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Neonatal oral PPI-Fc vaccination did not prevent diabetes development in PPI T-cell receptor-transgenic G9C8.NOD mice. However, PPI-Fc was efficiently transferred through the intestinal epithelium in an Fc- and FcRn-dependent manner, was taken up by antigen presenting cells, and reached the spleen and thymus. Although not statistically significant, neonatal oral PPI-Fc vaccination delayed diabetes onset in polyclonal <jats:italic>Ins2<\/jats:italic><jats:sup>-\/-<\/jats:sup>.NOD mice that spontaneously develop accelerated diabetes. Thus, this strategy shows promise in terms of systemic and thymic antigen delivery <jats:italic>via<\/jats:italic> the intestinal FcRn pathway, but the current PPI-Fc formulation\/regimen requires further improvements to achieve diabetes prevention.<\/jats:p>","DOI":"10.3389\/fimmu.2021.616215","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T04:30:07Z","timestamp":1628569807000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Oral Fc-Coupled Preproinsulin Achieves Systemic and Thymic Delivery Through the Neonatal Fc Receptor and Partially Delays Autoimmune 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