{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:46:01Z","timestamp":1790660761829,"version":"4.1.0"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,2,16]],"date-time":"2021-02-16T00:00:00Z","timestamp":1613433600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["19-15-00439, 20-15-00351"],"award-info":[{"award-number":["19-15-00439, 20-15-00351"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>T cells that express CD56 in peripheral blood of healthy humans represent a heterogeneous and poorly studied subset. In this work, we analyzed this subset for NKG2C expression. In both CD56<jats:sup>+<\/jats:sup> and CD56<jats:sup>\u2212<\/jats:sup> subsets most of the NKG2C<jats:sup>+<\/jats:sup> T cells had a phenotype of highly differentiated CD8<jats:sup>+<\/jats:sup> TEMRA cells. The CD56<jats:sup>+<\/jats:sup>NKG2C<jats:sup>+<\/jats:sup> T cells also expressed a number of NK cell receptors, such as NKG2D, CD16, KIR2DL2\/DL3, and maturation marker CD57 more often than the CD56<jats:sup>\u2212<\/jats:sup>NKG2C<jats:sup>+<\/jats:sup>CD3<jats:sup>+<\/jats:sup> cells. TCR \u03b2-chain repertoire of the CD3<jats:sup>+<\/jats:sup>CD56<jats:sup>+<\/jats:sup>NKG2C<jats:sup>+<\/jats:sup> cell fraction was limited by the prevalence of one or several clonotypes which can be found within the most abundant clonotypes in total or CD8<jats:sup>+<\/jats:sup> T cell fraction TCR\u03b2 repertoire. Thus, NKG2C expression in highly differentiated CD56<jats:sup>+<\/jats:sup> T cells was associated with the most expanded \u03b1\u03b2 T cell clones. NKG2C<jats:sup>+<\/jats:sup> T cells produced almost no IFN-\u03b3 in response to stimulation with HCMV pp65-derived peptides. This may be partially due to the high content of CD45RA<jats:sup>+<\/jats:sup>CD57<jats:sup>+<\/jats:sup> cells in the fraction. CD3<jats:sup>+<\/jats:sup>NKG2C<jats:sup>+<\/jats:sup> cells showed signs of activation, and the frequency of this T-cell subset in HCMV-positive individuals was positively correlated with the frequency of NKG2C<jats:sup>+<\/jats:sup> NK cells that may imply a coordinated in a certain extent development of the NKG2C<jats:sup>+<\/jats:sup> T and NK cell subsets under HCMV infection.<\/jats:p>","DOI":"10.3389\/fimmu.2020.613882","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T18:12:42Z","timestamp":1613671962000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Surface NKG2C Identifies Differentiated \u03b1\u03b2T-Cell Clones Expanded in Peripheral Blood"],"prefix":"10.3389","volume":"11","author":[{"given":"Elena I.","family":"Kovalenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan 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