{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:32:51Z","timestamp":1792632771739,"version":"4.5.0"},"reference-count":138,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>\n                    Primary Sj\u00f6gren\u2019s syndrome (pSS) is a chronic autoimmune disease associated with damage to multiple organs and glands. The most common clinical manifestations are dry eyes, dry mouth, and enlarged salivary glands. Currently, CD4\n                    <jats:sup>+<\/jats:sup>\n                    T lymphocytes are considered to be key factors in the immunopathogenesis of pSS, but various studies have shown that CD8\n                    <jats:sup>+<\/jats:sup>\n                    T lymphocytes contribute to acinar injury in the exocrine glands. Therefore, in this review, we discussed the classification and features of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T lymphocytes, specifically describing the role of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T lymphocytes in disease pathophysiology. Furthermore, we presented treatment strategies targeting CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells to capitalize on the pathogenic and regulatory potential of CD8\n                    <jats:sup>+<\/jats:sup>\n                    T lymphocytes in SS to provide promising new strategies for this inflammatory disease.\n                  <\/jats:p>","DOI":"10.3389\/fimmu.2020.602823","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T03:26:16Z","timestamp":1611804376000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":68,"title":["CD8+ T Lymphocytes: Crucial Players in Sj\u00f6gren\u2019s 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