{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T14:08:25Z","timestamp":1790431705738,"version":"4.1.0"},"reference-count":78,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003762","name":"Institut Pasteur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>The clinical presentation of dengue virus (DENV) infection is variable. Severe complications mainly result from exacerbated immune responses. Type I interferons (IFN-I) are important in antiviral responses and form a crucial link between innate and adaptive immunity. Their contribution to host defense during DENV infection remains under-studied, as direct quantification of IFN-I is challenging. We combined ultra-sensitive single-molecule array (Simoa) digital ELISA with IFN-I gene expression to elucidate the role of IFN-I in a well-characterized cohort of hospitalized Cambodian children undergoing acute DENV infection. Higher concentrations of type I IFN proteins were observed in blood of DENV patients, compared to healthy donors, and correlated with viral load. Stratifying patients for disease severity, we found a decreased expression of IFN-I in patients with a more severe clinical outcome, such as dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). This was seen in parallel to a correlation between low IFN\u03b1 protein concentrations and decreased platelet counts. Type I IFNs concentrations were correlated to frequencies of plasmacytoid DCs, not DENV-infected myloid DCs and correlated inversely with neutralizing anti-DENV antibody titers. Hence, type I IFN produced in the acute phase of infection is associated with less severe outcome of dengue disease.<\/jats:p>","DOI":"10.3389\/fimmu.2020.605087","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T22:25:56Z","timestamp":1610058356000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":22,"title":["Decreased Type I Interferon Production by Plasmacytoid Dendritic Cells Contributes to Severe Dengue"],"prefix":"10.3389","volume":"11","author":[{"given":"Vinit","family":"Upasani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Scagnolari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Frasca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nika\u00efa","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Bondet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axelle","family":"Vanderlinden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sokchea","family":"Lay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Auerswald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sothy","family":"Heng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Laurent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sowath","family":"Ly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veasna","family":"Duong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Antonelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Dussart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darragh","family":"Duffy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tineke","family":"Cantaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2020,12,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1386-6532(03)00010-6","article-title":"Dengue and dengue hemorrhagic fever in the Americas: Lessons and challenges","volume":"27","author":"Guzman","year":"2003","journal-title":"J Clin Virol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2010","journal-title":"Nature"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1110265","article-title":"Dengue","volume":"366","author":"Simmons","year":"2012","journal-title":"N Engl J Med"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan6836","article-title":"Antibody-dependent enhancement of severe dengue disease in humans","volume":"358","author":"Katzelnick","year":"2017","journal-title":"Science"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0157-4","article-title":"Reconstruction of antibody dynamics and infection histories to evaluate dengue risk","volume":"557","author":"Salje","year":"2018","journal-title":"Nature"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-017-0625-1","article-title":"Immune-mediated cytokine storm and its role in severe dengue","volume":"39","author":"Srikiatkhachorn","year":"2017","journal-title":"Semin Immunopathol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.coviro.2016.01.001","article-title":"Type i interferons in viral control and immune regulation","volume":"16","author":"Teijaro","year":"2016","journal-title":"Curr Opin Virol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41426-018-0168-0","article-title":"Dengue virus and the host innate immune response","volume":"7","author":"Uno","year":"2018","journal-title":"Emerg Microbes Infect"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/nri1900","article-title":"IRFs: Master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors","volume":"6","author":"Honda","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1099\/vir.0.83391-0","article-title":"Interferons and viruses: An interplay between induction, signalling, antiviral responses and virus countermeasures","volume":"89","author":"Randall","year":"2008","journal-title":"J Gen Virol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300799","article-title":"The Roles of IRF-3 and IRF-7 in Innate Antiviral Immunity against Dengue Virus","volume":"191","author":"Chen","year":"2013","journal-title":"J Immunol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/nature11428","article-title":"A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses","volume":"490","author":"Litvak","year":"2012","journal-title":"Nature"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2014.0129","article-title":"Dengue Virus Control of Type i IFN Responses: A History of Manipulation and Control","volume":"35","author":"Castillo Ramirez","year":"2015","journal-title":"J Interf Cytokine Res"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8403937","article-title":"Serum Cytokine Profiles in Patients with Dengue Fever at the Acute Infection Phase","volume":"2018","author":"Huang","year":"2018","journal-title":"Dis Markers"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2017.10.010","article-title":"Characterization of type I interferon responses in dengue and severe dengue in children in Paraguay","volume":"97","author":"Talarico","year":"2017","journal-title":"J Clin Virol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2014.04.002","article-title":"A strong interferon response correlates with a milder dengue clinical condition","volume":"60","author":"De La Cruz Hern\u00e1ndez","year":"2014","journal-title":"J Clin Virol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24343","article-title":"Serum levels of IFN-\u03b2 are associated with days of evolution but not with severity of dengue","volume":"88","author":"Pech Torres","year":"2016","journal-title":"J Med Virol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2007.06.019","article-title":"Different clinical and laboratory manifestations between dengue haemorrhagic fever and dengue fever with bleeding tendency","volume":"101","author":"Chen","year":"2007","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015631","article-title":"Both Viremia and Cytokine Levels Associate with the Lack of Severe Disease in Secondary Dengue 1 Infection among Adult Chinese Patients","volume":"5","author":"Tang","year":"2010","journal-title":"PloS One"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pntd.0002257","article-title":"Dengue Virus Activates Membrane TRAIL Relocalization and IFN-\u03b1 Production by Human Plasmacytoid Dendritic Cells In Vitro and In Vivo","volume":"7","author":"Gandini","year":"2013","journal-title":"PloS Negl Trop Dis"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/nri3865","article-title":"The multifaceted biology of plasmacytoid dendritic cells","volume":"15","author":"Swiecki","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1016\/j.chom.2019.03.005","article-title":"Plasmacytoid Dendritic Cells and Infected Cells Form an Interferogenic Synapse Required for Antiviral Responses","volume":"25","author":"Assil","year":"2019","journal-title":"Cell Host Microbe"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000474","article-title":"Dengue tropism for macrophages and dendritic cells: The host cell effect","volume":"97","author":"Flipse","year":"2016","journal-title":"J Gen Virol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fimmu.2014.00647","article-title":"Dendritic cells in dengue virus infection: targets of virus replication and mediators of immunity","volume":"5","author":"Schmid","year":"2014","journal-title":"Front Immunol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2008.10.022","article-title":"Functional characterization of ex vivo blood myeloid and plasmacytoid dendritic cells after infection with dengue virus","volume":"383","author":"Sun","year":"2009","journal-title":"Virology"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01051-10","article-title":"Inhibition of the Type I Interferon Response in Human Dendritic Cells by Dengue Virus Infection Requires a Catalytically Active NS2B3 Complex","volume":"84","author":"Rodriguez-Madoz","year":"2010","journal-title":"J Virol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0200564","article-title":"Identification of changes in dendritic cell subsets that correlate with disease severity in dengue infection","volume":"13","author":"Lertjuthaporn","year":"2018","journal-title":"PloS One"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-011-9592-9","article-title":"Decreased peripheral dendritic cell numbers in dengue virus infection","volume":"32","author":"Bittencourt","year":"2012","journal-title":"J Clin Immunol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.10.5571","article-title":"A Blunted Blood Plasmacytoid Dendritic Cell Response to an Acute Systemic Viral Infection Is Associated with Increased Disease Severity","volume":"171","author":"Pichyangkul","year":"2003","journal-title":"J Immunol"},{"key":"B30","volume-title":"Dengue haemorrhagic fever : diagnosis, treatment, prevention and control","year":"1997"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2011.08.002","article-title":"Validation of an internally controlled one-step real-time multiplex RT-PCR assay for the detection and quantitation of dengue virus RNA in plasma","volume":"177","author":"Hue","year":"2011","journal-title":"J Virol Methods"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001244","article-title":"Clinical and virological factors influencing the performance of a ns1 antigen-capture assay and potential use as a marker of dengue disease severity","volume":"5","author":"Duong","year":"2011","journal-title":"PloS Negl Trop Dis"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1958.7.561","article-title":"Techniques for hemagglutination and hemagglutination-inhibition with arthropod-borne viruses","volume":"7","author":"Clark","year":"1958","journal-title":"Am J Trop Med Hyg"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41426-017-0010-0","article-title":"Broad and long-lasting immune protection against various Chikungunya genotypes demonstrated by participants in a cross-sectional study in a Cambodian rural community article","volume":"7","author":"Auerswald","year":"2018","journal-title":"Emerg Microbes Infect"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161451","article-title":"Detection of interferon alpha protein reveals differential levels and cellular sources in disease","volume":"214","author":"Rodero","year":"2017","journal-title":"J Exp Med"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pntd.0008603","article-title":"Comparison of dengue case classification schemes and evaluation of biological changes in different dengue clinical patterns in a longitudinal follow-up of hospitalized children in cambodia","volume":"14","author":"Dussart","year":"2020","journal-title":"PloS Negl Trop Dis"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/rmv.2121","article-title":"The association between dengue viremia kinetics and dengue severity: A systemic review and meta-analysis","author":"Morsy","year":"2020","journal-title":"Rev Med Virol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1159\/000322904","article-title":"Frequency alterations in key innate immune cell components in the peripheral blood of dengue patients detected by FACS analysis","volume":"3","author":"Tsai","year":"2011","journal-title":"J Innate Immun"},{"key":"B39","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/nri3787","article-title":"Type I interferons in infectious disease","volume":"15","author":"McNab","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/art.21890","article-title":"Functional assay of type I interferon in systemic lupus erythematosus plasma and association with anti-RNA binding protein autoantibodies","volume":"54","author":"Hua","year":"2006","journal-title":"Arthritis Rheumatol"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1002\/art.24555","article-title":"NIH Public Access","volume":"60","author":"Niewold","year":"2010","journal-title":"Therapy"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1159\/000235158","article-title":"HeLa Mx2\/Luc reporter cell line for the quantification of human type i interferons","volume":"84","author":"Seo","year":"2009","journal-title":"Validation Pharmacol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.04057.x","article-title":"Interferon signature gene expression is correlated with autoantibody profiles in patients with incomplete lupus syndromes","volume":"159","author":"Li","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0025858","article-title":"A vesicular stomatitis virus replicon-based bioassay for the rapid and sensitive determination of multi-species type I interferon","volume":"6","author":"Rentsch","year":"2011","journal-title":"PloS One"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/77553","article-title":"Human skin Langerhans cells are targets of dengue virus infection","volume":"6","author":"Wu","year":"2000","journal-title":"Nat Med"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.00037.x","article-title":"Human dendritic cells as targets of dengue virus infection","volume":"6","author":"Marovich","year":"2001","journal-title":"J Invest Dermatol Symp Proc"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.3.1499","article-title":"Infection of Human Dendritic Cells by Dengue Virus Causes Cell Maturation and Cytokine Production","volume":"166","author":"Ho","year":"2001","journal-title":"J Immunol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1800820","article-title":"Effect of dengue serostatus on dengue vaccine safety and efficacy","volume":"379","author":"Sridhar","year":"2018","journal-title":"N Engl J Med"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0123-x","article-title":"Adaptive immune responses to primary and secondary dengue virus infections","volume":"19","author":"St. John","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200635993","article-title":"Early type I interferon-mediated signals on B cells specifically enhance antiviral humoral responses","volume":"36","author":"Fink","year":"2006","journal-title":"Eur J Immunol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.4.2074","article-title":"Cutting Edge: Enhancement of Antibody Responses Through Direct Stimulation of B and T Cells by Type I IFN","volume":"176","author":"Le Bon","year":"2006","journal-title":"J Immunol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1001\/jama.2017.19368","article-title":"Preexisting Antibody Titer Associated With Severe Dengue","volume":"318","author":"Friedrich","year":"2017","journal-title":"JAMA"},{"key":"B53","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1086\/382280","article-title":"Relationship of Preexisting Dengue Virus (DV ) Neutralizing Antibody Levels to Viremia and Severity of Disease in a Prospective Cohort Study of DV Infection in Thailand","volume":"1655","author":"Endy","year":"2004","journal-title":"J Infect Dis"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1086\/587699","article-title":"Differences in Global Gene Expression in Peripheral Blood Mononuclear Cells Indicate a Significant Role of the Innate Responses in Progression of Dengue Fever but Not Dengue Hemorrhagic Fever","volume":"197","author":"Ubol","year":"2008","journal-title":"J Infect Dis"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760150453","article-title":"Primary dengue haemorrhagic fever in patients from northeast of Brazil is associated with high levels of interferon-\u03b2 during acute phase","volume":"111","author":"Oliveira RA dos","year":"2016","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60572-9","article-title":"Dengue","volume":"385","author":"Guzman","year":"2015","journal-title":"Lancet"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011671","article-title":"Genome-wide expression profiling deciphers host responses altered during dengue shock syndrome and reveals the role of innate immunity in severe dengue","volume":"5","author":"Devignot","year":"2010","journal-title":"PloS One"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201141969","article-title":"FOXO3 as a new IKK-\u03f5-controlled check-point of regulation of IFN-\u03b2 expression","volume":"42","author":"Luron","year":"2012","journal-title":"Eur J Immunol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v97.2.473","article-title":"The soluble murine type I interferon receptor Ifnar-2 is present in serum, is independently regulated, and has both agonistic and antagonistic properties","volume":"97","author":"Hardy","year":"2001","journal-title":"Blood"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(92)81523-o","article-title":"Soluble interferon-\u03b1 receptor molecules are present in body fluids","volume":"314","author":"Novick","year":"1992","journal-title":"FEBS Lett"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1089\/107999004322813363","article-title":"Formation of Human IFN-\u03b2 Complex with the Soluble Type I Interferon Receptor IFNAR-2 Leads to Enhanced IFN Stability, Pharmacokinetics, and Antitumor Activity in Xenografted SCID Mice","volume":"24","author":"McKenna","year":"2004","journal-title":"J Interf Cytokine Res"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207955","article-title":"Regulated proteolysis of the IFNaR2 subunit of the interferon-alpha receptor","volume":"23","author":"Saleh","year":"2004","journal-title":"Oncogene"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg524","article-title":"SCFHOS ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-\u03b1 receptor","volume":"22","author":"Kumar","year":"2003","journal-title":"EMBO J"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.20.9602","article-title":"Role of interferon \u03b1\/\u03b2 receptor chain 1 in the structure and transmembrane signaling of the interferon \u03b1\/\u03b2 receptor complex","volume":"91","author":"Constantinescu","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1205742","article-title":"Differential responsiveness to IFN-alpha and IFN-beta\u00a0of human mature DC through modulation of IFNAR expression","volume":"79","author":"Severa","year":"2006","journal-title":"J Leukoc Biol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/hon.2900110103","article-title":"Post-transcriptional regulation of interferon-alpha 4 subtype production by lymphoblastoid cells","volume":"11","author":"Greenway","year":"1993","journal-title":"Hematol Oncol"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2007.02.008","article-title":"Post-transcriptional control of the interferon system","volume":"89","author":"Khabar","year":"2007","journal-title":"Biochimie"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2013.0117","article-title":"Post-transcriptional regulation of interferons and their signaling pathways","volume":"34","author":"Savan","year":"2014","journal-title":"J Interf Cytokine Res"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.5.1888-1897.2006","article-title":"Inquiring into the Differential Action of Interferons (IFNs ): an IFN- \u03b1 2 Mutant with Enhanced Affinity to IFNAR1 Is Functionally Similar to IFN- \u03b2","volume":"26","author":"Jaitin","year":"2014","journal-title":"Mol Cell Biol"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12001","article-title":"Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation","volume":"250","author":"Piehler","year":"2012","journal-title":"Immunol Rev"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2667","article-title":"Structural basis of a unique interferon-\u03b2 signaling axis mediated via the receptor IFNAR1","volume":"14","author":"De Weerd","year":"2013","journal-title":"Nat Immunol"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2015.04.005","article-title":"Blockade of interferon beta, but not interferon alpha, signaling controls persistent viral infection","volume":"17","author":"Ng","year":"2015","journal-title":"Cell Host Microbe"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pntd.0004497","article-title":"Immune Response to Dengue Virus Infection in Pediatric Patients in New Delhi , India \u2014 Association of Viremia , Inflammatory Mediators and Monocytes with Disease Severity","volume":"10","author":"Singla","year":"2016","journal-title":"PloS Neglected Trop Dis"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0056527","article-title":"Interferon-\u03b1 Is the Primary Plasma Type-I IFN in HIV-1 Infection and Correlates with Immune Activation and Disease Markers","volume":"8","author":"Hardy","year":"2013","journal-title":"PloS One"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-29235-7","article-title":"Immature particles and capsid-free viral RNA produced by Yellow fever virus-infected cells stimulate plasmacytoid dendritic cells to secrete interferons","volume":"8","author":"Sinigaglia","year":"2018","journal-title":"Sci Rep"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/s1074-7613(01)00126-1","article-title":"Type I interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo","volume":"14","author":"Le Bon","year":"2001","journal-title":"Immunity"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.7.4343","article-title":"Type I IFN Receptor Signals Directly Stimulate Local B Cells Early following Influenza Virus Infection","volume":"176","author":"Coro","year":"2006","journal-title":"J Immunol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01646-08","article-title":"Early B-Cell Activation after West Nile Virus Infection Requires Alpha\/Beta Interferon but Not Antigen Receptor Signaling","volume":"82","author":"Purtha","year":"2008","journal-title":"J Virol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.605087\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T07:29:45Z","timestamp":1610263785000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.605087\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,17]]},"references-count":78,"alternative-id":["10.3389\/fimmu.2020.605087"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.605087","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,17]]},"article-number":"605087"}}