{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T20:00:55Z","timestamp":1771704055975,"version":"3.50.1"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"abstract":"<jats:p>Cogan\u2019s syndrome is a rare autoimmune disease characterized by ocular inflammation and audiovestibular manifestations. Treatment consists of systemic glucocorticoids and other immunosuppressive agents including methotrexate, cyclophosphamide and TNF-\u03b1-inhibitors. Due to potential ovarian or fetal toxicity immunosuppressive treatment options are limited during pregnancies. Thus far there is a paucity of reports on pregnancies in Cogan\u2019s syndrome. With minimal transplacental transfer, Certolizumab pegol is considered to be safe for the use in pregnant patients with underlying inflammatory diseases. However, there is no literature on the use of this TNF-\u03b1-inhibitor in Cogan\u2019s syndrome in general and especially during gestation. Here we report three pregnancies in two Cogan\u2019s Syndrome-patients treated with Certolizumab pegol. Treatment with Certolizumab pegol was effective and well tolerated in patients with Cogan\u2019s syndrome and seems to be a safe treatment option during pregnancy.<\/jats:p>","DOI":"10.3389\/fimmu.2020.616992","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T04:38:44Z","timestamp":1610944724000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Case Report: Effective and Safe Treatment With Certolizumab Pegol in Pregnant Patients With Cogan\u2019s Syndrome: A Report of Three Pregnancies in Two Patients"],"prefix":"10.3389","volume":"11","author":[{"given":"Nils","family":"Venhoff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Thiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus A.","family":"Schramm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Jandova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard E.","family":"Voll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1945.00890140064007","article-title":"Syndrome of nonsyphilitic interstitial keratitis and vestibuloauditory symptoms","volume":"33","author":"Cogan","year":"1945","journal-title":"Arch Ophthal"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1498640","DOI":"10.1155\/2018\/14986","article-title":"Autoimmune Inner Ear Disease: Immune Biomarkers, Audiovestibular Aspects, and Therapeutic Modalities of Cogan\u2019s Syndrome","volume":"2018","author":"Shamriz","year":"2018","journal-title":"J Immunol Res"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.10.005","article-title":"Cogan syndrome: Characteristics, outcome and treatment in a French nationwide retrospective study and literature review","volume":"16","author":"Durtette","year":"2017","journal-title":"Autoimmun Rev"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2017.02.009","article-title":"Cogan\u2019s syndrome: State of the art of systemic immunosuppressive treatment in adult and pediatric patients","volume":"16","author":"Mora","year":"2017","journal-title":"Autoimmun Rev"},{"key":"B5","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1136\/annrheumdis-2015-208840","article-title":"The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation","volume":"75","author":"G\u00f6testam Skorpen","year":"2016","journal-title":"Ann Rheumatic Dis"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker302","article-title":"Rheumatoid arthritis and pregnancy: evolution of disease activity and pathophysiological considerations for drug use","volume":"50","author":"Hazes","year":"2011","journal-title":"Rheumatology"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212196","article-title":"Lack of placental transfer of certolizumab pegol during pregnancy: results from CRIB, a prospective, postmarketing, pharmacokinetic study","volume":"77","author":"Mariette","year":"2018","journal-title":"Ann Rheumatic Dis"},{"key":"B8","article-title":"Successful Pregnancy in a Patient with Atypical Cogan\u2019s Syndrome","volume":"18","author":"Riboni","year":"2016","journal-title":"Isr Med Assoc J"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e227917","DOI":"10.1136\/bcr-2018-227917","article-title":"Off-label application of intravenous immunoglobulin (IVIG) for treatment of Cogan\u2019s syndrome during pregnancy","volume":"12","author":"Scherg","year":"2019","journal-title":"BMJ Case Rep"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-007-0664-4","article-title":"Successful full-term pregnancy in a woman with Cogan\u2019s syndrome: a case report","volume":"26","author":"Deliveliotou","year":"2007","journal-title":"Clin Rheumatol"},{"key":"B11","article-title":"A rare case of uneventful pregnancy in a woman with Cogan\u2019s syndrome","volume":"35","author":"Bakalianou","year":"2008","journal-title":"Clin Exp Obstet Gynecol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1080\/14767050902974236","article-title":"Cogan\u2019s syndrome complicating pregnancy","volume":"22","author":"Currie","year":"2009","journal-title":"J Matern Fetal Neonatal Med"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000390","article-title":"Cogan syndrome in pregnancy","volume":"124","author":"Tarney","year":"2014","journal-title":"Obstet Gynecol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-211384","article-title":"Minimal to no transfer of certolizumab pegol into breast milk: results from CRADLE, a prospective, postmarketing, multicentre, pharmacokinetic study","volume":"76","author":"Clowse","year":"2017","journal-title":"Ann Rheum Dis"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.616992\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T04:38:45Z","timestamp":1610944725000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2020.616992\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,18]]},"references-count":14,"alternative-id":["10.3389\/fimmu.2020.616992"],"URL":"https:\/\/doi.org\/10.3389\/fimmu.2020.616992","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,18]]},"article-number":"616992"}}