Receptor Potential Channels in Peripheral Inflammation"],"prefix":"10.3389","volume":"11","author":[{"given":"Harold A.","family":"Silverman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel L.","family":"Kravatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeeta S.","family":"Chavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric H.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,10,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-018-4560-6","article-title":"Immune aspects of the bi-directional neuroimmune facilitator TRPV1","volume":"46","author":"Li","year":"2019","journal-title":"Mol Biol Rep"},{"key":"B2","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1152\/physrev.00021.2006","article-title":"Transient receptor potential cation channels in disease","volume":"87","author":"Nilius","year":"2007","journal-title":"Physiol Rev"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2020.00180","article-title":"Transient Receptor Potential Channels and Inflammatory Bowel Disease","volume":"11","author":"Chen","year":"2020","journal-title":"Front Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1146\/annurev-physiol-030212-183811","article-title":"TRPA1: A gatekeeper for inflammation","volume":"75","author":"Bautista","year":"2013","journal-title":"Annu Rev Physiol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-12-120","article-title":"Role of TRPM8 in dorsal root ganglion in nerve injury-induced chronic pain","volume":"12","author":"Su","year":"2011","journal-title":"BMC Neurosci"},{"key":"B6","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/mi.2014.82","article-title":"TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP","volume":"8","author":"de Jong","year":"2015","journal-title":"Mucosal Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217431110","article-title":"TRPM8 activation attenuates inflammatory responses in mouse models of colitis","volume":"110","author":"Ramachandran","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1101\/2020.04.30.069849","article-title":"Upregulation of TRPM3 drives hyperexcitability in nociceptors innervating inflamed tissue","author":"Mulier","year":"2020","journal-title":"bioRxiv"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/srep33841","article-title":"Pharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic mice","volume":"6","author":"Dalsgaard","year":"2016","journal-title":"Sci Rep"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.07.002","article-title":"TRPA1 and substance P mediate colitis in mice","volume":"141","author":"Engel","year":"2011","journal-title":"Gastroenterology"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.68.040204.100431","article-title":"An introduction to TRP channels","volume":"68","author":"Ramsey","year":"2006","journal-title":"Annu Rev Physiol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/35077544","article-title":"The TRP ion channel family","volume":"2","author":"Clapham","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"B13","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/sj.bjp.0705467","article-title":"Anandamide and vanilloid TRPV1 receptors","volume":"140","author":"Ross","year":"2003","journal-title":"Br J Pharmacol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.122196999","article-title":"An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors","volume":"99","author":"Huang","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.11.6155","article-title":"Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances","volume":"97","author":"Hwang","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"B17","article-title":"A pharmacological approach to elucidation of the role of different nerve fibres and receptor endings in mediation of pain","volume":"73","author":"Szolcs\u00e1nyi","year":"1977","journal-title":"J Physiol (Paris)"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.2174\/156802611796904898","article-title":"Therapeutic targeting of TRP channels\u2013the TR(i)P to pain relief","volume":"11","author":"Eid","year":"2011","journal-title":"Curr Top Med Chem"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.01.051","article-title":"Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial","volume":"152","author":"Rowbotham","year":"2011","journal-title":"Pain"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.10.005","article-title":"The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation","volume":"125","author":"Alawi","year":"2010","journal-title":"Pharmacol Ther"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.060496197","article-title":"Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human","volume":"97","author":"Mezey","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3009","article-title":"The ion channel TRPV1 regulates the activation and proinflammatory properties of CD4+ T cells","volume":"15","author":"Bertin","year":"2014","journal-title":"Nat Immunol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.01.173","article-title":"Differences in the effects of four TRPV1 channel antagonists on lipopolysaccharide-induced cytokine production and COX-2 expression in murine macrophages","volume":"484","author":"Ninomiya","year":"2017","journal-title":"Biochem Biophys Res Commun"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.08.023","article-title":"Dendritic cells do not transduce inflammatory stimuli via the capsaicin receptor TRPV1","volume":"579","author":"O\u2019Connell","year":"2005","journal-title":"FEBS Lett"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.040675","article-title":"Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes","volume":"304","author":"Southall","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2004.08.007","article-title":"Immunohistochemical evidence of vanilloid receptor 1 in normal human urinary bladder","volume":"46","author":"Lazzeri","year":"2004","journal-title":"Eur Urol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.231243698","article-title":"Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells","volume":"98","author":"Birder","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfg044","article-title":"Capsaicinoids cause inflammation and epithelial cell death through activation of vanilloid receptors","volume":"73","author":"Reilly","year":"2003","journal-title":"Toxicol Sci Off J Soc Toxicol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.06.149","article-title":"Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet beta cells modulates insulin secretion in rats","volume":"321","author":"Akiba","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"B30","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.molbrainres.2004.08.025","article-title":"Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors","volume":"132","author":"Golech","year":"2004","journal-title":"Brain Res Mol Brain Res"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.090712","article-title":"A 3.5-nm structure of rat TRPV4 cation channel revealed by Zernike phase-contrast cryoelectron microscopy","volume":"285","author":"Shigematsu","year":"2010","journal-title":"J Biol Chem"},{"key":"B32","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/s41419-019-1708-9","article-title":"Transient receptor potential ion-channel subfamily V member 4: a potential target for cancer treatment","volume":"10","author":"Yu","year":"2019","journal-title":"Cell Death Dis"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-4-51","article-title":"Quantitative Real-Time PCR detection of TRPV1-4 gene expression in human leukocytes from healthy and hyposensitive subjects","volume":"4","author":"Spinsanti","year":"2008","journal-title":"Mol Pain"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13306","article-title":"Functional expression of TRPV channels in T cells and their implications in immune regulation","volume":"282","author":"Majhi","year":"2015","journal-title":"FEBS J"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00315.2009","article-title":"TRPV4 channels augment macrophage activation and ventilator-induced lung injury","volume":"299","author":"Hamanaka","year":"2010","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00016.2015","article-title":"TRPV4: Molecular Conductor of a Diverse Orchestra","volume":"96","author":"White","year":"2016","journal-title":"Physiol Rev"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-15-06408.2002","article-title":"Heat-evoked activation of the ion channel, TRPV4","volume":"22","author":"G\u00fcler","year":"2002","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.01.074","article-title":"Selective role for TRPV4 ion channels in visceral sensory pathways","volume":"134","author":"Brierley","year":"2008","journal-title":"Gastroenterology"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.04.004","article-title":"Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion","volume":"154","author":"Chen","year":"2013","journal-title":"Pain"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-5-5","article-title":"Modulation of transient receptor potential Vanilloid 4-mediated membrane currents and synaptic transmission by protein kinase C","volume":"5","author":"Cao","year":"2009","journal-title":"Mol Pain"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302561200","article-title":"Impaired pressure sensation in mice lacking TRPV4","volume":"278","author":"Suzuki","year":"2003","journal-title":"J Biol Chem"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.12.028","article-title":"The molecular and cellular identity of peripheral osmoreceptors","volume":"69","author":"Lechner","year":"2011","journal-title":"Neuron"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.2001.4.3.165","article-title":"Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2","volume":"4","author":"Delany","year":"2001","journal-title":"Physiol Genomics"},{"key":"B44","article-title":"Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis","volume":"58","author":"Duncan","year":"1998","journal-title":"Cancer Res"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300945200","article-title":"Molecular and functional characterization of the melastatin-related cation channel TRPM3","volume":"278","author":"Grimm","year":"2003","journal-title":"J Biol Chem"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2019.102111","article-title":"A structural overview of the ion channels of the TRPM family","volume":"85","author":"Huang","year":"2020","journal-title":"Cell Calcium"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.02.051","article-title":"TRPM3 is a nociceptor channel involved in the detection of noxious heat","volume":"70","author":"Vriens","year":"2011","journal-title":"Neuron"},{"key":"B48","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/bs.pmbts.2015.01.002","article-title":"Sensory TRP channels: the key transducers of nociception and pain","volume":"131","author":"Mickle","year":"2015","journal-title":"Prog Mol Biol Transl Sci"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.4161\/23328940.2014.988524","article-title":"TRPM3 in temperature sensing and beyond","volume":"2","author":"Held","year":"2015","journal-title":"Temp Austin Tex"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.00174","article-title":"Functional Role of Transient Receptor Potential Channels in Immune Cells and Epithelia","volume":"9","author":"Khalil","year":"2018","journal-title":"Front Immunol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.04.029","article-title":"Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice","volume":"458","author":"Gauchan","year":"2009","journal-title":"Neurosci Lett"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/srep45155","article-title":"TRPM8 in the negative regulation of TNF\u03b1 expression during cold stress","volume":"7","author":"Wang","year":"2017","journal-title":"Sci Rep"},{"key":"B53","doi-asserted-by":"publisher","first-page":"e0117615","DOI":"10.1371\/journal.pone.0117615","article-title":"TRPM3 expression in mouse retina","volume":"10","author":"Brown","year":"2015","journal-title":"PloS One"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14994","article-title":"Functional expression and pharmacological modulation of TRPM3 in human sensory neurons","volume":"177","author":"Vangeel","year":"2020","journal-title":"Br J Pharmacol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/cne.24694","article-title":"Expression of the cold thermoreceptor TRPM8 in rodent brain thermoregulatory circuits","author":"Ord\u00e1s","year":"2019","journal-title":"J Comp Neurol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1152\/physrev.00005.2019","article-title":"Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease","volume":"100","author":"Talavera","year":"2020","journal-title":"Physiol Rev"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1021\/jm100062h","article-title":"Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents","volume":"53","author":"Baraldi","year":"2010","journal-title":"J Med Chem"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00524.2018","article-title":"TRPA1: a molecular view","volume":"121","author":"Meents","year":"2019","journal-title":"J Neurophysiol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808487106","article-title":"TRPA1 acts as a cold sensor in vitro and in vivo","volume":"106","author":"Karashima","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/srep28763","article-title":"Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity","volume":"6","author":"Moparthi","year":"2016","journal-title":"Sci Rep"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/nature26137","article-title":"A TRP channel trio mediates acute noxious heat sensing","volume":"555","author":"Vandewauw","year":"2018","journal-title":"Nature"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2020.102255","article-title":"Human TRPA1 is an inherently mechanosensitive bilayer-gated ion channel","volume":"91","author":"Moparthi","year":"2020","journal-title":"Cell Calcium"},{"key":"B63","doi-asserted-by":"publisher","first-page":"e0128242","DOI":"10.1371\/journal.pone.0128242","article-title":"Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice","volume":"10","author":"Mueller-Tribbensee","year":"2015","journal-title":"PloS One"},{"key":"B64","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.npep.2011.07.011","article-title":"TRPV1, TRPA1, and CB1 in the isolated vagus nerve\u2013axonal chemosensitivity and control of neuropeptide release","volume":"45","author":"Weller","year":"2011","journal-title":"Neuropeptides"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1098\/rsob.160314","article-title":"TRPA1 expression and its functional activation in rodent cortex","volume":"7","author":"Kheradpezhouh","year":"2017","journal-title":"Open Biol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.06.038","article-title":"Molecular cloning and characterization of dog TRPA1 and AITC stimulate the gastrointestinal motility through TRPA1 in conscious dogs","volume":"617","author":"Doihara","year":"2009","journal-title":"Eur J Pharmacol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.11.7325","article-title":"An ankyrin-like protein with transmembrane domains is specifically lost after oncogenic transformation of human fibroblasts","volume":"274","author":"Jaquemar","year":"1999","journal-title":"J Biol Chem"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2019.01253","article-title":"The TRPA1 Channel in the Cardiovascular System: Promising Features and Challenges","volume":"10","author":"Wang","year":"2019","journal-title":"Front Pharmacol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0042454","article-title":"Transient Receptor Potential Ankyrin 1 Channel Localized to Non-Neuronal Airway Cells Promotes Non-Neurogenic Inflammation","volume":"7","author":"Nassini","year":"2012","journal-title":"PloS One"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.148379","article-title":"Expression and function of the ion channel TRPA1 in vagal afferent nerves innervating mouse lungs","volume":"586","author":"Nassenstein","year":"2008","journal-title":"J Physiol"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310710","article-title":"The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1","volume":"66","author":"Bertin","year":"2017","journal-title":"Gut"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.02.023","article-title":"TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents","volume":"124","author":"Bautista","year":"2006","journal-title":"Cell"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms4125","article-title":"TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins","volume":"5","author":"Meseguer","year":"2014","journal-title":"Nat Commun"},{"key":"B74","doi-asserted-by":"publisher","first-page":"4381","DOI":"10.1038\/ncomms5381","article-title":"H 2 S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO\u2013TRPA1\u2013CGRP signalling pathway","volume":"5","author":"Eberhardt","year":"2014","journal-title":"Nat Commun"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.328674","article-title":"Methylglyoxal Activates Nociceptors through Transient Receptor Potential Channel A1 (TRPA1) A Possible Mechanism Of Metabolic Neuropathies","volume":"287","author":"Eberhardt","year":"2012","journal-title":"J Biol Chem"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/35082088","article-title":"Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition","volume":"411","author":"Chuang","year":"2001","journal-title":"Nature"},{"key":"B77","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/s0896-6273(02)00908-x","article-title":"p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia","volume":"36","author":"Ji","year":"2002","journal-title":"Neuron"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1726-06.2006","article-title":"Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo","volume":"26","author":"Malin","year":"2006","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-16-06081.1998","article-title":"The cAMP transduction cascade mediates the prostaglandin E2 enhancement of the capsaicin-elicited current in rat sensory neurons: whole-cell and single-channel studies","volume":"18","author":"Lopshire","year":"1998","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M311448200","article-title":"Phosphorylation of vanilloid receptor 1 by Ca2+\/calmodulin-dependent kinase II regulates its vanilloid binding","volume":"279","author":"Jung","year":"2004","journal-title":"J Biol Chem"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/s0896-6273(02)00802-4","article-title":"cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation","volume":"35","author":"Bhave","year":"2002","journal-title":"Neuron"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-1-3","article-title":"Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins","volume":"1","author":"Moriyama","year":"2005","journal-title":"Mol Pain"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.111025298","article-title":"Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia","volume":"98","author":"Tominaga","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-134346","article-title":"Differential contribution of SNARE-dependent exocytosis to inflammatory potentiation of TRPV1 in nociceptors","volume":"23","author":"Camprub\u00ed-Robles","year":"2009","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1038\/srep21226","article-title":"TNF\u03b1 induces co-trafficking of TRPV1\/TRPA1 in VAMP1-containing vesicles to the plasmalemma via Munc18-1\/syntaxin1\/SNAP-25 mediated fusion","volume":"6","author":"Meng","year":"2016","journal-title":"Sci Rep"},{"key":"B86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0091763","article-title":"Sensitization by Pulmonary Reactive Oxygen Species of Rat Vagal Lung C-Fibers: The Roles of the TRPV1, TRPA1, and P2X Receptors","volume":"9","author":"Ruan","year":"2014","journal-title":"PloS One"},{"key":"B87","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1523\/JNEUROSCI.12-01-00086.1992","article-title":"Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro","volume":"12","author":"Steen","year":"1992","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(94)90149-x","article-title":"Protons: small stimulants of capsaicin-sensitive sensory nerves","volume":"17","author":"Bevan","year":"1994","journal-title":"Trends Neurosci"},{"key":"B89","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.jcmgh.2014.11.002","article-title":"Acinar Cell Production of Leukotriene B4 Contributes to Development of Neurogenic Pancreatitis in Mice","volume":"1","author":"Shahid","year":"2015","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.06.015","article-title":"Transient receptor potential vanilloid 1 mediates hyperalgesia and is up-regulated in rats with chronic pancreatitis","volume":"133","author":"Xu","year":"2007","journal-title":"Gastroenterology"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200402-174OC","article-title":"Increased expression of transient receptor potential vanilloid-1 in airway nerves of chronic cough","volume":"170","author":"Groneberg","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2008.161042","article-title":"Altered expression of TRPV1 and sensitivity to capsaicin in pulmonary myelinated afferents following chronic airway inflammation in the rat","volume":"586","author":"Zhang","year":"2008","journal-title":"J Physiol"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00406.2006","article-title":"Role of transient receptor potential vanilloid 1 receptors in endotoxin-induced airway inflammation in the mouse","volume":"292","author":"Helyes","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.09295sc","article-title":"Effects of SA13353, a transient receptor potential vanilloid 1 agonist, on leukocyte infiltration in lipopolysaccharide-induced acute lung injury and ovalbumin-induced allergic airway inflammation","volume":"112","author":"Tsuji","year":"2010","journal-title":"J Pharmacol Sci"},{"key":"B95","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.jdermsci.2010.10.014","article-title":"TRPV1 antagonist can suppress the atopic dermatitis-like symptoms by accelerating skin barrier recovery","volume":"62","author":"Yun","year":"2011","journal-title":"J Dermatol Sci"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.048","article-title":"A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1","volume":"133","author":"Cevikbas","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1002\/art.21297","article-title":"Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation","volume":"52","author":"Keeble","year":"2005","journal-title":"Arthritis Rheum"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000132975.02854.65","article-title":"Small-dose capsaicin reduces systemic inflammatory responses in septic rats","volume":"99","author":"Demirbilek","year":"2004","journal-title":"Anesth Analg"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-7460com","article-title":"The transient receptor potential vanilloid 1 (TRPV1) receptor protects against the onset of sepsis after endotoxin","volume":"21","author":"Clark","year":"2007","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181c0df00","article-title":"Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis","volume":"38","author":"Ang","year":"2010","journal-title":"Crit Care Med"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(92)90046-r","article-title":"Treatment parameters of desensitization to capsaicin","volume":"51","author":"Craft","year":"1992","journal-title":"Life Sci"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.121111","article-title":"Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice","volume":"578","author":"Grant","year":"2007","journal-title":"J Physiol"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.438184","article-title":"Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling","volume":"288","author":"Poole","year":"2013","journal-title":"J Biol Chem"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1038\/JID.2015.388","article-title":"Involvement of TRPV4 in Serotonin-Evoked Scratching","volume":"136","author":"Akiyama","year":"2016","journal-title":"J Invest Dermatol"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1312933110","article-title":"UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling","volume":"110","author":"Moore","year":"2013","journal-title":"Proc Natl Acad Sci"},{"key":"B106","doi-asserted-by":"publisher","first-page":"93","DOI":"10.12688\/f1000research.6298.1","article-title":"Blockade or deletion of transient receptor potential vanilloid 4 (TRPV4) is not protective in a murine model of sepsis","volume":"4","author":"Sand","year":"2015","journal-title":"F1000Research"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/nature05910","article-title":"The menthol receptor TRPM8 is the principal detector of environmental cold","volume":"448","author":"Bautista","year":"2007","journal-title":"Nature"},{"key":"B108","doi-asserted-by":"publisher","first-page":"e7383","DOI":"10.1371\/journal.pone.0007383","article-title":"The contribution of TRPM8 and TRPA1 channels to cold allodynia and neuropathic pain","volume":"4","author":"Caspani","year":"2009","journal-title":"PloS One"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S197168","article-title":"Intrathecal TRPM8 blocking attenuates cold hyperalgesia via PKC and NF-\u03baB signaling in the dorsal root ganglion of rats with neuropathic pain","volume":"12","author":"Cao","year":"2019","journal-title":"J Pain Res"},{"key":"B110","doi-asserted-by":"publisher","first-page":"684","DOI":"10.4168\/aair.2020.12.4.684","article-title":"Activation of Transient Receptor Potential Melastatin Family Member 8 (TRPM8) Receptors Induces Proinflammatory Cytokine Expressions in Bronchial Epithelial Cells","volume":"12","author":"Kim","year":"2020","journal-title":"Allergy Asthma Immunol Res"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0440OC","article-title":"Human lung epithelial cells express a functional cold-sensing TRPM8 variant","volume":"39","author":"Sabnis","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"key":"B112","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.pain.2010.08.021","article-title":"TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation","volume":"152","author":"Kunkler","year":"2011","journal-title":"Pain"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0804-4","article-title":"The role of the transient receptor potential ankyrin type-1 (TRPA1) channel in migraine pain: evaluation in an animal model","volume":"18","author":"Demartini","year":"2017","journal-title":"J Headache Pain"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5318-12.2013","article-title":"The ion channel TRPA1 is required for chronic itch","volume":"33","author":"Wilson","year":"2013","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"B115","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/nn.2789","article-title":"TRPA1 is required for histamine-independent, Mas-related G protein-coupled receptor-mediated itch","volume":"14","author":"Wilson","year":"2011","journal-title":"Nat Neurosci"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000846","article-title":"Primidone inhibits TRPM3 and attenuates thermal nociception in vivo","volume":"158","author":"Kr\u00fcgel","year":"2017","journal-title":"Pain"},{"key":"B117","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ph9040070","article-title":"Blocking TRPA1 in Respiratory Disorders: Does It Hold a Promise","volume":"9","author":"Mukhopadhyay","year":"2016","journal-title":"Pharm Basel Switz"},{"key":"B118","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1136\/thoraxjnl-2011-200365","article-title":"A role for sensory nerves in the late asthmatic response","volume":"67","author":"Raemdonck","year":"2012","journal-title":"Thorax"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900591106","article-title":"A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma","volume":"106","author":"Caceres","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"B120","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ph12020048","article-title":"Role of TRPV1 and TRPA1 Ion Channels in Inflammatory Bowel Diseases: Potential Therapeutic Targets","volume":"12","author":"Csek\u0151","year":"2019","journal-title":"Pharmaceuticals"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-9848-7","article-title":"Protective roles of alpha-calcitonin and beta-calcitonin gene-related peptide in spontaneous and experimentally induced colitis","volume":"53","author":"Thompson","year":"2008","journal-title":"Dig Dis Sci"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1002\/art.30150","article-title":"A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor \u03b1-induced inflammatory hyperalgesia and Freund\u2019s complete adjuvant-induced monarthritis","volume":"63","author":"Fernandes","year":"2011","journal-title":"Arthritis Rheum"},{"key":"B123","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ph11040105","article-title":"Evidence for Transient Receptor Potential (TRP) Channel Contribution to Arthritis Pain and Pathogenesis","volume":"11","author":"Galindo","year":"2018","journal-title":"Pharmaceuticals"},{"key":"B124","article-title":"Transient receptor potential ankyrin 1 protects against sepsis-induced kidney injury by modulating mitochondrial biogenesis and mitophagy","volume":"10","author":"Zhu","year":"2018","journal-title":"Am J Transl Res"},{"key":"B125","doi-asserted-by":"publisher","first-page":"822734","DOI":"10.1101\/822734","article-title":"Transient Receptor Potential Ankyrin 1 Mediates Afferent Signals in the Inflammatory Reflex","author":"Silverman","year":"2019","journal-title":"bioRxiv"},{"key":"B126","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1053\/j.gastro.2010.12.033","article-title":"Synergistic role of TRPV1 and TRPA1 in pancreatic pain and inflammation","volume":"140","author":"Schwartz","year":"2011","journal-title":"Gastroenterology"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.281.5.G1322","article-title":"Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis","volume":"281","author":"Nathan","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2185-06.2006","article-title":"Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold","volume":"26","author":"Elitt","year":"2006","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01064","article-title":"The Role of Transient Receptor Potential Vanilloid 1 in Common Diseases of the Digestive Tract and the Cardiovascular and Respiratory System","volume":"10","author":"Du","year":"2019","journal-title":"Front Physiol"},{"key":"B130","doi-asserted-by":"crossref","DOI":"10.1164\/ajrccm-conference.2010.181.1_MeetingAbstracts.A2490","article-title":"The Sensory Receptor TRPV1 Is Expressed In Human Bronchial Epithelium And Upregulated In Refractory (Steroid Resistant) Asthma","volume-title":"B13. Mechanisms Of Epithelial Cell Dysfunction In Airway Disease American Thoracic Society International Conference Abstracts","author":"Butler","year":"2010"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.55.149","article-title":"Cough sensitivity in pure cough variant asthma elicited using continuous capsaicin inhalation","volume":"55","author":"Nakajima","year":"2006","journal-title":"Allergol Int Off J Jpn Soc Allergol"},{"key":"B132","article-title":"Cough reflex sensitivity testing in in seasonal allergic rhinitis patients and healthy volunteers","author":"Pecova","year":"2008","journal-title":"J Physiol Pharmacol Off J Pol Physiol Soc"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1995.79.4.1082","article-title":"Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs","volume":"79","author":"Lalloo","year":"1995","journal-title":"J Appl Physiol Bethesda Md 1985"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2003.012930","article-title":"Antitussive activity of iodo-resiniferatoxin in guinea pigs","volume":"59","author":"Trevisani","year":"2004","journal-title":"Thorax"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1186\/1745-9974-2-10","article-title":"TRPV1 antagonists attenuate antigen-provoked cough in ovalbumin sensitized guinea pigs","volume":"2","author":"McLeod","year":"2006","journal-title":"Cough Lond Engl"},{"key":"B136","doi-asserted-by":"publisher","first-page":"18954","DOI":"10.2147\/CCID.S56673","article-title":"Tachyphylaxis to topical glucocorticoids; what is the evidence","volume":"19","author":"Taheri","year":"2013","journal-title":"Dermatol Online J"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4501","article-title":"Nociceptor sensory neurons suppress neutrophil and \u03b3\u03b4 T cell responses in bacterial lung infections and lethal pneumonia","volume":"24","author":"Baral","year":"2018","journal-title":"Nat Med"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705768","article-title":"Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function","volume":"141","author":"Geppetti","year":"2004","journal-title":"Br J Pharmacol"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.11-0547","article-title":"Augmented activity of the pelvic nerve afferent mediated by TRP channels in dextran sulfate sodium (DSS)-induced colitis of rats","volume":"74","author":"Makimura","year":"2012","journal-title":"J Vet Med Sci"},{"key":"B140","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1097\/00042737-200409000-00014","article-title":"Increased capsaicin receptor TRPV1 nerve fibres in the inflamed human oesophagus","volume":"16","author":"Matthews","year":"2004","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4643-06.2007","article-title":"TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase","volume":"27","author":"Shim","year":"2007","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"B142","doi-asserted-by":"crossref","DOI":"10.33549\/physiolres.931478","article-title":"Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin","author":"Vyklick\u00fd","year":"2008","journal-title":"Physiol Res"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-3940(01)02093-6","article-title":"Peripheral capsaicin receptors increase in the inflamed rat hindpaw: a possible mechanism for peripheral sensitization","volume":"310","author":"Carlton","year":"2001","journal-title":"Neurosci Lett"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.06.015","article-title":"Vanilloid receptor TRPV1-mediated phosphorylation of ERK in murine adjuvant arthritis","volume":"17","author":"Chen","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12056","article-title":"TRPV1 and SP: key elements for sepsis outcome","volume":"170","author":"Bodkin","year":"2013","journal-title":"Br J Pharmacol"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00005.2008","article-title":"TRPV1-mediated protection against endotoxin-induced hypotension and mortality in rats","volume":"294","author":"Wang","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01851.x","article-title":"The functions of TRPA1 and TRPV1: moving away from sensory nerves","volume":"166","author":"Fernandes","year":"2012","journal-title":"Br J Pharmacol"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1038\/srep28621","article-title":"Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain","volume":"6","author":"Kistner","year":"2016","journal-title":"Sci Rep"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.118349","article-title":"Transient receptor potential vanilloid gene deletion exacerbates inflammation and atypical cardiac remodeling after myocardial infarction","volume":"53","author":"Huang","year":"2009","journal-title":"Hypertens Dallas Tex 1979"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1159\/000444439","article-title":"Transient Receptor Potential Vanilloid Subtype 1 Inhibits Inflammation and Apoptosis via the Release of Calcitonin Gene-Related Peptide in the Heart after Myocardial Infarction","volume":"134","author":"Lei","year":"2016","journal-title":"Cardiology"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.430220202","article-title":"Topical capsaicin in the treatment of cutaneous disorders","volume":"22","author":"Carter","year":"1991","journal-title":"Drug Dev Res"},{"key":"B152","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1097\/00002508-199806000-00003","article-title":"Review of the effectiveness of capsaicin for painful cutaneous disorders and neural dysfunction","volume":"14","author":"Hautkappe","year":"1998","journal-title":"Clin J Pain"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200767040-00006","article-title":"Diabetic painful neuropathy: current and future treatment options","volume":"67","author":"Chong","year":"2007","journal-title":"Drugs"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen354","article-title":"Capsaicin receptor antagonists: a promising new addition to the pain clinic","volume":"102","author":"Lambert","year":"2009","journal-title":"BJA Br J Anaesth"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.2174\/156802608786264254","article-title":"Recent progress in the development of selective TRPV1 antagonists for pain","volume":"8","author":"Broad","year":"2008","journal-title":"Curr Top Med Chem"},{"key":"B156","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ph10030064","article-title":"Transient Receptor Potential (TRP) Channels in Drug Discovery: Old Concepts & New Thoughts","volume":"10","author":"Huang","year":"2017","journal-title":"Pharm Basel Switz"},{"key":"B157","article-title":"TRPV1 Antagonism with XEN-D0501 in Chronic Obstructive Pulmonary Disease: Translation from Pre-Clinical Model to Clinical Trial","volume-title":"C74. Advances In Translational COPD American Thoracic Society International Conference Abstracts","author":"Smith","year":"2017"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201704-0769OC","article-title":"XEN-D0501, a Novel Transient Receptor Potential Vanilloid 1 Antagonist, Does Not Reduce Cough in Patients with Refractory Cough","volume":"196","author":"Belvisi","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.5414\/CP201890","article-title":"The effects of a TRPV1 antagonist, SB-705498, in the treatment of seasonal allergic rhinitis","volume":"51","author":"Bareille","year":"2013","journal-title":"Int J Clin Pharmacol Ther"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.02.004","article-title":"TRPV1 antagonistic analgesic effect: a randomized study of AZD1386 in pain after third molar extraction","volume":"154","author":"Quiding","year":"2013","journal-title":"Pain"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17455","article-title":"Efficacy and safety of PAC-14028 cream - a novel, topical, nonsteroidal, selective TRPV1 antagonist in patients with mild-to-moderate atopic dermatitis: a phase IIb randomized trial","volume":"180","author":"Lee","year":"2019","journal-title":"Br J Dermatol"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjpain.2017.07.021","article-title":"A randomized study to evaluate the analgesic efficacy of a single dose of the TRPV1 antagonist mavatrep in patients with osteoarthritis","volume":"17","author":"Mayorga","year":"2017","journal-title":"Scand J Pain"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1515\/sjpain-2017-0184","article-title":"A multiple-dose double-blind randomized study to evaluate the safety, pharmacokinetics, pharmacodynamics and analgesic efficacy of the TRPV1 antagonist JNJ-39439335 (mavatrep)","volume":"18","author":"Manitpisitkul","year":"2018","journal-title":"Scand J Pain"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04629.x","article-title":"Randomised clinical trial: the efficacy of a transient receptor potential vanilloid 1 antagonist AZD1386 in human oesophageal pain","volume":"33","author":"Krarup","year":"2011","journal-title":"Aliment Pharmacol Ther"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S128727","article-title":"A first-in-human, double-blind, placebo-controlled, randomized, dose escalation study of DWP05195, a novel TRPV1 antagonist, in healthy volunteers","volume":"11","author":"Lee","year":"2017","journal-title":"Drug Des Devel Ther"},{"key":"B166","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/PR9.0000000000000576","article-title":"TRPV1 antagonist JNJ-39439335 (mavatrep) demonstrates proof of pharmacology in healthy men: a first-in-human, double-blind, placebo-controlled, randomized, sequential group study","volume":"1","author":"Manitpisitkul","year":"2016","journal-title":"Pain Rep"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.01.024","article-title":"Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans","volume":"136","author":"Gavva","year":"2008","journal-title":"Pain"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2009.02.014","article-title":"Analgesic potential of TRPV1 antagonists","volume":"78","author":"Kym","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"B169","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/B978-0-12-396493-9.00002-9","article-title":"TRPV1 antagonists: clinical setbacks and prospects for future development","volume":"51","author":"Kort","year":"2012","journal-title":"Prog Med Chem"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2012.11.006","article-title":"Neuronal IL-17 receptor upregulates TRPV4 but not TRPV1 receptors in DRG neurons and mediates mechanical but not thermal hyperalgesia","volume":"52","author":"Segond von Banchet","year":"2013","journal-title":"Mol Cell Neurosci"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-013-0033-5","article-title":"Increased TRPV4 expression in urinary bladder and lumbosacral dorsal root ganglia in mice with chronic overexpression of NGF in urothelium","volume":"51","author":"Girard","year":"2013","journal-title":"J Mol Neurosci MN"},{"key":"B172","doi-asserted-by":"publisher","first-page":"e39959","DOI":"10.1371\/journal.pone.0039959","article-title":"The increased activity of TRPV4 channel in the astrocytes of the adult rat hippocampus after cerebral hypoxia\/ischemia","volume":"7","author":"Butenko","year":"2012","journal-title":"PloS One"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00296.2012","article-title":"Prolonged high fat\/alcohol exposure increases TRPV4 and its functional responses in pancreatic stellate cells","volume":"304","author":"Zhang","year":"2013","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.424","article-title":"Distribution and expression of non-neuronal transient receptor potential (TRPV) ion channels in rosacea","volume":"132","author":"Sulk","year":"2012","journal-title":"J Invest Dermatol"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-205467","article-title":"Role of transient receptor potential and pannexin channels in cigarette smoke-triggered ATP release in the lung","volume":"69","author":"Baxter","year":"2014","journal-title":"Thorax"},{"key":"B176","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1053\/j.gastro.2008.05.024","article-title":"Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms","volume":"135","author":"Cenac","year":"2008","journal-title":"Gastroenterology"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.192567","article-title":"Potentiation of TRPV4 signalling by histamine and serotonin: an important mechanism for visceral hypersensitivity","volume":"59","author":"Cenac","year":"2010","journal-title":"Gut"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.716464","article-title":"Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch","volume":"291","author":"Chen","year":"2016","journal-title":"J Biol Chem"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-017-1998-7","article-title":"Transient receptor potential vanilloid 4 (TRPV4) channel as a target of crotamiton and its bimodal effects","volume":"469","author":"Kittaka","year":"2017","journal-title":"Pflugers Arch"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b18-00361","article-title":"TRPV4 Channel-Regulated ATP Release Contributes to \u03b3-Irradiation-Induced Production of IL-6 and IL-8 in Epidermal Keratinocytes","volume":"41","author":"Ohsaki","year":"2018","journal-title":"Biol Pharm Bull"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2018.64.7.14","article-title":"Sustenance of endothelial cell stability in septic mice through appropriate activation of transient receptor potential vanilloid-4","volume":"64","author":"Zhu","year":"2018","journal-title":"Cell Mol Biol Noisy\u2013Gd Fr"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1124\/mol.113.086843","article-title":"Flavanones that selectively inhibit TRPM3 attenuate thermal nociception in vivo","volume":"84","author":"Straub","year":"2013","journal-title":"Mol Pharmacol"},{"key":"B183","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1085\/jgp.201411339","article-title":"Regulation of the transient receptor potential channel TRPM3 by phosphoinositides","volume":"146","author":"T\u00f3th","year":"2015","journal-title":"J Gen Physiol"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0882-19.2019","article-title":"Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by G\u03b2\u03b3 Subunits","volume":"39","author":"Alkhatib","year":"2019","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"B185","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7554\/eLife.26138","article-title":"G protein \u03b2\u03b3 subunits inhibit TRPM3 ion channels in sensory neurons","volume":"6","author":"Quallo","year":"2017","journal-title":"eLife"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2011.01.027","article-title":"A novel role for TRPM8 in visceral afferent function","volume":"152","author":"Harrington","year":"2011","journal-title":"Pain"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.16","article-title":"Transient receptor potential melastatin 8 ion channel in macrophages modulates colitis through a balance-shift in TNF-alpha and interleukin-10 production","volume":"9","author":"Khalil","year":"2016","journal-title":"Mucosal Immunol"},{"key":"B188","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1183\/13993003.congress-2016.PA3997","article-title":"The activation of transient receptor potential melastatin 8 (TRPM8) receptors of bronchial epithelial cells induces airway inflammation in bronchial asthma","volume":"48","author":"Cheon","year":"2016","journal-title":"Eur Respir J"},{"key":"B189","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1080\/19336950.2020.1734266","article-title":"Regulation of the cold-sensing TRPM8 channels by phosphoinositides and Gq-coupled receptors","volume":"14","author":"Liu","year":"2020","journal-title":"Channels Austin Tex"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1038\/nn1451","article-title":"PI(4,5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain","volume":"8","author":"Roh\u00e1cs","year":"2005","journal-title":"Nat Neurosci"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.05.080","article-title":"Direct G\u03b1q Gating Is the Sole Mechanism for TRPM8 Inhibition Caused by Bradykinin Receptor Activation","volume":"27","author":"Zhang","year":"2019","journal-title":"Cell Rep"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2529","article-title":"Direct inhibition of the cold-activated TRPM8 ion channel by G\u03b1q","volume":"14","author":"Zhang","year":"2012","journal-title":"Nat Cell Biol"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2304-18.2019","article-title":"G\u03b1q Sensitizes TRPM8 to Inhibition by PI(4,5)P2 Depletion upon Receptor Activation","volume":"39","author":"Liu","year":"2019","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.02.060","article-title":"The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists","volume":"22","author":"Matthews","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.01.060","article-title":"Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia","volume":"22","author":"Calvo","year":"2012","journal-title":"Bioorg Med Chem Lett"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1021\/jm101075v","article-title":"Design and Optimization of Benzimidazole-Containing Transient Receptor Potential Melastatin 8 (TRPM8) Antagonists","volume":"54","author":"Parks","year":"2011","journal-title":"J Med Chem"},{"key":"B197","doi-asserted-by":"publisher","first-page":"e25894","DOI":"10.1371\/journal.pone.0025894","article-title":"Pharmacological blockade of TRPM8 ion channels alters cold and cold pain responses in mice","volume":"6","author":"Knowlton","year":"2011","journal-title":"PloS One"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.80796","article-title":"Intragastric administration of TRPV1, TRPV3, TRPM8, and TRPA1 agonists modulates autonomic thermoregulation in different manners in mice","volume":"73","author":"Masamoto","year":"2009","journal-title":"Biosci Biotechnol Biochem"},{"key":"B199","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1136\/thoraxjnl-2013-203894","article-title":"Rhinovirus upregulates transient receptor potential channels in a human neuronal cell line: implications for respiratory virus-induced cough reflex sensitivity","volume":"69","author":"Abdullah","year":"2014","journal-title":"Thorax"},{"key":"B200","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0171681","article-title":"Respiratory virus infection up-regulates TRPV1, TRPA1 and ASICS3 receptors on airway cells","volume":"12","author":"Omar","year":"2017","journal-title":"PloS One"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.4161\/chan.5.6.18016","article-title":"The role of TRPA1 in visceral inflammation and pain","volume":"5","author":"Lapointe","year":"2011","journal-title":"Channels Austin Tex"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1172\/JCI25437","article-title":"TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury","volume":"115","author":"Obata","year":"2005","journal-title":"J Clin Invest"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705923104","article-title":"4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1","volume":"104","author":"Trevisani","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.06.012","article-title":"Activation of Trpa1 on Dural Afferents: A Potential Mechanism of Headache Pain","volume":"153","author":"Edelmayer","year":"2012","journal-title":"Pain"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12512","article-title":"The TRPA1 channel in migraine mechanism and treatment","volume":"171","author":"Benemei","year":"2014","journal-title":"Br J Pharmacol"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2011.03.017","article-title":"The involvement of TRPA1 channel activation in the inflammatory response evoked by topical application of cinnamaldehyde to mice","volume":"88","author":"Silva","year":"2011","journal-title":"Life Sci"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172460","article-title":"Role of TRPA1 receptors in skin inflammation induced by volatile chemical irritants in mice","volume":"858","author":"Nor\u00f5es","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.08.042","article-title":"The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice","volume":"147","author":"Lieu","year":"2014","journal-title":"Gastroenterology"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-229948","article-title":"TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis","volume":"27","author":"Liu","year":"2013","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201800395RR","article-title":"Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis","volume":"33","author":"Kodji","year":"2019","journal-title":"FASEB J"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2018.02.040","article-title":"TRPA1 Acts in a Protective Manner in Imiquimod-Induced Psoriasiform Dermatitis in Mice","volume":"138","author":"Kem\u00e9ny","year":"2018","journal-title":"J Invest Dermatol"},{"key":"B212","doi-asserted-by":"publisher","first-page":"e108164","DOI":"10.1371\/journal.pone.0108164","article-title":"Upregulation of the transient receptor potential ankyrin 1 ion channel in the inflamed human and mouse colon and its protective roles","volume":"9","author":"Kun","year":"2014","journal-title":"PloS One"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200905-0665OC","article-title":"TRPA1 Agonists Evoke Coughing in Guinea Pig and Human Volunteers","volume":"180","author":"Birrell","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00438.x","article-title":"Transient receptor potential ankyrin receptor 1 is a novel target for pro-tussive agents","volume":"158","author":"Andr\u00e8","year":"2009","journal-title":"Br J Pharmacol"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-017-0005-0","article-title":"Activation of planarian TRPA1 by reactive oxygen species reveals a conserved mechanism for animal nociception","volume":"20","author":"Arenas","year":"2017","journal-title":"Nat Neurosci"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2008.06093.x","article-title":"Activation of transient receptor potential ankyrin 1 by hydrogen peroxide","volume":"27","author":"Sawada","year":"2008","journal-title":"Eur J Neurosci"},{"key":"B217","doi-asserted-by":"publisher","first-page":"71","DOI":"10.2174\/1877381801002030071","article-title":"The Rising Role of TRPA1 in Asthma","volume":"2","author":"Facchinetti","year":"2010","journal-title":"Open Drug Discovery J"},{"key":"B218","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/joim.12591","article-title":"Sensory neuron regulation of gastrointestinal inflammation and bacterial host defence","volume":"282","author":"Lai","year":"2017","journal-title":"J Intern Med"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00464.2006","article-title":"Role of calcitonin receptor-like receptor in colonic motility and inflammation","volume":"293","author":"Clifton","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.05.093","article-title":"Transient receptor potential ankyrin-1 participates in visceral hyperalgesia following experimental colitis","volume":"440","author":"Yang","year":"2008","journal-title":"Neurosci Lett"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2011-0831","article-title":"Highlights in inflammatory bowel disease \u2013 from bench to bedside","volume":"50","author":"Engel","year":"2012","journal-title":"Clin Chem Lab Med CCLM"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12120","article-title":"The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis","volume":"169","author":"Romano","year":"2013","journal-title":"Br J Pharmacol"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104464","article-title":"The non-euphoric phytocannabinoid cannabidivarin counteracts intestinal inflammation in mice and cytokine expression in biopsies from UC pediatric patients","volume":"149","author":"Pagano","year":"2019","journal-title":"Pharmacol Res"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12818","article-title":"Carvacryl acetate, a novel semisynthetic monoterpene ester, binds to the TRPA1 receptor and is effective in attenuating irinotecan-induced intestinal mucositis in mice","volume":"69","author":"Alvarenga","year":"2017","journal-title":"J Pharm Pharmacol"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2016.11.009","article-title":"Carvacrol reduces irinotecan-induced intestinal mucositis through inhibition of inflammation and oxidative damage via TRPA1 receptor activation","volume":"260","author":"Alvarenga","year":"2016","journal-title":"Chem Biol Interact"},{"key":"B226","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13075-015-0905-x","article-title":"Environmental cold exposure increases blood flow and affects pain sensitivity in the knee joints of CFA-induced arthritic mice in a TRPA1-dependent manner","volume":"18","author":"Fernandes","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0904-y","article-title":"Transient receptor potential ankyrin 1 (TRPA1) receptor is involved in chronic arthritis: in vivo study using TRPA1-deficient mice","volume":"18","author":"Horv\u00e1th","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.09.008","article-title":"Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice\u2013potential role of TRPA1 in osteoarthritis","volume":"23","author":"Moilanen","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1038\/srep00380","article-title":"TRPA1 Contributes to the Acute Inflammatory Response and Mediates Carrageenan-Induced Paw Edema in the Mouse","volume":"2","author":"Moilanen","year":"2012","journal-title":"Sci Rep"},{"key":"B230","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.intimp.2016.02.012","article-title":"Cinnamaldehyde modulates LPS-induced systemic inflammatory response syndrome through TRPA1-dependent and independent mechanisms","volume":"34","author":"Mendes","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfda.2017.03.006","article-title":"Anti-inflammatory effect of cinnamaldehyde and linalool from the leaf essential oil of Cinnamomum osmophloeum Kanehira in endotoxin-induced mice","volume":"26","author":"Lee","year":"2018","journal-title":"J Food Drug Anal"},{"key":"B232","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s11655-015-2103-8","article-title":"Anti-oxidative and anti-inflammatory effects of cinnamaldehyde on protecting high glucose-induced damage in cultured dorsal root ganglion neurons of rats","volume":"22","author":"Yang","year":"2016","journal-title":"Chin J Integr Med"},{"key":"B233","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/13543776.2020.1797679","article-title":"Transient receptor potential ankyrin 1 (TRPA1) antagonists: a patent review (2015-2019)","volume":"30","author":"Chen","year":"2020","journal-title":"Expert Opin Ther Pat"},{"key":"B234","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms20122906","article-title":"Is TRPA1 Burning Down TRPV1 as Druggable Target for the Treatment of Chronic Pain","volume":"20","author":"Giorgi","year":"2019","journal-title":"Int J Mol Sci"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.590261\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T05:43:29Z","timestamp":1669268609000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.590261\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,23]]},"references-count":234,"alternative-id":["10.3389\/fimmu.2020.590261"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.590261","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,23]]},"article-number":"590261"}}