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Immunol."],"abstract":"<jats:p>Expression of tissue-restricted antigens (TRAs) in thymic epithelial cells (TECs) ensures negative selection of highly self-reactive T cells to establish central tolerance. Whether some of these TRAs could exert their canonical biological functions to shape thymic environment to regulate T cell development is unclear. Analyses of publicly available databases have revealed expression of transcripts at various levels of many cytokines and cytokine receptors such as IL-15, IL-15R\u03b1, IL-13, and IL-23a in both human and mouse TECs. Ablation of either IL-15 or IL-15R\u03b1 in TECs selectively impairs type 1 innate like T cell, such as <jats:italic>i<\/jats:italic>NKT1 and \u03b3\u03b4T1 cell, development in the thymus, indicating that TECs not only serve as an important source of IL-15 but also trans-present IL-15 to ensure type 1 innate like T cell development. Because type 1 innate like T cells are proinflammatory, our data suggest the possibility that TEC may intrinsically control thymic inflammatory innate like T cells to influence thymic environment.<\/jats:p>","DOI":"10.3389\/fimmu.2021.623280","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T05:34:37Z","timestamp":1614576877000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor \u03b1 Chain Foster Local Environment for Type 1 Innate Like T Cell 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