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Immunol."],"abstract":"<jats:p>Abdominal aortic aneurysms (AAAs) are local dilations of infrarenal segment of aortas. Molecular mechanisms underlying the pathogenesis of AAA remain not fully clear. However, inflammation has been considered as a central player in the development of AAA. In the past few decades, studies demonstrated a host of inflammatory cells, including T cells, macrophages, dendritic cells, neutrophils, B cells, and mast cells, etc. infiltrating into aortic walls, which implicated their crucial roles. In addition to direct cell contacts and cytokine or protease secretions, special structures like inflammasomes and neutrophil extracellular traps have been investigated to explore their functions in aneurysm formation. The above-mentioned inflammatory cells and associated structures may initiate and promote AAA expansion. Understanding their impacts and interaction networks formation is meaningful to develop new strategies of screening and pharmacological interventions for AAA. In this review, we aim to discuss the roles and mechanisms of these inflammatory cells in AAA pathogenesis.<\/jats:p>","DOI":"10.3389\/fimmu.2020.609161","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T04:52:32Z","timestamp":1612327952000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":180,"title":["Abdominal Aortic Aneurysm: Roles of Inflammatory Cells"],"prefix":"10.3389","volume":"11","author":[{"given":"Zhen","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhejun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,2,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2011.1","article-title":"Diagnostic and therapeutic strategies for small abdominal aortic aneurysms","volume":"8","author":"Klink","year":"2011","journal-title":"Nat Rev Cardiol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101702","article-title":"Abdominal aortic aneurysm in aged population","volume":"10","author":"Umebayashi","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.314264","article-title":"Tunica-Specific Transcriptome of Abdominal Aortic Aneurysm and the Effect of Intraluminal Thrombus, Smoking, and Diameter Growth Rate","volume":"40","author":"Lindquist Liljeqvist","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038809","article-title":"Abdominal Aortic Aneurysm Screening Is Safe yet Lacks Effectiveness","volume":"139","author":"Arnaoutakis","year":"2019","journal-title":"Circulation"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2009.0657","article-title":"Ultrasonographic screening for the detection of abdominal aortic aneurysms","volume":"106","author":"Eckstein","year":"2009","journal-title":"Dtsch Arztebl Int"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-007-0472-5","article-title":"Pathology, natural history and treatment of abdominal aortic aneurysms","volume":"96","author":"Zankl","year":"2007","journal-title":"Clin Res Cardiol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1161\/01.CIR.0000133279.07468.9F","article-title":"Participants UKSAT. 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