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A higher prevalence of HT in women with PCOS, relative to healthy individuals, is observed consistently. Combined occurrence of both diseases is associated with a higher risk of severe metabolic and reproductive complications. Genetic factors strongly impact the pathogenesis of both PCOS and HT and several susceptibility loci associated with a higher risk of both disorders have been identified. Furthermore, some candidate gene polymorphisms are thought to be functionally relevant; however, few genetic variants are proposed to be causally associated with the incidence of both disorders together.<\/jats:p>","DOI":"10.3389\/fimmu.2021.606620","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T13:32:30Z","timestamp":1614346350000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Genetic Susceptibility to Joint Occurrence of Polycystic Ovary Syndrome and Hashimoto\u2019s Thyroiditis: How Far Is Our Understanding?"],"prefix":"10.3389","volume":"12","author":[{"given":"Natalia","family":"Zeber-Lubecka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa 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