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Immunol."],"abstract":"<jats:p>T cell receptor (TCR) signaling influences multiple aspects of CD4<jats:sup>+<\/jats:sup>and CD8<jats:sup>+<\/jats:sup>T cell immunobiology including thymic development, peripheral homeostasis, effector subset differentiation\/function, and memory formation. Additional T cell signaling cues triggered by co-stimulatory molecules and cytokines also affect TCR signaling duration, as well as accessory pathways that further shape a T cell response. Type 1 diabetes (T1D) is a T cell-driven autoimmune disease targeting the insulin producing \u03b2 cells in the pancreas. Evidence indicates that dysregulated TCR signaling events in T1D impact the efficacy of central and peripheral tolerance-inducing mechanisms. In this review, we will discuss how the strength and nature of TCR signaling events influence the development of self-reactive T cells and drive the progression of T1D through effects on T cell gene expression, lineage commitment, and maintenance of pathogenic anti-self T cell effector function.<\/jats:p>","DOI":"10.3389\/fimmu.2020.615371","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T12:52:24Z","timestamp":1612270344000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["The Role of T Cell Receptor Signaling in the Development of Type 1 Diabetes"],"prefix":"10.3389","volume":"11","author":[{"given":"Matthew","family":"Clark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles 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