{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T23:10:08Z","timestamp":1771629008397,"version":"3.50.1"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Adipocytes are the largest cell type in terms of volume, but not number, in adipose tissue. Adipocytes are prominent contributors to systemic metabolic health. Obesity, defined by excess adipose tissue (AT), is recognized as a low-grade chronic inflammatory state. Cytokines are inflammatory mediators that are produced in adipose tissue (AT) and function in both AT homeostatic as well as pathological conditions. AT inflammation is associated with systemic metabolic dysfunction and obesity-associated infiltration and proliferation of immune cells occurs in a variety of fat depots in mice and humans. AT immune cells secrete a variety of chemokines and cytokines that act in a paracrine manner on adjacent adipocytes. TNF\u03b1, IL-6, and MCP-1, are well studied mediators of AT inflammation. Oncostatin M (OSM) is another proinflammatory cytokine that is elevated in AT in human obesity, and its specific receptor (OSMR\u03b2) is also induced in conditions of obesity and insulin resistance. OSM production and paracrine signaling in AT regulates adipogenesis and the functions of AT. This review summarizes the roles of the oncostatin M receptor (OSMR\u03b2) as a modulator of adipocyte development and function its contributions to immunological adaptations in AT in metabolic disease states.<\/jats:p>","DOI":"10.3389\/fimmu.2020.612013","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T06:26:00Z","timestamp":1616999160000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Adipocyte Oncostatin Receptor Regulates Adipose Tissue Homeostasis and Inflammation"],"prefix":"10.3389","volume":"11","author":[{"given":"David","family":"Sanchez-Infantes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacqueline M.","family":"Stephens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"B1","unstructured":""},{"key":"B2","doi-asserted-by":"publisher","first-page":"17034","DOI":"10.1038\/nrdp.2017.34","article-title":"Obesity","volume":"3","author":"Gonz\u00e1lez-Muniesa","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"B3","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1161\/CIRCULATIONAHA.120.047659","article-title":"Obesity Is a Risk Factor for Severe COVID-19 Infection: Multiple Potential Mechanisms","volume":"142","author":"Sattar","year":"2020","journal-title":"Circulation"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(20)30238-2","article-title":"COVID-19 in people with diabetes: understanding the reasons for worse outcomes","volume":"8","author":"Apicella","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0350","article-title":"Bariatric\/Metabolic Surgery to Treat Type 2 Diabetes in Patients With a BMI <35 kg\/m2","volume":"39","author":"Cummings","year":"2016","journal-title":"Diabetes Care"},{"key":"B6","article-title":"Adipose Tissue: Physiology to Metabolic Dysfunction","volume-title":"Endotext","author":"Richard","year":"2020"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nature06902","article-title":"Dynamics of fat cell turnover in humans","volume":"453","author":"Spalding","year":"2008","journal-title":"Nature"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/nature21363","article-title":"Inflammation, metaflammation and immunometabolic disorders","volume":"542","author":"Hotamisligil","year":"2017","journal-title":"Nature"},{"key":"B9","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1111\/joim.12803","article-title":"Inflammation of brown\/beige adipose tissues in obesity and metabolic disease","volume":"284","author":"Villarroya","year":"2018","journal-title":"J Intern Med"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.90","article-title":"Adapting to obesity with adipose tissue inflammation","volume":"13","author":"Reilly SM and Saltiel","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3555","article-title":"Oncostatin m is produced in adipose tissue and is regulated in conditions of obesity and type 2 diabetes","volume":"99","author":"Sanchez-Infantes","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.2174\/1381612823666170704122559","article-title":"Oncostatin M: Potential Implications for Malignancy and Metabolism","volume":"23","author":"Stephens","year":"2017","journal-title":"Curr Pharm Des"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgz090","article-title":"A Role for Oncostatin M in the Impairment of Glucose Homeostasis in Obesity","volume":"105","author":"Piquer-Garcia","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028415","article-title":"Interleukin-6 Family Cytokines","volume":"10","author":"Rose-John","year":"2018","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/BJ20030407","article-title":"Principles of Interleukin (Il)-6-Type Cytokine Signalling and Its Regulation","volume":"374","author":"Heinrich","year":"2003","journal-title":"Biochem J"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30453","article-title":"Gp130 Receptor Ligands as Potential Therapeutic Targets for Obesity","volume":"117","author":"Febbraio","year":"2007","journal-title":"J Clin Invest"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.51.32635","article-title":"Dual Oncostatin M (Osm) Receptors. Cloning and Characterization of an Alternative Signaling Subunit Conferring Osm-Specific Receptor Activation","volume":"271","author":"Mosley","year":"1996","journal-title":"J\u00a0Biol Chem"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.19.8641","article-title":"Oncostatin M Is a Member of a Cytokine Family That Includes Leukemia- Inhibitory Factor, Granulocyte Colony-Stimulating Factor, and Interleukin 6","volume":"88","author":"Rose","year":"1991","journal-title":"Proc Natl Acad Sci"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1993.1294","article-title":"The genes for oncostatin M (OSM) and leukemia inhibitory factor (LIF) are tightly linked on human chromosome 22","volume":"17","author":"Rose","year":"1993","journal-title":"Genomics"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.24.9739","article-title":"Oncostatin M: A Growth Regulator Produced by Differentiated Histiocytic Lymphoma Cells","volume":"83","author":"Zarling","year":"1986","journal-title":"Proc\u00a0Natl Acad Sci"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.8.2127","article-title":"Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer","volume":"18","author":"Kamiya","year":"1999","journal-title":"EMBO J"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20086","article-title":"Hepatocyte proliferation and tissue remodeling is impaired after liver injury in oncostatin M\u00a0receptor knockout mice","volume":"39","author":"Nakamura","year":"2004","journal-title":"Hepatology"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2011.47","article-title":"Oncostatin M produced in Kupffer cells in response to PGE2: possible contributor to hepatic insulin resistance and steatosis","volume":"91","author":"Henkel","year":"2011","journal-title":"Lab Invest"},{"key":"B24","first-page":"5531","article-title":"Regulation of inflammatory responses by oncostatin M","volume":"164","author":"Wallace","year":"2000","journal-title":"J Immunol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.08.013","article-title":"Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling","volume":"9","author":"Kubin","year":"2011","journal-title":"Cell Stem Cell"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1126\/science.1542794","article-title":"The Il-6 Signal Transducer, Gp130: An Oncostatin M Receptor and Affinity Converter for the Lif Receptor","volume":"255","author":"Gearing","year":"1992","journal-title":"Science"},{"key":"B27","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V90.1.165.165_165_173","article-title":"Oncostatin M and Leukemia Inhibitory Factor Do Not Use the Same Functional Receptor in Mice","volume":"90","author":"Ichihara","year":"1997","journal-title":"Blood"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.18.6.3357","article-title":"Cloning and Characterization of a Specific Receptor for Mouse Oncostatin M","volume":"18","author":"Lindberg","year":"1998","journal-title":"Mol Cell Biol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.bbrc.2010.03.132","article-title":"Neuropoietin Activates Stat3 Independent of Lifr Activation in Adipocytes","volume":"395","author":"White","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"B30","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.139.9.2977","article-title":"Purification and Characterization of Cytostatic Lymphokines Produced by Activated Human T Lymphocytes. Synergistic Antiproliferative Activity of Transforming Growth Factor Beta 1, Interferon-Gamma, and Oncostatin M for Human Melanoma Cells","volume":"139","author":"Brown","year":"1987","journal-title":"J\u00a0Immunol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2002.1023","article-title":"Oncostatin M Production by Human Dendritic Cells in Response to Bacterial Products","volume":"17","author":"Suda","year":"2002","journal-title":"Cytokine"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1136\/ard.56.3.184","article-title":"Detection of Oncostatin M in Synovial Fluid from Patients with Rheumatoid Arthritis","volume":"56","author":"Hui","year":"1997","journal-title":"Ann Rheum Dis"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.02.003","article-title":"Oncostatin M is expressed in atherosclerotic lesions: a role for Oncostatin M in the pathogenesis of atherosclerosis","volume":"216","author":"Albasanz-Puig","year":"2011","journal-title":"Atherosclerosis"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-0160","article-title":"Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak\/STAT3 signaling","volume":"74","author":"Lapeire","year":"2014","journal-title":"Cancer Res"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4307","article-title":"Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease","volume":"23","author":"West","year":"2017","journal-title":"Nat Med"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.739110","article-title":"Loss of Oncostatin M Signaling in Adipocytes Induces Insulin Resistance and Adipose Tissue Inflammation in Vivo","volume":"291","author":"Elks","year":"2016","journal-title":"J Biol Chem"},{"key":"B37","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/79111","article-title":"Failure of adipocyte differentiation causes type II diabetes mellitus","volume":"26","author":"Danforth","year":"2000","journal-title":"Nat Genet"},{"key":"B38","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/nri2921","article-title":"Adipokines in inflammation and\u00a0metabolic disease","volume":"11","author":"Ouchi","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M710462200","article-title":"Neuropoietin attenuates adipogenesis and induces insulin resistance in adipocytes","volume":"283","author":"White","year":"2008","journal-title":"J Biol Chem"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M606089200","article-title":"Oncostatin M inhibits adipogenesis through the RAS\/ERK and STAT5 signaling pathways","volume":"281","author":"Miyaoka","year":"2006","journal-title":"J Biol Chem"},{"key":"B41","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/oby.21679","article-title":"Oncostatin m impairs brown adipose tissue thermogenic function and the browning of subcutaneous white adipose tissue","volume":"25","author":"S\u00e1nchez-Infantes","year":"2017","journal-title":"Obesity (Silver Spring)"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.461905","article-title":"Lack of oncostatin M receptor \u03b2 leads to adipose tissue inflammation and insulin resistance by switching macrophage phenotype","volume":"288","author":"Komori","year":"2013","journal-title":"J Biol Chem"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.542399","article-title":"Deficiency of oncostatin M receptor \u03b2 (OSMR\u03b2) exacerbates high-fat diet-induced obesity and related metabolic disorders in mice","volume":"289","author":"Komori","year":"2014","journal-title":"J Biol Chem"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40568","article-title":"Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice","volume":"120","author":"Walker","year":"2010","journal-title":"J Clin Invest"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2015.12.028","article-title":"Hepatic Oncostatin M Receptor \u03b2 Regulates Obesity-Induced Steatosis and Insulin Resistance","volume":"186","author":"Luo","year":"2016","journal-title":"Am J Pathol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.14.7.4443","article-title":"Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide","volume":"14","author":"Dendorfer","year":"1994","journal-title":"Mol Cell Biol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199810)41:10<1760::AID-ART8>3.0.CO;2-M","article-title":"The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint","volume":"41","author":"Cawston","year":"1998","journal-title":"Arthritis Rheum"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-13-05334.2002","article-title":"Prostaglandin E2 is a novel inducer of oncostatin-M expression in macrophages and microglia","volume":"22","author":"Repovic","year":"2002","journal-title":"J Neurosci"},{"key":"B49","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3390\/biology8010019","article-title":"Oncostatin M Mediates Adipocyte Expression and Secretion of Stromal-Derived Factor 1","volume":"8","author":"Hang","year":"2019","journal-title":"Biology (Basel)"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1172\/JCI7615","article-title":"The chemokine SDF-1 stimulates integrin-mediated arrest of CD34 (+) cells on vascular endothelium under shear flow","volume":"104","author":"Peled","year":"1999","journal-title":"J Clin Invest"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031645","article-title":"CXCL12 mediates CCR7-independent homing of central memory cells, but not naive T cells, in peripheral lymph nodes","volume":"199","author":"Scimone","year":"2004","journal-title":"J Exp Med"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13669","article-title":"In vivo affinity and target engagement in skin and blood in a first-time-in-human study of an anti-oncostatin M monoclonal antibody","volume":"84","author":"Reid","year":"2018","journal-title":"Br J Clin Pharmacol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.05.005","article-title":"Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling","volume":"20","author":"Wernstedt Asterholm","year":"2014","journal-title":"Cell Metab"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101010","article-title":"Suppressing adipocyte inflammation promotes insulin resistance in mice","volume":"39","author":"Zhu","year":"2020","journal-title":"Mol Metab"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.612013\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T07:28:09Z","timestamp":1698132489000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.612013\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,29]]},"references-count":54,"alternative-id":["10.3389\/fimmu.2020.612013"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.612013","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,29]]},"article-number":"612013"}}