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Immunol."],"abstract":"<jats:p>Likely as in other viral respiratory diseases, SARS-CoV-2 elicit a local immune response, which includes production and releasing of both cytokines and secretory immunoglobulin (SIgA). Therefore, in this study, we investigated the levels of specific-SIgA for SARS-CoV-2 and cytokines in the airways mucosa 37 patients who were suspected of COVID-19. According to the RT-PCR results, the patients were separated into three groups: negative for COVID-19 and other viruses (NEGS,<jats:italic>n<\/jats:italic>= 5); negative for COVID-19 but positive for the presence of other viruses (OTHERS,<jats:italic>n<\/jats:italic>= 5); and the positive for COVID-19 (COVID-19,<jats:italic>n<\/jats:italic>= 27). Higher specific-SIgA for SARS-CoV-2, IFN-\u03b2, and IFN-\u03b3 were found in the COVID-19 group than in the other groups. Increased IL-12p70 levels were observed in OTHERS group as compared to COVID-19 group. When the COVID-19 group was sub stratified according to the illness severity, significant differences and correlations were found for the same parameters described above comparing severe COVID-19 to the mild COVID-19 group and other non-COVID-19 groups. For the first time, significant differences are shown in the airway's mucosa immune responses in different groups of patients with or without respiratory SARS-CoV-2 infection.<\/jats:p>","DOI":"10.3389\/fimmu.2021.595343","type":"journal-article","created":{"date-parts":[[2021,2,25]],"date-time":"2021-02-25T04:28:57Z","timestamp":1614227337000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["In Nasal Mucosal Secretions, Distinct IFN and IgA Responses Are Found in Severe and Mild SARS-CoV-2 Infection"],"prefix":"10.3389","volume":"12","author":[{"given":"Juliana de Melo Batista dos","family":"Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Pereira","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda 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